PubMed

Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.

Sacchetti P, Sousa KM, Hall AC, Liste I, Steffensen KR, Theofilopoulos S, Parish CL, Hazenberg C, Richter LA, Hovatta O, Gustafsson JA, Arenas E.

Cell Stem Cell. 2009 Oct 2;5(4):409-19.PMID: 19796621 [PubMed - in process]Related articles

Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.

Hellemans KH, Hannaert JC, Denys B, Steffensen KR, Raemdonck C, Martens GA, Van Veldhoven PP, Gustafsson JA, Pipeleers D.

PLoS One. 2009 Sep 29;4(9):e7266.PMID: 19787047 [PubMed - in process]Related articlesFree article

Separate and overlapping metabolic functions of LXR{alpha} and LXR{beta} in C57Bl/6 female mice.

Korach-Andre M, Parini P, Larsson L, Arner A, Steffensen KR, Gustafsson JA.

Am J Physiol Endocrinol Metab. 2009 Aug 18. [Epub ahead of print]PMID: 19690071 [PubMed - as supplied by publisher]Related articles

Activation of liver X receptor regulates substrate oxidation in white adipocytes.

Stenson BM, Rydén M, Steffensen KR, Wåhlén K, Pettersson AT, Jocken JW, Arner P, Laurencikiene J.

Endocrinology. 2009 Sep;150(9):4104-13. Epub 2009 Jun 25.PMID: 19556420 [PubMed - indexed for MEDLINE]Related articles

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.

Jakobsson T, Venteclef N, Toresson G, Damdimopoulos AE, Ehrlund A, Lou X, Sanyal S, Steffensen KR, Gustafsson JA, Treuter E.

Mol Cell. 2009 May 14;34(4):510-8.PMID: 19481530 [PubMed - indexed for MEDLINE]Related articles

Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice.

Korf H, Vander Beken S, Romano M, Steffensen KR, Stijlemans B, Gustafsson JA, Grooten J, Huygen K.

J Clin Invest. 2009 Jun;119(6):1626-37. doi: 10.1172/JCI35288. Epub 2009 May 11.PMID: 19436111 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages.

Wang YY, Dahle MK, Steffensen KR, Reinholt FP, Collins JL, Thiemermann C, Aasen AO, Gustafsson JA, Wang JE.

Shock. 2009 Nov;32(5):548-53.PMID: 19295476 [PubMed - in process]Related articles

Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study.

Dahlman I, Nilsson M, Gu HF, Lecoeur C, Efendic S, Ostenson CG, Brismar K, Gustafsson JA, Froguel P, Vaxillaire M, Dahlman-Wright K, Steffensen KR.

BMC Med Genet. 2009 Mar 17;10:27.PMID: 19292929 [PubMed - indexed for MEDLINE]Related articlesFree article

E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis.

Ehrlund A, Anthonisen EH, Gustafsson N, Venteclef N, Robertson Remen K, Damdimopoulos AE, Galeeva A, Pelto-Huikko M, Lalli E, Steffensen KR, Gustafsson JA, Treuter E.

Mol Cell Biol. 2009 Apr;29(8):2230-42. Epub 2009 Feb 23.PMID: 19237537 [PubMed - indexed for MEDLINE]Related articlesFree article

The oxysterol receptor LXR inhibits proliferation of human breast cancer cells.

Vedin LL, Lewandowski SA, Parini P, Gustafsson JA, Steffensen KR.

Carcinogenesis. 2009 Apr;30(4):575-9. Epub 2009 Jan 23.PMID: 19168586 [PubMed - indexed for MEDLINE]Related articles

Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose.

Dahlman I, Vaxillaire M, Nilsson M, Lecoeur C, Gu HF, Cavalcanti-Proença C, Efendic S, Ostenson CG, Brismar K, Charpentier G, Gustafsson JA, Froguel P, Dahlman-Wright K, Steffensen KR.

Pharmacogenet Genomics. 2008 Nov;18(11):967-75.PMID: 18854778 [PubMed - indexed for MEDLINE]Related articles

Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes.

Madsen L, Petersen RK, Steffensen KR, Pedersen LM, Hallenborg P, Ma T, Frøyland L, Døskeland SO, Gustafsson JA, Kristiansen K.

J Biol Chem. 2008 Aug 15;283(33):22723-36. Epub 2008 May 16.PMID: 18487205 [PubMed - indexed for MEDLINE]Related articlesFree article

RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3.

Antonson P, Jakobsson T, Almlöf T, Guldevall K, Steffensen KR, Gustafsson JA.

J Biol Chem. 2008 Apr 4;283(14):8995-9001. Epub 2008 Feb 7.PMID: 18263591 [PubMed - indexed for MEDLINE]Related articlesFree article

Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator.

Steffensen KR, Bouzga M, Skjeldal F, Kasi C, Karahasan A, Matre V, Bakke O, Guérin S, Eskild W.

BMC Mol Biol. 2007 Nov 16;8:106.PMID: 18021396 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965).

Kotokorpi P, Ellis E, Parini P, Nilsson LM, Strom S, Steffensen KR, Gustafsson JA, Mode A.

Mol Pharmacol. 2007 Oct;72(4):947-55. Epub 2007 Jul 12.PMID: 17628011 [PubMed - indexed for MEDLINE]Related articlesFree article

Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter.

Nilsson M, Dahlman-Wright K, Karelmo C, Ebeling M, Gustafsson JA, Steffensen KR.

Nucleic Acids Res. 2007;35(14):4858-68. Epub 2007 Jul 10. Erratum in: Nucleic Acids Res. 2008 Jan;36(1):352. Ebeling, Martin [added]. PMID: 17626048 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptors regulate adrenal steroidogenesis and hypothalamic-pituitary-adrenal feedback.

Nilsson M, Stulnig TM, Lin CY, Yeo AL, Nowotny P, Liu ET, Steffensen KR.

Mol Endocrinol. 2007 Jan;21(1):126-37. Epub 2006 Sep 14.PMID: 16973760 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes.

Steffensen KR, Robertson K, Gustafsson JA, Andersen CY.

Mol Cell Endocrinol. 2006 Aug 15;256(1-2):9-16. Epub 2006 Aug 8.PMID: 16895745 [PubMed - indexed for MEDLINE]Related articles

Pitavastatin effect on ATP binding cassette A1-mediated lipid efflux from macrophages: evidence for liver X receptor (LXR)-dependent and LXR-independent mechanisms of activation by cAMP.

Zanotti I, Potì F, Favari E, Steffensen KR, Gustafsson JA, Bernini F.

J Pharmacol Exp Ther. 2006 Apr;317(1):395-401. Epub 2006 Jan 13.PMID: 16415093 [PubMed - indexed for MEDLINE]Related articlesFree article

CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells.

Liu X, Lindberg R, Xiao BG, Steffensen KR, Leppert D, Link H, Huang YM.

J Neuroimmunol. 2006 Mar;172(1-2):137-44. Epub 2005 Dec 27.PMID: 16380169 [PubMed - indexed for MEDLINE]Related articles

Evidence for an indirect transcriptional regulation of glucose-6-phosphatase gene expression by liver X receptors.

Grempler R, Günther S, Steffensen KR, Nilsson M, Barthel A, Schmoll D, Walther R.

Biochem Biophys Res Commun. 2005 Dec 16;338(2):981-6. Epub 2005 Oct 17.PMID: 16256938 [PubMed - indexed for MEDLINE]Related articles

Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis.

Liu X, Ciumas C, Huang YM, Steffensen KR, Lian H, Link H, Xiao BG.

Mult Scler. 2005 Aug;11(4):381-9.PMID: 16042218 [PubMed - indexed for MEDLINE]Related articles

Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden.

Liu X, Steffensen KR, Sanna A, Arru G, Fois ML, Rosati G, Sotgiu S, Link H, Gustafsson JA, Huang YM.

Neurobiol Dis. 2005 Dec;20(3):961-8. Epub 2005 Jul 14.PMID: 16023861 [PubMed - indexed for MEDLINE]Related articles

Liver X receptors alpha and beta regulate renin expression in vivo.

Morello F, de Boer RA, Steffensen KR, Gnecchi M, Chisholm JW, Boomsma F, Anderson LM, Lawn RM, Gustafsson JA, Lopez-Ilasaca M, Pratt RE, Dzau VJ.

J Clin Invest. 2005 Jul;115(7):1913-22.PMID: 16007255 [PubMed - indexed for MEDLINE]Related articlesFree article

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function.

Gerin I, Dolinsky VW, Shackman JG, Kennedy RT, Chiang SH, Burant CF, Steffensen KR, Gustafsson JA, MacDougald OA.

J Biol Chem. 2005 Jun 17;280(24):23024-31. Epub 2005 Apr 13.PMID: 15831500 [PubMed - indexed for MEDLINE]Related articlesFree article

The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis.

Robertson KM, Schuster GU, Steffensen KR, Hovatta O, Meaney S, Hultenby K, Johansson LC, Svechnikov K, Söder O, Gustafsson JA.

Endocrinology. 2005 Jun;146(6):2519-30. Epub 2005 Mar 10.PMID: 15761042 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals.

Steffensen KR, Neo SY, Stulnig TM, Vega VB, Rahman SS, Schuster GU, Gustafsson JA, Liu ET.

J Mol Endocrinol. 2004 Dec;33(3):609-22.PMID: 15591022 [PubMed - indexed for MEDLINE]Related articlesFree article

Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.

Anderson SP, Dunn C, Laughter A, Yoon L, Swanson C, Stulnig TM, Steffensen KR, Chandraratna RA, Gustafsson JA, Corton JC.

Mol Pharmacol. 2004 Dec;66(6):1440-52. Epub 2004 Sep 15.PMID: 15371561 [PubMed - indexed for MEDLINE]Related articlesFree article

Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.

Corton JC, Apte U, Anderson SP, Limaye P, Yoon L, Latendresse J, Dunn C, Everitt JI, Voss KA, Swanson C, Kimbrough C, Wong JS, Gill SS, Chandraratna RA, Kwak MK, Kensler TW, Stulnig TM, Steffensen KR, Gustafsson JA, Mehendale HM.

J Biol Chem. 2004 Oct 29;279(44):46204-12. Epub 2004 Aug 9.PMID: 15302862 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression profiling identifies liver X receptor alpha as an estrogen-regulated gene in mouse adipose tissue.

Lundholm L, Movérare S, Steffensen KR, Nilsson M, Otsuki M, Ohlsson C, Gustafsson JA, Dahlman-Wright K.

J Mol Endocrinol. 2004 Jun;32(3):879-92.PMID: 15171719 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue.

Steffensen KR, Holter E, Båvner A, Nilsson M, Pelto-Huikko M, Tomarev S, Treuter E.

EMBO Rep. 2004 Jun;5(6):613-9. Epub 2004 May 14.PMID: 15143342 [PubMed - indexed for MEDLINE]Related articlesFree article

Purification of functional full-length liver X receptor beta produced in Escherichia coli.

Toresson G, Schuster GU, Steffensen KR, Bengtsson M, Ljunggren J, Dahlman-Wright K, Gustafsson JA.

Protein Expr Purif. 2004 Jun;35(2):190-8.PMID: 15135392 [PubMed - indexed for MEDLINE]Related articles

Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression.

Seo JB, Moon HM, Kim WS, Lee YS, Jeong HW, Yoo EJ, Ham J, Kang H, Park MG, Steffensen KR, Stulnig TM, Gustafsson JA, Park SD, Kim JB.

Mol Cell Biol. 2004 Apr;24(8):3430-44.PMID: 15060163 [PubMed - indexed for MEDLINE]Related articlesFree article

Putative metabolic effects of the liver X receptor (LXR).

Steffensen KR, Gustafsson JA.

Diabetes. 2004 Feb;53 Suppl 1:S36-42. Review.PMID: 14749264 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid response and promoter occupancy of the mouse LXRalpha gene.

Steffensen KR, Holter E, Alikhani N, Eskild W, Gustafsson JA.

Biochem Biophys Res Commun. 2003 Dec 19;312(3):716-24.PMID: 14680824 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively.

Steffensen KR, Nilsson M, Schuster GU, Stulnig TM, Dahlman-Wright K, Gustafsson JA.

Biochem Biophys Res Commun. 2003 Oct 17;310(2):589-93.PMID: 14521951 [PubMed - indexed for MEDLINE]Related articles

Activation of PPAR gamma in colon tumor cell lines by oxidized metabolites of linoleic acid, endogenous ligands for PPAR gamma.

Bull AW, Steffensen KR, Leers J, Rafter JJ.

Carcinogenesis. 2003 Nov;24(11):1717-22. Epub 2003 Aug 29.PMID: 12949056 [PubMed - indexed for MEDLINE]Related articlesFree article

TACC3 expression is tightly regulated during early differentiation.

Sadek CM, Pelto-Huikko M, Tujague M, Steffensen KR, Wennerholm M, Gustafsson JA.

Gene Expr Patterns. 2003 May;3(2):203-11.PMID: 12711550 [PubMed - indexed for MEDLINE]Related articles

Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue.

Stulnig TM, Steffensen KR, Gao H, Reimers M, Dahlman-Wright K, Schuster GU, Gustafsson JA.

Mol Pharmacol. 2002 Dec;62(6):1299-305.PMID: 12435796 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP.

Borgius LJ, Steffensen KR, Gustafsson JA, Treuter E.

J Biol Chem. 2002 Dec 20;277(51):49761-6. Epub 2002 Sep 24.PMID: 12324453 [PubMed - indexed for MEDLINE]Related articlesFree article

Accumulation of foam cells in liver X receptor-deficient mice.

Schuster GU, Parini P, Wang L, Alberti S, Steffensen KR, Hansson GK, Angelin B, Gustafsson JA.

Circulation. 2002 Aug 27;106(9):1147-53.PMID: 12196343 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

Stulnig TM, Oppermann U, Steffensen KR, Schuster GU, Gustafsson JA.

Diabetes. 2002 Aug;51(8):2426-33.PMID: 12145154 [PubMed - indexed for MEDLINE]Related articlesFree article

Different regulation of the LXRalpha promoter activity by isoforms of CCAAT/enhancer-binding proteins.

Steffensen KR, Schuster GU, Parini P, Holter E, Sadek CM, Cassel T, Eskild W, Gustafsson JA.

Biochem Biophys Res Commun. 2002 May 24;293(5):1333-40.PMID: 12054659 [PubMed - indexed for MEDLINE]Related articles

Members of the nuclear factor 1 family reduce the transcriptional potential of the nuclear receptor LXRalpha promoter.

Steffensen KR, Holter E, Tobin KA, Leclerc S, Gustafsson JA, Guérin SL, Eskild W.

Biochem Biophys Res Commun. 2001 Dec 21;289(5):1262-7.PMID: 11741331 [PubMed - indexed for MEDLINE]Related articles

Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta.

Alberti S, Steffensen KR, Gustafsson JA.

Gene. 2000 Feb 8;243(1-2):93-103.PMID: 10675617 [PubMed - indexed for MEDLINE]Related articles

Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-alpha nuclear receptor heterodimer.

Wiebel FF, Steffensen KR, Treuter E, Feltkamp D, Gustafsson JA.

Mol Endocrinol. 1999 Jul;13(7):1105-18.PMID: 10406462 [PubMed - indexed for MEDLINE]Related articlesFree article