PubMed

omega-3 polyunsaturated fatty acids prevent pressure overload-induced ventricular dilation and decrease in mitochondrial enzymes despite no change in adiponectin.

O'Shea KM, Chess DJ, Khairallah RJ, Hecker PA, Lei B, Walsh K, Des Rosiers C, Stanley WC.

Lipids Health Dis. 2010 Sep 6;9(1):95. [Epub ahead of print]PMID: 20819225 [PubMed - as supplied by publisher]

Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition.

Khairallah RJ, Sparagna GC, Khanna N, O'Shea KM, Hecker PA, Kristian T, Fiskum G, Des Rosiers C, Polster BM, Stanley WC.

Biochim Biophys Acta. 2010 Aug;1797(8):1555-62. Epub 2010 May 21.PMID: 20471951 [PubMed - indexed for MEDLINE]Related citations

Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload.

O'Shea KM, Chess DJ, Khairallah RJ, Rastogi S, Hecker PA, Sabbah HN, Walsh K, Stanley WC.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1639-45. Epub 2010 Mar 26.PMID: 20348222 [PubMed - indexed for MEDLINE]Related citations

Myocardial fatty acid metabolism in health and disease.

Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC.

Physiol Rev. 2010 Jan;90(1):207-58. Review.PMID: 20086077 [PubMed - indexed for MEDLINE]Related citations

Dipropionylcysteine ethyl ester compensates for loss of citric acid cycle intermediates during post ischemia reperfusion in the pig heart.

Kasumov T, Sharma N, Huang H, Kombu RS, Cendrowski A, Stanley WC, Brunengraber H.

Cardiovasc Drugs Ther. 2009 Dec;23(6):459-69.PMID: 19967553 [PubMed - indexed for MEDLINE]Related citations

Does junk food lead to heart failure? Importance of dietary macronutrient composition in hypertension.

Stanley WC, Shah KB, Essop MF.

Hypertension. 2009 Dec;54(6):1209-10. Epub 2009 Oct 19. No abstract available. PMID: 19841293 [PubMed - indexed for MEDLINE]Related citations

A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload.

Chess DJ, Khairallah RJ, O'Shea KM, Xu W, Stanley WC.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1585-93. Epub 2009 Sep 18.PMID: 19767529 [PubMed - indexed for MEDLINE]Related citations

Dietary omega-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca2+-induced permeability transition.

O'Shea KM, Khairallah RJ, Sparagna GC, Xu W, Hecker PA, Robillard-Frayne I, Des Rosiers C, Kristian T, Murphy RC, Fiskum G, Stanley WC.

J Mol Cell Cardiol. 2009 Dec;47(6):819-27. Epub 2009 Aug 22.PMID: 19703463 [PubMed - indexed for MEDLINE]Related citations

The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: role of cardiac phospholipid remodeling.

Shah KB, Duda MK, O'Shea KM, Sparagna GC, Chess DJ, Khairallah RJ, Robillard-Frayne I, Xu W, Murphy RC, Des Rosiers C, Stanley WC.

Hypertension. 2009 Sep;54(3):605-11. Epub 2009 Jul 13.PMID: 19597033 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance.

Solomon TP, Haus JM, Marchetti CM, Stanley WC, Kirwan JP.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E552-9. Epub 2009 Jun 16.PMID: 19531640 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential.

Duda MK, O'Shea KM, Stanley WC.

Cardiovasc Res. 2009 Oct 1;84(1):33-41. Epub 2009 May 27. Review.PMID: 19474179 [PubMed - indexed for MEDLINE]Related citations

Chronic treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function.

Zungu M, Young ME, Stanley WC, Essop MF.

Mol Cell Biochem. 2009 Oct;330(1-2):55-62. Epub 2009 Apr 10.PMID: 19360380 [PubMed - indexed for MEDLINE]Related citations

Altered expression of the adenine nucleotide translocase isoforms and decreased ATP synthase activity in skeletal muscle mitochondria in heart failure.

Rosca MG, Okere IA, Sharma N, Stanley WC, Recchia FA, Hoppel CL.

J Mol Cell Cardiol. 2009 Jun;46(6):927-35. Epub 2009 Feb 20.PMID: 19233197 [PubMed - indexed for MEDLINE]Related citations

Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.

Duda MK, O'Shea KM, Tintinu A, Xu W, Khairallah RJ, Barrows BR, Chess DJ, Azimzadeh AM, Harris WS, Sharov VG, Sabbah HN, Stanley WC.

Cardiovasc Res. 2009 Feb 1;81(2):319-27. Epub 2008 Nov 17.PMID: 19015135 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet.

Chess DJ, Xu W, Khairallah R, O'Shea KM, Kop WJ, Azimzadeh AM, Stanley WC.

Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2223-30. Epub 2008 Oct 17.PMID: 18931030 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Reverse changes in cardiac substrate oxidation in dogs recovering from heart failure.

Qanud K, Mamdani M, Pepe M, Khairallah RJ, Gravel J, Lei B, Gupte SA, Sharov VG, Sabbah HN, Stanley WC, Recchia FA.

Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2098-105. Epub 2008 Sep 26.PMID: 18820029 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure.

Rastogi S, Sharov VG, Mishra S, Gupta RC, Blackburn B, Belardinelli L, Stanley WC, Sabbah HN.

Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2149-55. Epub 2008 Sep 26.PMID: 18820026 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia.

Zhou L, Huang H, McElfresh TA, Prosdocimo DA, Stanley WC.

Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H939-H945. Epub 2008 Jul 25.PMID: 18660443 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Transient activation of p38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK.

Lei B, Chess DJ, Keung W, O'Shea KM, Lopaschuk GD, Stanley WC.

J Mol Cell Cardiol. 2008 Sep;45(3):404-10. Epub 2008 Jul 1.PMID: 18639556 [PubMed - indexed for MEDLINE]Related citations

Expression of mitochondrial regulatory genes parallels respiratory capacity and contractile function in a rat model of hypoxia-induced right ventricular hypertrophy.

Zungu M, Young ME, Stanley WC, Essop MF.

Mol Cell Biochem. 2008 Nov;318(1-2):175-81. Epub 2008 Jul 5.PMID: 18604475 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia.

Lu M, Zhou L, Stanley WC, Cabrera ME, Saidel GM, Yu X.

J Theor Biol. 2008 Sep 21;254(2):466-75. Epub 2008 Jul 7.PMID: 18603266 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

High-sugar diets increase cardiac dysfunction and mortality in hypertension compared to low-carbohydrate or high-starch diets.

Sharma N, Okere IC, Barrows BR, Lei B, Duda MK, Yuan CL, Previs SF, Sharov VG, Azimzadeh AM, Ernsberger P, Hoit BD, Sabbah H, Stanley WC.

J Hypertens. 2008 Jul;26(7):1402-10.PMID: 18551017 [PubMed - indexed for MEDLINE]Related citations

Low-carbohydrate/high-fat diet attenuates pressure overload-induced ventricular remodeling and dysfunction.

Duda MK, O'Shea KM, Lei B, Barrows BR, Azimzadeh AM, McElfresh TE, Hoit BD, Kop WJ, Stanley WC.

J Card Fail. 2008 May;14(4):327-35.PMID: 18474346 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Preserved protein synthesis in the heart in response to acute fasting and chronic food restriction despite reductions in liver and skeletal muscle.

Yuan CL, Sharma N, Gilge DA, Stanley WC, Li Y, Hatzoglou M, Previs SF.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E216-22. Epub 2008 Apr 29.PMID: 18445754 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Metabolism under control.

Stanley WC.

Trends Endocrinol Metab. 1998 Jan-Feb;9(1):44.PMID: 18406236 [PubMed - in process]Related citations

Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids.

Lockridge JB, Sailors ML, Durgan DJ, Egbejimi O, Jeong WJ, Bray MS, Stanley WC, Young ME.

J Lipid Res. 2008 Jul;49(7):1395-408. Epub 2008 Apr 2.PMID: 18387886 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

The role of Ca2+ in coupling cardiac metabolism with regulation of contraction: in silico modeling.

Yaniv Y, Stanley WC, Saidel GM, Cabrera ME, Landesberg A.

Ann N Y Acad Sci. 2008 Mar;1123:69-78.PMID: 18375579 [PubMed - indexed for MEDLINE]Related citations

Myocardial Metabolism-Therapeutic Aspects.

Glatz JF, Stanley WC.

Cardiovasc Drugs Ther. 2008 Mar 28. [Epub ahead of print] No abstract available. PMID: 18369714 [PubMed - as supplied by publisher]Related citations

Role of diet and fuel overabundance in the development and progression of heart failure.

Chess DJ, Stanley WC.

Cardiovasc Res. 2008 Jul 15;79(2):269-78. Epub 2008 Mar 14. Review.PMID: 18343896 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Effects of a high saturated fat diet on cardiac hypertrophy and dysfunction in response to pressure overload.

Chess DJ, Lei B, Hoit BD, Azimzadeh AM, Stanley WC.

J Card Fail. 2008 Feb;14(1):82-8.PMID: 18226777 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.

Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, Stanley WC.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H954-60. Epub 2007 Dec 14.PMID: 18083904 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion.

Kung TA, Egbejimi O, Cui J, Ha NP, Durgan DJ, Essop MF, Bray MS, Shaw CA, Hardin PE, Stanley WC, Young ME.

J Mol Cell Cardiol. 2007 Dec;43(6):744-53. Epub 2007 Sep 5.PMID: 17959196 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy.

Neglia D, De Caterina A, Marraccini P, Natali A, Ciardetti M, Vecoli C, Gastaldelli A, Ciociaro D, Pellegrini P, Testa R, Menichetti L, L'Abbate A, Stanley WC, Recchia FA.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3270-8. Epub 2007 Oct 5.PMID: 17921325 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Fatty acid oxidation in cardiac and skeletal muscle mitochondria is unaffected by deletion of CD36.

King KL, Stanley WC, Rosca M, Kerner J, Hoppel CL, Febbraio M.

Arch Biochem Biophys. 2007 Nov 15;467(2):234-8. Epub 2007 Aug 29.PMID: 17904092 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Cardiac energy metabolism in obesity.

Lopaschuk GD, Folmes CD, Stanley WC.

Circ Res. 2007 Aug 17;101(4):335-47. Review.PMID: 17702980 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Dietary supplementation with omega-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload.

Duda MK, O'Shea KM, Lei B, Barrows BR, Azimzadeh AM, McElfresh TE, Hoit BD, Kop WJ, Stanley WC.

Cardiovasc Res. 2007 Nov 1;76(2):303-10. Epub 2007 Jul 23.PMID: 17643403 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload.

Chess DJ, Lei B, Hoit BD, Azimzadeh AM, Stanley WC.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1853-60. Epub 2007 Jul 6.PMID: 17616744 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure.

Imai M, Rastogi S, Gupta RC, Mishra S, Sharov VG, Stanley WC, Mika Y, Rousso B, Burkhoff D, Ben-Haim S, Sabbah HN.

J Am Coll Cardiol. 2007 May 29;49(21):2120-8. Epub 2007 May 17.PMID: 17531662 [PubMed - indexed for MEDLINE]Related citations

Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart.

King KL, Young ME, Kerner J, Huang H, O'Shea KM, Alexson SE, Hoppel CL, Stanley WC.

J Lipid Res. 2007 Jul;48(7):1511-7. Epub 2007 Apr 16.PMID: 17438340 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet.

Sharma N, Okere IC, Duda MK, Johnson J, Yuan CL, Chandler MP, Ernsberger P, Hoit BD, Stanley WC.

Am J Hypertens. 2007 Apr;20(4):403-9.PMID: 17386347 [PubMed - indexed for MEDLINE]Related citations

Assay of the activity of malonyl-coenzyme A decarboxylase by gas chromatography-mass spectrometry.

Wang X, Stanley WC, Darrow CJ, Brunengraber H, Kasumov T.

Anal Biochem. 2007 Apr 15;363(2):169-74. Epub 2007 Jan 13. Erratum in: Anal Biochem. 2008 Apr 1;375(1):162. Darrow, Cory J [added]. PMID: 17316539 [PubMed - indexed for MEDLINE]Related citations

Chronic activation of peroxisome proliferator-activated receptor-alpha with fenofibrate prevents alterations in cardiac metabolic phenotype without changing the onset of decompensation in pacing-induced heart failure.

Labinskyy V, Bellomo M, Chandler MP, Young ME, Lionetti V, Qanud K, Bigazzi F, Sampietro T, Stanley WC, Recchia FA.

J Pharmacol Exp Ther. 2007 Apr;321(1):165-71. Epub 2007 Jan 10.PMID: 17215446 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet.

Okere IC, Chandler MP, McElfresh TA, Rennison JH, Kung TA, Hoit BD, Ernsberger P, Young ME, Stanley WC.

Clin Exp Pharmacol Physiol. 2007 Jan-Feb;34(1-2):113-9.PMID: 17201745 [PubMed - indexed for MEDLINE]Related citations

Mouse strain-specific differences in cardiac metabolic enzyme activities observed in a model of isoproterenol-induced cardiac hypertrophy.

Faulx MD, Chandler MP, Zawaneh MS, Stanley WC, Hoit BD.

Clin Exp Pharmacol Physiol. 2007 Jan-Feb;34(1-2):77-80.PMID: 17201739 [PubMed - indexed for MEDLINE]Related citations

Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs.

Zhou L, Cabrera ME, Huang H, Yuan CL, Monika DK, Sharma N, Bian F, Stanley WC.

J Physiol. 2007 Mar 15;579(Pt 3):811-21. Epub 2006 Dec 21.PMID: 17185335 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy.

Sharma N, Okere IC, Duda MK, Chess DJ, O'Shea KM, Stanley WC.

Cardiovasc Res. 2007 Jan 15;73(2):257-68. Epub 2006 Nov 11. Review.PMID: 17166490 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Nutrition and cardiovascular disease: putting a pathogenic framework into focus.

Napoli C, Stanley WC, Ignarro LJ.

Cardiovasc Res. 2007 Jan 15;73(2):253-6. Epub 2006 Nov 29. No abstract available. PMID: 17161832 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Malonyl-CoA decarboxylase inhibition as a novel approach to treat ischemic heart disease.

Lopaschuk GD, Stanley WC.

Cardiovasc Drugs Ther. 2006 Dec;20(6):433-9. Review.PMID: 17136490 [PubMed - indexed for MEDLINE]Related citations

Role of cellular compartmentation in the metabolic response to stress: mechanistic insights from computational models.

Zhou L, Yu X, Cabrera ME, Stanley WC.

Ann N Y Acad Sci. 2006 Oct;1080:120-39. Review.PMID: 17132780 [PubMed - indexed for MEDLINE]Related citations

CVT-4325 inhibits myocardial fatty acid uptake and improves left ventricular systolic function without increasing myocardial oxygen consumption in dogs with chronic heart failure.

Imai M, Rastogi S, Sharma N, Chandler MP, Sharov VG, Blackburn B, Belardinelli L, Stanley WC, Sabbah HN.

Cardiovasc Drugs Ther. 2007 Feb;21(1):9-15.PMID: 17119875 [PubMed - indexed for MEDLINE]Related citations