PubMed

Synergistic effect of the human GLP-1 analogue liraglutide and a dual PPARalpha/gamma agonist on glycaemic control in Zucker diabetic fatty rats.

Brand CL, Galsgaard ED, Tornehave D, Rømer J, Gotfredsen CF, Wassermann K, Knudsen LB, Vølund A, Sturis J.

Diabetes Obes Metab. 2009 Aug;11(8):795-803. Epub 2009 Jun 10.PMID: 19519868 [PubMed - in process]Related articles

A novel high-affinity peptide antagonist to the insulin receptor.

Schäffer L, Brand CL, Hansen BF, Ribel U, Shaw AC, Slaaby R, Sturis J.

Biochem Biophys Res Commun. 2008 Nov 14;376(2):380-3. Epub 2008 Sep 7.PMID: 18782558 [PubMed - indexed for MEDLINE]Related articles

Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats.

Larsen PJ, Wulff EM, Gotfredsen CF, Brand CL, Sturis J, Vrang N, Knudsen LB, Lykkegaard K.

Diabetes Obes Metab. 2008 Apr;10(4):301-11.PMID: 18333889 [PubMed - indexed for MEDLINE]Related articles

Small-molecule agonists for the glucagon-like peptide 1 receptor.

Knudsen LB, Kiel D, Teng M, Behrens C, Bhumralkar D, Kodra JT, Holst JJ, Jeppesen CB, Johnson MD, de Jong JC, Jorgensen AS, Kercher T, Kostrowicki J, Madsen P, Olesen PH, Petersen JS, Poulsen F, Sidelmann UG, Sturis J, Truesdale L, May J, Lau J.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):937-42. Epub 2007 Jan 9.PMID: 17213325 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurements of insulin responses as predictive markers of pancreatic beta-cell mass in normal and beta-cell-reduced lean and obese Göttingen minipigs in vivo.

Larsen MO, Rolin B, Sturis J, Wilken M, Carr RD, Pørksen N, Gotfredsen CF.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E670-7. Epub 2005 Nov 8.PMID: 16278249 [PubMed - indexed for MEDLINE]Related articlesFree article

Repaglinide treatment amplifies first-phase insulin secretion and high-frequency pulsatile insulin release in Type 2 diabetes.

Hollingdal M, Sturis J, Gall MA, Damsbo P, Pincus S, Veldhuis JD, Pørksen N, Schmitz O, Juhl CB.

Diabet Med. 2005 Oct;22(10):1408-13.PMID: 16176204 [PubMed - indexed for MEDLINE]Related articles

Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats.

Moesgaard SG, Brand CL, Sturis J, Ahrén B, Wilken M, Fleckner J, Carr RD, Svendsen O, Hansen AJ, Gram DX.

Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1137-45.PMID: 15883192 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute insulin responses to intravenous glucose and GLP-1 are independent of preceding high-frequency insulin pulse-defects induced by glucose entrainment in healthy humans.

Juhl CB, Sturis J, Hollingdal M, Schmitz O.

Horm Metab Res. 2005 Jan;37(1):40-4.PMID: 15702438 [PubMed - indexed for MEDLINE]Related articles

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.

Degn KB, Juhl CB, Sturis J, Jakobsen G, Brock B, Chandramouli V, Rungby J, Landau BR, Schmitz O.

Diabetes. 2004 May;53(5):1187-94.PMID: 15111485 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved beta-cell survival and reduced insulitis in a type 1 diabetic rat model after treatment with a beta-cell-selective K(ATP) channel opener.

Skak K, Gotfredsen CF, Lundsgaard D, Hansen JB, Sturis J, Markholst H.

Diabetes. 2004 Apr;53(4):1089-95.PMID: 15047626 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.

Alemzadeh R, Fledelius C, Bodvarsdottir T, Sturis J.

Metabolism. 2004 Apr;53(4):441-7.PMID: 15045689 [PubMed - indexed for MEDLINE]Related articles

NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat.

Carr RD, Brand CL, Bodvarsdottir TB, Hansen JB, Sturis J.

Diabetes. 2003 Oct;52(10):2513-8.PMID: 14514634 [PubMed - indexed for MEDLINE]Related articlesFree article

GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.

Sturis J, Gotfredsen CF, Rømer J, Rolin B, Ribel U, Brand CL, Wilken M, Wassermann K, Deacon CF, Carr RD, Knudsen LB.

Br J Pharmacol. 2003 Sep;140(1):123-32. Epub 2003 Jul 29.PMID: 12967942 [PubMed - indexed for MEDLINE]Related articlesFree article

The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose.

Chang AM, Jakobsen G, Sturis J, Smith MJ, Bloem CJ, An B, Galecki A, Halter JB.

Diabetes. 2003 Jul;52(7):1786-91.PMID: 12829647 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual PPARalpha /gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats.

Brand CL, Sturis J, Gotfredsen CF, Fleckner J, Fledelius C, Hansen BF, Andersen B, Ye JM, Sauerberg P, Wassermann K.

Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E841-54. Epub 2002 Dec 10.PMID: 12475752 [PubMed - indexed for MEDLINE]Related articlesFree article

The conscious Göttingen minipig as a model for studying rapid pulsatile insulin secretion in vivo.

Larsen MO, Elander M, Sturis J, Wilken M, Carr RD, Rolin B, Pørksen N.

Diabetologia. 2002 Oct;45(10):1389-96. Epub 2002 Sep 5.PMID: 12378379 [PubMed - indexed for MEDLINE]Related articles

NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs.

Ribel U, Larsen MO, Rolin B, Carr RD, Wilken M, Sturis J, Westergaard L, Deacon CF, Knudsen LB.

Eur J Pharmacol. 2002 Sep 13;451(2):217-25.PMID: 12231394 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects.

Elbrønd B, Jakobsen G, Larsen S, Agersø H, Jensen LB, Rolan P, Sturis J, Hatorp V, Zdravkovic M.

Diabetes Care. 2002 Aug;25(8):1398-404.PMID: 12145241 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute hyperglycemia alters the ability of the normal beta-cell to sense and respond to glucose.

Meyer J, Sturis J, Katschinski M, Arnold R, Göke B, Byrne MM.

Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E917-22.PMID: 11882513 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid induced insulin resistance impairs basal but not glucose entrained high-frequency insulin pulsatility in humans.

Hollingdal M, Juhl CB, Dall R, Sturis J, Veldhuis JD, Schmitz O, Pørksen N.

Diabetologia. 2002 Jan;45(1):49-55.PMID: 11845223 [PubMed - indexed for MEDLINE]Related articles

Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.

Sauerberg P, Pettersson I, Jeppesen L, Bury PS, Mogensen JP, Wassermann K, Brand CL, Sturis J, Wöldike HF, Fleckner J, Andersen AS, Mortensen SB, Svensson LA, Rasmussen HB, Lehmann SV, Polivka Z, Sindelar K, Panajotova V, Ynddal L, Wulff EM.

J Med Chem. 2002 Feb 14;45(4):789-804.PMID: 11831892 [PubMed - indexed for MEDLINE]Related articles

Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes.

Juhl CB, Hollingdal M, Sturis J, Jakobsen G, Agersø H, Veldhuis J, Pørksen N, Schmitz O.

Diabetes. 2002 Feb;51(2):424-9.PMID: 11812750 [PubMed - indexed for MEDLINE]Related articlesFree article

Explosion of limit cycles and chaotic waves in a simple nonlinear chemical system.

Brøns M, Sturis J.

Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Aug;64(2 Pt 2):026209. Epub 2001 Jul 18.PMID: 11497679 [PubMed]Related articles

Modeling the insulin-glucose feedback system: the significance of pulsatile insulin secretion.

Tolić IM, Mosekilde E, Sturis J.

J Theor Biol. 2000 Dec 7;207(3):361-75.PMID: 11082306 [PubMed - indexed for MEDLINE]Related articles

Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes.

Hollingdal M, Juhl CB, Pincus SM, Sturis J, Veldhuis JD, Polonsky KS, Pørksen N, Schmitz O.

Diabetes. 2000 Aug;49(8):1334-40.PMID: 10923634 [PubMed - indexed for MEDLINE]Related articlesFree article

Repaglinide acutely amplifies pulsatile insulin secretion by augmentation of burst mass with no effect on burst frequency.

Juhl CB, Pørksen N, Hollingdal M, Sturis J, Pincus S, Veldhuis JD, Dejgaard A, Schmitz O.

Diabetes Care. 2000 May;23(5):675-81.PMID: 10834429 [PubMed - indexed for MEDLINE]Related articlesFree article

High-frequency oscillations in circulating amylin concentrations in healthy humans.

Juhl CB, Pørksen N, Sturis J, Hansen AP, Veldhuis JD, Pincus S, Fineman M, Schmitz O.

Am J Physiol Endocrinol Metab. 2000 Mar;278(3):E484-90.PMID: 10710503 [PubMed - indexed for MEDLINE]Related articlesFree article

Concordant induction of rapid in vivo pulsatile insulin secretion by recurrent punctuated glucose infusions.

Pørksen N, Juhl C, Hollingdal M, Pincus SM, Sturis J, Veldhuis JD, Schmitz O.

Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E162-70.PMID: 10644551 [PubMed - indexed for MEDLINE]Related articlesFree article

Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations.

Nyholm B, Walker M, Gravholt CH, Shearing PA, Sturis J, Alberti KG, Holst JJ, Schmitz O.

Diabetologia. 1999 Nov;42(11):1314-23.PMID: 10550415 [PubMed - indexed for MEDLINE]Related articles

Temporal profiles and clinical significance of pulsatile insulin secretion.

Polonsky KS, Sturis J, Van Cauter E.

Horm Res. 1998;49(3-4):178-84. Review.PMID: 9550122 [PubMed - indexed for MEDLINE]Related articles

Local and global bifurcations at infinity in models of glycolytic oscillations.

Sturis J, Brøns M.

J Math Biol. 1997 Dec;36(2):119-32.PMID: 9463107 [PubMed - indexed for MEDLINE]Related articles

Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.

Cockburn BN, Ostrega DM, Sturis J, Kubstrup C, Polonsky KS, Bell GI.

Diabetes. 1997 Sep;46(9):1434-9.PMID: 9287043 [PubMed - indexed for MEDLINE]Related articles

Alternative insulin delivery systems: how demanding should the patient be?

Polonsky KS, Byrne MM, Sturis J.

Diabetologia. 1997 Jul;40 Suppl 2:S97-101. Review. No abstract available. PMID: 9248709 [PubMed - indexed for MEDLINE]Related articles

Sleepiness, performance, and neuroendocrine function during sleep deprivation: effects of exposure to bright light or exercise.

Leproult R, Van Reeth O, Byrne MM, Sturis J, Van Cauter E.

J Biol Rhythms. 1997 Jun;12(3):245-58.PMID: 9181436 [PubMed - indexed for MEDLINE]Related articles

Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome.

Ehrmann DA, Cavaghan MK, Imperial J, Sturis J, Rosenfield RL, Polonsky KS.

J Clin Endocrinol Metab. 1997 Feb;82(2):524-30.PMID: 9024248 [PubMed - indexed for MEDLINE]Related articlesFree article

Ultradian oscillations of leptin secretion in humans.

Sinha MK, Sturis J, Ohannesian J, Magosin S, Stephens T, Heiman ML, Polonsky KS, Caro JF.

Biochem Biophys Res Commun. 1996 Nov 21;228(3):733-8.PMID: 8941346 [PubMed - indexed for MEDLINE]Related articles

Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.

Byrne MM, Sturis J, Menzel S, Yamagata K, Fajans SS, Dronsfield MJ, Bain SC, Hattersley AT, Velho G, Froguel P, Bell GI, Polonsky KS.

Diabetes. 1996 Nov;45(11):1503-10.PMID: 8866553 [PubMed - indexed for MEDLINE]Related articles

Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone.

Sreenan S, Sturis J, Pugh W, Burant CF, Polonsky KS.

Am J Physiol. 1996 Oct;271(4 Pt 1):E742-7.PMID: 8897863 [PubMed - indexed for MEDLINE]Related articles

Alterations in the ultradian oscillations of insulin secretion and plasma glucose in aging.

Scheen AJ, Sturis J, Polonsky KS, Van Cauter E.

Diabetologia. 1996 May;39(5):564-72.PMID: 8739916 [PubMed - indexed for MEDLINE]Related articles

Elevated plasma glucose 2 h postchallenge predicts defects in beta-cell function.

Byrne MM, Sturis J, Sobel RJ, Polonsky KS.

Am J Physiol. 1996 Apr;270(4 Pt 1):E572-9.PMID: 8928761 [PubMed - indexed for MEDLINE]Related articles

Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation.

Velho G, Byrne MM, Clément K, Sturis J, Pueyo ME, Blanché H, Vionnet N, Fiet J, Passa P, Robert JJ, Polonsky KS, Froguel P.

Diabetes. 1996 Apr;45(4):478-87.PMID: 8603770 [PubMed - indexed for MEDLINE]Related articles

Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance.

Polonsky KS, Sturis J, Bell GI.

N Engl J Med. 1996 Mar 21;334(12):777-83. Review. No abstract available. PMID: 8592553 [PubMed - indexed for MEDLINE]Related articles

NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity.

Roe MW, Worley JF 3rd, Tokuyama Y, Philipson LH, Sturis J, Tang J, Dukes ID, Bell GI, Polonsky KS.

Am J Physiol. 1996 Jan;270(1 Pt 1):E133-40.PMID: 8772485 [PubMed - indexed for MEDLINE]Related articles

Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans.

Plat L, Byrne MM, Sturis J, Polonsky KS, Mockel J, Féry F, Van Cauter E.

Am J Physiol. 1996 Jan;270(1 Pt 1):E36-42.PMID: 8772471 [PubMed - indexed for MEDLINE]Related articles

Effects of aging on glucose regulation during wakefulness and sleep.

Frank SA, Roland DC, Sturis J, Byrne MM, Refetoff S, Polonsky KS, Van Cauter E.

Am J Physiol. 1995 Dec;269(6 Pt 1):E1006-16.PMID: 8572190 [PubMed - indexed for MEDLINE]Related articles

Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.

Tokuyama Y, Sturis J, DePaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, Bell GI.

Diabetes. 1995 Dec;44(12):1447-57.PMID: 7589853 [PubMed - indexed for MEDLINE]Related articles

Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat.

Sturis J, Pugh WL, Tang J, Polonsky KS.

Am J Physiol. 1995 Oct;269(4 Pt 1):E786-92.PMID: 7485496 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion in insulin-resistant women with a history of gestational diabetes.

Byrne MM, Sturis J, O'Meara NM, Polonsky KS.

Metabolism. 1995 Aug;44(8):1067-73.PMID: 7637649 [PubMed - indexed for MEDLINE]Related articles

Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.

Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL, Polonsky KS.

J Clin Invest. 1995 Jul;96(1):520-7.PMID: 7615824 [PubMed - indexed for MEDLINE]Related articlesFree article