PubMed

Smoking, Clopidogrel, and Mortality in Patients With Established Cardiovascular Disease.

Berger JS, Bhatt DL, Steinhubl SR, Shao M, Steg PG, Montalescot G, Hacke W, Fox KA, Lincoff AM, Topol EJ, Berger PB; for the CHARISMA (Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance) Investigators.

Circulation. 2009 Nov 23. [Epub ahead of print]PMID: 19933933 [PubMed - as supplied by publisher]

Enoxaparin versus unfractionated heparin in elective percutaneous coronary intervention 1-year results from the STEEPLE (SafeTy and efficacy of enoxaparin in percutaneous coronary intervention patients, an international randomized evaluation) trial.

Montalescot G, Gallo R, White HD, Cohen M, Steg PG, Aylward PE, Bode C, Chiariello M, King SB 3rd, Harrington RA, Desmet WJ, Macaya C, Steinhubl SR; STEEPLE Investigators.

JACC Cardiovasc Interv. 2009 Nov;2(11):1083-91.PMID: 19926048 [PubMed - in process]Related articles

The relative efficacy and safety of clopidogrel in women and men a sex-specific collaborative meta-analysis.

Berger JS, Bhatt DL, Cannon CP, Chen Z, Jiang L, Jones JB, Mehta SR, Sabatine MS, Steinhubl SR, Topol EJ, Berger PB.

J Am Coll Cardiol. 2009 Nov 17;54(21):1935-45.PMID: 19909874 [PubMed - in process]Related articles

Pharmacokinetics and Pharmacodynamics of a Bolus and Infusion of Cangrelor: A Direct, Parenteral P2Y12 Receptor Antagonist.

Akers WS, Oh JJ, Oestreich JH, Ferraris S, Wethington M, Steinhubl SR.

J Clin Pharmacol. 2009 Sep 24. [Epub ahead of print]PMID: 19779037 [PubMed - as supplied by publisher]Related articles

Clinical outcomes according to permanent discontinuation of clopidogrel or placebo in the CHARISMA trial.

Collet JP, Montalescot G, Steg PG, Steinhubl SR, Fox KA, Hu TF, Johnston SC, Hamm CW, Bhatt DL, Topol EJ.

Arch Cardiovasc Dis. 2009 Jun-Jul;102(6-7):485-96. Epub 2009 Jun 11.PMID: 19664568 [PubMed - in process]Related articles

Influence of timing of clopidogrel treatment on the efficacy and safety of bivalirudin in patients with non-ST-segment elevation acute coronary syndromes undergoing percutaneous coronary intervention: an analysis of the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial.

Lincoff AM, Steinhubl SR, Manoukian SV, Chew D, Pollack CV Jr, Feit F, Ware JH, Bertrand ME, Ohman EM, Desmet W, Cox DA, Mehran R, Stone GW; Acute Catheterization and Urgent Intervention Triage strategY of Trial Investigators.

JACC Cardiovasc Interv. 2008 Dec;1(6):639-48.PMID: 19463378 [PubMed - indexed for MEDLINE]Related articles

Clinical outcomes of patients with diabetic nephropathy randomized to clopidogrel plus aspirin versus aspirin alone (a post hoc analysis of the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance [CHARISMA] trial).

Dasgupta A, Steinhubl SR, Bhatt DL, Berger PB, Shao M, Mak KH, Fox KA, Montalescot G, Weber MA, Haffner SM, Dimas AP, Steg PG, Topol EJ; CHARISMA Investigators.

Am J Cardiol. 2009 May 15;103(10):1359-63. Epub 2009 Apr 1.PMID: 19427428 [PubMed - indexed for MEDLINE]Related articles

Evaluation and management of thrombocytopenia and suspected heparin-induced thrombocytopenia in hospitalized patients: The Complications After Thrombocytopenia Caused by Heparin (CATCH) registry.

Crespo EM, Oliveira GB, Honeycutt EF, Becker RC, Berger PB, Moliterno DJ, Anstrom KJ, Abrams CS, Kleiman NS, Moll S, Rice L, Rodgers JE, Steinhubl SR, Tapson VF, Granger CB, Ohman EM; CATCH Registry Investigators.

Am Heart J. 2009 Apr;157(4):651-7. Epub 2009 Mar 17.PMID: 19332191 [PubMed - indexed for MEDLINE]Related articles

Considerable variability in platelet activity among patients with coronary artery disease in response to an increased maintenance dose of clopidogrel.

Oestreich JH, Holt J, Dunn SP, Smyth SS, Campbell CL, Charnigo R, Akers WS, Steinhubl SR.

Coron Artery Dis. 2009 May;20(3):207-13.PMID: 19318928 [PubMed - indexed for MEDLINE]Related articles

Aspirin following PCI: too much of a good thing?

Steinhubl SR, Berger PB.

Eur Heart J. 2009 Apr;30(8):882-4. Epub 2009 Mar 17. No abstract available. PMID: 19293194 [PubMed - indexed for MEDLINE]Related articles

Aspirin to prevent cardiovascular disease: the association of aspirin dose and clopidogrel with thrombosis and bleeding.

Steinhubl SR, Bhatt DL, Brennan DM, Montalescot G, Hankey GJ, Eikelboom JW, Berger PB, Topol EJ; CHARISMA Investigators.

Ann Intern Med. 2009 Mar 17;150(6):379-86.PMID: 19293071 [PubMed - indexed for MEDLINE]Related articlesFree article

The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease.

Mak KH, Bhatt DL, Shao M, Haffner SM, Hamm CW, Hankey GJ, Johnston SC, Montalescot G, Steg PG, Steinhubl SR, Fox KA, Topol EJ.

Eur Heart J. 2009 Apr;30(7):857-65. Epub 2009 Feb 20.PMID: 19233855 [PubMed - indexed for MEDLINE]Related articles

Impact of anticoagulation regimens on sheath management and bleeding in patients undergoing elective percutaneous coronary intervention in the STEEPLE trial.

Gallo R, Steinhubl SR, White HD, Montalescot G; STEEPLE Investigators.

Catheter Cardiovasc Interv. 2009 Feb 15;73(3):319-25.PMID: 19213086 [PubMed - indexed for MEDLINE]Related articles

Bleeding risk associated with 1 year of dual antiplatelet therapy after percutaneous coronary intervention: Insights from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial.

Aronow HD, Steinhubl SR, Brennan DM, Berger PB, Topol EJ; CREDO Investigators.

Am Heart J. 2009 Feb;157(2):369-74. Epub 2008 Nov 1.PMID: 19185647 [PubMed - indexed for MEDLINE]Related articles

G-protein-coupled receptors as signaling targets for antiplatelet therapy.

Smyth SS, Woulfe DS, Weitz JI, Gachet C, Conley PB, Goodman SG, Roe MT, Kuliopulos A, Moliterno DJ, French PA, Steinhubl SR, Becker RC; 2008 Platelet Colloquium Participants.

Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):449-57. Epub 2008 Nov 20. Review.PMID: 19023091 [PubMed - indexed for MEDLINE]Related articles

Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis.

Berger JS, Frye CB, Harshaw Q, Edwards FH, Steinhubl SR, Becker RC.

J Am Coll Cardiol. 2008 Nov 18;52(21):1693-701.PMID: 19007688 [PubMed - indexed for MEDLINE]Related articles

Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk.

Eikelboom JW, Hankey GJ, Thom J, Bhatt DL, Steg PG, Montalescot G, Johnston SC, Steinhubl SR, Mak KH, Easton JD, Hamm C, Hu T, Fox KA, Topol EJ; Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) Investigators.

Circulation. 2008 Oct 21;118(17):1705-12. Epub 2008 Oct 6.PMID: 18838564 [PubMed - indexed for MEDLINE]Related articlesFree article

Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development.

Kleiman NS, Freedman JE, Tracy PB, Furie BC, Bray PF, Rao SV, Phillips DR, Storey RF, Rusconi CP, French PA, Steinhubl SR, Becker RC.

Platelets. 2008 Jun;19(4):239-51. Review.PMID: 18569859 [PubMed - indexed for MEDLINE]Related articles

Why have antioxidants failed in clinical trials?

Steinhubl SR.

Am J Cardiol. 2008 May 22;101(10A):14D-19D. Review.PMID: 18474268 [PubMed - indexed for MEDLINE]Related articles

Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease.

Chan MY, Cohen MG, Dyke CK, Myles SK, Aberle LG, Lin M, Walder J, Steinhubl SR, Gilchrist IC, Kleiman NS, Vorchheimer DA, Chronos N, Melloni C, Alexander JH, Harrington RA, Tonkens RM, Becker RC, Rusconi CP.

Circulation. 2008 Jun 3;117(22):2865-74. Epub 2008 May 27.PMID: 18506005 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy and safety of clopidogrel pretreatment before percutaneous coronary intervention with and without glycoprotein IIb/IIIa inhibitor use.

Sabatine MS, Hamdalla HN, Mehta SR, Fox KA, Topol EJ, Steinhubl SR, Cannon CP.

Am Heart J. 2008 May;155(5):910-7. Epub 2008 Feb 21.PMID: 18440341 [PubMed - indexed for MEDLINE]Related articles

Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial.

Nissen SE, Nicholls SJ, Wolski K, Rodés-Cabau J, Cannon CP, Deanfield JE, Després JP, Kastelein JJ, Steinhubl SR, Kapadia S, Yasin M, Ruzyllo W, Gaudin C, Job B, Hu B, Bhatt DL, Lincoff AM, Tuzcu EM; STRADIVARIUS Investigators.

JAMA. 2008 Apr 2;299(13):1547-60. Epub 2008 Apr 1.PMID: 18387931 [PubMed - indexed for MEDLINE]Related articlesFree article

The efficacy and safety of short- and long-term dual antiplatelet therapy in patients with mild or moderate chronic kidney disease: results from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial.

Best PJ, Steinhubl SR, Berger PB, Dasgupta A, Brennan DM, Szczech LA, Califf RM, Topol EJ; CREDO Investigators.

Am Heart J. 2008 Apr;155(4):687-93. Epub 2008 Feb 21.PMID: 18371477 [PubMed - indexed for MEDLINE]Related articles

Vulnerable plaque intervention: State of the art.

Young JJ, Phillips HR, Marso SP, Granada JF, McPherson JA, Waksman R, Steinhubl SR, Schwartz RS, Stone GW.

Catheter Cardiovasc Interv. 2008 Feb 15;71(3):367-74. Review.PMID: 18288729 [PubMed - indexed for MEDLINE]Related articles

Impact of anticoagulation levels on outcomes in patients undergoing elective percutaneous coronary intervention: insights from the STEEPLE trial.

Montalescot G, Cohen M, Salette G, Desmet WJ, Macaya C, Aylward PE, Steg PG, White HD, Gallo R, Steinhubl SR; STEEPLE Investigators.

Eur Heart J. 2008 Feb;29(4):462-71.PMID: 18276619 [PubMed - indexed for MEDLINE]Related articlesFree article

Atrial fibrillation in the setting of acute myocardial infarction--irregularly irregular treatment.

Campbell CL, Steinhubl SR.

Am Heart J. 2008 Feb;155(2):197-9. No abstract available. PMID: 18215586 [PubMed - indexed for MEDLINE]Related articles

Incidence and prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy.

Oliveira GB, Crespo EM, Becker RC, Honeycutt EF, Abrams CS, Anstrom KJ, Berger PB, Davidson-Ray LD, Eisenstein EL, Kleiman NS, Moliterno DJ, Moll S, Rice L, Rodgers JE, Steinhubl SR, Tapson VF, Ohman EM, Granger CB; Complications After Thrombocytopenia Caused by Heparin (CATCH) Registry Investigators.

Arch Intern Med. 2008 Jan 14;168(1):94-102.PMID: 18195201 [PubMed - indexed for MEDLINE]Related articlesFree article

Intravenous low-molecular-weight heparins compared with unfractionated heparin in percutaneous coronary intervention: quantitative review of randomized trials.

Dumaine R, Borentain M, Bertel O, Bode C, Gallo R, White HD, Collet JP, Steinhubl SR, Montalescot G.

Arch Intern Med. 2007 Dec 10;167(22):2423-30. Review.PMID: 18071163 [PubMed - indexed for MEDLINE]Related articlesFree article

Time to coronary angiography and outcomes among patients with high-risk non ST-segment elevation acute coronary syndromes: results from the SYNERGY trial.

Tricoci P, Lokhnygina Y, Berdan LG, Steinhubl SR, Gulba DC, White HD, Kleiman NS, Aylward PE, Langer A, Califf RM, Ferguson JJ, Antman EM, Newby LK, Harrington RA, Goodman SG, Mahaffey KW.

Circulation. 2007 Dec 4;116(23):2669-77. Epub 2007 Nov 19.PMID: 18025532 [PubMed - indexed for MEDLINE]Related articlesFree article

Platelet function monitoring in patients with coronary artery disease.

Gurbel PA, Becker RC, Mann KG, Steinhubl SR, Michelson AD.

J Am Coll Cardiol. 2007 Nov 6;50(19):1822-34. Epub 2007 Oct 23. Review.PMID: 17980247 [PubMed - indexed for MEDLINE]Related articles

Determining the efficacy of antiplatelet therapies for the individual: lessons from clinical trials.

Steinhubl SR, Schneider DJ, Berger PB, Becker RC.

J Thromb Thrombolysis. 2008 Aug;26(1):8-13. Epub 2007 Nov 1.PMID: 17973080 [PubMed - indexed for MEDLINE]Related articles

Platelet activation and its patient-specific consequences.

Smyth SS, Monroe DM 3rd, Wysokinski WE, McBane RD 2nd, Whiteheart SW, Becker RC, Steinhubl SR.

Thromb Res. 2008;122(4):435-41. Epub 2007 Oct 22. Review.PMID: 17949794 [PubMed - indexed for MEDLINE]Related articles

Risk stratifying the acute coronary syndrome patient: a focus on treatable risk.

Steinhubl SR.

Rev Cardiovasc Med. 2007;8 Suppl 3:S3-8. Review.PMID: 17917619 [PubMed - indexed for MEDLINE]Related articles

The evolving algorithm concerning higher-risk PCI (TEACH-PCI). Introduction.

Steinhubl SR.

Rev Cardiovasc Med. 2007;8 Suppl 3:S1-2. No abstract available. PMID: 17917616 [PubMed - indexed for MEDLINE]Related articles

An analysis of mortality rates with dual-antiplatelet therapy in the primary prevention population of the CHARISMA trial.

Wang TH, Bhatt DL, Fox KA, Steinhubl SR, Brennan DM, Hacke W, Mak KH, Pearson TA, Boden WE, Steg PG, Flather MD, Montalescot G, Topol EJ; CHARISMA Investigators.

Eur Heart J. 2007 Sep;28(18):2200-7. Epub 2007 Aug 2.PMID: 17673448 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of evidence of a clopidogrel-statin interaction in the CHARISMA trial.

Saw J, Brennan DM, Steinhubl SR, Bhatt DL, Mak KH, Fox K, Topol EJ; CHARISMA Investigators.

J Am Coll Cardiol. 2007 Jul 24;50(4):291-5. Epub 2007 Jul 10.PMID: 17659194 [PubMed - indexed for MEDLINE]Related articles

Transitioning patients from cangrelor to clopidogrel: pharmacodynamic evidence of a competitive effect.

Steinhubl SR, Oh JJ, Oestreich JH, Ferraris S, Charnigo R, Akers WS.

Thromb Res. 2008;121(4):527-34. Epub 2007 Jul 13.PMID: 17631948 [PubMed - indexed for MEDLINE]Related articles

Prolonged dual antiplatelet therapy after percutaneous coronary intervention reduces ischemic events without affecting the need for repeat revascularization: insights from the CREDO trial.

Brener SJ, Steinhubl SR, Berger PB, Brennan DM, Topol EJ; for the CREDO Investigators.

J Invasive Cardiol. 2007 Jul;19(7):287-90.PMID: 17620671 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease.

Steinhubl SR, Badimon JJ, Bhatt DL, Herbert JM, Lüscher TF.

Vasc Med. 2007 May;12(2):113-22. Review.PMID: 17615799 [PubMed - indexed for MEDLINE]Related articles

Variation in the definitions of bleeding in clinical trials of patients with acute coronary syndromes and undergoing percutaneous coronary interventions and its impact on the apparent safety of antithrombotic drugs.

Steinhubl SR, Kastrati A, Berger PB.

Am Heart J. 2007 Jul;154(1):3-11. Review.PMID: 17584547 [PubMed - indexed for MEDLINE]Related articles

Effects of unfractionated heparin and glycoprotein IIb/IIIa antagonists versus bivalirdin on myeloperoxidase release from neutrophils.

Li G, Keenan AC, Young JC, Hall MJ, Pamuklar Z, Ohman EM, Steinhubl SR, Smyth SS.

Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1850-6. Epub 2007 May 24.PMID: 17525363 [PubMed - indexed for MEDLINE]Related articlesFree article

Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial.

Bhatt DL, Flather MD, Hacke W, Berger PB, Black HR, Boden WE, Cacoub P, Cohen EA, Creager MA, Easton JD, Hamm CW, Hankey GJ, Johnston SC, Mak KH, Mas JL, Montalescot G, Pearson TA, Steg PG, Steinhubl SR, Weber MA, Fabry-Ribaudo L, Hu T, Topol EJ, Fox KA; CHARISMA Investigators.

J Am Coll Cardiol. 2007 May 15;49(19):1982-8. Epub 2007 Apr 11.PMID: 17498584 [PubMed - indexed for MEDLINE]Related articles

Aspirin dose for the prevention of cardiovascular disease: a systematic review.

Campbell CL, Smyth S, Montalescot G, Steinhubl SR.

JAMA. 2007 May 9;297(18):2018-24. Review.PMID: 17488967 [PubMed - indexed for MEDLINE]Related articlesFree article

Variable response to antiplatelet therapy: what does it mean to clinicians?

Falluji N, Steinhubl SR.

Cleve Clin J Med. 2007 Jan;74(1):49-55. Review.PMID: 17373347 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral antiplatelet therapy for percutaneous coronary revascularization.

Hamdalla H, Steinhubl SR.

Catheter Cardiovasc Interv. 2007 Apr 1;69(5):637-42. Review.PMID: 17351930 [PubMed - indexed for MEDLINE]Related articles

Platelets as mediators of inflammation.

Steinhubl SR.

Hematol Oncol Clin North Am. 2007 Feb;21(1):115-21. Review.PMID: 17258122 [PubMed - indexed for MEDLINE]Related articles

Optimizing antiplatelet therapy for the ACS patient: reacting to clinical trial data from the ISAR-REACT-2 studies.

Steinhubl SR.

Rev Cardiovasc Med. 2006;7 Suppl 4:S12-9. Review.PMID: 17224886 [PubMed - indexed for MEDLINE]Related articles

Clopidogrel bisulfate: in ST-segment elevation myocardial infarction: a viewpoint by Steven R Steinhubl.

Steinhubl SR.

Am J Cardiovasc Drugs. 2006;6(6):415-6. No abstract available. PMID: 17192133 [PubMed - indexed for MEDLINE]Related articles

Risk stratification for patients undergoing nonurgent percutaneous coronary intervention using N-terminal pro-B-type natriuretic peptide: a Clopidogrel for the Reduction of Events During Observation (CREDO) substudy.

Tang WH, Steinhubl SR, Van Lente F, Brennan D, McErlean E, Maroo A, Francis GS, Topol EJ.

Am Heart J. 2007 Jan;153(1):36-41.PMID: 17174634 [PubMed - indexed for MEDLINE]Related articles

First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity.

Dyke CK, Steinhubl SR, Kleiman NS, Cannon RO, Aberle LG, Lin M, Myles SK, Melloni C, Harrington RA, Alexander JH, Becker RC, Rusconi CP.

Circulation. 2006 Dec 5;114(23):2490-7. Epub 2006 Nov 13.PMID: 17101847 [PubMed - indexed for MEDLINE]Related articlesFree article