PubMed

Roles of Kisspeptins in the Control of Hypothalamic-Gonadotropic Function: Focus on Sexual Differentiation and Puberty Onset.

Tena-Sempere M.

Endocr Dev. 2010;17:52-62. Epub 2009 Nov 24.PMID: 19955756 [PubMed - as supplied by publisher]Related articles

Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist.

Pineda R, Garcia-Galiano D, Roseweir A, Romero M, Sanchez-Garrido MA, Ruiz-Pino F, Morgan K, Pinilla L, Millar RP, Tena-Sempere M.

Endocrinology. 2009 Dec 1. [Epub ahead of print]PMID: 19952274 [PubMed - as supplied by publisher]Related articles

Maturation of kisspeptinergic neurons coincides with puberty onset in male rats.

Bentsen AH, Ansel L, Simonneaux V, Tena-Sempere M, Juul A, Mikkelsen JD.

Peptides. 2009 Nov 26. [Epub ahead of print]PMID: 19944729 [PubMed - as supplied by publisher]Related articles

Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function.

Tena-Sempere M.

Int J Androl. 2009 Nov 10. [Epub ahead of print]PMID: 19906185 [PubMed - as supplied by publisher]Related articles

Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific manner.

González CR, Caminos JE, Gallego R, Tovar S, Vázquez MJ, Garcés MF, Lopez M, García-Caballero T, Tena-Sempere M, Nogueiras R, Diéguez C.

Physiol Behav. 2009 Nov 1. [Epub ahead of print]PMID: 19887079 [PubMed - as supplied by publisher]Related articles

Orexins (hypocretins) actions on the GHRH/somatostatin-GH axis.

López M, Nogueiras R, Tena-Sempere M, Diéguez C.

Acta Physiol (Oxf). 2009 Sep 21. [Epub ahead of print]PMID: 19769635 [PubMed - as supplied by publisher]Related articles

The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

Roa J, Garcia-Galiano D, Varela L, Sánchez-Garrido MA, Pineda R, Castellano JM, Ruiz-Pino F, Romero M, Aguilar E, López M, Gaytan F, Diéguez C, Pinilla L, Tena-Sempere M.

Endocrinology. 2009 Nov;150(11):5016-26. Epub 2009 Sep 4.PMID: 19734277 [PubMed - indexed for MEDLINE]Related articles

Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes).

López M, Tena-Sempere M, Diéguez C.

Front Neuroendocrinol. 2009 Aug 3. [Epub ahead of print]PMID: 19654017 [PubMed - as supplied by publisher]Related articles

[Neuroendocrinology of reproduction: the kisspeptin age]

Tena-Sempere M.

Endocrinol Nutr. 2009 Mar;56(3):103-5. Epub 2009 May 18. Spanish. No abstract available. PMID: 19627721 [PubMed - indexed for MEDLINE]Related articles

Orexins and the regulation of the hypothalamic-pituitary-testicular axis.

Nurmio M, Tena-Sempere M, Toppari J.

Acta Physiol (Oxf). 2009 May 20. [Epub ahead of print]PMID: 19476455 [PubMed - as supplied by publisher]Related articles

Kisspeptin signaling in the brain: Recent developments and future challenges.

Tena-Sempere M.

Mol Cell Endocrinol. 2009 May 21. [Epub ahead of print]PMID: 19464345 [PubMed - as supplied by publisher]Related articles

In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides.

Gutiérrez-Pascual E, Leprince J, Martínez-Fuentes AJ, Ségalas-Milazzo I, Pineda R, Roa J, Duran-Prado M, Guilhaudis L, Desperrois E, Lebreton A, Pinilla L, Tonon MC, Malagón MM, Vaudry H, Tena-Sempere M, Castaño JP.

Mol Pharmacol. 2009 Jul;76(1):58-67. Epub 2009 Apr 23.PMID: 19389922 [PubMed - indexed for MEDLINE]Related articles

Ovarian luteinizing hormone priming preceding follicle-stimulating hormone stimulation: clinical and endocrine effects in women with long-term hypogonadotropic hypogonadism.

Balasch J, Fábregues F, Carmona F, Casamitjana R, Tena-Sempere M.

J Clin Endocrinol Metab. 2009 Jul;94(7):2367-73. Epub 2009 Apr 14.PMID: 19366842 [PubMed - indexed for MEDLINE]Related articles

Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation.

Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP.

J Neurosci. 2009 Mar 25;29(12):3920-9.PMID: 19321788 [PubMed - indexed for MEDLINE]Related articlesFree article

Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system.

Pinilla L, Castellano JM, Romero M, Tena-Sempere M, Gaytán F, Aguilar E.

Endocrinology. 2009 Jun;150(6):2889-97. Epub 2009 Feb 19.PMID: 19228890 [PubMed - indexed for MEDLINE]Related articles

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction.

Gaytán F, Gaytán M, Castellano JM, Romero M, Roa J, Aparicio B, Garrido N, Sánchez-Criado JE, Millar RP, Pellicer A, Fraser HM, Tena-Sempere M.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E520-31. Epub 2009 Jan 13.PMID: 19141682 [PubMed - indexed for MEDLINE]Related articles

Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation.

Navarro VM, Sánchez-Garrido MA, Castellano JM, Roa J, García-Galiano D, Pineda R, Aguilar E, Pinilla L, Tena-Sempere M.

Endocrinology. 2009 May;150(5):2359-67. Epub 2008 Dec 23.PMID: 19106226 [PubMed - indexed for MEDLINE]Related articles

Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals.

Felip A, Zanuy S, Pineda R, Pinilla L, Carrillo M, Tena-Sempere M, Gómez A.

Mol Cell Endocrinol. 2009 Nov 27;312(1-2):61-71. Epub 2008 Nov 25.PMID: 19084576 [PubMed - in process]Related articles

Timeline: the role of kisspeptins in reproductive biology.

Tena-Sempere M.

Nat Med. 2008 Nov;14(11):1196. No abstract available. PMID: 18989306 [PubMed - indexed for MEDLINE]Related articles

Ghrelin as a pleotrophic modulator of gonadal function and reproduction.

Tena-Sempere M.

Nat Clin Pract Endocrinol Metab. 2008 Dec;4(12):666-74. Epub 2008 Nov 4. Review.PMID: 18981992 [PubMed - indexed for MEDLINE]Related articles

Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences.

Castellano JM, Navarro VM, Roa J, Pineda R, Sánchez-Garrido MA, García-Galiano D, Vigo E, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Endocrinology. 2009 Feb;150(2):784-94. Epub 2008 Oct 9.PMID: 18845637 [PubMed - indexed for MEDLINE]Related articles

Kisspeptins and the control of gonadotropin secretion in male and female rodents.

Roa J, Castellano JM, Navarro VM, Handelsman DJ, Pinilla L, Tena-Sempere M.

Peptides. 2009 Jan;30(1):57-66. Epub 2008 Aug 22. Review.PMID: 18793689 [PubMed - indexed for MEDLINE]Related articles

Intracellular signaling pathways activated by kisspeptins through GPR54: do multiple signals underlie function diversity?

Castaño JP, Martínez-Fuentes AJ, Gutiérrez-Pascual E, Vaudry H, Tena-Sempere M, Malagón MM.

Peptides. 2009 Jan;30(1):10-5. Epub 2008 Aug 15. Review.PMID: 18775460 [PubMed - indexed for MEDLINE]Related articles

Editorial.

Tena-Sempere M, Vaudry H.

Peptides. 2009 Jan;30(1):1-3. Epub 2008 Aug 14. No abstract available. PMID: 18771699 [PubMed - indexed for MEDLINE]Related articles

Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors.

Roa J, Vigo E, Castellano JM, Gaytan F, García-Galiano D, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG, Pinilla L, van Noort PI, Tena-Sempere M.

Endocrinology. 2008 Nov;149(11):5783-90. Epub 2008 Jul 17.PMID: 18635654 [PubMed - indexed for MEDLINE]Related articlesFree article

KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications.

Castellano JM, Roa J, Luque RM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Peptides. 2009 Jan;30(1):139-45. Epub 2008 Jun 21. Review.PMID: 18634841 [PubMed - indexed for MEDLINE]Related articles

Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats.

Sirotkin AV, Chrenková M, Nitrayová S, Patras P, Darlak K, Valenzuela F, Pinilla L, Tena-Sempere M.

Peptides. 2008 Aug;29(8):1362-8. Epub 2008 Mar 21.PMID: 18455268 [PubMed - indexed for MEDLINE]Related articles

Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states.

Roa J, Vigo E, García-Galiano D, Castellano JM, Navarro VM, Pineda R, Diéguez C, Aguilar E, Pinilla L, Tena-Sempere M.

Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1088-96. Epub 2008 Apr 15.PMID: 18413669 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel expression and direct effects of adiponectin in the rat testis.

Caminos JE, Nogueiras R, Gaytán F, Pineda R, González CR, Barreiro ML, Castaño JP, Malagón MM, Pinilla L, Toppari J, Diéguez C, Tena-Sempere M.

Endocrinology. 2008 Jul;149(7):3390-402. Epub 2008 Apr 10.PMID: 18403483 [PubMed - indexed for MEDLINE]Related articlesFree article

The ovary-mediated FSH attenuation of the LH surge in the rat involves a decreased gonadotroph progesterone receptor (PR) action but not PR expression.

Gordon A, Garrido-Gracia JC, Aguilar R, Bellido C, Velasco JA, Millan Y, Tena-Sempere M, Martín de Las Mulas J, Sánchez-Criado JE.

J Endocrinol. 2008 Mar;196(3):583-92.PMID: 18310454 [PubMed - indexed for MEDLINE]Related articlesFree article

Maternal serum ghrelin levels in early IVF pregnancies: lack of prognostic value for viable pregnancy and altered post-prandial responses.

Vidal C, Roa J, Pinilla L, Pellicer A, Tena-Sempere M.

Hum Reprod. 2008 Apr;23(4):958-63. Epub 2008 Feb 15.PMID: 18281683 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin induces growth hormone secretion via a nitric oxide/cGMP signalling pathway.

Rodríguez-Pacheco F, Luque RM, Tena-Sempere M, Malagón MM, Castaño JP.

J Neuroendocrinol. 2008 Mar;20(3):406-12. Epub 2008 Jan 15.PMID: 18208548 [PubMed - indexed for MEDLINE]Related articles

Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge.

Roa J, Vigo E, Castellano JM, Gaytan F, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG, Pinilla L, van Noort PI, Tena-Sempere M.

Endocrinology. 2008 Apr;149(4):1627-37. Epub 2008 Jan 3.PMID: 18174277 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis.

Tena-Sempere M.

Vitam Horm. 2008;77:285-300. Review.PMID: 17983861 [PubMed - indexed for MEDLINE]Related articles

The KiSS-1/GPR54 system: putative target for endocrine disruption of reproduction at hypothalamic-pituitary unit?

Navarro VM, Tena-Sempere M.

Int J Androl. 2008 Apr;31(2):224-32. Epub 2007 Oct 31. Review.PMID: 17971159 [PubMed - indexed for MEDLINE]Related articles

New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function.

Roa J, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M.

Front Neuroendocrinol. 2008 Jan;29(1):48-69. Epub 2007 Aug 11. Review.PMID: 17870152 [PubMed - indexed for MEDLINE]Related articles

Roles of ghrelin and leptin in the control of reproductive function.

Tena-Sempere M.

Neuroendocrinology. 2007;86(3):229-41. Epub 2007 Sep 12.PMID: 17851226 [PubMed - indexed for MEDLINE]Related articles

Selective role of neuropeptide Y receptor subtype Y2 in the control of gonadotropin secretion in the rat.

Pinilla L, Fernández-Fernández R, Roa J, Castellano JM, Tena-Sempere M, Aguilar E.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1385-92. Epub 2007 Sep 4.PMID: 17785504 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod.

Vigo E, Roa J, Pineda R, Castellano JM, Navarro VM, Aguilar E, Pinilla L, Tena-Sempere M.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1265-73. Epub 2007 Aug 28.PMID: 17726140 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen.

Fernández-Fernández R, Tena-Sempere M, Roa J, Castellano JM, Navarro VM, Aguilar E, Pinilla L.

Reproduction. 2007 Jun;133(6):1223-32.PMID: 17636176 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line.

Luque RM, Kineman RD, Tena-Sempere M.

Endocrinology. 2007 Oct;148(10):4601-11. Epub 2007 Jun 26.PMID: 17595226 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of leptin and adiponectin in the rat oviduct.

Archanco M, Gómez-Ambrosi J, Tena-Sempere M, Frühbeck G, Burrell MA.

J Histochem Cytochem. 2007 Oct;55(10):1027-37. Epub 2007 Jun 12.PMID: 17565119 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion.

Gutiérrez-Pascual E, Martínez-Fuentes AJ, Pinilla L, Tena-Sempere M, Malagón MM, Castaño JP.

J Neuroendocrinol. 2007 Jul;19(7):521-30.PMID: 17532794 [PubMed - indexed for MEDLINE]Related articles

Expression of KiSS-1 in rat oviduct: possible involvement in prevention of ectopic implantation?

Gaytán M, Castellano JM, Roa J, Sánchez-Criado JE, Tena-Sempere M, Gaytán F.

Cell Tissue Res. 2007 Sep;329(3):571-9. Epub 2007 May 15.PMID: 17503086 [PubMed - indexed for MEDLINE]Related articles

Role of ghrelin in reproduction.

García MC, López M, Alvarez CV, Casanueva F, Tena-Sempere M, Diéguez C.

Reproduction. 2007 Mar;133(3):531-40. Review.PMID: 17379649 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin.

Navarro VM, Castellano JM, García-Galiano D, Tena-Sempere M.

Rev Endocr Metab Disord. 2007 Mar;8(1):11-20. Review.PMID: 17340172 [PubMed - indexed for MEDLINE]Related articles

KiSS-1 system and reproduction: comparative aspects and roles in the control of female gonadotropic axis in mammals.

Roa J, Tena-Sempere M.

Gen Comp Endocrinol. 2007 Aug-Sep;153(1-3):132-40. Epub 2007 Jan 30. Review.PMID: 17324425 [PubMed - indexed for MEDLINE]Related articles

Sexual differentiation of Kiss1 gene expression in the brain of the rat.

Kauffman AS, Gottsch ML, Roa J, Byquist AC, Crown A, Clifton DK, Hoffman GE, Steiner RA, Tena-Sempere M.

Endocrinology. 2007 Apr;148(4):1774-83. Epub 2007 Jan 4.PMID: 17204549 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuromedin s as novel putative regulator of luteinizing hormone secretion.

Vigo E, Roa J, López M, Castellano JM, Fernandez-Fernandez R, Navarro VM, Pineda R, Aguilar E, Diéguez C, Pinilla L, Tena-Sempere M.

Endocrinology. 2007 Feb;148(2):813-23. Epub 2006 Nov 16.PMID: 17110433 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pituitary cell function by adiponectin.

Rodriguez-Pacheco F, Martinez-Fuentes AJ, Tovar S, Pinilla L, Tena-Sempere M, Dieguez C, Castaño JP, Malagon MM.

Endocrinology. 2007 Jan;148(1):401-10. Epub 2006 Oct 12.PMID: 17038552 [PubMed - indexed for MEDLINE]Related articlesFree article