PubMed

Borrelia burgdorferi stimulates macrophages to secrete higher levels of cytokines and chemokines than Borrelia afzelii or Borrelia garinii.

Strle K, Drouin EE, Shen S, Khoury JE, McHugh G, Ruzic-Sabljic E, Strle F, Steere AC.

J Infect Dis. 2009 Dec 15;200(12):1936-43.PMID: 19909078 [PubMed - in process]Related articles

Analysis of Borrelia burgdorferi genotypes in patients with Lyme arthritis: High frequency of ribosomal RNA intergenic spacer type 1 strains in antibiotic-refractory arthritis.

Jones KL, McHugh GA, Glickstein LJ, Steere AC.

Arthritis Rheum. 2009 Jul;60(7):2174-82.PMID: 19565522 [PubMed - indexed for MEDLINE]Related articlesFree article

Strong IgG antibody responses to Borrelia burgdorferi glycolipids in patients with Lyme arthritis, a late manifestation of the infection.

Jones KL, Seward RJ, Ben-Menachem G, Glickstein LJ, Costello CE, Steere AC.

Clin Immunol. 2009 Jul;132(1):93-102. Epub 2009 Apr 2.PMID: 19342303 [PubMed - indexed for MEDLINE]Related articles

Reply to letter by Volkman commenting on the possible onset of seronegative disease in Lyme arthritis.

Steere AC.

Arthritis Rheum. 2009 Jan;60(1):310. No abstract available. PMID: 19116916 [PubMed - indexed for MEDLINE]Related articles

Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis.

Codolo G, Amedei A, Steere AC, Papinutto E, Cappon A, Polenghi A, Benagiano M, Paccani SR, Sambri V, Del Prete G, Baldari CT, Zanotti G, Montecucco C, D'Elios MM, de Bernard M.

Arthritis Rheum. 2008 Nov;58(11):3609-17.PMID: 18975343 [PubMed - indexed for MEDLINE]Related articlesFree article

Prospective study of serologic tests for lyme disease.

Steere AC, McHugh G, Damle N, Sikand VK.

Clin Infect Dis. 2008 Jul 15;47(2):188-95.PMID: 18532885 [PubMed - indexed for MEDLINE]Related articles

A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi.

Barbour AG, Jasinskas A, Kayala MA, Davies DH, Steere AC, Baldi P, Felgner PL.

Infect Immun. 2008 Aug;76(8):3374-89. Epub 2008 May 12.PMID: 18474646 [PubMed - indexed for MEDLINE]Related articlesFree article

Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis.

Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC.

Mol Immunol. 2008 Apr;45(8):2323-32. Epub 2008 Jan 11. Erratum in: Mol Immunol. 2008 Jul;45(12):3508. PMID: 18191206 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-tumor necrosis factor-alpha activation of Borrelia burgdorferi spirochetes in antibiotic-treated murine Lyme borreliosis: an unproven conclusion.

Wormser GP, Barthold SW, Shapiro ED, Dattwyler RJ, Bakken JS, Steere AC, Bockenstedt LK, Radolf JD.

J Infect Dis. 2007 Dec 15;196(12):1865-6; author reply 1866-7. No abstract available. PMID: 18190269 [PubMed - indexed for MEDLINE]Related articles

Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis.

Jones KL, Muellegger RR, Means TK, Lee M, Glickstein LJ, Damle N, Sikand VK, Luster AD, Steere AC.

Clin Infect Dis. 2008 Jan 1;46(1):85-92.PMID: 18171218 [PubMed - indexed for MEDLINE]Related articles

Antibody responses to Borrelia burgdorferi in patients with antibiotic-refractory, antibiotic-responsive, or non-antibiotic-treated Lyme arthritis.

Kannian P, McHugh G, Johnson BJ, Bacon RM, Glickstein LJ, Steere AC.

Arthritis Rheum. 2007 Dec;56(12):4216-25.PMID: 18050219 [PubMed - indexed for MEDLINE]Related articlesFree article

Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractory lyme arthritis.

Kannian P, Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC.

J Immunol. 2007 Nov 1;179(9):6336-42.PMID: 17947711 [PubMed - indexed for MEDLINE]Related articlesFree article

A critical appraisal of "chronic Lyme disease".

Feder HM Jr, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP; Ad Hoc International Lyme Disease Group, Agger WA, Artsob H, Auwaerter P, Dumler JS, Bakken JS, Bockenstedt LK, Green J, Dattwyler RJ, Munoz J, Nadelman RB, Schwartz I, Draper T, McSweegan E, Halperin JJ, Klempner MS, Krause PJ, Mead P, Morshed M, Porwancher R, Radolf JD, Smith RP Jr, Sood S, Weinstein A, Wong SJ, Zemel L.

N Engl J Med. 2007 Oct 4;357(14):1422-30. Review. No abstract available. Erratum in: N Engl J Med. 2008 Mar 6;358(10):1084. Agger, WA [added]; Artsob, H [added]; Auwaerter, P [added]; Dumler, JS [added]; Bakken, JS [added]; Bockenstedt, LK [added]; Green, J [added]; Dattwyler, RJ [added]; Munoz, J [added]; Nadelman, RB [added]; Schwartz, I [added]; Draper, T [added]; McSweegan, E [added]; Halperin, JJ [added]; Klempner, MS [added]; Krause, PJ [added]; Mead, P[added]; Morshed, M [added]; Porwancher, R [added]; Radolf, JD [added]; Smith RP Jr [added]; Sood, S [added]; Weinstein, A [added]; Wong, SJ [added]; Zemel, L [added]. PMID: 17914043 [PubMed - indexed for MEDLINE]Related articles

Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma.

Müllegger RR, Means TK, Shin JJ, Lee M, Jones KL, Glickstein LJ, Luster AD, Steere AC.

Infect Immun. 2007 Sep;75(9):4621-8. Epub 2007 Jul 2.PMID: 17606602 [PubMed - indexed for MEDLINE]Related articlesFree article

Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis.

Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC.

Mol Immunol. 2008 Jan;45(1):180-9. Epub 2007 Jun 6.PMID: 17555819 [PubMed - indexed for MEDLINE]Related articlesFree article

Case records of the Massachusetts General Hospital. Case 11-2007. A 59-year-old man with neck pain, weakness in the arms, and cranial-nerve palsies.

Greer DM, Schaefer PW, Plotkin SR, Hasserjian RP, Steere AC.

N Engl J Med. 2007 Apr 12;356(15):1561-70. No abstract available. PMID: 17429088 [PubMed - indexed for MEDLINE]Related articles

High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis.

Shin JJ, Glickstein LJ, Steere AC.

Arthritis Rheum. 2007 Apr;56(4):1325-35.PMID: 17393419 [PubMed - indexed for MEDLINE]Related articlesFree article

Lyme borreliosis in 2005, 30 years after initial observations in Lyme Connecticut.

Steere AC.

Wien Klin Wochenschr. 2006 Nov;118(21-22):625-33. Review.PMID: 17160599 [PubMed - indexed for MEDLINE]Related articles

Borrelia burgdorferi genetic markers and disseminated disease in patients with early Lyme disease.

Jones KL, Glickstein LJ, Damle N, Sikand VK, McHugh G, Steere AC.

J Clin Microbiol. 2006 Dec;44(12):4407-13. Epub 2006 Oct 11.PMID: 17035489 [PubMed - indexed for MEDLINE]Related articlesFree article

The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America.

Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB.

Clin Infect Dis. 2006 Nov 1;43(9):1089-134. Epub 2006 Oct 2. Erratum in: Clin Infect Dis. 2007 Oct 1;45(7):941. PMID: 17029130 [PubMed - indexed for MEDLINE]Related articles

Role of aggrecanase 1 in Lyme arthritis.

Behera AK, Hildebrand E, Szafranski J, Hung HH, Grodzinsky AJ, Lafyatis R, Koch AE, Kalish R, Perides G, Steere AC, Hu LT.

Arthritis Rheum. 2006 Oct;54(10):3319-29.PMID: 17009305 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis.

Steere AC, Angelis SM.

Arthritis Rheum. 2006 Oct;54(10):3079-86. Review. No abstract available. PMID: 17009226 [PubMed - indexed for MEDLINE]Related articlesFree article

Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide.

Steere AC, Klitz W, Drouin EE, Falk BA, Kwok WW, Nepom GT, Baxter-Lowe LA.

J Exp Med. 2006 Apr 17;203(4):961-71. Epub 2006 Apr 3.PMID: 16585267 [PubMed - indexed for MEDLINE]Related articlesFree article

Case records of the Massachusetts General Hospital. Case 14-2005. A 38-year-old man with fever and blurred vision.

Kathiresan S, Kelsey PB, Steere AC, Foster CS, Curvelo MS, Stone JR.

N Engl J Med. 2005 May 12;352(19):2003-12. No abstract available. PMID: 15888702 [PubMed - indexed for MEDLINE]Related articles

Human Lyme arthritis and the immunoglobulin G antibody response to the 37-kilodalton arthritis-related protein of Borrelia burgdorferi.

Salazar CA, Rothemich M, Drouin EE, Glickstein L, Steere AC.

Infect Immun. 2005 May;73(5):2951-7.PMID: 15845501 [PubMed - indexed for MEDLINE]Related articlesFree article

In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium.

Ghosh S, Steere AC, Stollar BD, Huber BT.

J Immunol. 2005 Mar 1;174(5):2860-9.PMID: 15728496 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.

Behera AK, Hildebrand E, Scagliotti J, Steere AC, Hu LT.

Infect Immun. 2005 Jan;73(1):126-34.PMID: 15618147 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular characterization of the OspA(161-175) T cell epitope associated with treatment-resistant Lyme arthritis: differences among the three pathogenic species of Borrelia burgdorferi sensu lato.

Drouin EE, Glickstein LJ, Steere AC.

J Autoimmun. 2004 Nov;23(3):281-92.PMID: 15501399 [PubMed - indexed for MEDLINE]Related articles

The VlsE (IR6) peptide ELISA in the serodiagnosis of lyme facial paralysis.

Peltomaa M, McHugh G, Steere AC.

Otol Neurotol. 2004 Sep;25(5):838-41.PMID: 15354020 [PubMed - indexed for MEDLINE]Related articles

The emergence of Lyme disease.

Steere AC, Coburn J, Glickstein L.

J Clin Invest. 2004 Apr;113(8):1093-101. Review.PMID: 15085185 [PubMed - indexed for MEDLINE]Related articlesFree article

Elucidation of Lyme arthritis.

Steere AC, Glickstein L.

Nat Rev Immunol. 2004 Feb;4(2):143-52. Review.PMID: 15040587 [PubMed - indexed for MEDLINE]Related articles

Inflammatory cytokine production predominates in early Lyme disease in patients with erythema migrans.

Glickstein L, Moore B, Bledsoe T, Damle N, Sikand V, Steere AC.

Infect Immun. 2003 Oct;71(10):6051-3.PMID: 14500528 [PubMed - indexed for MEDLINE]Related articlesFree article

Asymptomatic infection with Borrelia burgdorferi.

Steere AC, Sikand VK, Schoen RT, Nowakowski J.

Clin Infect Dis. 2003 Aug 15;37(4):528-32. Epub 2003 Jul 30.PMID: 12905137 [PubMed - indexed for MEDLINE]Related articles

The presenting manifestations of Lyme disease and the outcomes of treatment.

Steere AC, Sikand VK.

N Engl J Med. 2003 Jun 12;348(24):2472-4. No abstract available. PMID: 12802042 [PubMed - indexed for MEDLINE]Related articles

Duration of antibiotic therapy for Lyme disease.

Steere AC.

Ann Intern Med. 2003 May 6;138(9):761-2. No abstract available. PMID: 12729432 [PubMed - indexed for MEDLINE]Related articlesFree article

Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates.

Bacon RM, Biggerstaff BJ, Schriefer ME, Gilmore RD Jr, Philipp MT, Steere AC, Wormser GP, Marques AR, Johnson BJ.

J Infect Dis. 2003 Apr 15;187(8):1187-99. Epub 2003 Apr 2.PMID: 12695997 [PubMed - indexed for MEDLINE]Related articles

Persistence of the antibody response to the VlsE sixth invariant region (IR6) peptide of Borrelia burgdorferi after successful antibiotic treatment of Lyme disease.

Peltomaa M, McHugh G, Steere AC.

J Infect Dis. 2003 Apr 15;187(8):1178-86. Epub 2003 Apr 2.PMID: 12695996 [PubMed - indexed for MEDLINE]Related articles

Prospective study of coinfection in patients with erythema migrans.

Steere AC, McHugh G, Suarez C, Hoitt J, Damle N, Sikand VK.

Clin Infect Dis. 2003 Apr 15;36(8):1078-81. Epub 2003 Mar 31.PMID: 12684924 [PubMed - indexed for MEDLINE]Related articles

Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis.

Steere AC, Falk B, Drouin EE, Baxter-Lowe LA, Hammer J, Nepom GT.

Arthritis Rheum. 2003 Feb;48(2):534-40.PMID: 12571864 [PubMed - indexed for MEDLINE]Related articlesFree article

Systemic symptoms without erythema migrans as the presenting picture of early Lyme disease.

Steere AC, Dhar A, Hernandez J, Fischer PA, Sikand VK, Schoen RT, Nowakowski J, McHugh G, Persing DH.

Am J Med. 2003 Jan;114(1):58-62. No abstract available. PMID: 12543291 [PubMed - indexed for MEDLINE]Related articles

A 58-year-old man with a diagnosis of chronic lyme disease.

Steere AC.

JAMA. 2002 Aug 28;288(8):1002-10. No abstract available. PMID: 12190371 [PubMed - indexed for MEDLINE]Related articles

Cerebellar ataxia as the presenting manifestation of Lyme disease.

Arav-Boger R, Crawford T, Steere AC, Halsey NA.

Pediatr Infect Dis J. 2002 Apr;21(4):353-6.PMID: 12075773 [PubMed - indexed for MEDLINE]Related articles

Clinical characteristics and treatment outcome of early Lyme disease in patients with microbiologically confirmed erythema migrans.

Smith RP, Schoen RT, Rahn DW, Sikand VK, Nowakowski J, Parenti DL, Holman MS, Persing DH, Steere AC.

Ann Intern Med. 2002 Mar 19;136(6):421-8.PMID: 11900494 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mimicry and Lyme arthritis.

Gross D, Huber BT, Steere AC.

Curr Dir Autoimmun. 2001;3:94-111. Review. No abstract available. PMID: 11791473 [PubMed - indexed for MEDLINE]Related articles

Cellular and humoral immune responses to Borrelia burgdorferi antigens in patients with culture-positive early Lyme disease.

Vaz A, Glickstein L, Field JA, McHugh G, Sikand VK, Damle N, Steere AC.

Infect Immun. 2001 Dec;69(12):7437-44.PMID: 11705918 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10-20 years after active Lyme disease.

Kalish RA, McHugh G, Granquist J, Shea B, Ruthazer R, Steere AC.

Clin Infect Dis. 2001 Sep 15;33(6):780-5. Epub 2001 Aug 10.PMID: 11512082 [PubMed - indexed for MEDLINE]Related articles

Optic neuropathy in children with Lyme disease.

Rothermel H, Hedges TR 3rd, Steere AC.

Pediatrics. 2001 Aug;108(2):477-81.PMID: 11483820 [PubMed - indexed for MEDLINE]Related articlesFree article

Lyme disease.

Steere AC.

N Engl J Med. 2001 Jul 12;345(2):115-25. Review. No abstract available. PMID: 11450660 [PubMed - indexed for MEDLINE]Related articles

Differences in synovial fluid levels of matrix metalloproteinases suggest separate mechanisms of pathogenesis in Lyme arthritis before and after antibiotic treatment.

Lin B, Kidder JM, Noring R, Steere AC, Klempner MS, Hu LT.

J Infect Dis. 2001 Jul 15;184(2):174-80. Epub 2001 Jun 25.PMID: 11424014 [PubMed - indexed for MEDLINE]Related articles

Host metalloproteinases in Lyme arthritis.

Hu LT, Eskildsen MA, Masgala C, Steere AC, Arner EC, Pratta MA, Grodzinsky AJ, Loening A, Perides G.

Arthritis Rheum. 2001 Jun;44(6):1401-10.PMID: 11407701 [PubMed - indexed for MEDLINE]Related articlesFree article