PubMed

The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo.

Wray JA, Sugden MC, Zeldin DC, Greenwood GK, Samsuddin S, Miller-Degraff L, Bradbury JA, Holness MJ, Warner TD, Bishop-Bailey D.

PLoS One. 2009 Oct 12;4(10):e7421.PMID: 19823578 [PubMed - in process]Related articlesFree article

PPAR control: it's SIRTainly as easy as PGC.

Sugden MC, Caton PW, Holness MJ.

J Endocrinol. 2009 Oct 14. [Epub ahead of print]PMID: 19770177 [PubMed - as supplied by publisher]Related articles

PPARs and the orchestration of metabolic fuel selection.

Sugden MC, Zariwala MG, Holness MJ.

Pharmacol Res. 2009 Sep;60(3):141-50. Epub 2009 Apr 2. Review.PMID: 19646653 [PubMed - indexed for MEDLINE]Related articles

The role of PPARs in modulating cardiac metabolism in diabetes.

Holness MJ, Samsuddin S, Sugden MC.

Pharmacol Res. 2009 Sep;60(3):185-94. Epub 2009 Apr 17. Review.PMID: 19376230 [PubMed - indexed for MEDLINE]Related articles

PPARalpha activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism.

Holness MJ, Greenwood GK, Smith ND, Sugden MC.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1380-9. Epub 2008 Oct 14.PMID: 18854422 [PubMed - indexed for MEDLINE]Related articles

Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance.

Sugden MC, Holness MJ.

Biochem Soc Trans. 2008 Oct;36(Pt 5):891-900. Review.PMID: 18793157 [PubMed - indexed for MEDLINE]Related articles

PDC deletion: the way to a man's heart disease.

Sugden MC.

Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H917-H919. Epub 2008 Jul 18. No abstract available. PMID: 18641270 [PubMed - indexed for MEDLINE]Related articlesFree article

In appreciation of Sir Philip Randle: the glucose-fatty acid cycle.

Sugden MC.

Br J Nutr. 2007 May;97(5):809-13.PMID: 17408519 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor alpha deficiency modifies glucose handling by isolated mouse adipocytes.

Walker CG, Sugden MC, Gibbons GF, Holness MJ.

J Endocrinol. 2007 Apr;193(1):39-43.PMID: 17400801 [PubMed - indexed for MEDLINE]Related articlesFree article

Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency.

Walker CG, Holness MJ, Gibbons GF, Sugden MC.

Int J Obes (Lond). 2007 Jul;31(7):1165-71. Epub 2007 Jan 23.PMID: 17245390 [PubMed - indexed for MEDLINE]Related articles

PPARalpha activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy.

Holness MJ, Smith ND, Greenwood GK, Sugden MC.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1087-94. Epub 2006 Dec 12.PMID: 17164438 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet, obesity and diabetes: a current update.

Walker CG, Zariwala MG, Holness MJ, Sugden MC.

Clin Sci (Lond). 2007 Jan;112(2):93-111. Review.PMID: 17155931 [PubMed - indexed for MEDLINE]Related articles

Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases.

Sugden MC, Holness MJ.

Arch Physiol Biochem. 2006 Jul;112(3):139-49. Review.PMID: 17132539 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-alpha and glucocorticoids interactively regulate insulin secretion during pregnancy.

Holness MJ, Greenwood GK, Smith ND, Sugden MC.

Diabetes. 2006 Dec;55(12):3501-8.PMID: 17130498 [PubMed - indexed for MEDLINE]Related articlesFree article

Epigenetic regulation of metabolism in children born small for gestational age.

Holness MJ, Sugden MC.

Curr Opin Clin Nutr Metab Care. 2006 Jul;9(4):482-8. Review.PMID: 16778581 [PubMed - indexed for MEDLINE]Related articles

Hyperthyroidism impairs pancreatic beta cell adaptations to late pregnancy and maternal liporegulation in the rat.

Holness MJ, Greenwood GK, Smith ND, Sugden MC.

Diabetologia. 2005 Nov;48(11):2305-12. Epub 2005 Oct 5.PMID: 16205881 [PubMed - indexed for MEDLINE]Related articles

Interactive influences of peroxisome proliferator-activated receptor alpha activation and glucocorticoids on pancreatic beta cell compensation in insulin resistance induced by dietary saturated fat in the rat.

Holness MJ, Smith ND, Greenwood GK, Sugden MC.

Diabetologia. 2005 Oct;48(10):2062-8. Epub 2005 Aug 19.PMID: 16132960 [PubMed - indexed for MEDLINE]Related articles

Acute omega-3 fatty acid enrichment selectively reverses high-saturated fat feeding-induced insulin hypersecretion but does not improve peripheral insulin resistance.

Holness MJ, Smith ND, Greenwood GK, Sugden MC.

Diabetes. 2004 Feb;53 Suppl 1:S166-71.PMID: 14749283 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential role of peroxisome proliferator-activated receptor-alpha in the modulation of glucose-stimulated insulin secretion.

Sugden MC, Holness MJ.

Diabetes. 2004 Feb;53 Suppl 1:S71-81. Review.PMID: 14749269 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation.

Holness MJ, Sugden MC.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1143-51. Review.PMID: 14641014 [PubMed - indexed for MEDLINE]Related articles

Trials, tribulations and finally, a transporter: the identification of the mitochondrial pyruvate transporter.

Sugden MC, Holness MJ.

Biochem J. 2003 Sep 15;374(Pt 3):e1-2. Review.PMID: 12954079 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetogenic impact of long-chain omega-3 fatty acids on pancreatic beta-cell function and the regulation of endogenous glucose production.

Holness MJ, Greenwood GK, Smith ND, Sugden MC.

Endocrinology. 2003 Sep;144(9):3958-68.PMID: 12933670 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets.

Holness MJ, Smith ND, Greenwood GK, Sugden MC.

J Endocrinol. 2003 May;177(2):197-205.PMID: 12740007 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.

Sugden MC, Holness MJ.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E855-62. Review.PMID: 12676647 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.

Hopkins TA, Sugden MC, Holness MJ, Kozak R, Dyck JR, Lopaschuk GD.

Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H270-6. Epub 2003 Mar 27.PMID: 12663261 [PubMed - indexed for MEDLINE]Related articlesFree article

PDK4: A factor in fatness?

Sugden MC.

Obes Res. 2003 Feb;11(2):167-9. Review. No abstract available. PMID: 12582209 [PubMed - indexed for MEDLINE]Related articles

Effects of prenatal glucocorticoid exposure on cardiac calreticulin and calsequestrin protein expression during early development and in adulthood.

Langdown ML, Holness MJ, Sugden MC.

Biochem J. 2003 Apr 1;371(Pt 1):61-9.PMID: 12519072 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-alpha activation during pregnancy attenuates glucose-stimulated insulin hypersecretion in vivo by increasing insulin sensitivity, without impairing pregnancy-induced increases in beta-cell glucose sensing and responsiveness.

Sugden MC, Greenwood GK, Smith ND, Holness MJ.

Endocrinology. 2003 Jan;144(1):146-53.PMID: 12488340 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.

Sugden MC, Holness MJ.

Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul;2(2):151-65. Review.PMID: 12476789 [PubMed - indexed for MEDLINE]Related articles

Gender-specific programming of insulin secretion and action.

Sugden MC, Holness MJ.

J Endocrinol. 2002 Dec;175(3):757-67.PMID: 12475386 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.

Holness MJ, Bulmer K, Smith ND, Sugden MC.

Biochem J. 2003 Feb 1;369(Pt 3):687-95.PMID: 12435272 [PubMed - indexed for MEDLINE]Related articlesFree article

Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha).

Holness MJ, Bulmer K, Gibbons GF, Sugden MC.

Biochem J. 2002 Sep 15;366(Pt 3):839-46.PMID: 12099888 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism.

Holness MJ, Smith ND, Bulmer K, Hopkins T, Gibbons GF, Sugden MC.

Biochem J. 2002 Jun 15;364(Pt 3):687-94.PMID: 12049632 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin.

Sugden MC, Bulmer K, Gibbons GF, Knight BL, Holness MJ.

Biochem J. 2002 Jun 1;364(Pt 2):361-8.PMID: 12023878 [PubMed - indexed for MEDLINE]Related articlesFree article

Possible involvement of PKC isoforms in signalling placental apoptosis in intrauterine growth retardation.

Sugden MC, Langdown ML.

Mol Cell Endocrinol. 2001 Dec 20;185(1-2):119-26.PMID: 11738801 [PubMed - indexed for MEDLINE]Related articles

Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation.

Langdown ML, Sugden MC.

Mol Cell Endocrinol. 2001 Dec 20;185(1-2):109-17.PMID: 11738800 [PubMed - indexed for MEDLINE]Related articles

Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.

Sugden MC, Bulmer K, Augustine D, Holness MJ.

Diabetes. 2001 Dec;50(12):2729-36.PMID: 11723055 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding.

Sugden MC, Bulmer K, Gibbons GF, Holness MJ.

Arch Biochem Biophys. 2001 Nov 15;395(2):246-52.PMID: 11697863 [PubMed - indexed for MEDLINE]Related articles

Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno-fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinaemia in the early-growth-retarded adult offspring.

Sugden MC, Langdown ML, Munns MJ, Holness MJ.

Eur J Endocrinol. 2001 Oct;145(4):529-39.PMID: 11581014 [PubMed - indexed for MEDLINE]Related articlesFree article

Dexamethasone during late gestation exacerbates peripheral insulin resistance and selectively targets glucose-sensitive functions in beta cell and liver.

Holness MJ, Sugden MC.

Endocrinology. 2001 Sep;142(9):3742-8.PMID: 11517149 [PubMed - indexed for MEDLINE]Related articlesFree article

Excessive glucocorticoid exposure during late intrauterine development modulates the expression of cardiac uncoupling proteins in adult hypertensive male offspring.

Langdown ML, Smith ND, Sugden MC, Holness MJ.

Pflugers Arch. 2001 May;442(2):248-55.PMID: 11417222 [PubMed - indexed for MEDLINE]Related articles

Fuel-sensing mechanisms integrating lipid and carbohydrate utilization.

Sugden MC, Bulmer K, Holness MJ.

Biochem Soc Trans. 2001 May;29(Pt 2):272-8.PMID: 11356166 [PubMed - indexed for MEDLINE]Related articles

Early growth retardation induced by excessive exposure to glucocorticoids in utero selectively increases cardiac GLUT1 protein expression and Akt/protein kinase B activity in adulthood.

Langdown ML, Holness MJ, Sugden MC.

J Endocrinol. 2001 Apr;169(1):11-22.PMID: 11250642 [PubMed - indexed for MEDLINE]Related articlesFree article

Antecedent protein restriction and high-fat feeding interactively sensitise the leptin response to elevated insulin.

Holness MJ, Sugden MC.

Mol Cell Endocrinol. 2001 Feb 28;173(1-2):53-62.PMID: 11223177 [PubMed - indexed for MEDLINE]Related articles

Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply.

Sugden MC, Langdown ML, Harris RA, Holness MJ.

Biochem J. 2000 Dec 15;352 Pt 3:731-8.PMID: 11104680 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective modification of the pyruvate dehydrogenase kinase isoform profile in skeletal muscle in hyperthyroidism: implications for the regulatory impact of glucose on fatty acid oxidation.

Sugden MC, Lall HS, Harris RA, Holness MJ.

J Endocrinol. 2000 Nov;167(2):339-45.PMID: 11054649 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.

Holness MJ, Kraus A, Harris RA, Sugden MC.

Diabetes. 2000 May;49(5):775-81.PMID: 10905486 [PubMed - indexed for MEDLINE]Related articlesFree article

Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of Type 2 diabetes mellitus.

Holness MJ, Langdown ML, Sugden MC.

Biochem J. 2000 Aug 1;349 Pt 3:657-65. Review.PMID: 10903125 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression.

Sugden MC, Kraus A, Harris RA, Holness MJ.

Biochem J. 2000 Mar 15;346 Pt 3:651-7.PMID: 10698691 [PubMed - indexed for MEDLINE]Related articlesFree article

Current concepts concerning the role of leptin in reproductive function.

Holness MJ, Munns MJ, Sugden MC.

Mol Cell Endocrinol. 1999 Nov 25;157(1-2):11-20. Review.PMID: 10619393 [PubMed - indexed for MEDLINE]Related articles