PubMed

PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells.

Woodward HN, Anwar A, Riddle S, Taraseviciene-Stewart L, Fragoso M, Stenmark KR, Gerasimovskaya EV.

Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L954-64. Epub 2009 Aug 14.PMID: 19684203 [PubMed - indexed for MEDLINE]Related articles

Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone.

Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, Fagan KA, McMurtry IF, Oka M.

Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L71-8. Epub 2008 May 9.PMID: 18469113 [PubMed - indexed for MEDLINE]Related articlesFree article

Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study.

Ulrich S, Taraseviciene-Stewart L, Huber LC, Speich R, Voelkel N.

Respir Res. 2008 Feb 12;9:20.PMID: 18269757 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular pathogenesis of emphysema.

Taraseviciene-Stewart L, Voelkel NF.

J Clin Invest. 2008 Feb;118(2):394-402. Review.PMID: 18246188 [PubMed - indexed for MEDLINE]Related articlesFree article

Pulmonary arterial remodeling induced by a Th2 immune response.

Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J, Kurup VP, Hogaboam C, Taraseviciene-Stewart L, Voelkel NF, Rabinovitch M, Grunig E, Grunig G.

J Exp Med. 2008 Feb 18;205(2):361-72. Epub 2008 Jan 28.PMID: 18227220 [PubMed - indexed for MEDLINE]Related articlesFree article

VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells.

Sakao S, Taraseviciene-Stewart L, Cool CD, Tada Y, Kasahara Y, Kurosu K, Tanabe N, Takiguchi Y, Tatsumi K, Kuriyama T, Voelkel NF.

FASEB J. 2007 Nov;21(13):3640-52. Epub 2007 Jun 13.PMID: 17567571 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling.

Taraseviciene-Stewart L, Nicolls MR, Kraskauskas D, Scerbavicius R, Burns N, Cool C, Wood K, Parr JE, Boackle SA, Voelkel NF.

Am J Respir Crit Care Med. 2007 Jun 15;175(12):1280-9. Epub 2007 Apr 5.PMID: 17413127 [PubMed - indexed for MEDLINE]Related articlesFree article

Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.

Oka M, Homma N, Taraseviciene-Stewart L, Morris KG, Kraskauskas D, Burns N, Voelkel NF, McMurtry IF.

Circ Res. 2007 Mar 30;100(6):923-9. Epub 2007 Mar 1.PMID: 17332430 [PubMed - indexed for MEDLINE]Related articlesFree article

Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease?

Taraseviciene-Stewart L, Douglas IS, Nana-Sinkam PS, Lee JD, Tuder RM, Nicolls MR, Voelkel NF.

Proc Am Thorac Soc. 2006 Nov;3(8):687-90. Review.PMID: 17065374 [PubMed - indexed for MEDLINE]Related articlesFree article

N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema.

Demura Y, Taraseviciene-Stewart L, Scerbavicius R, Tuder RM, Voelkel NF.

COPD. 2004 Apr;1(1):25-32.PMID: 16997736 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of autoimmune emphysema.

Taraseviciene-Stewart L, Burns N, Kraskauskas D, Nicolls MR, Tuder RM, Voelkel NF.

Proc Am Thorac Soc. 2006 Aug;3(6):486-7. No abstract available. PMID: 16921121 [PubMed - indexed for MEDLINE]Related articlesFree article

Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension.

Taraseviciene-Stewart L, Scerbavicius R, Choe KH, Cool C, Wood K, Tuder RM, Burns N, Kasper M, Voelkel NF.

Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L668-76. Epub 2006 May 12.PMID: 16698853 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptosis of pulmonary microvascular endothelial cells stimulates vascular smooth muscle cell growth.

Sakao S, Taraseviciene-Stewart L, Wood K, Cool CD, Voelkel NF.

Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L362-8. Epub 2006 Apr 14.PMID: 16617095 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of caveolin and heme oxygenase expression in severe pulmonary hypertension.

Achcar RO, Demura Y, Rai PR, Taraseviciene-Stewart L, Kasper M, Voelkel NF, Cool CD.

Chest. 2006 Mar;129(3):696-705.PMID: 16537870 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema.

Petrache I, Fijalkowska I, Zhen L, Medler TR, Brown E, Cruz P, Choe KH, Taraseviciene-Stewart L, Scerbavicius R, Shapiro L, Zhang B, Song S, Hicklin D, Voelkel NF, Flotte T, Tuder RM.

Am J Respir Crit Care Med. 2006 Jun 1;173(11):1222-8. Epub 2006 Mar 2.PMID: 16514110 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular endothelial growth factor receptor blockade by SU5416 combined with pulsatile shear stress causes apoptosis and subsequent proliferation of apoptosis-resistant endothelial cells.

Sakao S, Taraseviciene-Stewart L, Lee JD, Wood K, Cool CD, Voelkel NF.

Chest. 2005 Dec;128(6 Suppl):610S-611S. No abstract available. PMID: 16373861 [PubMed - indexed for MEDLINE]Related articlesFree article

The expression of prostacyclin synthase is decreased in the small pulmonary arteries from patients with emphysema.

Lee JD, Taraseviciene-Stewart L, Keith R, Geraci MW, Voelkel NF.

Chest. 2005 Dec;128(6 Suppl):575S. No abstract available. PMID: 16373836 [PubMed - indexed for MEDLINE]Related articlesFree article

The protective role of T-lymphocytes in pulmonary vascular remodeling.

Taraseviciene-Stewart L, Scerbavicius DK, Burns N, Cool CD, Nicolls MR, Voelkel NF.

Chest. 2005 Dec;128(6 Suppl):571S-572S. No abstract available. PMID: 16373829 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmunity and pulmonary hypertension: a perspective.

Nicolls MR, Taraseviciene-Stewart L, Rai PR, Badesch DB, Voelkel NF.

Eur Respir J. 2005 Dec;26(6):1110-8. Review.PMID: 16319344 [PubMed - indexed for MEDLINE]Related articlesFree article

Emphysema: an autoimmune vascular disease?

Voelkel N, Taraseviciene-Stewart L.

Proc Am Thorac Soc. 2005;2(1):23-5. Review.PMID: 16113465 [PubMed - indexed for MEDLINE]Related articlesFree article

Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells.

Sakao S, Taraseviciene-Stewart L, Lee JD, Wood K, Cool CD, Voelkel NF.

FASEB J. 2005 Jul;19(9):1178-80. Epub 2005 May 16.PMID: 15897232 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination cancer chemotherapy with one compound: pluripotent bradykinin antagonists.

Stewart JM, Gera L, Chan DC, York EJ, Simkeviciene V, Bunn PA Jr, Taraseviciene-Stewart L.

Peptides. 2005 Aug;26(8):1288-91.PMID: 15878795 [PubMed - indexed for MEDLINE]Related articles

Treatment of severe pulmonary hypertension: a bradykinin receptor 2 agonist B9972 causes reduction of pulmonary artery pressure and right ventricular hypertrophy.

Taraseviciene-Stewart L, Scerbavicius R, Stewart JM, Gera L, Demura Y, Cool C, Kasper M, Voelkel NF.

Peptides. 2005 Aug;26(8):1292-300.PMID: 15878794 [PubMed - indexed for MEDLINE]Related articles

An animal model of autoimmune emphysema.

Taraseviciene-Stewart L, Scerbavicius R, Choe KH, Moore M, Sullivan A, Nicolls MR, Fontenot AP, Tuder RM, Voelkel NF.

Am J Respir Crit Care Med. 2005 Apr 1;171(7):734-42. Epub 2004 Nov 24.PMID: 15563631 [PubMed - indexed for MEDLINE]Related articlesFree article

Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth.

Golpon HA, Fadok VA, Taraseviciene-Stewart L, Scerbavicius R, Sauer C, Welte T, Henson PM, Voelkel NF.

FASEB J. 2004 Nov;18(14):1716-8. Epub 2004 Sep 2.PMID: 15345697 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade.

Tuder RM, Zhen L, Cho CY, Taraseviciene-Stewart L, Kasahara Y, Salvemini D, Voelkel NF, Flores SC.

Am J Respir Cell Mol Biol. 2003 Jul;29(1):88-97. Epub 2003 Jan 31.PMID: 12600822 [PubMed - indexed for MEDLINE]Related articlesFree article

Methylprednisolone causes matrix metalloproteinase-dependent emphysema in adult rats.

Choe KH, Taraseviciene-Stewart L, Scerbavicius R, Gera L, Tuder RM, Voelkel NF.

Am J Respir Crit Care Med. 2003 Jun 1;167(11):1516-21. Epub 2003 Jan 9.PMID: 12522028 [PubMed - indexed for MEDLINE]Related articlesFree article

Bradykinin antagonists as new drugs for prostate cancer.

Stewart JM, Chan DC, Simkeviciene V, Bunn PA Jr, Helfrich B, York EJ, Taraseviciene-Stewart L, Bironaite D, Gera L.

Int Immunopharmacol. 2002 Dec;2(13-14):1781-6.PMID: 12489792 [PubMed - indexed for MEDLINE]Related articles

A bradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in a rat model.

Taraseviciene-Stewart L, Gera L, Hirth P, Voelkel NF, Tuder RM, Stewart JM.

Can J Physiol Pharmacol. 2002 Apr;80(4):269-74.PMID: 12025960 [PubMed - indexed for MEDLINE]Related articles

Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis.

Tuder RM, Chacon M, Alger L, Wang J, Taraseviciene-Stewart L, Kasahara Y, Cool CD, Bishop AE, Geraci M, Semenza GL, Yacoub M, Polak JM, Voelkel NF.

J Pathol. 2001 Oct;195(3):367-74.PMID: 11673836 [PubMed - indexed for MEDLINE]Related articles

The pathobiology of pulmonary hypertension. Endothelium.

Tuder RM, Cool CD, Yeager M, Taraseviciene-Stewart L, Bull TM, Voelkel NF.

Clin Chest Med. 2001 Sep;22(3):405-18. Review.PMID: 11590837 [PubMed - indexed for MEDLINE]Related articles

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension.

Taraseviciene-Stewart L, Kasahara Y, Alger L, Hirth P, Mc Mahon G, Waltenberger J, Voelkel NF, Tuder RM.

FASEB J. 2001 Feb;15(2):427-38.PMID: 11156958 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema.

Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, Waltenberger J, Voelkel NF.

J Clin Invest. 2000 Dec;106(11):1311-9.PMID: 11104784 [PubMed - indexed for MEDLINE]Related articlesFree article