PubMed

A brief perspective on insulin production.

Steiner DF, Park SY, Støy J, Philipson LH, Bell GI.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:189-96.PMID: 19817801 [PubMed - in process]Related articles

beta-Cell research - A decade of rapid growth.

Ahrén B, Accili D, Boitard C, Efendic S, Henquin JC, Seino S, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:iv-ix. No abstract available. PMID: 19817782 [PubMed - in process]Related articles

Identification of genetic loci involved in diabetes using a rat model of depression.

Solberg Woods LC, Ahmadiyeh N, Baum A, Shimomura K, Li Q, Steiner DF, Turek FW, Takahashi JS, Churchill GA, Redei EE.

Mamm Genome. 2009 Aug;20(8):486-97. Epub 2009 Aug 22.PMID: 19697080 [PubMed - in process]Related articlesFree article

No mantle formation in rodent islets -- the prototype of islet revisited.

Kharouta M, Miller K, Kim A, Wojcik P, Kilimnik G, Dey A, Steiner DF, Hara M.

Diabetes Res Clin Pract. 2009 Sep;85(3):252-7.PMID: 19595468 [PubMed - in process]Related articles

Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains.

Zhan S, Zhao H, J White A, Minami M, Pignataro G, Yang T, Zhu X, Lan J, Xiong Z, Steiner DF, Simon RP, Zhou A.

J Cereb Blood Flow Metab. 2009 Apr;29(4):698-706. Epub 2009 Jan 14.PMID: 19142196 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta-cell mass or beta-cell function? That is the question!

Henquin JC, Cerasi E, Efendic S, Steiner DF, Boitard C.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:1-4. No abstract available. PMID: 18834427 [PubMed - indexed for MEDLINE]Related articles

Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.

Rehfeld JF, Zhu X, Norrbom C, Bundgaard JR, Johnsen AH, Nielsen JE, Vikesaa J, Stein J, Dey A, Steiner DF, Friis-Hansen L.

Biochem J. 2008 Oct 1;415(1):35-43.PMID: 18554181 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.

Molven A, Ringdal M, Nordbø AM, Raeder H, Støy J, Lipkind GM, Steiner DF, Philipson LH, Bergmann I, Aarskog D, Undlien DE, Joner G, Søvik O; Norwegian Childhood Diabetes Study Group, Bell GI, Njølstad PR.

Diabetes. 2008 Apr;57(4):1131-5. Epub 2008 Jan 11.PMID: 18192540 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.

Edghill EL, Flanagan SE, Patch AM, Boustred C, Parrish A, Shields B, Shepherd MH, Hussain K, Kapoor RR, Malecki M, MacDonald MJ, Støy J, Steiner DF, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group, Hattersley AT, Ellard S.

Diabetes. 2008 Apr;57(4):1034-42. Epub 2007 Dec 27.PMID: 18162506 [PubMed - indexed for MEDLINE]Related articlesFree article

The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6.

Rehfeld JF, Bundgaard JR, Hannibal J, Zhu X, Norrbom C, Steiner DF, Friis-Hansen L.

Endocrinology. 2008 Apr;149(4):1600-8. Epub 2007 Dec 20.PMID: 18096669 [PubMed - indexed for MEDLINE]Related articlesFree article

Of mighty mice and diabetic men: animal models of islet dysfunction.

Efendic S, Boitard C, Ferrannini E, Henquin JC, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:1-4. No abstract available. PMID: 17919172 [PubMed - indexed for MEDLINE]Related articles

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice.

Huang K, Chan SJ, Hua QX, Chu YC, Wang RY, Klaproth B, Jia W, Whittaker J, De Meyts P, Nakagawa SH, Steiner DF, Katsoyannis PG, Weiss MA.

J Biol Chem. 2007 Nov 30;282(48):35337-49. Epub 2007 Sep 20.PMID: 17884811 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin gene mutations as a cause of permanent neonatal diabetes.

Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, Lipton RB, Greeley SA, Patch AM, Ellard S, Steiner DF, Hattersley AT, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15040-4. Epub 2007 Sep 12.PMID: 17855560 [PubMed - indexed for MEDLINE]Related articlesFree article

Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling.

Kedees MH, Guz Y, Vuguin PM, Vargas C, Cui L, Steiner DF, Charron MJ, Teitelman G.

Dev Dyn. 2007 Apr;236(4):1126-33.PMID: 17366624 [PubMed - indexed for MEDLINE]Related articlesFree article

Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer.

Chan SJ, Nakagawa S, Steiner DF.

J Biol Chem. 2007 May 4;282(18):13754-8. Epub 2007 Mar 5.PMID: 17339314 [PubMed - indexed for MEDLINE]Related articlesFree article

On the processing of proghrelin to ghrelin.

Zhu X, Cao Y, Voogd K, Steiner DF.

J Biol Chem. 2006 Dec 15;281(50):38867-70. Epub 2006 Oct 18. Erratum in: J Biol Chem. 2007 Jan 19;282(3):2124. Voodg, Keith [corrected to Voogd, Keith]. PMID: 17050541 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study.

Pan H, Che FY, Peng B, Steiner DF, Pintar JE, Fricker LD.

J Neurochem. 2006 Sep;98(6):1763-77. Epub 2006 Aug 11.PMID: 16903874 [PubMed - indexed for MEDLINE]Related articles

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.

Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB.

Diabetes. 2006 Aug;55(8):2192-201.PMID: 16873681 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival.

Wang J, Cao Y, Chen Y, Chen Y, Gardner P, Steiner DF.

Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10636-41. Epub 2006 Jun 30.PMID: 16815968 [PubMed - indexed for MEDLINE]Related articlesFree article

RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor.

Stein J, Shah R, Steiner DF, Dey A.

Biochem J. 2006 Nov 15;400(1):209-15.PMID: 16800814 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of cocaine- and amphetamine-regulated transcript (CART) precursor proteins by prohormone convertases (PCs) and its implications.

Stein J, Steiner DF, Dey A.

Peptides. 2006 Aug;27(8):1919-25. Epub 2006 Jun 19. Review.PMID: 16784796 [PubMed - indexed for MEDLINE]Related articles

Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors.

Schlueter PJ, Royer T, Farah MH, Laser B, Chan SJ, Steiner DF, Duan C.

FASEB J. 2006 Jun;20(8):1230-2. Epub 2006 May 16.PMID: 16705083 [PubMed - indexed for MEDLINE]Related articlesFree article

Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.

Ugleholdt R, Poulsen ML, Holst PJ, Irminger JC, Orskov C, Pedersen J, Rosenkilde MM, Zhu X, Steiner DF, Holst JJ.

J Biol Chem. 2006 Apr 21;281(16):11050-7. Epub 2006 Feb 13.PMID: 16476726 [PubMed - indexed for MEDLINE]Related articlesFree article

Nhp6 is a transcriptional initiation fidelity factor for RNA polymerase III transcription in vitro and in vivo.

Kassavetis GA, Steiner DF.

J Biol Chem. 2006 Mar 17;281(11):7445-51. Epub 2006 Jan 11.PMID: 16407207 [PubMed - indexed for MEDLINE]Related articlesFree article

Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3.

Creemers JW, Pritchard LE, Gyte A, Le Rouzic P, Meulemans S, Wardlaw SL, Zhu X, Steiner DF, Davies N, Armstrong D, Lawrence CB, Luckman SM, Schmitz CA, Davies RA, Brennand JC, White A.

Endocrinology. 2006 Apr;147(4):1621-31. Epub 2005 Dec 29.PMID: 16384863 [PubMed - indexed for MEDLINE]Related articlesFree article

A tale of two cousins: type 1 and type 2 diabetes.

Boitard C, Efendic S, Ferrannini E, Henquin JC, Steiner DF, Cerasi E.

Diabetes. 2005 Dec;54 Suppl 2:S1-3. No abstract available. PMID: 16306326 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry.

Hardiman A, Friedman TC, Grunwald WC Jr, Furuta M, Zhu Z, Steiner DF, Cool DR.

J Mol Endocrinol. 2005 Jun;34(3):739-51.PMID: 15956344 [PubMed - indexed for MEDLINE]Related articlesFree article

Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes.

Peinado JR, Laurent V, Lee SN, Peng BW, Pintar JE, Steiner DF, Lindberg I.

Endocrinology. 2005 Aug;146(8):3438-44. Epub 2005 May 5.PMID: 15878971 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuropeptide processing profile in mice lacking prohormone convertase-1.

Pan H, Nanno D, Che FY, Zhu X, Salton SR, Steiner DF, Fricker LD, Devi LA.

Biochemistry. 2005 Mar 29;44(12):4939-48.PMID: 15779921 [PubMed - indexed for MEDLINE]Related articles

Impact of treatment on islet function in type 2 diabetes.

Henquin JC, Boitard C, Cerasi E, Ferrannini E, Steiner DF, Efendic S.

Diabetes. 2004 Dec;53 Suppl 3:S1-5. No abstract available. PMID: 15561896 [PubMed - indexed for MEDLINE]Related articlesFree article

Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon.

Dey A, Lipkind GM, Rouillé Y, Norrbom C, Stein J, Zhang C, Carroll R, Steiner DF.

Endocrinology. 2005 Feb;146(2):713-27. Epub 2004 Nov 4.PMID: 15528303 [PubMed - indexed for MEDLINE]Related articlesFree article

The proinsulin C-peptide--a multirole model.

Steiner DF.

Exp Diabesity Res. 2004 Jan-Mar;5(1):7-14. Review.PMID: 15198367 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.

Ma L, Bindokas VP, Kuznetsov A, Rhodes C, Hays L, Edwardson JM, Ueda K, Steiner DF, Philipson LH.

Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9266-71. Epub 2004 Jun 14.PMID: 15197259 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets.

Webb GC, Dey A, Wang J, Stein J, Milewski M, Steiner DF.

J Biol Chem. 2004 Jul 23;279(30):31068-75. Epub 2004 May 13.PMID: 15143067 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain.

Cain BM, Connolly K, Blum AC, Vishnuvardhan D, Marchand JE, Zhu X, Steiner DF, Beinfeld MC.

J Neurochem. 2004 Apr;89(2):307-13.PMID: 15056274 [PubMed - indexed for MEDLINE]Related articles

Novel factors in the regulation of beta-cell function.

Boitard C, Cerasi E, Efendic S, Henquin JC, Steiner DF, Ferrannini E.

Diabetes. 2004 Feb;53 Suppl 1:S1-3. No abstract available. PMID: 14749258 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.

Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB.

Diabetes. 2004 Jan;53(1):141-8.PMID: 14693708 [PubMed - indexed for MEDLINE]Related articlesFree article

Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone.

Dey A, Norrbom C, Zhu X, Stein J, Zhang C, Ueda K, Steiner DF.

Endocrinology. 2004 Apr;145(4):1961-71. Epub 2003 Dec 18.PMID: 14684599 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.

Ugleholdt R, Zhu X, Deacon CF, Ørskov C, Steiner DF, Holst JJ.

Endocrinology. 2004 Mar;145(3):1349-55. Epub 2003 Nov 20.PMID: 14630721 [PubMed - indexed for MEDLINE]Related articlesFree article

Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells.

Wang J, Webb G, Cao Y, Steiner DF.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12660-5. Epub 2003 Oct 13.PMID: 14557546 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter.

Wang J, Cao Y, Steiner DF.

J Biol Chem. 2003 Aug 29;278(35):32899-904. Epub 2003 Jun 18.PMID: 12815047 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1).

Ueda K, Lipkind GM, Zhou A, Zhu X, Kuznetsov A, Philipson L, Gardner P, Zhang C, Steiner DF.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):5622-7. Epub 2003 Apr 29.PMID: 12721373 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines.

Lilla V, Webb G, Rickenbach K, Maturana A, Steiner DF, Halban PA, Irminger JC.

Endocrinology. 2003 Apr;144(4):1368-79.PMID: 12639920 [PubMed - indexed for MEDLINE]Related articlesFree article

Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3.

Dey A, Xhu X, Carroll R, Turck CW, Stein J, Steiner DF.

J Biol Chem. 2003 Apr 25;278(17):15007-14. Epub 2003 Feb 12.PMID: 12584191 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid polypeptide is expressed in the pancreatic islet parenchyma of the teleostean fish, Myoxocephalus (cottus) scorpius.

Westermark GT, Falkmer S, Steiner DF, Chan SJ, Engström U, Westermark P.

Comp Biochem Physiol B Biochem Mol Biol. 2002 Sep;133(1):119-25.PMID: 12223219 [PubMed - indexed for MEDLINE]Related articles

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.

Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, Zhang C, Laurent V, Lindberg I, Ugleholdt R, Holst JJ, Steiner DF.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10293-8. Epub 2002 Jul 26.PMID: 12145326 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.

Zhu X, Orci L, Carroll R, Norrbom C, Ravazzola M, Steiner DF.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10299-304. Epub 2002 Jul 22.PMID: 12136131 [PubMed - indexed for MEDLINE]Related articlesFree article

Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion.

Laurent V, Kimble A, Peng B, Zhu P, Pintar JE, Steiner DF, Lindberg I.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3087-92. Epub 2002 Feb 19.PMID: 11854475 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion: movement at all levels.

Henquin JC, Boitard C, Efendic S, Ferrannini E, Steiner DF, Cerasi E.

Diabetes. 2002 Feb;51 Suppl 1:S1-2. No abstract available. PMID: 11815449 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon replacement via micro-osmotic pump corrects hypoglycemia and alpha-cell hyperplasia in prohormone convertase 2 knockout mice.

Webb GC, Akbar MS, Zhao C, Swift HH, Steiner DF.

Diabetes. 2002 Feb;51(2):398-405.PMID: 11812747 [PubMed - indexed for MEDLINE]Related articlesFree article