PubMed

Overexpression of Reg3alpha increases cell growth and the levels of cyclin D1 and CDK4 in insulinoma cells.

Cui W, De Jesus K, Zhao H, Takasawa S, Shi B, Srikant CB, Liu JL.

Growth Factors. 2009 Jun;27(3):195-202.PMID: 19343564 [PubMed - indexed for MEDLINE]Related articles

Important role of heparan sulfate in postnatal islet growth and insulin secretion.

Takahashi I, Noguchi N, Nata K, Yamada S, Kaneiwa T, Mizumoto S, Ikeda T, Sugihara K, Asano M, Yoshikawa T, Yamauchi A, Shervani NJ, Uruno A, Kato I, Unno M, Sugahara K, Takasawa S, Okamoto H, Sugawara A.

Biochem Biophys Res Commun. 2009 May 22;383(1):113-8. Epub 2009 Mar 29.PMID: 19336225 [PubMed - indexed for MEDLINE]Related articles

Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal cancer cells.

Yamauchi A, Takahashi I, Takasawa S, Nata K, Noguchi N, Ikeda T, Yoshikawa T, Shervani NJ, Suzuki I, Uruno A, Unno M, Okamoto H, Sugawara A.

Biochem Biophys Res Commun. 2009 Feb 13;379(3):743-8. Epub 2008 Dec 30.PMID: 19118520 [PubMed - indexed for MEDLINE]Related articles

Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice.

Suzuki H, Kato I, Usui I, Takasaki I, Tabuchi Y, Oya T, Tsuneyama K, Kawaguchi H, Hiraga K, Takasawa S, Okamoto H, Tobe K, Sasahara M.

Biochem Biophys Res Commun. 2009 Jan 30;379(1):38-42. Epub 2008 Dec 12.PMID: 19070598 [PubMed - indexed for MEDLINE]Related articles

REG I enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells.

Hayashi K, Motoyama S, Koyota S, Koizumi Y, Wang J, Takasawa S, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Maruyama K, Saito H, Minamiya Y, Ogawa J, Sugiyama T.

Cancer Sci. 2008 Dec;99(12):2491-5. Epub 2008 Nov 20.PMID: 19032369 [PubMed - indexed for MEDLINE]Related articles

Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice.

Liu HX, Lopatina O, Higashida C, Tsuji T, Kato I, Takasawa S, Okamoto H, Yokoyama S, Higashida H.

Neurosci Lett. 2008 Dec 19;448(1):67-70. Epub 2008 Oct 8.PMID: 18926879 [PubMed - indexed for MEDLINE]Related articles

A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cells.

Kato I, Oya T, Suzuki H, Takasawa K, Ichsan AM, Nakada S, Ishii Y, Shimada Y, Sasahara M, Tobe K, Takasawa S, Okamoto H, Hiraga K.

Diabetes Metab Res Rev. 2008 Sep;24(6):486-97.PMID: 18551708 [PubMed - indexed for MEDLINE]Related articles

FKBP12.6 disruption impairs glucose-induced insulin secretion.

Noguchi N, Yoshikawa T, Ikeda T, Takahashi I, Shervani NJ, Uruno A, Yamauchi A, Nata K, Takasawa S, Okamoto H, Sugawara A.

Biochem Biophys Res Commun. 2008 Jul 11;371(4):735-40. Epub 2008 May 6.PMID: 18466757 [PubMed - indexed for MEDLINE]Related articles

REG Ialpha protein expression in Barrett's esophagus.

Chinuki D, Amano Y, Ishihara S, Moriyama N, Ishimura N, Kazumori H, Kadowaki Y, Takasawa S, Okamoto H, Kinoshita Y.

J Gastroenterol Hepatol. 2008 Feb;23(2):296-302.PMID: 18289358 [PubMed - indexed for MEDLINE]Related articles

REG Ialpha is a reliable marker of chemoradiosensitivity in squamous cell esophageal cancer patients.

Hayashi K, Motoyama S, Sugiyama T, Izumi J, Anbai A, Nanjo H, Watanabe H, Maruyama K, Minamiya Y, Koyota S, Koizumi Y, Takasawa S, Murata K, Ogawa J.

Ann Surg Oncol. 2008 Apr;15(4):1224-31. Epub 2008 Feb 8.PMID: 18259819 [PubMed - indexed for MEDLINE]Related articles

Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets.

Kim BJ, Park KH, Yim CY, Takasawa S, Okamoto H, Im MJ, Kim UH.

Diabetes. 2008 Apr;57(4):868-78. Epub 2008 Jan 9.PMID: 18184929 [PubMed - indexed for MEDLINE]Related articlesFree article

CD38 is critical for social behaviour by regulating oxytocin secretion.

Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M, Higashida H.

Nature. 2007 Mar 1;446(7131):41-5. Epub 2007 Feb 7.PMID: 17287729 [PubMed - indexed for MEDLINE]Related articles

Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells.

Higashida H, Bowden SE, Yokoyama S, Salmina A, Hashii M, Hoshi N, Zhang JS, Knijnik R, Noda M, Zhong ZG, Jin D, Higashida K, Takeda H, Akita T, Kuba K, Yamagishi S, Shimizu N, Takasawa S, Okamoto H, Robbins J.

Neurosci Res. 2007 Mar;57(3):339-46. Epub 2006 Dec 14.PMID: 17173996 [PubMed - indexed for MEDLINE]Related articles

REG I expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy.

Motoyama S, Sugiyama T, Ueno Y, Okamoto H, Takasawa S, Nanjo H, Watanabe H, Maruyama K, Okuyama M, Ogawa J.

Ann Surg Oncol. 2006 Dec;13(12):1724-31. Epub 2006 Sep 30.PMID: 17009160 [PubMed - indexed for MEDLINE]Related articles

RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin.

Myint KM, Yamamoto Y, Doi T, Kato I, Harashima A, Yonekura H, Watanabe T, Shinohara H, Takeuchi M, Tsuneyama K, Hashimoto N, Asano M, Takasawa S, Okamoto H, Yamamoto H.

Diabetes. 2006 Sep;55(9):2510-22.PMID: 16936199 [PubMed - indexed for MEDLINE]Related articlesFree article

Reg I-knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine.

Ose T, Kadowaki Y, Fukuhara H, Kazumori H, Ishihara S, Udagawa J, Otani H, Takasawa S, Okamoto H, Kinoshita Y.

Oncogene. 2007 Jan 18;26(3):349-59. Epub 2006 Aug 14.PMID: 16909126 [PubMed - indexed for MEDLINE]Related articles

Reg (regenerating) gene overexpression in islets from non-obese diabetic mice with accelerated diabetes: role of IFNbeta.

Planas R, Alba A, Carrillo J, Puertas MC, Ampudia R, Pastor X, Okamoto H, Takasawa S, Gurr W, Pujol-Borrell R, Verdaguer J, Vives-Pi M.

Diabetologia. 2006 Oct;49(10):2379-87. Epub 2006 Aug 10.PMID: 16900387 [PubMed - indexed for MEDLINE]Related articles

Identification of mouse orthologue of endogenous secretory receptor for advanced glycation end-products: structure, function and expression.

Harashima A, Yamamoto Y, Cheng C, Tsuneyama K, Myint KM, Takeuchi A, Yoshimura K, Li H, Watanabe T, Takasawa S, Okamoto H, Yonekura H, Yamamoto H.

Biochem J. 2006 May 15;396(1):109-15.PMID: 16503878 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas.

Lu Y, Ponton A, Okamoto H, Takasawa S, Herrera PL, Liu JL.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E50-8. Epub 2006 Jan 31.PMID: 16449294 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration.

Takasawa S, Ikeda T, Akiyama T, Nata K, Nakagawa K, Shervani NJ, Noguchi N, Murakami-Kawaguchi S, Yamauchi A, Takahashi I, Tomioka-Kumagai T, Okamoto H.

FEBS Lett. 2006 Jan 23;580(2):585-91. Epub 2005 Dec 29.PMID: 16405968 [PubMed - indexed for MEDLINE]Related articles

Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6.

Nakazawa T, Takasawa S, Noguchi N, Nata K, Tohgo A, Mori M, Nakagawara K, Akiyama T, Ikeda T, Yamauchi A, Takahashi I, Yoshikawa T, Okamoto H.

Gene. 2005 Oct 24;360(1):55-64. Epub 2005 Aug 24.PMID: 16122887 [PubMed - indexed for MEDLINE]Related articles

Receptor for advanced glycation end products is a promising target of diabetic nephropathy.

Yamamoto Y, Doi T, Kato I, Shinohara H, Sakurai S, Yonekura H, Watanabe T, Myint KM, Harashima A, Takeuchi M, Takasawa S, Okamoto H, Hashimoto N, Asano M, Yamamoto H.

Ann N Y Acad Sci. 2005 Jun;1043:562-6.PMID: 16037279 [PubMed - indexed for MEDLINE]Related articles

Expression of Reg/PAP family members during motor nerve regeneration in rat.

Namikawa K, Fukushima M, Murakami K, Suzuki A, Takasawa S, Okamoto H, Kiyama H.

Biochem Biophys Res Commun. 2005 Jun 24;332(1):126-34.PMID: 15896308 [PubMed - indexed for MEDLINE]Related articles

Activation of regenerating gene Reg in rat and human hearts in response to acute stress.

Kiji T, Dohi Y, Takasawa S, Okamoto H, Nonomura A, Taniguchi S.

Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H277-84. Epub 2005 Mar 18.PMID: 15778284 [PubMed - indexed for MEDLINE]Related articlesFree article

REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer.

Sekikawa A, Fukui H, Fujii S, Takeda J, Nanakin A, Hisatsune H, Seno H, Takasawa S, Okamoto H, Fujimori T, Chiba T.

Gastroenterology. 2005 Mar;128(3):642-53.PMID: 15765400 [PubMed - indexed for MEDLINE]Related articles

Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III.

Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, Onogawa T, Takasawa S, Okamoto H.

Gene. 2004 Sep 29;340(1):161-70.PMID: 15556304 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients.

Shervani NJ, Takasawa S, Uchigata Y, Akiyama T, Nakagawa K, Noguchi N, Takada H, Takahashi I, Yamauchi A, Ikeda T, Iwamoto Y, Nata K, Okamoto H.

Eur J Clin Invest. 2004 Nov;34(11):752-8.PMID: 15530148 [PubMed - indexed for MEDLINE]Related articles

Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages.

Miyaoka Y, Kadowaki Y, Ishihara S, Ose T, Fukuhara H, Kazumori H, Takasawa S, Okamoto H, Chiba T, Kinoshita Y.

Oncogene. 2004 Apr 29;23(20):3572-9.PMID: 15116092 [PubMed - indexed for MEDLINE]Related articles

Expression of regenerating gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival.

Dhar DK, Udagawa J, Ishihara S, Otani H, Kinoshita Y, Takasawa S, Okamoto H, Kubota H, Fujii T, Tachibana M, Nagasue N.

Cancer. 2004 Mar 15;100(6):1130-6.PMID: 15022278 [PubMed - indexed for MEDLINE]Related articlesFree article

REG I as a marker for human pancreatic acinoductular cells.

Tezel E, Nagasaka T, Tezel G, Kaneko T, Takasawa S, Okamoto H, Nakao A.

Hepatogastroenterology. 2004 Jan-Feb;51(55):91-6.PMID: 15011837 [PubMed - indexed for MEDLINE]Related articles

Cyclic ADP-ribose, a putative Ca2+-mobilizing second messenger, operates in submucosal gland acinar cells.

Sasamori K, Sasaki T, Takasawa S, Tamada T, Nara M, Irokawa T, Shimura S, Shirato K, Hattori T.

Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L69-78. Epub 2004 Feb 27.PMID: 14990397 [PubMed - indexed for MEDLINE]Related articlesFree article

CD38 gene disruption inhibits the contraction induced by alpha-adrenoceptor stimulation in mouse aorta.

Mitsui-Saito M, Kato I, Takasawa S, Okamoto H, Yanagisawa T.

J Vet Med Sci. 2003 Dec;65(12):1325-30.PMID: 14709821 [PubMed - indexed for MEDLINE]Related articles

Temporal changes of neurogenesis in the mouse hippocampus after experimental subarachnoid hemorrhage.

Mino M, Kamii H, Fujimura M, Kondo T, Takasawa S, Okamoto H, Yoshimoto T.

Neurol Res. 2003 Dec;25(8):839-45.PMID: 14669527 [PubMed - indexed for MEDLINE]Related articles

Recent advances in physiological and pathological significance of NAD metabolites: roles of poly(ADP-ribose) and cyclic ADP-ribose in insulin secretion and diabetogenesis.

Okamoto H, Takasawa S.

Nutr Res Rev. 2003 Dec;16(2):253-66.PMID: 19087393 [PubMed - in process]Related articles

Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender.

Takahashi J, Kagaya Y, Kato I, Ohta J, Isoyama S, Miura M, Sugai Y, Hirose M, Wakayama Y, Ninomiya M, Watanabe J, Takasawa S, Okamoto H, Shirato K.

Biochem Biophys Res Commun. 2003 Dec 12;312(2):434-40.PMID: 14637156 [PubMed - indexed for MEDLINE]Related articles

REG gene expression is associated with the infiltrating growth of gastric carcinoma.

Yonemura Y, Sakurai S, Yamamoto H, Endou Y, Kawamura T, Bandou E, Elnemr A, Sugiyama K, Sasaki T, Akiyama T, Takasawa S, Okamoto H.

Cancer. 2003 Oct 1;98(7):1394-400.PMID: 14508825 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of cell viability in cryopreserved rat vascular grafts by administration of regenerating gene (REG) inducers.

Kiji T, Dohi Y, Nishizaki K, Takasawa S, Okamoto H, Nagasaka S, Naito H, Yonemasu K, Taniguchi S.

J Vasc Res. 2003 Mar-Apr;40(2):132-9.PMID: 12808349 [PubMed - indexed for MEDLINE]Related articles

Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model.

Ogawa H, Fukushima K, Naito H, Funayama Y, Unno M, Takahashi K, Kitayama T, Matsuno S, Ohtani H, Takasawa S, Okamoto H, Sasaki I.

Inflamm Bowel Dis. 2003 May;9(3):162-70.PMID: 12792221 [PubMed - indexed for MEDLINE]Related articles

Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma.

Munaka M, Kohshi K, Kawamoto T, Takasawa S, Nagata N, Itoh H, Oda S, Katoh T.

J Cancer Res Clin Oncol. 2003 Jun;129(6):355-60. Epub 2003 May 21.PMID: 12759747 [PubMed - indexed for MEDLINE]Related articles

Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.

Yonekura H, Yamamoto Y, Sakurai S, Petrova RG, Abedin MJ, Li H, Yasui K, Takeuchi M, Makita Z, Takasawa S, Okamoto H, Watanabe T, Yamamoto H.

Biochem J. 2003 Mar 15;370(Pt 3):1097-109.PMID: 12495433 [PubMed - indexed for MEDLINE]Related articlesFree article

Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice.

Unno M, Nata K, Noguchi N, Narushima Y, Akiyama T, Ikeda T, Nakagawa K, Takasawa S, Okamoto H.

Diabetes. 2002 Dec;51 Suppl 3:S478-83.PMID: 12475793 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in beta-cells.

Okamoto H, Takasawa S.

Diabetes. 2002 Dec;51 Suppl 3:S462-73. Review.PMID: 12475791 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes.

Petrova R, Yamamoto Y, Muraki K, Yonekura H, Sakurai S, Watanabe T, Li H, Takeuchi M, Makita Z, Kato I, Takasawa S, Okamoto H, Imaizumi Y, Yamamoto H.

J Mol Cell Cardiol. 2002 Oct;34(10):1425-31.PMID: 12393002 [PubMed - indexed for MEDLINE]Related articles

Reg protein is overexpressed in gastric cancer cells, where it activates a signal transduction pathway that converges on ERK1/2 to stimulate growth.

Kadowaki Y, Ishihara S, Miyaoka Y, Rumi MA, Sato H, Kazumori H, Adachi K, Takasawa S, Okamoto H, Chiba T, Kinoshita Y.

FEBS Lett. 2002 Oct 23;530(1-3):59-64.PMID: 12387866 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta-cell death, regeneration and insulin secretion: roles of poly(ADP-ribose) polymerase and cyclic ADP-ribose.

Takasawa S, Okamoto H.

Int J Exp Diabetes Res. 2002 Apr-Jun;3(2):79-96. Review.PMID: 11991201 [PubMed - indexed for MEDLINE]Related articlesFree article

CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.

Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H.

Biochem J. 2002 Feb 15;362(Pt 1):125-30.PMID: 11829748 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-CD38 autoimmunity in patients with chronic autoimmune thyroiditis or Graves' disease.

Antonelli A, Fallahi P, Nesti C, Pupilli C, Marchetti P, Takasawa S, Okamoto H, Ferrannini E.

Clin Exp Immunol. 2001 Dec;126(3):426-31.PMID: 11737057 [PubMed - indexed for MEDLINE]Related articlesFree article

Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1.

Nakazawa T, Satoh J, Takahashi K, Sakata Y, Ikehata F, Takizawa Y, Bando SI, Housai T, Li Y, Chen C, Masuda T, Kure S, Kato I, Takasawa S, Taniguchi T, Okamoto H, Toyota T.

J Autoimmun. 2001 Sep;17(2):119-25.PMID: 11591120 [PubMed - indexed for MEDLINE]Related articles

Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice.

Yamamoto Y, Kato I, Doi T, Yonekura H, Ohashi S, Takeuchi M, Watanabe T, Yamagishi S, Sakurai S, Takasawa S, Okamoto H, Yamamoto H.

J Clin Invest. 2001 Jul;108(2):261-8.PMID: 11457879 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic CuZn-superoxide dismutase inhibits NO synthase induction in experimental subarachnoid hemorrhage.

Saito A, Kamii H, Kato I, Takasawa S, Kondo T, Chan PH, Okamoto H, Yoshimoto T.

Stroke. 2001 Jul;32(7):1652-7.PMID: 11441215 [PubMed - indexed for MEDLINE]Related articlesFree article