PubMed

A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.

Jung SR, Reed BJ, Sweet IR.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E717-27. Epub 2009 Jul 7.PMID: 19584201 [PubMed - indexed for MEDLINE]Related articles

Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation.

Maloney E, Sweet IR, Hockenbery DM, Pham M, Rizzo NO, Tateya S, Handa P, Schwartz MW, Kim F.

Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1370-5. Epub 2009 Jun 18.PMID: 19542021 [PubMed - indexed for MEDLINE]Related articles

The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury.

Bollyky PL, Bice JB, Sweet IR, Falk BA, Gebe JA, Clark AE, Gersuk VH, Aderem A, Hawn TR, Nepom GT.

PLoS One. 2009;4(4):e5063. Epub 2009 Apr 1.PMID: 19357791 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration.

Sweet IR, Gilbert M, Maloney E, Hockenbery DM, Schwartz MW, Kim F.

Diabetologia. 2009 May;52(5):921-31. Epub 2009 Feb 14.PMID: 19219423 [PubMed - indexed for MEDLINE]Related articles

Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat.

Cummings BP, Digitale EK, Stanhope KL, Graham JL, Baskin DG, Reed BJ, Sweet IR, Griffen SC, Havel PJ.

Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1782-93. Epub 2008 Oct 1.PMID: 18832086 [PubMed - indexed for MEDLINE]Related articles

Islet oxygen consumption and insulin secretion tightly coupled to calcium derived from L-type calcium channels but not from the endoplasmic reticulum.

Gilbert M, Jung SR, Reed BJ, Sweet IR.

J Biol Chem. 2008 Sep 5;283(36):24334-42. Epub 2008 Jul 1.PMID: 18593707 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine.

Raffo A, Hancock K, Polito T, Xie Y, Andan G, Witkowski P, Hardy M, Barba P, Ferrara C, Maffei A, Freeby M, Goland R, Leibel RL, Sweet IR, Harris PE.

J Endocrinol. 2008 Jul;198(1):41-9.PMID: 18577569 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of diabetic rats with encapsulated islets.

Sweet IR, Yanay O, Waldron L, Gilbert M, Fuller JM, Tupling T, Lernmark A, Osborne WR.

J Cell Mol Med. 2008 Dec;12(6B):2644-50. Epub 2008 Mar 28.PMID: 18373735 [PubMed - indexed for MEDLINE]Related articles

Glucose-stimulated increment in oxygen consumption rate as a standardized test of human islet quality.

Sweet IR, Gilbert M, Scott S, Todorov I, Jensen R, Nair I, Al-Abdullah I, Rawson J, Kandeel F, Ferreri K.

Am J Transplant. 2008 Jan;8(1):183-92. Epub 2007 Nov 12.PMID: 18021279 [PubMed - indexed for MEDLINE]Related articles

2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition.

Schwartz PS, Manion MK, Emerson CB, Fry JS, Schulz CM, Sweet IR, Hockenbery DM.

Mol Cancer Ther. 2007 Jul;6(7):2073-80.PMID: 17620436 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of calcium influx in mediating glucose-stimulated oxygen consumption in pancreatic islets.

Sweet IR, Gilbert M.

Diabetes. 2006 Dec;55(12):3509-19.PMID: 17130499 [PubMed - indexed for MEDLINE]Related articlesFree article

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.

Weydt P, Pineda VV, Torrence AE, Libby RT, Satterfield TF, Lazarowski ER, Gilbert ML, Morton GJ, Bammler TK, Strand AD, Cui L, Beyer RP, Easley CN, Smith AC, Krainc D, Luquet S, Sweet IR, Schwartz MW, La Spada AR.

Cell Metab. 2006 Nov;4(5):349-62. Epub 2006 Oct 19.PMID: 17055784 [PubMed - indexed for MEDLINE]Related articles

Identification and characterization of a novel isoform of the vesicular gamma-aminobutyric acid transporter with glucose-regulated expression in rat islets.

Suckow AT, Sweet IR, Van Yserloo B, Rutledge EA, Hall TR, Waldrop M, Chessler SD.

J Mol Endocrinol. 2006 Feb;36(1):187-99.PMID: 16461938 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose stimulation of cytochrome C reduction and oxygen consumption as assessment of human islet quality.

Sweet IR, Gilbert M, Jensen R, Sabek O, Fraga DW, Gaber AO, Reems J.

Transplantation. 2005 Oct 27;80(8):1003-11.PMID: 16278578 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion in the conscious mouse is biphasic and pulsatile.

Nunemaker CS, Wasserman DH, McGuinness OP, Sweet IR, Teague JC, Satin LS.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E523-9. Epub 2005 Oct 25.PMID: 16249252 [PubMed - indexed for MEDLINE]Related articlesFree article

Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.

Niswender CM, Willis BS, Wallen A, Sweet IR, Jetton TL, Thompson BR, Wu C, Lange AJ, McKnight GS.

Genesis. 2005 Nov;43(3):109-19.PMID: 16155866 [PubMed - indexed for MEDLINE]Related articles

Quantitative evaluation of a monoclonal antibody and its fragment as potential markers for pancreatic beta cell mass.

Hampe CS, Wallen AR, Schlosser M, Ziegler M, Sweet IR.

Exp Clin Endocrinol Diabetes. 2005 Jul;113(7):381-7.PMID: 16025399 [PubMed - indexed for MEDLINE]Related articles

Non-invasive imaging of beta cell mass: a quantitative analysis.

Sweet IR, Cook DL, Lernmark A, Greenbaum CJ, Krohn KA.

Diabetes Technol Ther. 2004 Oct;6(5):652-9.PMID: 15628819 [PubMed - indexed for MEDLINE]Related articles

Systematic screening of potential beta-cell imaging agents.

Sweet IR, Cook DL, Lernmark A, Greenbaum CJ, Wallen AR, Marcum ES, Stekhova SA, Krohn KA.

Biochem Biophys Res Commun. 2004 Feb 20;314(4):976-83.PMID: 14751228 [PubMed - indexed for MEDLINE]Related articles

Regulation of ATP/ADP in pancreatic islets.

Sweet IR, Cook DL, DeJulio E, Wallen AR, Khalil G, Callis J, Reems J.

Diabetes. 2004 Feb;53(2):401-9.PMID: 14747291 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol.

Matsumoto S, Qualley SA, Goel S, Hagman DK, Sweet IR, Poitout V, Strong DM, Robertson RP, Reems JA.

Transplantation. 2002 Nov 27;74(10):1414-9.PMID: 12451242 [PubMed - indexed for MEDLINE]Related articles

Continuous measurement of oxygen consumption by pancreatic islets.

Sweet IR, Khalil G, Wallen AR, Steedman M, Schenkman KA, Reems JA, Kahn SE, Callis JB.

Diabetes Technol Ther. 2002;4(5):661-72.PMID: 12450449 [PubMed - indexed for MEDLINE]Related articles

Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets.

Chessler SD, Simonson WT, Sweet IR, Hammerle LP.

Diabetes. 2002 Jun;51(6):1763-71.PMID: 12031963 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic perifusion to maintain and assess isolated pancreatic islets.

Sweet IR, Cook DL, Wiseman RW, Greenbaum CJ, Lernmark A, Matsumoto S, Teague JC, Krohn KA.

Diabetes Technol Ther. 2002;4(1):67-76.PMID: 12017423 [PubMed - indexed for MEDLINE]Related articles

Measurement and modeling of glucose-6-phosphatase in pancreatic islets.

Sweet IR, Najafi H, Li G, Grodberg J, Matschinsky FM.

Am J Physiol. 1997 Apr;272(4 Pt 1):E696-711.PMID: 9142893 [PubMed - indexed for MEDLINE]Related articles

Simultaneous measurement of oxygen consumption and 13C16O2 production from 13C-pyruvate in diabetic rat heart mitochondria.

Doliba NM, Sweet IR, Babsky A, Doliba N, Forster RE, Osbakken M.

Adv Exp Med Biol. 1997;428:269-75. No abstract available. PMID: 9500057 [PubMed - indexed for MEDLINE]Related articles

Are there kinetic advantages of GLUT2 in pancreatic glucose sensing?

Sweet IR, Matschinsky FM.

Diabetologia. 1997 Jan;40(1):112-9. Review. No abstract available. PMID: 9028727 [PubMed - indexed for MEDLINE]Related articles

Effect of a glucokinase inhibitor on energy production and insulin release in pancreatic islets.

Sweet IR, Li G, Najafi H, Berner D, Matschinsky FM.

Am J Physiol. 1996 Sep;271(3 Pt 1):E606-25.PMID: 8843758 [PubMed - indexed for MEDLINE]Related articles

Effect of glucose on uptake of radiolabeled glucose, 2-DG, and 3-O-MG by the perfused rat liver.

Sweet IR, Peterson L, Kroll K, Goodner CJ, Berry M, Graham MM.

Am J Physiol. 1996 Aug;271(2 Pt 1):E384-96.PMID: 8770034 [PubMed - indexed for MEDLINE]Related articles

Mathematical model of beta-cell glucose metabolism and insulin release. I. Glucokinase as glucosensor hypothesis.

Sweet IR, Matschinsky FM.

Am J Physiol. 1995 Apr;268(4 Pt 1):E775-88.PMID: 7733279 [PubMed - indexed for MEDLINE]Related articles

Comprehensive model of transport and metabolism of adenosine and S-adenosylhomocysteine in the guinea pig heart.

Kroll K, Deussen A, Sweet IR.

Circ Res. 1992 Sep;71(3):590-604.PMID: 1499107 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin binding to individual rat skeletal muscles.

Koerker DJ, Sweet IR, Baskin DG.

Am J Physiol. 1990 Oct;259(4 Pt 1):E517-23.PMID: 2221053 [PubMed - indexed for MEDLINE]Related articles

Rapid reduction and return of surface insulin receptors after exposure to brief pulses of insulin in perifused rat hepatocytes.

Goodner CJ, Sweet IR, Harrison HC Jr.

Diabetes. 1988 Oct;37(10):1316-23.PMID: 3046965 [PubMed - indexed for MEDLINE]Related articles

A kinetic analysis of hepatocyte responses to a glucagon pulse: mechanism and metabolic consequences of differences in response decay times.

Weigle DS, Sweet IR, Goodner CJ.

Endocrinology. 1987 Aug;121(2):732-7.PMID: 2439320 [PubMed - indexed for MEDLINE]Related articles