PubMed

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.

Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, Stoffers DA.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19090-5. Epub 2009 Oct 23.PMID: 19855005 [PubMed - in process]Related articles

Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats.

Raab EL, Vuguin PM, Stoffers DA, Simmons RA.

Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1785-94. Epub 2009 Oct 21.PMID: 19846744 [PubMed - in process]Related articles

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.

Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA.

J Clin Invest. 2009 Jul;119(7):1888-98.PMID: 19487809 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 normalizes islet vascularity in intrauterine growth restricted rats: potential role of VEGF.

Ham JN, Crutchlow MF, Desai BM, Simmons RA, Stoffers DA.

Pediatr Res. 2009 Jul;66(1):42-6.PMID: 19287346 [PubMed - indexed for MEDLINE]Related articles

Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion.

Sachdeva MM, Stoffers DA.

Mol Endocrinol. 2009 Jun;23(6):747-58. Epub 2009 Feb 5. Review.PMID: 19196831 [PubMed - indexed for MEDLINE]Related articles

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice.

Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach SD, Maitra A.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18913-8. Epub 2008 Nov 21.PMID: 19028870 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward a cell-based cure for diabetes: advances in production and transplant of beta cells.

Claiborn KC, Stoffers DA.

Mt Sinai J Med. 2008 Aug;75(4):362-71. Review.PMID: 18729181 [PubMed - indexed for MEDLINE]Related articles

On the origin of the beta cell.

Oliver-Krasinski JM, Stoffers DA.

Genes Dev. 2008 Aug 1;22(15):1998-2021. Review.PMID: 18676806 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.

De León DD, Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA.

J Biol Chem. 2008 Sep 19;283(38):25786-93. Epub 2008 Jul 17.PMID: 18635551 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 does not promote Beta-cell proliferation or survival during the early post-islet transplant period in mice.

Crutchlow MF, Yu M, Bae YS, Deng S, Stoffers DA.

Transplant Proc. 2008 Jun;40(5):1650-7. Erratum in: Transplant Proc. 2009 Jan-Feb;41(1):450. PMID: 18589167 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.

Park JH, Stoffers DA, Nicholls RD, Simmons RA.

J Clin Invest. 2008 Jun;118(6):2316-24.PMID: 18464933 [PubMed - indexed for MEDLINE]Related articlesFree article

Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration.

Desai BM, Oliver-Krasinski J, De Leon DD, Farzad C, Hong N, Leach SD, Stoffers DA.

J Clin Invest. 2007 Apr;117(4):971-7.PMID: 17404620 [PubMed - indexed for MEDLINE]Related articlesFree article

Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1.

Liu A, Oliver-Krasinski J, Stoffers DA.

FEBS Lett. 2006 Dec 11;580(28-29):6701-6. Epub 2006 Nov 17.PMID: 17126328 [PubMed - indexed for MEDLINE]Related articles

The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter.

Deramaudt TB, Sachdeva MM, Wescott MP, Chen Y, Stoffers DA, Rustgi AK.

J Biol Chem. 2006 Dec 15;281(50):38385-95. Epub 2006 Oct 20.PMID: 17056599 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment.

De León DD, Farzad C, Crutchlow MF, Brestelli J, Tobias J, Kaestner KH, Stoffers DA.

Physiol Genomics. 2006 Jan 12;24(2):133-43.PMID: 16410542 [PubMed - indexed for MEDLINE]Related articlesFree article

Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3.

Lee CS, De León DD, Kaestner KH, Stoffers DA.

Diabetes. 2006 Feb;55(2):269-72. Epub 2005 Dec 16.PMID: 16361411 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus.

De León DD, Crutchlow MF, Ham JY, Stoffers DA.

Int J Biochem Cell Biol. 2006;38(5-6):845-59. Epub 2005 Sep 15. Review.PMID: 16202636 [PubMed - indexed for MEDLINE]Related articles

Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates.

Means AL, Meszoely IM, Suzuki K, Miyamoto Y, Rustgi AK, Coffey RJ Jr, Wright CV, Stoffers DA, Leach SD.

Development. 2005 Aug;132(16):3767-76. Epub 2005 Jul 14.PMID: 16020518 [PubMed - indexed for MEDLINE]Related articlesFree article

The development of beta-cell mass: recent progress and potential role of GLP-1.

Stoffers DA.

Horm Metab Res. 2004 Nov-Dec;36(11-12):811-21. Review.PMID: 15655713 [PubMed - indexed for MEDLINE]Related articles

Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene.

Schreiber FS, Deramaudt TB, Brunner TB, Boretti MI, Gooch KJ, Stoffers DA, Bernhard EJ, Rustgi AK.

Gastroenterology. 2004 Jul;127(1):250-60.PMID: 15236190 [PubMed - indexed for MEDLINE]Related articles

Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity.

Liu A, Desai BM, Stoffers DA.

Mol Cell Biol. 2004 May;24(10):4372-83.PMID: 15121856 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity.

Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB 3rd, Madsen OD, Serup P.

Dev Biol. 2004 Apr 1;268(1):123-34.PMID: 15031110 [PubMed - indexed for MEDLINE]Related articles

Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas.

Esni F, Stoffers DA, Takeuchi T, Leach SD.

Mech Dev. 2004 Jan;121(1):15-25.PMID: 14706696 [PubMed - indexed for MEDLINE]Related articles

The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.

Brembeck FH, Schreiber FS, Deramaudt TB, Craig L, Rhoades B, Swain G, Grippo P, Stoffers DA, Silberg DG, Rustgi AK.

Cancer Res. 2003 May 1;63(9):2005-9.PMID: 12727809 [PubMed - indexed for MEDLINE]Related articlesFree article

Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat.

Stoffers DA, Desai BM, DeLeon DD, Simmons RA.

Diabetes. 2003 Mar;52(3):734-40.PMID: 12606515 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy.

De León DD, Deng S, Madani R, Ahima RS, Drucker DJ, Stoffers DA.

Diabetes. 2003 Feb;52(2):365-71.PMID: 12540609 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.

Lee CS, Sund NJ, Vatamaniuk MZ, Matschinsky FM, Stoffers DA, Kaestner KH.

Diabetes. 2002 Aug;51(8):2546-51.PMID: 12145169 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia.

Sund NJ, Vatamaniuk MZ, Casey M, Ang SL, Magnuson MA, Stoffers DA, Matschinsky FM, Kaestner KH.

Genes Dev. 2001 Jul 1;15(13):1706-15.PMID: 11445544 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas.

Heller RS, Stoffers DA, Bock T, Svenstrup K, Jensen J, Horn T, Miller CP, Habener JF, Madsen OD, Serup P.

Diabetes. 2001 Jul;50(7):1553-61.PMID: 11423476 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

Clocquet AR, Egan JM, Stoffers DA, Muller DC, Wideman L, Chin GA, Clarke WL, Hanks JB, Habener JF, Elahi D.

Diabetes. 2000 Nov;49(11):1856-64.PMID: 11078452 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM.

Diabetes. 2000 May;49(5):741-8.PMID: 10905482 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

Xu G, Stoffers DA, Habener JF, Bonner-Weir S.

Diabetes. 1999 Dec;48(12):2270-6.PMID: 10580413 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus.

Hani EH, Stoffers DA, Chèvre JC, Durand E, Stanojevic V, Dina C, Habener JF, Froguel P.

J Clin Invest. 1999 Nov;104(9):R41-8.PMID: 10545531 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter.

Stoffers DA, Heller RS, Miller CP, Habener JF.

Endocrinology. 1999 Nov;140(11):5374-81.PMID: 10537169 [PubMed - indexed for MEDLINE]Related articlesFree article

Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum.

Heller RS, Stoffers DA, Hussain MA, Miller CP, Habener JF.

Gastroenterology. 1998 Aug;115(2):381-7.PMID: 9679043 [PubMed - indexed for MEDLINE]Related articles

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein.

Stoffers DA, Stanojevic V, Habener JF.

J Clin Invest. 1998 Jul 1;102(1):232-41.PMID: 9649577 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin promoter factor 1 gene is not a major cause of maturity-onset diabetes of the young in French Caucasians.

Chèvre JC, Hani EH, Stoffers DA, Habener JF, Froguel P.

Diabetes. 1998 May;47(5):843-4. No abstract available. PMID: 9588460 [PubMed - indexed for MEDLINE]Related articlesFree article

A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus.

Habener JF, Stoffers DA.

Proc Assoc Am Physicians. 1998 Jan-Feb;110(1):12-21. Review.PMID: 9460079 [PubMed - indexed for MEDLINE]Related articles

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1.

Stoffers DA, Ferrer J, Clarke WL, Habener JF.

Nat Genet. 1997 Oct;17(2):138-9. No abstract available. PMID: 9326926 [PubMed - indexed for MEDLINE]Related articles

Homeodomain Protein IDX-1 A Master Regulator of Pancreas Development and Insulin Gene Expression.

Stoffers DA, Thomas MK, Habener JF.

Trends Endocrinol Metab. 1997 May-Jun;8(4):145-51.PMID: 18406800 [PubMed - in process]Related articles

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence.

Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF.

Nat Genet. 1997 Jan;15(1):106-10.PMID: 8988180 [PubMed - indexed for MEDLINE]Related articles

The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains.

Ouafik LH, Stoffers DA, Campbell TA, Johnson RC, Bloomquist BT, Mains RE, Eipper BA.

Mol Endocrinol. 1992 Oct;6(10):1571-84.PMID: 1448112 [PubMed - indexed for MEDLINE]Related articles

Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM).

Eipper BA, Green CB, Campbell TA, Stoffers DA, Keutmann HT, Mains RE, Ouafik L.

J Biol Chem. 1992 Feb 25;267(6):4008-15.PMID: 1740449 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of peptidylglycine alpha-amidating monooxygenase (EC 1.14.17.3) in the rat central nervous system.

Schafer MK, Stoffers DA, Eipper BA, Watson SJ.

J Neurosci. 1992 Jan;12(1):222-34.PMID: 1729435 [PubMed - indexed for MEDLINE]Related articlesFree article

The biosynthesis of neuropeptides: peptide alpha-amidation.

Eipper BA, Stoffers DA, Mains RE.

Annu Rev Neurosci. 1992;15:57-85. Review. No abstract available. PMID: 1575450 [PubMed - indexed for MEDLINE]Related articles

Characterization of novel mRNAs encoding enzymes involved in peptide alpha-amidation.

Stoffers DA, Ouafik L, Eipper BA.

J Biol Chem. 1991 Jan 25;266(3):1701-7.PMID: 1988445 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue specific expression of rat peptidylglycine alpha-amidating monooxygenase activity and mRNA.

Braas KM, Stoffers DA, Eipper BA, May V.

Mol Endocrinol. 1989 Sep;3(9):1387-98.PMID: 2575217 [PubMed - indexed for MEDLINE]Related articles

Alternative mRNA splicing generates multiple forms of peptidyl-glycine alpha-amidating monooxygenase in rat atrium.

Stoffers DA, Green CB, Eipper BA.

Proc Natl Acad Sci U S A. 1989 Jan;86(2):735-9.PMID: 2911604 [PubMed - indexed for MEDLINE]Related articlesFree article

Proadrenocorticotropin/endorphin production and messenger ribonucleic acid levels in primary intermediate pituitary cultures: effects of serum, isoproterenol, and dibutyryl adenosine 3',5'-monophosphate.

May V, Stoffers DA, Eipper BA.

Endocrinology. 1989 Jan;124(1):157-66.PMID: 2535803 [PubMed - indexed for MEDLINE]Related articles

Transduction proteins of olfactory receptor cells: identification of guanine nucleotide binding proteins and protein kinase C.

Anholt RR, Mumby SM, Stoffers DA, Girard PR, Kuo JF, Snyder SH.

Biochemistry. 1987 Feb 10;26(3):788-95.PMID: 3105575 [PubMed - indexed for MEDLINE]Related articles