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Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycaemia in non-obese diabetic mice.
Suarez-Pinzon WL, Cembrowski GS, Rabinovitch A.
Diabetologia. 2009 Aug;52(8):1680-2. Epub 2009 May 20. No abstract available. PMID: 19455306 [PubMed - indexed for MEDLINE]Related articles
Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice.
Suarez-Pinzon WL, Power RF, Yan Y, Wasserfall C, Atkinson M, Rabinovitch A.
Diabetes. 2008 Dec;57(12):3281-8. Epub 2008 Oct 3.PMID: 18835930 [PubMed - indexed for MEDLINE]Related articlesFree article
Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice.
Suarez-Pinzon WL, Lakey JR, Rabinovitch A.
Cell Transplant. 2008;17(6):631-40.PMID: 18819251 [PubMed - indexed for MEDLINE]Related articles
Combination therapy with epidermal growth factor and gastrin delays autoimmune diabetes recurrence in nonobese diabetic mice transplanted with syngeneic islets.
Suarez-Pinzon WL, Rabinovitch A.
Transplant Proc. 2008 Mar;40(2):529-32.PMID: 18374121 [PubMed - indexed for MEDLINE]Related articles
Roles of cytokines in the pathogenesis and therapy of type 1 diabetes.
Rabinovitch A, Suarez-Pinzon WL.
Cell Biochem Biophys. 2007;48(2-3):159-63.PMID: 17709885 [PubMed - indexed for MEDLINE]Related articles
The role of islet neogenesis-associated protein (INGAP) in islet neogenesis.
Lipsett M, Hanley S, Castellarin M, Austin E, Suarez-Pinzon WL, Rabinovitch A, Rosenberg L.
Cell Biochem Biophys. 2007;48(2-3):127-37. Review.PMID: 17709882 [PubMed - indexed for MEDLINE]Related articles
Combination therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice.
Suarez-Pinzon WL, Yan Y, Power R, Brand SJ, Rabinovitch A.
Diabetes. 2005 Sep;54(9):2596-601.PMID: 16123347 [PubMed - indexed for MEDLINE]Related articlesFree article
Mechanisms underlying resistance of pancreatic islets from ALR/Lt mice to cytokine-induced destruction.
Mathews CE, Suarez-Pinzon WL, Baust JJ, Strynadka K, Leiter EH, Rabinovitch A.
J Immunol. 2005 Jul 15;175(2):1248-56.PMID: 16002729 [PubMed - indexed for MEDLINE]Related articlesFree article
Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass.
Suarez-Pinzon WL, Lakey JR, Brand SJ, Rabinovitch A.
J Clin Endocrinol Metab. 2005 Jun;90(6):3401-9. Epub 2005 Mar 15.PMID: 15769977 [PubMed - indexed for MEDLINE]Related articlesFree article
Role of cytokines in the pathogenesis of autoimmune diabetes mellitus.
Rev Endocr Metab Disord. 2003 Sep;4(3):291-9. Review. No abstract available. PMID: 14501180 [PubMed - indexed for MEDLINE]Related articles
Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes.
Suarez-Pinzon WL, Mabley JG, Power R, Szabó C, Rabinovitch A.
Diabetes. 2003 Jul;52(7):1683-8.PMID: 12829633 [PubMed - indexed for MEDLINE]Related articlesFree article
Imbalance between tissue inhibitor of metalloproteinase-4 and matrix metalloproteinases during acute myocardial [correction of myoctardial] ischemia-reperfusion injury.
Schulze CJ, Wang W, Suarez-Pinzon WL, Sawicka J, Sawicki G, Schulz R.
Circulation. 2003 May 20;107(19):2487-92. Epub 2003 Apr 21.PMID: 12707244 [PubMed - indexed for MEDLINE]Related articlesFree article
Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction.
Gao CQ, Sawicki G, Suarez-Pinzon WL, Csont T, Wozniak M, Ferdinandy P, Schulz R.
Cardiovasc Res. 2003 Feb;57(2):426-33.PMID: 12566115 [PubMed - indexed for MEDLINE]Related articlesFree article
Gene transfection and expression of transforming growth factor-beta1 in nonobese diabetic mouse islets protects beta-cells in syngeneic islet grafts from autoimmune destruction.
Suarez-Pinzon WL, Marcoux Y, Ghahary A, Rabinovitch A.
Cell Transplant. 2002;11(6):519-28.PMID: 12428741 [PubMed - indexed for MEDLINE]Related articles
Approaches to type 1 diabetes prevention by intervention in cytokine immunoregulatory circuits.
Int J Exp Diabetes Res. 2001;2(1):3-17. Review.PMID: 12369724 [PubMed - indexed for MEDLINE]Related articlesFree article
Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury.
Wang W, Schulze CJ, Suarez-Pinzon WL, Dyck JR, Sawicki G, Schulz R.
Circulation. 2002 Sep 17;106(12):1543-9.PMID: 12234962 [PubMed - indexed for MEDLINE]Related articlesFree article
Combination therapy with low dose sirolimus and tacrolimus is synergistic in preventing spontaneous and recurrent autoimmune diabetes in non-obese diabetic mice.
Shapiro AM, Suarez-Pinzon WL, Power R, Rabinovitch A.
Diabetologia. 2002 Feb;45(2):224-30.PMID: 11935154 [PubMed - indexed for MEDLINE]Related articles
Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice.
Rabinovitch A, Suarez-Pinzon WL, Shapiro AM, Rajotte RV, Power R.
Diabetes. 2002 Mar;51(3):638-45.PMID: 11872661 [PubMed - indexed for MEDLINE]Related articlesFree article
Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells.
Lakey JR, Suarez-Pinzon WL, Strynadka K, Korbutt GS, Rajotte RV, Mabley JG, Szabó C, Rabinovitch A.
Lab Invest. 2001 Dec;81(12):1683-92.PMID: 11742038 [PubMed - indexed for MEDLINE]Related articles
Expression of calbindin-D(28k) in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis.
Rabinovitch A, Suarez-Pinzon WL, Sooy K, Strynadka K, Christakos S.
Endocrinology. 2001 Aug;142(8):3649-55.PMID: 11459814 [PubMed - indexed for MEDLINE]Related articlesFree article
Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes.
Mabley JG, Suarez-Pinzon WL, Haskó G, Salzman AL, Rabinovitch A, Kun E, Szabó C.
Br J Pharmacol. 2001 Jul;133(6):909-19.PMID: 11454665 [PubMed - indexed for MEDLINE]Related articlesFree article
An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice.
Suarez-Pinzon WL, Mabley JG, Strynadka K, Power RF, Szabó C, Rabinovitch A.
J Autoimmun. 2001 Jun;16(4):449-55.PMID: 11437493 [PubMed - indexed for MEDLINE]Related articles
Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation.
Serreze DV, Chapman HD, Post CM, Johnson EA, Suarez-Pinzon WL, Rabinovitch A.
J Immunol. 2001 Jan 15;166(2):1352-9.PMID: 11145720 [PubMed - indexed for MEDLINE]Related articlesFree article
Fas ligand-mediated mechanisms are involved in autoimmune destruction of islet beta cells in non-obese diabetic mice.
Suarez-Pinzon WL, Power RF, Rabinovitch A.
Diabetologia. 2000 Sep;43(9):1149-56.PMID: 11043861 [PubMed - indexed for MEDLINE]Related articles
Testicular Sertoli cells exert both protective and destructive effects on syngeneic islet grafts in non-obese diabetic mice.
Korbutt GS, Suarez-Pinzon WL, Power RF, Rajotte RV, Rabinovitch A.
Diabetologia. 2000 Apr;43(4):474-80.PMID: 10819241 [PubMed - indexed for MEDLINE]Related articles
Both CD4(+)and CD8(+)T cells are required for IFN-gamma gene expression in pancreatic islets and autoimmune diabetes development in biobreeding rats.
El-Sheikh A, Suarez-Pinzon WL, Power RF, Rabinovitch A.
J Autoimmun. 1999 Mar;12(2):109-19.PMID: 10047431 [PubMed - indexed for MEDLINE]Related articles
Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus.
Biochem Pharmacol. 1998 Apr 15;55(8):1139-49. Review.PMID: 9719467 [PubMed - indexed for MEDLINE]Related articles
Improved survival of biolistically transfected mouse islet allografts expressing CTLA4-Ig or soluble Fas ligand.
Gainer AL, Suarez-Pinzon WL, Min WP, Swiston JR, Hancock-Friesen C, Korbutt GS, Rajotte RV, Warnock GL, Elliott JF.
Transplantation. 1998 Jul 27;66(2):194-9.PMID: 9701263 [PubMed - indexed for MEDLINE]Related articles
TNF-alpha down-regulates type 1 cytokines and prolongs survival of syngeneic islet grafts in nonobese diabetic mice.
Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Rajotte RV, Power RF.
J Immunol. 1997 Dec 15;159(12):6298-303.PMID: 9550435 [PubMed - indexed for MEDLINE]Related articles
Neonatal porcine islet xenografts in nonobese diabetic mice: effects on blood glucose and analysis of cytokines expressed in the islet grafts.
Suarez-Pinzon WL, Korbutt GS, Rayat G, Sorensen O, Power RF, Rajotte RV, Rabinovitch A.
Transplant Proc. 1998 Mar;30(2):654-5. No abstract available. PMID: 9532219 [PubMed - indexed for MEDLINE]Related articles
Prolongation of allograft survival of transfected islets expressing human CTLA4-Ig, human soluble Fas ligand or a combination of the two.
Gainer AL, Suarez-Pinzon WL, Min WP, Hancock-Friesen C, Korbutt GS, Rajotte RV, Rabinovitch A, Warnock GL, Elliott JF.
Transplant Proc. 1998 Mar;30(2):534. No abstract available. PMID: 9532165 [PubMed - indexed for MEDLINE]Related articles
Transplantation of microencapsulated syngeneic and xenogeneic (neonatal porcine) islets in nonobese diabetic mice.
Ao Z, Suarez-Pinzon WL, Rajotte RV, Korbutt GS, Flashner M, Rabinovitch A.
Transplant Proc. 1998 Mar;30(2):500. No abstract available. PMID: 9532147 [PubMed - indexed for MEDLINE]Related articles
Combination therapy with cyclosporine and interleukin-4 or interleukin-10 prolongs survival of synergeneic pancreatic islet grafts in nonobese diabetic mice: islet graft survival does not correlate with mRNA levels of type 1 or type 2 cytokines, or transforming growth factor-beta in the islet grafts.
Transplantation. 1997 Dec 15;64(11):1525-31.PMID: 9415551 [PubMed - indexed for MEDLINE]Related articles
Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent beta cell destruction in diabetic NOD mice.
Smith DK, Korbutt GS, Suarez-Pinzon WL, Kao D, Rajotte RV, Elliott JF.
Transplantation. 1997 Oct 15;64(7):1040-9.PMID: 9381527 [PubMed - indexed for MEDLINE]Related articles
Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet beta-cells.
Suarez-Pinzon WL, Szabó C, Rabinovitch A.
Diabetes. 1997 May;46(5):907-11.PMID: 9133563 [PubMed - indexed for MEDLINE]Related articles
Destruction of rat pancreatic islet beta-cells by cytokines involves the production of cytotoxic aldehydes.
Suarez-Pinzon WL, Strynadka K, Rabinovitch A.
Endocrinology. 1996 Dec;137(12):5290-6.PMID: 8940348 [PubMed - indexed for MEDLINE]Related articles
Interleukin 12 mRNA expression in islets correlates with beta-cell destruction in NOD mice.
Rabinovitch A, Suarez-Pinzon WL, Sorensen O.
J Autoimmun. 1996 Oct;9(5):645-51.PMID: 8933280 [PubMed - indexed for MEDLINE]Related articles
Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production.
Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Lakey JR, Rajotte RV.
J Clin Endocrinol Metab. 1996 Sep;81(9):3197-202.PMID: 8784069 [PubMed - indexed for MEDLINE]Related articles
Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS- expressing cells and relationships to cytokines expressed in the islets.
Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC.
Endocrinology. 1996 May;137(5):2093-9.PMID: 8612552 [PubMed - indexed for MEDLINE]Related articles
Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Analysis of cytokine mRNA expression in the graft.
Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC, Power RF, Rajotte RV.
Transplantation. 1995 Aug 27;60(4):368-74.PMID: 7652767 [PubMed - indexed for MEDLINE]Related articles
Tumor necrosis factor mediates the protective effect of Freund's adjuvant against autoimmune diabetes in BB rats.
Rabinovitch A, Suarez-Pinzon WL, Lapchak PH, Meager A, Power RF.
J Autoimmun. 1995 Jun;8(3):357-66.PMID: 7575997 [PubMed - indexed for MEDLINE]Related articles
IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice.
Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC, Power RF.
J Immunol. 1995 May 1;154(9):4874-82.PMID: 7722337 [PubMed - indexed for MEDLINE]Related articles
Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production.
Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Schulz R, Lakey JR, Warnock GL, Rajotte RV.
J Clin Endocrinol Metab. 1994 Oct;79(4):1058-62.PMID: 7962274 [PubMed - indexed for MEDLINE]Related articles
Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice: interleukin 2 and interferon gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival.
Rabinovitch A, Sorensen O, Suarez-Pinzon WL, Power RF, Rajotte RV, Bleackley RC.
Diabetologia. 1994 Aug;37(8):833-7.PMID: 7988786 [PubMed - indexed for MEDLINE]Related articles
DNA fragmentation is an early event in cytokine-induced islet beta-cell destruction.
Rabinovitch A, Suarez-Pinzon WL, Shi Y, Morgan AR, Bleackley RC.
Diabetologia. 1994 Aug;37(8):733-8.PMID: 7988773 [PubMed - indexed for MEDLINE]Related articles
Mechanisms of cytokine-induced destruction of rat insulinoma cells: the role of nitric oxide.
Suarez-Pinzon WL, Strynadka K, Schulz R, Rabinovitch A.
Endocrinology. 1994 Mar;134(3):1006-10.PMID: 8119136 [PubMed - indexed for MEDLINE]Related articles
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