PubMed

Effects of an Endothelin Receptor Antagonist on a Model of Hypertensive Retinopathy.

McDonald L, Lee GR, Degooyer TE, McDonald D, Canning P, Kelso EJ, McDermott BJ, Stitt AW.

Ophthalmic Res. 2009 Oct 15;43(2):99-107. [Epub ahead of print]PMID: 19829016 [PubMed - as supplied by publisher]Related articles

Upregulation of oxidative stress markers in human microvascular endothelial cells by complexes of serum albumin and digestion products of glycated casein.

Deo P, Glenn JV, Powell LA, Stitt AW, Ames JM.

J Biochem Mol Toxicol. 2009 Sep;23(5):364-72.PMID: 19827132 [PubMed - in process]Related articles

Advanced glycation of the Arg-Gly-Asp (RGD) tripeptide motif modulates retinal microvascular endothelial cell dysfunction.

McDonald DM, Coleman G, Bhatwadekar A, Gardiner TA, Stitt AW.

Mol Vis. 2009 Aug 5;15:1509-20.PMID: 19668595 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal endothelial cell apoptosis stimulates recruitment of endothelial progenitor cells.

Bhatwadekar AD, Glenn JV, Curtis TM, Grant MB, Stitt AW, Gardiner TA.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4967-73. Epub 2009 May 27.PMID: 19474402 [PubMed - indexed for MEDLINE]Related articles

Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?

Curtis TM, Gardiner TA, Stitt AW.

Eye (Lond). 2009 Jul;23(7):1496-508. Epub 2009 May 15.PMID: 19444297 [PubMed - in process]Related articles

The role of advanced glycation end products in retinal ageing and disease.

Glenn JV, Stitt AW.

Biochim Biophys Acta. 2009 Oct;1790(10):1109-16. Epub 2009 May 3.PMID: 19409449 [PubMed - in process]Related articles

Protein expression profiling during chick retinal maturation: a proteomics-based approach.

Finnegan S, Robson JL, Wylie M, Healy A, Stitt AW, Curry WJ.

Proteome Sci. 2008 Dec 10;6:34.PMID: 19077203 [PubMed - in process]Related articlesFree article

Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction.

Glenn JV, Mahaffy H, Wu K, Smith G, Nagai R, Simpson DA, Boulton ME, Stitt AW.

Invest Ophthalmol Vis Sci. 2009 Jan;50(1):441-51. Epub 2008 Aug 1.PMID: 18676633 [PubMed - indexed for MEDLINE]Related articles

The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies.

Medina RJ, O'Neill CL, Devine AB, Gardiner TA, Stitt AW.

PLoS One. 2008 Jul 9;3(7):e2584.PMID: 18612412 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of N (epsilon)-(3-formyl-3,4-dehydropiperidino)lysine as a novel biomarker for the severity of diabetic retinopathy.

Zhang X, Lai Y, McCance DR, Uchida K, McDonald DM, Gardiner TA, Stitt AW, Curtis TM.

Diabetologia. 2008 Sep;51(9):1723-30. Epub 2008 Jun 28.PMID: 18587559 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation as a basis for understanding retinal aging and noninvasive risk prediction.

Pawlak AM, Glenn JV, Beattie JR, McGarvey JJ, Stitt AW.

Ann N Y Acad Sci. 2008 Apr;1126:59-65.PMID: 18448796 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: implications for vasodegeneration in diabetic retinopathy.

Bhatwadekar AD, Glenn JV, Li G, Curtis TM, Gardiner TA, Stitt AW.

Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1232-41.PMID: 18326753 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end products accumulate in the reproductive tract of men with diabetes.

Mallidis C, Agbaje IM, Rogers DA, Glenn JV, Pringle R, Atkinson AB, Steger K, Stitt AW, McClure N.

Int J Androl. 2009 Aug;32(4):295-305. Epub 2008 Jan 22.PMID: 18217985 [PubMed - indexed for MEDLINE]Related articles

A new advanced glycation inhibitor, LR-90, prevents experimental diabetic retinopathy in rats.

Bhatwadekar A, Glenn JV, Figarola JL, Scott S, Gardiner TA, Rahbar S, Stitt AW.

Br J Ophthalmol. 2008 Apr;92(4):545-7. Epub 2008 Jan 22.PMID: 18211931 [PubMed - indexed for MEDLINE]Related articles

Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes.

Canning P, Glenn JV, Hsu DK, Liu FT, Gardiner TA, Stitt AW.

Exp Diabetes Res. 2007;2007:51837.PMID: 17641742 [PubMed - indexed for MEDLINE]Related articlesFree article

Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch's membrane leading to accurate, nondestructive prediction of ocular aging.

Glenn JV, Beattie JR, Barrett L, Frizzell N, Thorpe SR, Boulton ME, McGarvey JJ, Stitt AW.

FASEB J. 2007 Nov;21(13):3542-52. Epub 2007 Jun 12.PMID: 17567569 [PubMed - indexed for MEDLINE]Related articlesFree article

Arteriolar involvement in the microvascular lesions of diabetic retinopathy: implications for pathogenesis.

Gardiner TA, Archer DB, Curtis TM, Stitt AW.

Microcirculation. 2007 Jan;14(1):25-38. Review.PMID: 17365659 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina.

Hughes JM, Kuiper EJ, Klaassen I, Canning P, Stitt AW, Van Bezu J, Schalkwijk CG, Van Noorden CJ, Schlingemann RO.

Diabetologia. 2007 May;50(5):1089-98. Epub 2007 Feb 28.PMID: 17333105 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of MAPKs in endostatin-mediated regulation of blood-retinal barrier function.

Campbell M, Collery R, McEvoy A, Gardiner TA, Stitt AW, Brankin B.

Curr Eye Res. 2006 Dec;31(12):1033-45.PMID: 17169842 [PubMed - indexed for MEDLINE]Related articles

Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration.

de Gooyer TE, Stevenson KA, Humphries P, Simpson DA, Gardiner TA, Stitt AW.

Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5561-8.PMID: 17122149 [PubMed - indexed for MEDLINE]Related articlesFree article

Rod photoreceptor loss in Rho-/- mice reduces retinal hypoxia and hypoxia-regulated gene expression.

de Gooyer TE, Stevenson KA, Humphries P, Simpson DA, Curtis TM, Gardiner TA, Stitt AW.

Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5553-60.PMID: 17122148 [PubMed - indexed for MEDLINE]Related articlesFree article

Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.

McGahon MK, Dawicki JM, Arora A, Simpson DA, Gardiner TA, Stitt AW, Scholfield CN, McGeown JG, Curtis TM.

Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1001-8. Epub 2006 Oct 13.PMID: 17040965 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant alpha2(IV)NC1 domain of type IV collagen is an effective regulator of retinal capillary endothelial cell proliferation and inhibits pre-retinal neovascularisation.

Coleman G, Gardiner TA, Boutaud A, Stitt AW.

Graefes Arch Clin Exp Ophthalmol. 2007 Apr;245(4):581-7. Epub 2006 Aug 17.PMID: 16915401 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation and retinal pathology during diabetes.

Stitt AW, Curtis TM.

Pharmacol Rep. 2005;57 Suppl:156-68.PMID: 16415497 [PubMed - in process]Related articlesFree article

Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose.

Kane R, Stevenson L, Godson C, Stitt AW, O'Brien C.

Br J Ophthalmol. 2005 Dec;89(12):1638-42.PMID: 16299147 [PubMed - indexed for MEDLINE]Related articlesFree article

The maillard reaction in eye diseases.

Stitt AW.

Ann N Y Acad Sci. 2005 Jun;1043:582-97. Review.PMID: 16037281 [PubMed - indexed for MEDLINE]Related articles

Endostatin modulates VEGF-mediated barrier dysfunction in the retinal microvascular endothelium.

Brankin B, Campbell M, Canning P, Gardiner TA, Stitt AW.

Exp Eye Res. 2005 Jul;81(1):22-31.PMID: 15978251 [PubMed - indexed for MEDLINE]Related articles

Impaired retinal angiogenesis in diabetes: role of advanced glycation end products and galectin-3.

Stitt AW, McGoldrick C, Rice-McCaldin A, McCance DR, Glenn JV, Hsu DK, Liu FT, Thorpe SR, Gardiner TA.

Diabetes. 2005 Mar;54(3):785-94.PMID: 15734857 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy.

Gardiner TA, Gibson DS, de Gooyer TE, de la Cruz VF, McDonald DM, Stitt AW.

Am J Pathol. 2005 Feb;166(2):637-44.PMID: 15681845 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation endproduct modified basement membrane attenuates endothelin-1 induced [Ca2+]i signalling and contraction in retinal microvascular pericytes.

Hughes SJ, Wall N, Scholfield CN, McGeown JG, Gardiner TA, Stitt AW, Curtis TM.

Mol Vis. 2004 Dec 27;10:996-1004.PMID: 15635291 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterisation of the advanced glycation endproduct receptor complex in the retinal pigment epithelium.

McFarlane S, Glenn JV, Lichanska AM, Simpson DA, Stitt AW.

Br J Ophthalmol. 2005 Jan;89(1):107-12.PMID: 15615757 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation and advanced lipoxidation: possible role in initiation and progression of diabetic retinopathy.

Stitt AW, Frizzell N, Thorpe SR.

Curr Pharm Des. 2004;10(27):3349-60. Review.PMID: 15544520 [PubMed - indexed for MEDLINE]Related articles

Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor.

Stitt AW, Hughes SJ, Canning P, Lynch O, Cox O, Frizzell N, Thorpe SR, Cotter TG, Curtis TM, Gardiner TA.

Diabetologia. 2004 Oct;47(10):1735-46. Epub 2004 Oct 22.PMID: 15502926 [PubMed - indexed for MEDLINE]Related articles

Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat.

Alderson NL, Chachich ME, Frizzell N, Canning P, Metz TO, Januszewski AS, Youssef NN, Stitt AW, Baynes JW, Thorpe SR.

Diabetologia. 2004 Aug;47(8):1385-95. Epub 2004 Jul 28.PMID: 15309289 [PubMed - indexed for MEDLINE]Related articles

Chloroquine causes lysosomal dysfunction in neural retina and RPE: implications for retinopathy.

Mahon GJ, Anderson HR, Gardiner TA, McFarlane S, Archer DB, Stitt AW.

Curr Eye Res. 2004 Apr;28(4):277-84.PMID: 15259297 [PubMed - indexed for MEDLINE]Related articles

Ocular wounding prevents pre-retinal neovascularization and upregulates PEDF expression in the inner retina.

Stitt AW, Graham D, Gardiner TA.

Mol Vis. 2004 Jun 28;10:432-8.PMID: 15235573 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy.

Wilkinson-Berka JL, Babic S, De Gooyer T, Stitt AW, Jaworski K, Ong LG, Kelly DJ, Gilbert RE.

Am J Pathol. 2004 Apr;164(4):1263-73.PMID: 15039215 [PubMed - indexed for MEDLINE]Related articlesFree article

Sources of PDGF expression in murine retina and the effect of short-term diabetes.

Cox OT, Simpson DA, Stitt AW, Gardiner TA.

Mol Vis. 2003 Dec 10;9:665-72.PMID: 14685146 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of advanced glycation end-products protects against retinal capillary basement membrane expansion during long-term diabetes.

Gardiner TA, Anderson HR, Stitt AW.

J Pathol. 2003 Oct;201(2):328-33.PMID: 14517851 [PubMed - indexed for MEDLINE]Related articles

The role of advanced glycation end products in retinal microvascular leukostasis.

Moore TC, Moore JE, Kaji Y, Frizzell N, Usui T, Poulaki V, Campbell IL, Stitt AW, Gardiner TA, Archer DB, Adamis AP.

Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4457-64.PMID: 14507893 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of retinal capillary basement membrane thickening in diabetic dogs by a non-steroidal anti-inflammatory drug.

Gardiner TA, Anderson HR, Degenhardt T, Thorpe SR, Baynes JW, Archer DB, Stitt AW.

Diabetologia. 2003 Sep;46(9):1269-75. Epub 2003 Jul 12.PMID: 12861449 [PubMed - indexed for MEDLINE]Related articles

The role of advanced glycation in the pathogenesis of diabetic retinopathy.

Stitt AW.

Exp Mol Pathol. 2003 Aug;75(1):95-108. Review.PMID: 12834631 [PubMed - indexed for MEDLINE]Related articles

Characterisation of WE-14 in porcine ocular tissue.

Curry WJ, McCollum AP, Brockbank S, Gardiner TA, Maule AG, Stitt AW.

Regul Pept. 2003 May 15;113(1-3):41-7.PMID: 12686459 [PubMed - indexed for MEDLINE]Related articles

Role of vascular endothelial growth factor and placental growth factors during retinal vascular development and hyaloid regression.

Feeney SA, Simpson DA, Gardiner TA, Boyle C, Jamison P, Stitt AW.

Invest Ophthalmol Vis Sci. 2003 Feb;44(2):839-47.PMID: 12556420 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end products and diabetic complications.

Stitt AW, Jenkins AJ, Cooper ME.

Expert Opin Investig Drugs. 2002 Sep;11(9):1205-23. Review.PMID: 12225243 [PubMed - indexed for MEDLINE]Related articles

Anti-angiogenic therapy for uveal melanoma--more haste, less speed.

Stitt AW, Gardiner TA.

Br J Ophthalmol. 2002 Apr;86(4):368-9. No abstract available. PMID: 11914199 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthetic peptides interacting with the 67-kd laminin receptor can reduce retinal ischemia and inhibit hypoxia-induced retinal neovascularization.

Gebarowska D, Stitt AW, Gardiner TA, Harriott P, Greer B, Nelson J.

Am J Pathol. 2002 Jan;160(1):307-13.PMID: 11786424 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the 67 kDa laminin receptor (67LR) during retinal development: correlations with angiogenesis.

McKenna DJ, Simpson DA, Feeney S, Gardiner TA, Boyle C, Nelson J, Stitt AW.

Exp Eye Res. 2001 Jul;73(1):81-92.PMID: 11428865 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation alters expression of the 67kDa laminin receptor in retinal microvascular endothelial cells.

McKenna DJ, Nelson J, Stitt AW.

Life Sci. 2001 May 4;68(24):2695-703.PMID: 11400912 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation: an important pathological event in diabetic and age related ocular disease.

Stitt AW.

Br J Ophthalmol. 2001 Jun;85(6):746-53. Review. No abstract available. PMID: 11371498 [PubMed - indexed for MEDLINE]Related articlesFree article