PubMed

Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects.

Moller L, Norrelund H, Jessen N, Flyvbjerg A, Pedersen SB, Gaylinn BD, Liu J, Thorner MO, Moller N, Lunde Jorgensen JO.

J Clin Endocrinol Metab. 2009 Nov;94(11):4524-32. Epub 2009 Oct 9.PMID: 19820031 [PubMed - in process]Related articles

Statement by the Growth Hormone Research Society on the GH/IGF-I axis in extending health span.

Thorner MO.

J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1039-44. Epub 2009 Jul 8.PMID: 19587105 [PubMed - indexed for MEDLINE]Related articles

Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase.

Tham E, Liu J, Innis S, Thompson D, Gaylinn BD, Bogarin R, Haim A, Thorner MO, Chanoine JP.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E1093-100. Epub 2009 Feb 24.PMID: 19240252 [PubMed - indexed for MEDLINE]Related articles

AutoDecon: a robust numerical method for the quantification of pulsatile events.

Johnson ML, Pipes L, Veldhuis PP, Farhy LS, Nass R, Thorner MO, Evans WS.

Methods Enzymol. 2009;454:367-404.PMID: 19216935 [PubMed - indexed for MEDLINE]Related articles

Does low-dose growth hormone therapy improve the body composition of patients infected with HIV?

Nass R, Thorner MO.

Nat Clin Pract Endocrinol Metab. 2009 Mar;5(3):142-3. Epub 2009 Jan 20.PMID: 19153561 [PubMed]Related articles

Growth hormone increases mRNA levels of PPARdelta and Foxo1 in skeletal muscle of growth hormone deficient lit/lit mice.

Kim DS, Itoh E, Iida K, Thorner MO.

Endocr J. 2009 Mar;56(1):141-7. Epub 2008 Nov 8.PMID: 18997443 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.

Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE Jr, Clasey JL, Heymsfield SB, Bach MA, Vance ML, Thorner MO.

Ann Intern Med. 2008 Nov 4;149(9):601-11.PMID: 18981485 [PubMed - indexed for MEDLINE]Related articlesFree article

The aging population--is there a role for endocrine interventions?

Nass R, Johannsson G, Christiansen JS, Kopchick JJ, Thorner MO.

Growth Horm IGF Res. 2009 Apr;19(2):89-100. Epub 2008 Nov 1. Review.PMID: 18977675 [PubMed - indexed for MEDLINE]Related articles

Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models.

Berryman DE, Christiansen JS, Johannsson G, Thorner MO, Kopchick JJ.

Growth Horm IGF Res. 2008 Dec;18(6):455-71. Epub 2008 Aug 16. Review.PMID: 18710818 [PubMed - indexed for MEDLINE]Related articles

Follow-up of pituitary tumor volume in patients with acromegaly treated with pegvisomant in clinical trials.

Jimenez C, Burman P, Abs R, Clemmons DR, Drake WM, Hutson KR, Messig M, Thorner MO, Trainer PJ, Gagel RF.

Eur J Endocrinol. 2008 Nov;159(5):517-23. Epub 2008 Aug 15.PMID: 18708436 [PubMed - indexed for MEDLINE]Related articlesFree article

Cranially irradiated adult cancer survivors may have normal spontaneous GH secretion in the presence of discordant peak GH responses to stimulation tests (compensated GH deficiency).

Darzy KH, Thorner MO, Shalet SM.

Clin Endocrinol (Oxf). 2009 Feb;70(2):287-93. Epub 2008 Jul 31.PMID: 18673465 [PubMed - indexed for MEDLINE]Related articles

The discovery of growth hormone-releasing hormone: an update.

Thorner MO.

J Neuroendocrinol. 2008 Jun;20(6):653-4. No abstract available. PMID: 18601685 [PubMed - indexed for MEDLINE]Related articles

The discovery of growth hormone-releasing hormone.

Thorner MO.

J Neuroendocrinol. 2008 Jun;20(6):647-52. No abstract available. PMID: 18601684 [PubMed]Related articles

William Parson: 1913-2002.

Thorner MO, Gibson R, Virginia C.

Trans Am Clin Climatol Assoc. 2006;117:liii-lvii. No abstract available. PMID: 18528453 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin does not mediate short-term fasting-induced changes in growth hormone pulsatility but increases IGF-I in leptin deficiency states.

Chan JL, Williams CJ, Raciti P, Blakeman J, Kelesidis T, Kelesidis I, Johnson ML, Thorner MO, Mantzoros CS.

J Clin Endocrinol Metab. 2008 Jul;93(7):2819-27. Epub 2008 Apr 29.PMID: 18445667 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men.

Liu J, Prudom CE, Nass R, Pezzoli SS, Oliveri MC, Johnson ML, Veldhuis P, Gordon DA, Howard AD, Witcher DR, Geysen HM, Gaylinn BD, Thorner MO.

J Clin Endocrinol Metab. 2008 May;93(5):1980-7. Epub 2008 Mar 18.PMID: 18349056 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for acyl-ghrelin modulation of growth hormone release in the fed state.

Nass R, Farhy LS, Liu J, Prudom CE, Johnson ML, Veldhuis P, Pezzoli SS, Oliveri MC, Gaylinn BD, Geysen HM, Thorner MO.

J Clin Endocrinol Metab. 2008 May;93(5):1988-94. Epub 2008 Mar 11. Erratum in: J Clin Endocrinol Metab. 2008 Jul;93(7):2922. PMID: 18334589 [PubMed - indexed for MEDLINE]Related articlesFree article

Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates.

Foster-Schubert KE, Overduin J, Prudom CE, Liu J, Callahan HS, Gaylinn BD, Thorner MO, Cummings DE.

J Clin Endocrinol Metab. 2008 May;93(5):1971-9. Epub 2008 Jan 15.PMID: 18198223 [PubMed - indexed for MEDLINE]Related articlesFree article

Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice.

Varady KA, Roohk DJ, McEvoy-Hein BK, Gaylinn BD, Thorner MO, Hellerstein MK.

FASEB J. 2008 Jun;22(6):2090-6. Epub 2008 Jan 9.PMID: 18184721 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone exerts acute vascular effects independent of systemic or muscle insulin-like growth factor I.

Li G, Del Rincon JP, Jahn LA, Wu Y, Gaylinn B, Thorner MO, Liu Z.

J Clin Endocrinol Metab. 2008 Apr;93(4):1379-85. Epub 2008 Jan 8.PMID: 18182451 [PubMed - indexed for MEDLINE]Related articlesFree article

Late recurrences of Cushing's disease after initial successful transsphenoidal surgery.

Patil CG, Prevedello DM, Lad SP, Vance ML, Thorner MO, Katznelson L, Laws ER Jr.

J Clin Endocrinol Metab. 2008 Feb;93(2):358-62. Epub 2007 Dec 4.PMID: 18056770 [PubMed - indexed for MEDLINE]Related articlesFree article

Human studies of growth hormone and aging.

Thorner MO, Nass R.

Pediatr Endocrinol Rev. 2007 Mar;4(3):233-4. Review.PMID: 17551487 [PubMed - indexed for MEDLINE]Related articles

Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.

del Rincon JP, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO.

Diabetes. 2007 Jun;56(6):1638-46. Epub 2007 Mar 15.PMID: 17363744 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone supplementation in the elderly.

Nass R, Park J, Thorner MO.

Endocrinol Metab Clin North Am. 2007 Mar;36(1):233-45. Review.PMID: 17336743 [PubMed - indexed for MEDLINE]Related articles

Cranial irradiation and growth hormone neurosecretory dysfunction: a critical appraisal.

Darzy KH, Pezzoli SS, Thorner MO, Shalet SM.

J Clin Endocrinol Metab. 2007 May;92(5):1666-72. Epub 2007 Feb 6.PMID: 17284618 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning of the chicken pituitary receptor for growth hormone-releasing hormone.

Toogood AA, Harvey S, Thorner MO, Gaylinn BD.

Endocrinology. 2006 Apr;147(4):1838-46. Epub 2006 Jan 5.PMID: 16396988 [PubMed - indexed for MEDLINE]Related articlesFree article

The impact of short-term fasting on the dynamics of 24-hour growth hormone (GH) secretion in patients with severe radiation-induced GH deficiency.

Darzy KH, Murray RD, Gleeson HK, Pezzoli SS, Thorner MO, Shalet SM.

J Clin Endocrinol Metab. 2006 Mar;91(3):987-94. Epub 2005 Dec 29.PMID: 16384844 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of ghrelin protects against early-onset obesity.

Wortley KE, del Rincon JP, Murray JD, Garcia K, Iida K, Thorner MO, Sleeman MW.

J Clin Invest. 2005 Dec;115(12):3573-8.PMID: 16322795 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic differences in the IGF-I gene among inbred strains of mice with different serum IGF-I levels.

Iida K, Rosen CJ, Ackert-Bicknell C, Thorner MO.

J Endocrinol. 2005 Sep;186(3):481-9.PMID: 16135668 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyethylene glycol-conjugated growth hormone-releasing hormone is long acting and stimulates GH in healthy young and elderly subjects.

Munafo A, Nguyen TX, Papasouliotis O, Lécuelle H, Priestley A, Thorner MO.

Eur J Endocrinol. 2005 Aug;153(2):249-56.PMID: 16061831 [PubMed - indexed for MEDLINE]Related articlesFree article

Acromegaly and serum insulin-like growth factor I.

Thorner MO.

Horm Res. 2004;62 Suppl 1:34-6.PMID: 15761230 [PubMed - indexed for MEDLINE]Related articles

The dynamics of growth hormone (GH) secretion in adult cancer survivors with severe GH deficiency acquired after brain irradiation in childhood for nonpituitary brain tumors: evidence for preserved pulsatility and diurnal variation with increased secretory disorderliness.

Darzy KH, Pezzoli SS, Thorner MO, Shalet SM.

J Clin Endocrinol Metab. 2005 May;90(5):2794-803. Epub 2005 Feb 22.PMID: 15728206 [PubMed - indexed for MEDLINE]Related articlesFree article

Diurnal variation in growth hormone receptor messenger ribonucleic acid in liver and skeletal muscle of lit/+ and lit/lit mice.

Itoh E, Iida K, del Rincon JP, Kim DS, Thorner MO.

Endocr J. 2004 Dec;51(6):529-35.PMID: 15644570 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of contribution of 11betaHSD1 and glucocorticoid action to reduced muscle mass associated with reduced growth hormone action.

Itoh E, Iida K, Kim DS, Del Rincon JP, Coschigano KT, Kopchick JJ, Thorner MO.

Growth Horm IGF Res. 2004 Dec;14(6):462-6.PMID: 15519255 [PubMed - indexed for MEDLINE]Related articles

Hexarelin modulates the expression of growth hormone secretagogue receptor type 1a mRNA at hypothalamic and pituitary sites.

Bresciani E, Nass R, Torsello A, Gaylinn B, Avallone R, Locatelli V, Thorner MO, Müller EE.

Neuroendocrinology. 2004;80(1):52-9. Epub 2004 Sep 10.PMID: 15361691 [PubMed - indexed for MEDLINE]Related articles

Primary hypophysitis: a single-center experience in 16 cases.

Leung GK, Lopes MB, Thorner MO, Vance ML, Laws ER Jr.

J Neurosurg. 2004 Aug;101(2):262-71.PMID: 15309917 [PubMed - indexed for MEDLINE]Related articles

Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone-deficient lit/lit mice.

Iida K, Itoh E, Kim DS, del Rincon JP, Coschigano KT, Kopchick JJ, Thorner MO.

J Physiol. 2004 Oct 15;560(Pt 2):341-9. Epub 2004 Aug 12.PMID: 15308683 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic changes in peripheral growth hormone levels do not affect ghrelin stomach mRNA expression and serum ghrelin levels in three transgenic mouse models.

Nass R, Liu J, Hellmann P, Coschigano KT, Gaylinn B, Berryman DE, Kopchick JJ, Thorner MO.

J Neuroendocrinol. 2004 Aug;16(8):669-75.PMID: 15271059 [PubMed - indexed for MEDLINE]Related articles

Life extension versus improving quality of life.

Nass R, Thorner MO.

Best Pract Res Clin Endocrinol Metab. 2004 Sep;18(3):381-91. Review.PMID: 15261844 [PubMed - indexed for MEDLINE]Related articles

Regulation of full-length and truncated growth hormone (GH) receptor by GH in tissues of lit/lit or bovine GH transgenic mice.

Iida K, del Rincon JP, Kim DS, Itoh E, Coschigano KT, Kopchick JJ, Thorner MO.

Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E566-73. Epub 2004 May 27.PMID: 15165994 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone (GH) replacement therapy in adult-onset gh deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial.

Hoffman AR, Kuntze JE, Baptista J, Baum HB, Baumann GP, Biller BM, Clark RV, Cook D, Inzucchi SE, Kleinberg D, Klibanski A, Phillips LS, Ridgway EC, Robbins RJ, Schlechte J, Sharma M, Thorner MO, Vance ML.

J Clin Endocrinol Metab. 2004 May;89(5):2048-56.PMID: 15126520 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific regulation of growth hormone (GH) receptor and insulin-like growth factor-I gene expression in the pituitary and liver of GH-deficient (lit/lit) mice and transgenic mice that overexpress bovine GH (bGH) or a bGH antagonist.

Iida K, Del Rincon JP, Kim DS, Itoh E, Nass R, Coschigano KT, Kopchick JJ, Thorner MO.

Endocrinology. 2004 Apr;145(4):1564-70. Epub 2004 Jan 15.PMID: 14726438 [PubMed - indexed for MEDLINE]Related articlesFree article

Optimizing control of acromegaly: integrating a growth hormone receptor antagonist into the treatment algorithm.

Clemmons DR, Chihara K, Freda PU, Ho KK, Klibanski A, Melmed S, Shalet SM, Strasburger CJ, Trainer PJ, Thorner MO.

J Clin Endocrinol Metab. 2003 Oct;88(10):4759-67. Review.PMID: 14557452 [PubMed - indexed for MEDLINE]Related articlesFree article

The research community now and in the future: APM's recommendations for NIH priorities.

Crist TB, Walsh RA, Alexander RW, Bremner WJ, Schafer AI, Swain JL, Thorner MO, Weisfeldt ML; Association of Professors of Medicine.

Am J Med. 2003 Jun 1;114(8):710-3. No abstract available. PMID: 12798468 [PubMed - indexed for MEDLINE]Related articles

Controversy: radiotherapy for acromegaly.

Thorner MO.

Clin Endocrinol (Oxf). 2003 Feb;58(2):136-7. No abstract available. PMID: 12580926 [PubMed - indexed for MEDLINE]Related articles

Impact of abdominal visceral fat, growth hormone, fitness, and insulin on lipids and lipoproteins in older adults.

Weltman A, Despres JP, Clasey JL, Weltman JY, Wideman L, Kanaley J, Patrie J, Bergeron J, Thorner MO, Bouchard C, Hartman ML.

Metabolism. 2003 Jan;52(1):73-80.PMID: 12524665 [PubMed - indexed for MEDLINE]Related articles

Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity.

Swords FM, Baig A, Malchoff DM, Malchoff CD, Thorner MO, King PJ, Hunyady L, Clark AJ.

Mol Endocrinol. 2002 Dec;16(12):2746-53.PMID: 12456795 [PubMed - indexed for MEDLINE]Related articlesFree article

IGF-I does not affect the net increase in GH release in response to arginine.

Nass R, Pezzoli SS, Chapman IM, Patrie J, Hintz RL, Hartman ML, Thorner MO.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E702-10.PMID: 12217887 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of the GH-cortisol ratio on the age-dependent changes in body composition.

Nass R, Thorner MO.

Growth Horm IGF Res. 2002 Jun;12(3):147-61. Review.PMID: 12162996 [PubMed - indexed for MEDLINE]Related articles

Pulsatile growth hormone secretion persists in genetic growth hormone-releasing hormone resistance.

Maheshwari HG, Pezzoli SS, Rahim A, Shalet SM, Thorner MO, Baumann G.

Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E943-51.PMID: 11882517 [PubMed - indexed for MEDLINE]Related articlesFree article