PubMed

Investigation of regional mechanisms responsible for poor oral absorption in humans of a modified release preparation of the alpha-adrenoreceptor antagonist, 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4 tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline (UK-338,003): the rational use of ex vivo intestine to predict in vivo absorption.

Collett A, Stephens RH, Harwood MD, Humphrey M, Dallman L, Bennett J, Davis J, Carlson GL, Warhurst G.

Drug Metab Dispos. 2008 Jan;36(1):87-94. Epub 2007 Oct 11.PMID: 17932223 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.

Salonen JT, Uimari P, Aalto JM, Pirskanen M, Kaikkonen J, Todorova B, Hyppönen J, Korhonen VP, Asikainen J, Devine C, Tuomainen TP, Luedemann J, Nauck M, Kerner W, Stephens RH, New JP, Ollier WE, Gibson JM, Payton A, Horan MA, Pendleton N, Mahoney W, Meyre D, Delplanque J, Froguel P, Luzzatto O, Yakir B, Darvasi A.

Am J Hum Genet. 2007 Aug;81(2):338-45. Epub 2007 Jun 26.PMID: 17668382 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in IGF-binding protein 1 are associated with impaired renal function in type 2 diabetes.

Stephens RH, McElduff P, Heald AH, New JP, Worthington J, Ollier WE, Gibson JM.

Diabetes. 2005 Dec;54(12):3547-53.PMID: 16306374 [PubMed - indexed for MEDLINE]Related articlesFree article

Region-dependent modulation of intestinal permeability by drug efflux transporters: in vitro studies in mdr1a(-/-) mouse intestine.

Stephens RH, Tanianis-Hughes J, Higgs NB, Humphrey M, Warhurst G.

J Pharmacol Exp Ther. 2002 Dec;303(3):1095-101.PMID: 12438532 [PubMed - indexed for MEDLINE]Related articlesFree article

Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice.

Stephens RH, O'Neill CA, Bennett J, Humphrey M, Henry B, Rowland M, Warhurst G.

Br J Pharmacol. 2002 Apr;135(8):2038-46.PMID: 11959808 [PubMed - indexed for MEDLINE]Related articlesFree article

Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia.

Stephens RH, O'Neill CA, Warhurst A, Carlson GL, Rowland M, Warhurst G.

J Pharmacol Exp Ther. 2001 Feb;296(2):584-91.PMID: 11160647 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential identification of the O2-sensitive K+ current in a human neuroepithelial body-derived cell line.

O'Kelly I, Stephens RH, Peers C, Kemp PJ.

Am J Physiol. 1999 Jan;276(1 Pt 1):L96-L104.PMID: 9887061 [PubMed - indexed for MEDLINE]Related articlesFree article

The regulation of lung liquid absorption by endogenous cAMP in postnatal sheep lungs perfused in situ.

Stephens RH, Benjamin AR, Walters DV.

J Physiol. 1998 Sep 1;511 ( Pt 2):587-97.PMID: 9706033 [PubMed - indexed for MEDLINE]Related articlesFree article

Volume and protein concentration of epithelial lining liquid in perfused in situ postnatal sheep lungs.

Stephens RH, Benjamin AR, Walters DV.

J Appl Physiol. 1996 Jun;80(6):1911-20.PMID: 8806894 [PubMed - indexed for MEDLINE]Related articles

Computed tomography in the evaluation of metastatic adenocarcinoma from an unknown primary site. A retrospective study.

McMillan JH, Levine E, Stephens RH.

Radiology. 1982 Apr;143(1):143-6.PMID: 7063718 [PubMed - indexed for MEDLINE]Related articlesFree article