PubMed

Novel role of erythropoietin in proliferative diabetic retinopathy.

Takagi H, Watanabe D, Suzuma K, Kurimoto M, Suzuma I, Ohashi H, Ojima T, Murakami T.

Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S62-4. Epub 2007 May 3.PMID: 17481772 [PubMed - indexed for MEDLINE]Related articles

Cyclic stretch-induced reactive oxygen species generation enhances apoptosis in retinal pericytes through c-jun NH2-terminal kinase activation.

Suzuma I, Murakami T, Suzuma K, Kaneto H, Watanabe D, Ojima T, Honda Y, Takagi H, Yoshimura N.

Hypertension. 2007 Feb;49(2):347-54. Epub 2006 Dec 11.PMID: 17159082 [PubMed - indexed for MEDLINE]Related articlesFree article

EphrinA1 inhibits vascular endothelial growth factor-induced intracellular signaling and suppresses retinal neovascularization and blood-retinal barrier breakdown.

Ojima T, Takagi H, Suzuma K, Oh H, Suzuma I, Ohashi H, Watanabe D, Suganami E, Murakami T, Kurimoto M, Honda Y, Yoshimura N.

Am J Pathol. 2006 Jan;168(1):331-9.PMID: 16400034 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy.

Watanabe D, Suzuma K, Matsui S, Kurimoto M, Kiryu J, Kita M, Suzuma I, Ohashi H, Ojima T, Murakami T, Kobayashi T, Masuda S, Nagao M, Yoshimura N, Takagi H.

N Engl J Med. 2005 Aug 25;353(8):782-92.PMID: 16120858 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells.

Murakami T, Takagi H, Suzuma K, Suzuma I, Ohashi H, Watanabe D, Ojima T, Suganami E, Kurimoto M, Kaneto H, Honda Y, Yoshimura N.

J Biol Chem. 2005 Sep 9;280(36):31841-9. Epub 2005 Jul 6.PMID: 16000309 [PubMed - indexed for MEDLINE]Related articlesFree article

Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy.

Watanabe D, Suzuma K, Suzuma I, Ohashi H, Ojima T, Kurimoto M, Murakami T, Kimura T, Takagi H.

Am J Ophthalmol. 2005 Mar;139(3):476-81.PMID: 15767056 [PubMed - indexed for MEDLINE]Related articles

Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.

Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF.

J Neurosci. 2005 Feb 2;25(5):1240-8.PMID: 15689562 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells.

Suganami E, Takagi H, Ohashi H, Suzuma K, Suzuma I, Oh H, Watanabe D, Ojima T, Suganami T, Fujio Y, Nakao K, Ogawa Y, Yoshimura N.

Diabetes. 2004 Sep;53(9):2443-8.PMID: 15331557 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.

Watanabe D, Takagi H, Suzuma K, Suzuma I, Oh H, Ohashi H, Kemmochi S, Uemura A, Ojima T, Suganami E, Miyamoto N, Sato Y, Honda Y.

Am J Pathol. 2004 May;164(5):1827-35.PMID: 15111329 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphatidylinositol 3-kinase/Akt regulates angiotensin II-induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and suppression of caspase-3 activity.

Ohashi H, Takagi H, Oh H, Suzuma K, Suzuma I, Miyamoto N, Uemura A, Watanabe D, Murakami T, Sugaya T, Fukamizu A, Honda Y.

Circ Res. 2004 Apr 2;94(6):785-93. Epub 2004 Feb 12.PMID: 14963002 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.

Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL.

J Biol Chem. 2003 Aug 22;278(34):31964-71. Epub 2003 May 29.PMID: 12775712 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes.

Joussen AM, Poulaki V, Mitsiades N, Cai WY, Suzuma I, Pak J, Ju ST, Rook SL, Esser P, Mitsiades CS, Kirchhof B, Adamis AP, Aiello LP.

FASEB J. 2003 Jan;17(1):76-8. Epub 2002 Nov 15.PMID: 12475915 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of estrogen receptor in the choroidal neovascular membranes in highly myopic eyes.

Kobayashi K, Mandai M, Suzuma I, Kobayashi H, Okinami S.

Retina. 2002 Aug;22(4):418-22.PMID: 12172107 [PubMed - indexed for MEDLINE]Related articles

Contrasting effect of estrogen on VEGF induction under different oxygen status and its role in murine ROP.

Miyamoto N, Mandai M, Takagi H, Suzuma I, Suzuma K, Koyama S, Otani A, Oh H, Honda Y.

Invest Ophthalmol Vis Sci. 2002 Jun;43(6):2007-14.PMID: 12037012 [PubMed - indexed for MEDLINE]Related articlesFree article

Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth.

Duh EJ, Yang HS, Suzuma I, Miyagi M, Youngman E, Mori K, Katai M, Yan L, Suzuma K, West K, Davarya S, Tong P, Gehlbach P, Pearlman J, Crabb JW, Aiello LP, Campochiaro PA, Zack DJ.

Invest Ophthalmol Vis Sci. 2002 Mar;43(3):821-9.PMID: 11867604 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization.

Suzuma K, Takahara N, Suzuma I, Isshiki K, Ueki K, Leitges M, Aiello LP, King GL.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):721-6.PMID: 11805327 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue.

Chou E, Suzuma I, Way KJ, Opland D, Clermont AC, Naruse K, Suzuma K, Bowling NL, Vlahos CJ, Aiello LP, King GL.

Circulation. 2002 Jan 22;105(3):373-9.PMID: 11804995 [PubMed - indexed for MEDLINE]Related articlesFree article

Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways.

Suzuma I, Suzuma K, Ueki K, Hata Y, Feener EP, King GL, Aiello LP.

J Biol Chem. 2002 Jan 11;277(2):1047-57. Epub 2001 Nov 1.PMID: 11694503 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic stretch and hypertension induce retinal expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2: potential mechanisms for exacerbation of diabetic retinopathy by hypertension.

Suzuma I, Hata Y, Clermont A, Pokras F, Rook SL, Suzuma K, Feener EP, Aiello LP.

Diabetes. 2001 Feb;50(2):444-54.PMID: 11272159 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells.

Suzuma K, Naruse K, Suzuma I, Takahara N, Ueki K, Aiello LP, King GL.

J Biol Chem. 2000 Dec 29;275(52):40725-31.PMID: 11018037 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal expression, regulation, and functional bioactivity of prostacyclin-stimulating factor.

Hata Y, Clermont A, Yamauchi T, Pierce EA, Suzuma I, Kagokawa H, Yoshikawa H, Robinson GS, Ishibashi T, Hashimoto T, Umeda F, Bursell SE, Aiello LP.

J Clin Invest. 2000 Aug;106(4):541-50.PMID: 10953029 [PubMed - indexed for MEDLINE]Related articlesFree article

17 Beta-estradiol increases VEGF receptor-2 and promotes DNA synthesis in retinal microvascular endothelial cells.

Suzuma I, Mandai M, Takagi H, Suzuma K, Otani A, Oh H, Kobayashi K, Honda Y.

Invest Ophthalmol Vis Sci. 1999 Aug;40(9):2122-9.PMID: 10440269 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogen protects against cellular infiltration by reducing the expressions of E-selectin and IL-6 in endotoxin-induced uveitis.

Miyamoto N, Mandai M, Suzuma I, Suzuma K, Kobayashi K, Honda Y.

J Immunol. 1999 Jul 1;163(1):374-9.PMID: 10384138 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative analysis of diabetic macular edema after scatter laser photocoagulation with the scanning retinal thickness analyzer.

Tsujikawa A, Kiryu J, Dong J, Yasukawa T, Suzuma I, Takagi H, Ogura Y.

Retina. 1999;19(1):59-64.PMID: 10048375 [PubMed - indexed for MEDLINE]Related articles

Increased expression of KDR/Flk-1 (VEGFR-2) in murine model of ischemia-induced retinal neovascularization.

Suzuma K, Takagi H, Otani A, Suzuma I, Honda Y.

Microvasc Res. 1998 Nov;56(3):183-91.PMID: 9828156 [PubMed - indexed for MEDLINE]Related articles

Contribution of E-selectin to cellular infiltration during endotoxin-induced uveitis.

Suzuma I, Mandai M, Suzuma K, Ishida K, Tojo SJ, Honda Y.

Invest Ophthalmol Vis Sci. 1998 Aug;39(9):1620-30.PMID: 9699551 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative analysis of foveal retinal thickness in diabetic retinopathy with the scanning retinal thickness analyzer.

Yasukawa T, Kiryu J, Tsujikawa A, Dong J, Suzuma I, Takagi H, Ogura Y.

Retina. 1998;18(2):150-5.PMID: 9564696 [PubMed - indexed for MEDLINE]Related articles