PubMed

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D; Western Regional Research Alliance for Pediatric IBD; International IBD Genetics Consortium, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson H, Silber G, Wrobel I, Quiros A, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ; NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E; Belgian-French IBD consortium; Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Mathew CG, Parkes M, Georges M.

Nat Genet. 2009 Dec;41(12):1335-40. Epub 2009 Nov 15.PMID: 19915574 [PubMed - in process]Related articles

Insights into IBD Pathogenesis.

Shih DQ, Targan SR.

Curr Gastroenterol Rep. 2009 Dec;11(6):473-80.PMID: 19903423 [PubMed - in process]Related articles

Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells.

Shih DQ, Kwan LY, Chavez V, Cohavy O, Gonsky R, Chang EY, Chang C, Elson CO, Targan SR.

Eur J Immunol. 2009 Oct 16;39(11):3239-3250. [Epub ahead of print]PMID: 19839006 [PubMed - as supplied by publisher]Related articles

Immunosuppression Impairs Response to Pneumococcal Polysaccharide Vaccination in Patients With Inflammatory Bowel Disease.

Melmed GY, Agarwal N, Frenck RW, Ippoliti AF, Ibanez P, Papadakis KA, Simpson P, Barolet-Garcia C, Ward J, Targan SR, Vasiliauskas EA.

Am J Gastroenterol. 2009 Sep 15. [Epub ahead of print]PMID: 19755964 [PubMed - as supplied by publisher]Related articles

Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis.

Baumgart DC, Targan SR, Dignass AU, Mayer L, Assche GV, Hommes DW, Hanauer SB, Mahadevan U, Reinisch W, Plevy SE, Salzberg BA, Buchman AL, Mechkov GM, Krastev ZA, Lowder JN, Frankel MB, Sandborn WJ.

Inflamm Bowel Dis. 2009 Aug 27. [Epub ahead of print]PMID: 19714757 [PubMed - as supplied by publisher]Related articles

TLR8-mediated activation of human monocytes inhibits TL1A expression.

Saruta M, Michelsen KS, Thomas LS, Yu QT, Landers CJ, Targan SR.

Eur J Immunol. 2009 Aug;39(8):2195-202.PMID: 19637197 [PubMed - indexed for MEDLINE]Related articles

A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis.

Murrell ZA, Melmed GY, Ippoliti A, Vasiliauskas EA, Dubinsky M, Targan SR, Fleshner PR.

Dis Colon Rectum. 2009 May;52(5):872-8.PMID: 19502850 [PubMed - indexed for MEDLINE]Related articles

Corrigendum: Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, Bossa F, Griffiths AM, Ippoliti AF, Lahaie RG, Latiano A, Paré P, Proctor DD, Regueiro MD, Steinhart AH, Targan SR, Schumm LP, Kistner EO, Lee AT, Gregersen PK, Rotter JI, Brant SR, Taylor KD, Roeder K, Duerr RH.

Nat Genet. 2009 Jun;41(6):762. No abstract available. PMID: 19471306 [PubMed - in process]Related articles

Distinct Methylation of IFNG in the Gut.

Gonsky R, Deem RL, Targan SR.

J Interferon Cytokine Res. 2009 Jul;29(7):407-14.PMID: 19450149 [PubMed - indexed for MEDLINE]Related articles

IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.

Michelsen KS, Thomas LS, Taylor KD, Yu QT, Mei L, Landers CJ, Derkowski C, McGovern DP, Rotter JI, Targan SR.

PLoS One. 2009;4(3):e4719. Epub 2009 Mar 5.PMID: 19262684 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease.

Baumgart DC, Lowder JN, Targan SR, Sandborn WJ, Frankel MB.

Am J Gastroenterol. 2009 Apr;104(4):868-76. Epub 2009 Feb 24.PMID: 19240707 [PubMed - indexed for MEDLINE]Related articles

Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.

McGovern DP, Rotter JI, Mei L, Haritunians T, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mengesha E, King L, Pressman S, Targan SR, Taylor KD.

Inflamm Bowel Dis. 2009 Jun;15(6):883-9.PMID: 19235914 [PubMed - indexed for MEDLINE]Related articles

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, Bossa F, Griffiths AM, Ippoliti AF, Lahaie RG, Latiano A, Paré P, Proctor DD, Regueiro MD, Steinhart AH, Targan SR, Schumm LP, Kistner EO, Lee AT, Gregersen PK, Rotter JI, Brant SR, Taylor KD, Roeder K, Duerr RH.

Nat Genet. 2009 Feb;41(2):216-20. Epub 2009 Jan 4.PMID: 19122664 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent advances in IBD pathogenesis: genetics and immunobiology.

Shih DQ, Targan SR, McGovern D.

Curr Gastroenterol Rep. 2008 Dec;10(6):568-75. Review.PMID: 19006613 [PubMed - indexed for MEDLINE]Related articlesFree article

High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females.

Saruta M, Targan SR, Mei L, Ippoliti AF, Taylor KD, Rotter JI.

Inflamm Bowel Dis. 2009 Mar;15(3):321-7.PMID: 18942751 [PubMed - indexed for MEDLINE]Related articles

Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation.

Takedatsu H, Taylor KD, Mei L, McGovern DP, Landers CJ, Gonsky R, Cong Y, Vasiliauskas EA, Ippoliti A, Elson CO, Rotter JI, Targan SR.

Gut. 2009 Jan;58(1):60-7. Epub 2008 Oct 2.PMID: 18832525 [PubMed - indexed for MEDLINE]Related articles

Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease.

Shen C, Landers CJ, Derkowski C, Elson CO, Targan SR.

Inflamm Bowel Dis. 2008 Dec;14(12):1641-51.PMID: 18825772 [PubMed - indexed for MEDLINE]Related articlesFree article

MAGI2 genetic variation and inflammatory bowel disease.

McGovern DP, Taylor KD, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mei L, Mengesha E, King L, Pressman S, Targan SR, Rotter JI.

Inflamm Bowel Dis. 2009 Jan;15(1):75-83.PMID: 18720471 [PubMed - indexed for MEDLINE]Related articles

Certolizumab pegol.

Melmed GY, Targan SR, Yasothan U, Hanicq D, Kirkpatrick P.

Nat Rev Drug Discov. 2008 Aug;7(8):641-2.PMID: 18670430 [PubMed - indexed for MEDLINE]Related articles

Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography.

Brewer S, McPherson M, Fujiwara D, Turovskaya O, Ziring D, Chen L, Takedatsu H, Targan SR, Wei B, Braun J.

Gastroenterology. 2008 Sep;135(3):744-55. Epub 2008 Jul 17.PMID: 18639553 [PubMed - indexed for MEDLINE]Related articles

Increased immune reactivity predicts aggressive complicating Crohn's disease in children.

Dubinsky MC, Kugathasan S, Mei L, Picornell Y, Nebel J, Wrobel I, Quiros A, Silber G, Wahbeh G, Katzir L, Vasiliauskas E, Bahar R, Otley A, Mack D, Evans J, Rosh J, Hemker MO, Leleiko N, Crandall W, Langton C, Landers C, Taylor KD, Targan SR, Rotter JI, Markowitz J, Hyams J; Western Regional Pediatric IBD Research Alliance; Pediatric IBD Collaborative Research Group; Wisconsin Pediatric IBD Alliance.

Clin Gastroenterol Hepatol. 2008 Oct;6(10):1105-11. Epub 2008 Jul 10.PMID: 18619921 [PubMed - indexed for MEDLINE]Related articles

TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.

Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR.

Gastroenterology. 2008 Aug;135(2):552-67. Epub 2008 May 7.PMID: 18598698 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ; NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ.

Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.PMID: 18587394 [PubMed - indexed for MEDLINE]Related articlesFree article

2007 annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN).

Colbert RA, Deodhar AA, Khan MA, Lories RJ, Maksymowych WP, Reveille JD, Ritchlin CT, Rosenbaum JT, Targan SR, Weisman M, Clegg DO; SPARTAN Group.

J Rheumatol. 2008 Jul;35(7):1398-402. Epub 2008 May 15.PMID: 18484685 [PubMed - indexed for MEDLINE]Related articles

IL23R haplotypes provide a large population attributable risk for Crohn's disease.

Taylor KD, Targan SR, Mei L, Ippoliti AF, McGovern D, Mengesha E, King L, Rotter JI.

Inflamm Bowel Dis. 2008 Sep;14(9):1185-91.PMID: 18470928 [PubMed - indexed for MEDLINE]Related articlesFree article

Ex vivo simulation of IgG Fc and T-cell receptor functions: an application to inflammatory bowel disease.

Mitsuhashi M, Targan SR.

Inflamm Bowel Dis. 2008 Aug;14(8):1061-7.PMID: 18340639 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunopathogenesis of inflammatory bowel disease.

Shih DQ, Targan SR.

World J Gastroenterol. 2008 Jan 21;14(3):390-400. Review.PMID: 18200661 [PubMed - indexed for MEDLINE]Related articlesFree article

Ex vivo induction of mRNA in human whole blood as a new platform of drug and dietary supplement development.

Mitsuhashi M, Ogura M, Endo K, Obara K, Izutsu H, Targan SR, Maemura M, Tachikawa D, Shinagawa A.

Pharm Res. 2008 May;25(5):1116-24. Epub 2008 Jan 9.PMID: 18183479 [PubMed - indexed for MEDLINE]Related articlesFree article

Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis.

Melmed GY, Fleshner PR, Bardakcioglu O, Ippoliti A, Vasiliauskas EA, Papadakis KA, Dubinsky M, Landers C, Rotter JI, Targan SR.

Dis Colon Rectum. 2008 Jan;51(1):100-8. Epub 2007 Dec 18.PMID: 18085333 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection of antisynthetic mannoside antibodies (ASigmaMA) reveals heterogeneity in the ASCA response of Crohn's disease patients and contributes to differential diagnosis, stratification, and prediction.

Vandewalle-El Khoury P, Colombel JF, Joossens S, Standaert-Vitse A, Collot M, Halfvarson J, Ayadi A, Landers CJ, Vermeire S, Rutgeerts P, Targan SR, Chamaillard M, Mallet JM, Sendid B, Poulain D.

Am J Gastroenterol. 2008 Apr;103(4):949-57. Epub 2007 Nov 28.PMID: 18047546 [PubMed - indexed for MEDLINE]Related articles

Differences in the management of Crohn's disease among experts and community providers, based on a national survey of sample case vignettes.

Esrailian E, Spiegel BM, Targownik LE, Dubinsky MC, Targan SR, Gralnek IM.

Aliment Pharmacol Ther. 2007 Oct 1;26(7):1005-18.PMID: 17877507 [PubMed - indexed for MEDLINE]Related articlesFree article

Does infliximab influence surgical morbidity of ileal pouch-anal anastomosis in patients with ulcerative colitis?

Schluender SJ, Ippoliti A, Dubinsky M, Vasiliauskas EA, Papadakis KA, Mei L, Targan SR, Fleshner PR.

Dis Colon Rectum. 2007 Nov;50(11):1747-53.PMID: 17704969 [PubMed - indexed for MEDLINE]Related articles

TNFSF15 is an ethnic-specific IBD gene.

Picornell Y, Mei L, Taylor K, Yang H, Targan SR, Rotter JI.

Inflamm Bowel Dis. 2007 Nov;13(11):1333-8.PMID: 17663424 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammatory bowel disease diagnosis, evaluation and classification: state-of-the art approach.

Targan SR, Karp LC.

Curr Opin Gastroenterol. 2007 Jul;23(4):390-4. Review.PMID: 17545774 [PubMed - indexed for MEDLINE]Related articles

Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial.

Targan SR, Feagan BG, Fedorak RN, Lashner BA, Panaccione R, Present DH, Spehlmann ME, Rutgeerts PJ, Tulassay Z, Volfova M, Wolf DC, Hernandez C, Bornstein J, Sandborn WJ; International Efficacy of Natalizumab in Crohn's Disease Response and Remission (ENCORE) Trial Group.

Gastroenterology. 2007 May;132(5):1672-83. Epub 2007 Mar 21.PMID: 17484865 [PubMed - indexed for MEDLINE]Related articles

Predicting a change in diagnosis from ulcerative colitis to Crohn's disease: a nested, case-control study.

Melmed GY, Elashoff R, Chen GC, Nastaskin I, Papadakis KA, Vasiliauskas EA, Liu W, Landers C, Ippoliti AF, Targan SR.

Clin Gastroenterol Hepatol. 2007 May;5(5):602-8; quiz 525.PMID: 17478347 [PubMed - indexed for MEDLINE]Related articles

CD56 marks an effector T cell subset in the human intestine.

Cohavy O, Targan SR.

J Immunol. 2007 May 1;178(9):5524-32.PMID: 17442934 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ, Brant SR.

Nat Genet. 2007 May;39(5):596-604. Epub 2007 Apr 15.PMID: 17435756 [PubMed - indexed for MEDLINE]Related articlesFree article

The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells.

Prehn JL, Thomas LS, Landers CJ, Yu QT, Michelsen KS, Targan SR.

J Immunol. 2007 Apr 1;178(7):4033-8.PMID: 17371957 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease.

Saruta M, Yu QT, Avanesyan A, Fleshner PR, Targan SR, Papadakis KA.

J Immunol. 2007 Mar 1;178(5):3293-300.PMID: 17312180 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease.

Dubinsky MC, Wang D, Picornell Y, Wrobel I, Katzir L, Quiros A, Dutridge D, Wahbeh G, Silber G, Bahar R, Mengesha E, Targan SR, Taylor KD, Rotter JI; Western Regional Research Alliance for Pediatric IBD.

Inflamm Bowel Dis. 2007 May;13(5):511-5.PMID: 17309073 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations.

Papadakis KA, Yang H, Ippoliti A, Mei L, Elson CO, Hershberg RM, Vasiliauskas EA, Fleshner PR, Abreu MT, Taylor K, Landers CJ, Rotter JI, Targan SR.

Inflamm Bowel Dis. 2007 May;13(5):524-30.PMID: 17260364 [PubMed - indexed for MEDLINE]Related articlesFree article

NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives.

Devlin SM, Yang H, Ippoliti A, Taylor KD, Landers CJ, Su X, Abreu MT, Papadakis KA, Vasiliauskas EA, Melmed GY, Fleshner PR, Mei L, Rotter JI, Targan SR.

Gastroenterology. 2007 Feb;132(2):576-86. Epub 2006 Nov 10.PMID: 17258734 [PubMed - indexed for MEDLINE]Related articles

Antibodies to I2 predict clinical response to fecal diversion in Crohn's disease.

Spivak J, Landers CJ, Vasiliauskas EA, Abreu MT, Dubinsky MC, Papadakis KA, Ippoliti A, Targan SR, Fleshner PR.

Inflamm Bowel Dis. 2006 Dec;12(12):1122-30.PMID: 17119386 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular approaches to the role of the microbiota in inflammatory bowel disease.

Elson CO, Cong Y, Qi F, Hershberg RM, Targan SR.

Ann N Y Acad Sci. 2006 Aug;1072:39-51.PMID: 17057189 [PubMed - indexed for MEDLINE]Related articles

Current limitations of IBD treatment: where do we go from here?

Targan SR.

Ann N Y Acad Sci. 2006 Aug;1072:1-8. Review.PMID: 17057185 [PubMed - indexed for MEDLINE]Related articles

Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn.

Vasiliauskas EA, Church JA, Silverman N, Barry M, Targan SR, Dubinsky MC.

Clin Gastroenterol Hepatol. 2006 Oct;4(10):1255-8.PMID: 17045211 [PubMed - indexed for MEDLINE]Related articles

Cytokine-based therapies in inflammatory bowel disease.

Kam LY, Targan SR.

Curr Opin Gastroenterol. 1999 Jul;15(4):302-7.PMID: 17023962 [PubMed]Related articles

Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses.

Melmed GY, Ippoliti AF, Papadakis KA, Tran TT, Birt JL, Lee SK, Frenck RW, Targan SR, Vasiliauskas EA.

Am J Gastroenterol. 2006 Aug;101(8):1834-40. Epub 2006 Jun 30.PMID: 16817843 [PubMed - indexed for MEDLINE]Related articles

Immunogenetic phenotypes in inflammatory bowel disease.

Dubinsky MC, Taylor K, Targan SR, Rotter JI.

World J Gastroenterol. 2006 Jun 21;12(23):3645-50. Review.PMID: 16773679 [PubMed - indexed for MEDLINE]Related articlesFree article