PubMed

Astrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacity.

Tang KS, Suh SW, Alano CC, Shao Z, Hunt WT, Swanson RA, Anderson CM.

Glia. 2009 Sep 30. [Epub ahead of print]PMID: 19795500 [PubMed - as supplied by publisher]Related articles

Pyruvate protects against experimental stroke via an anti-inflammatory mechanism.

Wang Q, van Hoecke M, Tang XN, Lee H, Zheng Z, Swanson RA, Yenari MA.

Neurobiol Dis. 2009 Oct;36(1):223-31. Epub 2009 Jul 25.PMID: 19635562 [PubMed - in process]Related articles

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.

Brennan AM, Suh SW, Won SJ, Narasimhan P, Kauppinen TM, Lee H, Edling Y, Chan PH, Swanson RA.

Nat Neurosci. 2009 Jul;12(7):857-63. Epub 2009 Jun 7.PMID: 19503084 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase.

Burns DM, Ying W, Kauppinen TM, Zhu K, Swanson RA.

PLoS One. 2009;4(3):e4896. Epub 2009 Mar 25.PMID: 19319190 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury.

Kauppinen TM, Suh SW, Berman AE, Hamby AM, Swanson RA.

J Cereb Blood Flow Metab. 2009 Apr;29(4):820-9. Epub 2009 Feb 4.PMID: 19190653 [PubMed - indexed for MEDLINE]Related articles

Glucose and NADPH oxidase drive neuronal superoxide formation in stroke.

Suh SW, Shin BS, Ma H, Van Hoecke M, Brennan AM, Yenari MA, Swanson RA.

Ann Neurol. 2008 Dec;64(6):654-63.PMID: 19107988 [PubMed - indexed for MEDLINE]Related articles

Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands.

Nagasawa K, Escartin C, Swanson RA.

Glia. 2009 Apr 15;57(6):622-33.PMID: 18942742 [PubMed - indexed for MEDLINE]Related articles

Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death.

Suh SW, Hamby AM, Gum ET, Shin BS, Won SJ, Sheline CT, Chan PH, Swanson RA.

J Cereb Blood Flow Metab. 2008 Oct;28(10):1697-706. Epub 2008 Jun 11.PMID: 18545258 [PubMed - indexed for MEDLINE]Related articles

Zinc triggers microglial activation.

Kauppinen TM, Higashi Y, Suh SW, Escartin C, Nagasawa K, Swanson RA.

J Neurosci. 2008 May 28;28(22):5827-35.PMID: 18509044 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes.

Alano CC, Tran A, Tao R, Ying W, Karliner JS, Swanson RA.

J Neurosci Res. 2007 Nov 15;85(15):3378-85.PMID: 17853438 [PubMed - indexed for MEDLINE]Related articles

Zinc inhibits astrocyte glutamate uptake by activation of poly(ADP-ribose) polymerase-1.

Suh SW, Aoyama K, Alano CC, Anderson CM, Hamby AM, Swanson RA.

Mol Med. 2007 Jul-Aug;13(7-8):344-9.PMID: 17728843 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoglycemia, brain energetics, and hypoglycemic neuronal death.

Suh SW, Hamby AM, Swanson RA.

Glia. 2007 Sep;55(12):1280-6. Review.PMID: 17659530 [PubMed - indexed for MEDLINE]Related articles

Inhibition of mitochondrial function in astrocytes: implications for neuroprotection.

Voloboueva LA, Suh SW, Swanson RA, Giffard RG.

J Neurochem. 2007 Aug;102(4):1383-94.PMID: 17488276 [PubMed - indexed for MEDLINE]Related articles

INTRODUCTION: Immune mechanisms of neurodegeneration.

Yenari MA, Swanson RA.

Clin Neurosci Res. 2006 Dec;6(5):225. No abstract available. PMID: 17464366 [PubMed]Related articlesFree article

Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.

Suh SW, Gum ET, Hamby AM, Chan PH, Swanson RA.

J Clin Invest. 2007 Apr;117(4):910-8.PMID: 17404617 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes.

Bourguignon LY, Gilad E, Peyrollier K, Brightman A, Swanson RA.

J Neurochem. 2007 May;101(4):1002-17. Epub 2007 Mar 30.PMID: 17403031 [PubMed - indexed for MEDLINE]Related articles

Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion.

Hamby AM, Suh SW, Kauppinen TM, Swanson RA.

Stroke. 2007 Feb;38(2 Suppl):632-6.PMID: 17261705 [PubMed - indexed for MEDLINE]Related articlesFree article

Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide).

Suh SW, Bergher JP, Anderson CM, Treadway JL, Fosgerau K, Swanson RA.

J Pharmacol Exp Ther. 2007 Apr;321(1):45-50. Epub 2007 Jan 24.PMID: 17251391 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of poly(ADP-ribose) polymerase-1 in CNS disease.

Kauppinen TM, Swanson RA.

Neuroscience. 2007 Apr 14;145(4):1267-72. Epub 2006 Nov 2. Review.PMID: 17084037 [PubMed - indexed for MEDLINE]Related articles

Novel modulators of poly(ADP-ribose) polymerase.

Szabo C, Pacher P, Swanson RA.

Trends Pharmacol Sci. 2006 Dec;27(12):626-30. Epub 2006 Oct 19.PMID: 17055069 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracerebral hematoma: beyond the mass lesion.

Swanson RA.

Stroke. 2006 Oct;37(10):2445. Epub 2006 Sep 7. No abstract available. PMID: 16960087 [PubMed - indexed for MEDLINE]Related articlesFree article

Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations.

Alano CC, Kauppinen TM, Valls AV, Swanson RA.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9685-90. Epub 2006 Jun 12.PMID: 16769901 [PubMed - indexed for MEDLINE]Related articlesFree article

Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices.

Zeng J, Yang GY, Ying W, Kelly M, Hirai K, James TL, Swanson RA, Litt L.

J Cereb Blood Flow Metab. 2007 Feb;27(2):304-15. Epub 2006 May 24.PMID: 16736046 [PubMed - indexed for MEDLINE]Related articles

Players in the PARP-1 cell-death pathway: JNK1 joins the cast.

Alano CC, Swanson RA.

Trends Biochem Sci. 2006 Jun;31(6):309-11. Epub 2006 May 6. Review.PMID: 16679020 [PubMed - indexed for MEDLINE]Related articles

Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.

Kauppinen TM, Chan WY, Suh SW, Wiggins AK, Huang EJ, Swanson RA.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7136-41. Epub 2006 Apr 20.PMID: 16627622 [PubMed - indexed for MEDLINE]Related articlesFree article

Poly(ADP-ribose) polymerase-1 hyperactivation and impairment of mitochondrial respiratory chain complex I function in reperfused mouse hearts.

Zhou HZ, Swanson RA, Simonis U, Ma X, Cecchini G, Gray MO.

Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H714-23. Epub 2006 Mar 31.PMID: 16582021 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.

Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA.

Nat Neurosci. 2006 Jan;9(1):119-26. Epub 2005 Nov 27.PMID: 16311588 [PubMed - indexed for MEDLINE]Related articles

NADH can enter into astrocytes and block poly(ADP-ribose) polymerase-1-mediated astrocyte death.

Zhu K, Swanson RA, Ying W.

Neuroreport. 2005 Aug 1;16(11):1209-12.PMID: 16012350 [PubMed - indexed for MEDLINE]Related articles

Poly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis.

Kauppinen TM, Suh SW, Genain CP, Swanson RA.

J Neurosci Res. 2005 Jul 15;81(2):190-8.PMID: 15931673 [PubMed - indexed for MEDLINE]Related articles

Post-traumatic epidermoid cyst presenting with headache.

Green AJ, Roberts DR, Swanson RA.

Neurology. 2005 May 10;64(9):1657. No abstract available. PMID: 15883342 [PubMed - indexed for MEDLINE]Related articles

Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment.

Suh SW, Aoyama K, Matsumori Y, Liu J, Swanson RA.

Diabetes. 2005 May;54(5):1452-8.PMID: 15855333 [PubMed - indexed for MEDLINE]Related articlesFree article

Ischemia-induced programmed cell death in astrocytes.

Giffard RG, Swanson RA.

Glia. 2005 Jun;50(4):299-306. Review.PMID: 15846803 [PubMed - indexed for MEDLINE]Related articles

Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death.

Kauppinen TM, Swanson RA.

J Immunol. 2005 Feb 15;174(4):2288-96.PMID: 15699164 [PubMed - indexed for MEDLINE]Related articlesFree article

Acidosis causes endoplasmic reticulum stress and caspase-12-mediated astrocyte death.

Aoyama K, Burns DM, Suh SW, Garnier P, Matsumori Y, Shiina H, Swanson RA.

J Cereb Blood Flow Metab. 2005 Mar;25(3):358-70.PMID: 15689959 [PubMed - indexed for MEDLINE]Related articles

Hypoglycemia induces transient neurogenesis and subsequent progenitor cell loss in the rat hippocampus.

Suh SW, Fan Y, Hong SM, Liu Z, Matsumori Y, Weinstein PR, Swanson RA, Liu J.

Diabetes. 2005 Feb;54(2):500-9.PMID: 15677508 [PubMed - indexed for MEDLINE]Related articlesFree article

NAD+ as a metabolic link between DNA damage and cell death.

Ying W, Alano CC, Garnier P, Swanson RA.

J Neurosci Res. 2005 Jan 1-15;79(1-2):216-23.PMID: 15562437 [PubMed - indexed for MEDLINE]Related articles

Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices.

Zeng J, Hirai K, Yang GY, Ying W, Swanson RA, Kelly M, Mayer M, James TL, Litt L.

J Bioenerg Biomembr. 2004 Aug;36(4):415-9.PMID: 15377881 [PubMed - indexed for MEDLINE]Related articles

Hypoxia induces caspase-9 and caspase-3 activation without neuronal death in gerbil brains.

Garnier P, Prigent-Tessier A, Van Hoecke M, Bertrand N, Demougeot C, Sordet O, Swanson RA, Marie C, Beley A.

Eur J Neurosci. 2004 Aug;20(4):937-46.PMID: 15305862 [PubMed - indexed for MEDLINE]Related articles

Zinc release contributes to hypoglycemia-induced neuronal death.

Suh SW, Garnier P, Aoyama K, Chen Y, Swanson RA.

Neurobiol Dis. 2004 Aug;16(3):538-45.PMID: 15262265 [PubMed - indexed for MEDLINE]Related articles

Vitamin B12 deficiency.

Nakamura K, Mukherjee P, Swanson RA.

Arch Neurol. 2004 Jun;61(6):960. No abstract available. PMID: 15210541 [PubMed - indexed for MEDLINE]Related articlesFree article

Astrocyte influences on ischemic neuronal death.

Swanson RA, Ying W, Kauppinen TM.

Curr Mol Med. 2004 Mar;4(2):193-205. Review.PMID: 15032713 [PubMed - indexed for MEDLINE]Related articles

Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition.

Alano CC, Ying W, Swanson RA.

J Biol Chem. 2004 Apr 30;279(18):18895-902. Epub 2004 Feb 11.PMID: 14960594 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.

Castro-Obregón S, Rao RV, del Rio G, Chen SF, Poksay KS, Rabizadeh S, Vesce S, Zhang XK, Swanson RA, Bredesen DE.

J Biol Chem. 2004 Apr 23;279(17):17543-53. Epub 2004 Feb 9.PMID: 14769794 [PubMed - indexed for MEDLINE]Related articlesFree article

Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death.

Gum ET, Swanson RA, Alano C, Liu J, Hong S, Weinstein PR, Panter SS.

Stroke. 2004 Feb;35(2):590-5. Epub 2004 Jan 15.PMID: 14726550 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-induced ATP release from astrocytes.

Anderson CM, Bergher JP, Swanson RA.

J Neurochem. 2004 Jan;88(1):246-56.PMID: 14675168 [PubMed - indexed for MEDLINE]Related articles

Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia.

Suh SW, Aoyama K, Chen Y, Garnier P, Matsumori Y, Gum E, Liu J, Swanson RA.

J Neurosci. 2003 Nov 19;23(33):10681-90.PMID: 14627653 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures.

Tsuchiya D, Hong S, Matsumori Y, Kayama T, Swanson RA, Dillman WH, Liu J, Panter SS, Weinstein PR.

Neurosurgery. 2003 Nov;53(5):1179-87; discussion 1187-8.PMID: 14580286 [PubMed - indexed for MEDLINE]Related articles

Expression and activity of poly(ADP-ribose) glycohydrolase in cultured astrocytes, neurons, and C6 glioma cells.

Sevigny MB, Silva JM, Lan WC, Alano CC, Swanson RA.

Brain Res Mol Brain Res. 2003 Oct 7;117(2):213-20.PMID: 14559156 [PubMed - indexed for MEDLINE]Related articles

Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1.

Garnier P, Ying W, Swanson RA.

J Neurosci. 2003 Sep 3;23(22):7967-73.PMID: 12954857 [PubMed - indexed for MEDLINE]Related articlesFree article

NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes.

Ying W, Garnier P, Swanson RA.

Biochem Biophys Res Commun. 2003 Sep 5;308(4):809-13.PMID: 12927790 [PubMed - indexed for MEDLINE]Related articles