PubMed

The Role of 11ss-Hydroxysteroid Dehydrogenase 1 in Adipogenesis in Thyroid-Associated Ophthalmopathy.

Tomlinson JW, Durrani OM, Bujalska IJ, Gathercole LL, Tomlins PJ, Reuser TT, Rose GE, Curnow SJ, Stewart PM, Walker EA, Rauz S.

J Clin Endocrinol Metab. 2009 Oct 30. [Epub ahead of print]PMID: 19880789 [PubMed - as supplied by publisher]Related articles

11{beta}-Hydroxysteroid Dehydrogenase Type 1 and Its Role in the Hypothalamus-Pituitary-Adrenal Axis, Metabolic Syndrome, and Inflammation.

Cooper MS, Stewart PM.

J Clin Endocrinol Metab. 2009 Oct 16. [Epub ahead of print]PMID: 19837912 [PubMed - as supplied by publisher]Related articles

The hypertensiogenetic steroid 19-nor-progesterone does not influence cortisol inactivation by 11beta-hydroxysteroid dehydrogenase type 2.

Lepenies J, Stewart PM, Quinkler M.

Clin Exp Hypertens. 2009 Jun;31(4):376-9.PMID: 19811365 [PubMed - in process]Related articles

ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly.

Sherlock M, Reulen RC, Alonso AA, Ayuk J, Clayton RN, Sheppard MC, Hawkins MM, Bates AS, Stewart PM.

J Clin Endocrinol Metab. 2009 Nov;94(11):4216-23. Epub 2009 Oct 6.PMID: 19808848 [PubMed - in process]Related articles

Adrenal vein sampling for Primary Aldosteronism: Time for a reality check.

Stewart PM, Allolio B.

Clin Endocrinol (Oxf). 2009 Sep 21. [Epub ahead of print] No abstract available. PMID: 19769616 [PubMed - as supplied by publisher]Related articles

NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases - a diagnostic tool?

Sinclair AJ, Viant MR, Ball AK, Burdon MA, Walker EA, Stewart PM, Rauz S, Young SP.

NMR Biomed. 2009 Aug 18. [Epub ahead of print]PMID: 19691132 [PubMed - as supplied by publisher]Related articles

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.

Morgan SA, Sherlock M, Gathercole LL, Lavery GG, Lenaghan C, Bujalska IJ, Laber D, Yu A, Convey G, Mayers R, Hegyi K, Sethi JK, Stewart PM, Smith DM, Tomlinson JW.

Diabetes. 2009 Nov;58(11):2506-15. Epub 2009 Aug 12.PMID: 19675138 [PubMed - in process]Related articles

Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: a randomized controlled trial.

Edwards NC, Steeds RP, Stewart PM, Ferro CJ, Townend JN.

J Am Coll Cardiol. 2009 Aug 4;54(6):505-12.PMID: 19643310 [PubMed - indexed for MEDLINE]Related articles

Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome.

Vassiliadi DA, Barber TM, Hughes BA, McCarthy MI, Wass JA, Franks S, Nightingale P, Tomlinson JW, Arlt W, Stewart PM.

J Clin Endocrinol Metab. 2009 Sep;94(9):3558-66. Epub 2009 Jun 30.PMID: 19567518 [PubMed - indexed for MEDLINE]Related articles

Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss.

Kaur K, Hardy R, Ahasan MM, Eijken M, van Leeuwen JP, Filer A, Thomas AM, Raza K, Buckley CD, Stewart PM, Rabbitt EH, Hewison M, Cooper MS.

Ann Rheum Dis. 2009 Jun 22. [Epub ahead of print]PMID: 19549618 [PubMed - as supplied by publisher]Related articlesFree article

Adrenal function: An overlooked cause of glucocorticoid deficiency?

Krone N, Stewart PM.

Nat Rev Endocrinol. 2009 Jul;5(7):362-3. No abstract available. PMID: 19543294 [PubMed - indexed for MEDLINE]Related articles

Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system.

Lawson AJ, Walker EA, White SA, Dafforn TR, Stewart PM, Ride JP.

Protein Sci. 2009 Jul;18(7):1552-63.PMID: 19507261 [PubMed - indexed for MEDLINE]Related articles

Investigating hypertension in a young person.

Hammer F, Stewart PM.

BMJ. 2009 Apr 6;338:b1043. doi: 10.1136/bmj.b1043. Review. No abstract available. PMID: 19349343 [PubMed - indexed for MEDLINE]Related articles

Can licorice lick colon cancer?

Stewart PM, Prescott SM.

J Clin Invest. 2009 Apr;119(4):760-3.PMID: 19348044 [PubMed - indexed for MEDLINE]Related articles

Monitoring disease activity using GH and IGF-I in the follow-up of 501 patients with acromegaly.

Sherlock M, Aragon Alonso A, Reulen RC, Ayuk J, Clayton RN, Holder G, Sheppard MC, Bates A, Stewart PM.

Clin Endocrinol (Oxf). 2009 Jul;71(1):74-81. Epub 2008 Oct 26.PMID: 19178529 [PubMed - indexed for MEDLINE]Related articles

Adipophilin distribution and colocalization with lipid droplets in skeletal muscle.

Shaw CS, Sherlock M, Stewart PM, Wagenmakers AJ.

Histochem Cell Biol. 2009 May;131(5):575-81. Epub 2009 Jan 24.PMID: 19169702 [PubMed - indexed for MEDLINE]Related articles

Medical therapy in patients with acromegaly: predictors of response and comparison of efficacy of dopamine agonists and somatostatin analogues.

Sherlock M, Fernandez-Rodriguez E, Alonso AA, Reulen RC, Ayuk J, Clayton RN, Holder G, Sheppard MC, Bates A, Stewart PM.

J Clin Endocrinol Metab. 2009 Apr;94(4):1255-63. Epub 2009 Jan 21.PMID: 19158203 [PubMed - indexed for MEDLINE]Related articles

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?

Stewart PM, Tomlinson JW.

Diabetes. 2009 Jan;58(1):14-5. No abstract available. PMID: 19114723 [PubMed - indexed for MEDLINE]Related articlesFree article

The low-dose corticotropin-stimulation test revisited: the less, the better?

Stewart PM, Clark PM.

Nat Clin Pract Endocrinol Metab. 2009 Feb;5(2):68-9. Epub 2008 Dec 2. No abstract available. PMID: 19047996 [PubMed]Related articles

Regulation--the real threat to clinical research.

Stewart PM, Stears A, Tomlinson JW, Brown MJ.

BMJ. 2008 Oct 16;337:a1732. doi: 10.1136/bmj.a1732. No abstract available. PMID: 18927171 [PubMed - indexed for MEDLINE]Related articles

Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation.

Zehnder D, Quinkler M, Eardley KS, Bland R, Lepenies J, Hughes SV, Raymond NT, Howie AJ, Cockwell P, Stewart PM, Hewison M.

Kidney Int. 2008 Nov;74(10):1343-53. Epub 2008 Sep 10.PMID: 18784644 [PubMed - indexed for MEDLINE]Related articlesFree article

11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.

Swali A, Walker EA, Lavery GG, Tomlinson JW, Stewart PM.

Diabetologia. 2008 Nov;51(11):2003-11. Epub 2008 Sep 9.PMID: 18779947 [PubMed - indexed for MEDLINE]Related articles

Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?

Ball AK, Sinclair AJ, Curnow SJ, Tomlinson JW, Burdon MA, Walker EA, Stewart PM, Nightingale PG, Clarke CE, Rauz S.

Clin Endocrinol (Oxf). 2009 Jun;70(6):863-9. Epub 2008 Sep 2.PMID: 18771566 [PubMed - indexed for MEDLINE]Related articles

Exploring the pathogenesis of IIH: an inflammatory perspective.

Sinclair AJ, Ball AK, Burdon MA, Clarke CE, Stewart PM, Curnow SJ, Rauz S.

J Neuroimmunol. 2008 Sep 15;201-202:212-20. Epub 2008 Aug 3. Review.PMID: 18676028 [PubMed - indexed for MEDLINE]Related articles

Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis.

Konopelska S, Kienitz T, Hughes B, Pirlich M, Bauditz J, Lochs H, Strasburger CJ, Stewart PM, Quinkler M.

Clin Endocrinol (Oxf). 2009 Apr;70(4):554-60.PMID: 18665910 [PubMed - indexed for MEDLINE]Related articles

Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.

Tomlinson JW, Finney J, Gay C, Hughes BA, Hughes SV, Stewart PM.

Diabetes. 2008 Oct;57(10):2652-60. Epub 2008 Jul 15.PMID: 18633104 [PubMed - indexed for MEDLINE]Related articlesFree article

Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.

Lavery GG, Walker EA, Tiganescu A, Ride JP, Shackleton CH, Tomlinson JW, Connell JM, Ray DW, Biason-Lauber A, Malunowicz EM, Arlt W, Stewart PM.

J Clin Endocrinol Metab. 2008 Oct;93(10):3827-32. Epub 2008 Jul 15.PMID: 18628520 [PubMed - indexed for MEDLINE]Related articlesFree article

Progesterone is extensively metabolized in osteoblasts: implications for progesterone action on bone.

Quinkler M, Kaur K, Hewison M, Stewart PM, Cooper MS.

Horm Metab Res. 2008 Oct;40(10):679-84. Epub 2008 Jun 6.PMID: 18537080 [PubMed - indexed for MEDLINE]Related articles

Adrenal suppression in bronchiectasis and the impact of inhaled corticosteroids.

Holme J, Tomlinson JW, Stockley RA, Stewart PM, Barlow N, Sullivan AL.

Eur Respir J. 2008 Oct;32(4):1047-52. Epub 2008 May 28.PMID: 18508829 [PubMed - indexed for MEDLINE]Related articles

The corticosteroid metabolic profile of the mouse.

Shackleton CH, Hughes BA, Lavery GG, Walker EA, Stewart PM.

Steroids. 2008 Oct;73(11):1066-76. Epub 2008 Apr 15.PMID: 18502460 [PubMed - indexed for MEDLINE]Related articles

A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.

Bujalska IJ, Gathercole LL, Tomlinson JW, Darimont C, Ermolieff J, Fanjul AN, Rejto PA, Stewart PM.

J Endocrinol. 2008 May;197(2):297-307.PMID: 18434359 [PubMed - indexed for MEDLINE]Related articlesFree article

Local and systemic glucocorticoid metabolism in inflammatory arthritis.

Hardy R, Rabbitt EH, Filer A, Emery P, Hewison M, Stewart PM, Gittoes NJ, Buckley CD, Raza K, Cooper MS.

Ann Rheum Dis. 2008 Sep;67(9):1204-10. Epub 2008 Apr 17.PMID: 18420938 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement.

Biller BM, Grossman AB, Stewart PM, Melmed S, Bertagna X, Bertherat J, Buchfelder M, Colao A, Hermus AR, Hofland LJ, Klibanski A, Lacroix A, Lindsay JR, Newell-Price J, Nieman LK, Petersenn S, Sonino N, Stalla GK, Swearingen B, Vance ML, Wass JA, Boscaro M.

J Clin Endocrinol Metab. 2008 Jul;93(7):2454-62. Epub 2008 Apr 15. Review.PMID: 18413427 [PubMed - indexed for MEDLINE]Related articlesFree article

17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites.

Shackleton CH, Neres MS, Hughes BA, Stewart PM, Kater CE.

Steroids. 2008 Jul;73(6):652-6. Epub 2008 Feb 13.PMID: 18355883 [PubMed - indexed for MEDLINE]Related articles

Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss.

Tomlinson JW, Finney J, Hughes BA, Hughes SV, Stewart PM.

Diabetes. 2008 Jun;57(6):1536-43. Epub 2008 Mar 13.PMID: 18340018 [PubMed - indexed for MEDLINE]Related articlesFree article

The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline.

Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM.

J Clin Endocrinol Metab. 2008 May;93(5):1526-40. Epub 2008 Mar 11.PMID: 18334580 [PubMed - indexed for MEDLINE]Related articlesFree article

The pituitary-adrenal axis and body composition.

Fernandez-Rodriguez E, Stewart PM, Cooper MS.

Pituitary. 2009;12(2):105-15. Review.PMID: 18324475 [PubMed - indexed for MEDLINE]Related articles

Human Delta4-3-oxosteroid 5beta-reductase (AKR1D1) deficiency and steroid metabolism.

Palermo M, Marazzi MG, Hughes BA, Stewart PM, Clayton PT, Shackleton CH.

Steroids. 2008 Apr;73(4):417-23. Epub 2007 Dec 14.PMID: 18243262 [PubMed - indexed for MEDLINE]Related articles

Hypopituitarism: clinical features, diagnosis, and management.

Toogood AA, Stewart PM.

Endocrinol Metab Clin North Am. 2008 Mar;37(1):235-61, x. Review.PMID: 18226739 [PubMed - indexed for MEDLINE]Related articles

Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy.

Lavery GG, Walker EA, Turan N, Rogoff D, Ryder JW, Shelton JM, Richardson JA, Falciani F, White PC, Stewart PM, Parker KL, McMillan DR.

J Biol Chem. 2008 Mar 28;283(13):8453-61. Epub 2008 Jan 25.PMID: 18222920 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue.

Bujalska IJ, Hewitt KN, Hauton D, Lavery GG, Tomlinson JW, Walker EA, Stewart PM.

Endocrinology. 2008 May;149(5):2584-91. Epub 2008 Jan 24.PMID: 18218694 [PubMed - indexed for MEDLINE]Related articlesFree article

Mortality following pituitary radiotherapy.

Ayuk J, Stewart PM.

Pituitary. 2009;12(1):35-9. Review.PMID: 18175222 [PubMed - indexed for MEDLINE]Related articles

Modulation of glucocorticoid action and the treatment of type-2 diabetes.

Tomlinson JW, Stewart PM.

Best Pract Res Clin Endocrinol Metab. 2007 Dec;21(4):607-19. Review.PMID: 18054738 [PubMed - indexed for MEDLINE]Related articles

Adrenal insufficiency in critical illness.

Cooper MS, Stewart PM.

J Intensive Care Med. 2007 Nov-Dec;22(6):348-62. Review.PMID: 18048877 [PubMed - indexed for MEDLINE]Related articles

Expression and functional consequences of oestrogen and progesterone receptors in human insulinomas.

Alabraba EB, Taniere P, Reynolds GM, Stewart PM, Wigmore SJ, Bramhall SR.

Endocr Relat Cancer. 2007 Dec;14(4):1081-8.PMID: 18045959 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of hepatic 11beta-hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease.

Ahmed A, Saksena S, Sherlock M, Olliff SP, Elias E, Stewart PM.

Clin Endocrinol (Oxf). 2008 Jun;68(6):898-903. Epub 2007 Nov 19.PMID: 18031327 [PubMed - indexed for MEDLINE]Related articles

Modulation of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11betaHSD1 inhibitor.

Courtney R, Stewart PM, Toh M, Ndongo MN, Calle RA, Hirshberg B.

J Clin Endocrinol Metab. 2008 Feb;93(2):550-6. Epub 2007 Nov 6.PMID: 17986636 [PubMed - indexed for MEDLINE]Related articlesFree article

Cushing's syndrome in women with polycystic ovaries and hyperandrogenism.

Fegan PG, Sandeman DD, Krone N, Bosman D, Wood PJ, Stewart PM, Hanley NA.

Nat Clin Pract Endocrinol Metab. 2007 Nov;3(11):778-83.PMID: 17955019 [PubMed - indexed for MEDLINE]Related articles

Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys.

Bhat BG, Hosea N, Fanjul A, Herrera J, Chapman J, Thalacker F, Stewart PM, Rejto PA.

J Pharmacol Exp Ther. 2008 Jan;324(1):299-305. Epub 2007 Oct 5.PMID: 17921190 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation.

Chan J, Rabbitt EH, Innes BA, Bulmer JN, Stewart PM, Kilby MD, Hewison M.

J Endocrinol. 2007 Oct;195(1):7-15.PMID: 17911392 [PubMed - indexed for MEDLINE]Related articlesFree article