PubMed

Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance.

Sajan MP, Standaert ML, Rivas J, Miura A, Kanoh Y, Soto J, Taniguchi CM, Kahn CR, Farese RV.

Diabetologia. 2009 Jun;52(6):1197-207. Epub 2009 Apr 9.PMID: 19357831 [PubMed - indexed for MEDLINE]Related articles

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.

Sajan MP, Standaert ML, Nimal S, Varanasi U, Pastoor T, Mastorides S, Braun U, Leitges M, Farese RV.

J Lipid Res. 2009 Jun;50(6):1133-45. Epub 2009 Feb 6.PMID: 19202134 [PubMed - indexed for MEDLINE]Related articles

Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle.

Temofonte N, Sajan MP, Nimal S, Pastoor T, Fumero C, Casaubon L, Powe JL, Standaert ML, Farese RV.

Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30.PMID: 18972094 [PubMed - indexed for MEDLINE]Related articles

Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome.

Beeson M, Sajan MP, Daspet JG, Luna V, Dizon M, Grebenev D, Powe JL, Lucidi S, Miura A, Kanoh Y, Bandyopadhyay G, Standaert ML, Yeko TR, Farese RV.

Metab Syndr Relat Disord. 2004 Spring;2(1):49-56.PMID: 18370676 [PubMed - in process]Related articles

Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans.

Casaubon L, Sajan MP, Rivas J, Powe JL, Standaert ML, Farese RV.

Diabetologia. 2006 Dec;49(12):3000-8. Epub 2006 Oct 7.PMID: 17028898 [PubMed - indexed for MEDLINE]Related articles

Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport.

Sajan MP, Rivas J, Li P, Standaert ML, Farese RV.

J Biol Chem. 2006 Jun 23;281(25):17466-73. Epub 2006 Apr 27.PMID: 16644736 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.

Luna V, Casauban L, Sajan MP, Gomez-Daspet J, Powe JL, Miura A, Rivas J, Standaert ML, Farese RV.

Diabetologia. 2006 Feb;49(2):375-82. Epub 2006 Jan 5.PMID: 16395615 [PubMed - indexed for MEDLINE]Related articles

Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes.

Farese RV, Sajan MP, Standaert ML.

Exp Biol Med (Maywood). 2005 Oct;230(9):593-605. Review.PMID: 16179727 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical protein kinase C in insulin action and insulin resistance.

Farese RV, Sajan MP, Standaert ML.

Biochem Soc Trans. 2005 Apr;33(Pt 2):350-3. Review.PMID: 15787604 [PubMed - indexed for MEDLINE]Related articles

Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes.

Miura A, Sajan MP, Standaert ML, Bandyopadhyay G, Kahn CR, Farese RV.

Biochemistry. 2004 Dec 14;43(49):15503-9.PMID: 15581362 [PubMed - indexed for MEDLINE]Related articles

Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes.

Standaert ML, Sajan MP, Miura A, Bandyopadhyay G, Farese RV.

Biochemistry. 2004 Dec 14;43(49):15494-502.PMID: 15581361 [PubMed - indexed for MEDLINE]Related articles

Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects.

Sajan MP, Standaert ML, Miura A, Bandyopadhyay G, Vollenweider P, Franklin DM, Lea-Currie R, Farese RV.

J Clin Endocrinol Metab. 2004 Aug;89(8):3994-8.PMID: 15292339 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice.

Sajan MP, Standaert ML, Miura A, Kahn CR, Farese RV.

Mol Endocrinol. 2004 Oct;18(10):2513-21. Epub 2004 Jul 15.PMID: 15256535 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states.

Standaert ML, Sajan MP, Miura A, Kanoh Y, Chen HC, Farese RV Jr, Farese RV.

J Biol Chem. 2004 Jun 11;279(24):24929-34. Epub 2004 Apr 6.PMID: 15069067 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased atypical PKC activity in endurance-trained human skeletal muscle.

Nielsen JN, Frøsig C, Sajan MP, Miura A, Standaert ML, Graham DA, Wojtaszewski JF, Farese RV, Richter EA.

Biochem Biophys Res Commun. 2003 Dec 26;312(4):1147-53.PMID: 14651992 [PubMed - indexed for MEDLINE]Related articles

Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes.

Miura A, Sajan MP, Standaert ML, Bandyopadhyay G, Franklin DM, Lea-Currie R, Farese RV.

Biochemistry. 2003 Dec 9;42(48):14335-41.PMID: 14640702 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C-lambda knockout in embryonic stem cells and adipocytes impairs insulin-stimulated glucose transport.

Bandyopadhyay G, Standaert ML, Sajan MP, Kanoh Y, Miura A, Braun U, Kruse F, Leitges M, Farese RV.

Mol Endocrinol. 2004 Feb;18(2):373-83. Epub 2003 Nov 13.PMID: 14615604 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.

Beeson M, Sajan MP, Dizon M, Grebenev D, Gomez-Daspet J, Miura A, Kanoh Y, Powe J, Bandyopadhyay G, Standaert ML, Farese RV.

Diabetes. 2003 Aug;52(8):1926-34.PMID: 12882907 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes.

Kanoh Y, Sajan MP, Bandyopadhyay G, Miura A, Standaert ML, Farese RV.

Endocrinology. 2003 Mar;144(3):947-54.PMID: 12586772 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota.

Standaert ML, Ortmeyer HK, Sajan MP, Kanoh Y, Bandyopadhyay G, Hansen BC, Farese RV.

Diabetes. 2002 Oct;51(10):2936-43.PMID: 12351430 [PubMed - indexed for MEDLINE]Related articlesFree article

Cbl, IRS-1, and IRS-2 mediate effects of rosiglitazone on PI3K, PKC-lambda, and glucose transport in 3T3/L1 adipocytes.

Standaert ML, Kanoh Y, Sajan MP, Bandyopadhyay G, Farese RV.

Endocrinology. 2002 May;143(5):1705-16.PMID: 11956152 [PubMed - indexed for MEDLINE]Related articlesFree article

Knockout of PKC alpha enhances insulin signaling through PI3K.

Leitges M, Plomann M, Standaert ML, Bandyopadhyay G, Sajan MP, Kanoh Y, Farese RV.

Mol Endocrinol. 2002 Apr;16(4):847-58. Erratum in: Mol Endocrinol 2002 Jun;16(60:1203. Letiges, Michael [corrected to Leitges, Michael]. PMID: 11923480 [PubMed - indexed for MEDLINE]Related articlesFree article

Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.

Sajan MP, Bandyopadhyay G, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV.

Biochem J. 2002 Mar 15;362(Pt 3):665-74.PMID: 11879194 [PubMed - indexed for MEDLINE]Related articlesFree article

PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes.

Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Lea-Currie R, Sen A, Farese RV.

J Clin Endocrinol Metab. 2002 Feb;87(2):716-23.PMID: 11836310 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.

Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV.

J Biol Chem. 2001 Sep 21;276(38):35537-45. Epub 2001 Jul 19.PMID: 11463795 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-zeta/lambda by insulin in vastus lateralis muscles and adipocytes of diabetic rats.

Kanoh Y, Bandyopadhyay G, Sajan MP, Standaert ML, Farese RV.

Endocrinology. 2001 Apr;142(4):1595-605.PMID: 11250941 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites.

Standaert ML, Bandyopadhyay G, Kanoh Y, Sajan MP, Farese RV.

Biochemistry. 2001 Jan 9;40(1):249-55.PMID: 11141077 [PubMed - indexed for MEDLINE]Related articles

Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes.

Bandyopadhyay G, Kanoh Y, Sajan MP, Standaert ML, Farese RV.

Endocrinology. 2000 Nov;141(11):4120-7.PMID: 11089544 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter.

Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Burke TR Jr, Quon MJ, Reed BC, Dikic I, Noel LE, Newgard CB, Farese R.

J Biol Chem. 2000 Dec 29;275(52):40817-26.PMID: 11007796 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinedione treatment enhances insulin effects on protein kinase C-zeta /lambda activation and glucose transport in adipocytes of nondiabetic and Goto-Kakizaki type II diabetic rats.

Kanoh Y, Bandyopadhyay G, Sajan MP, Standaert ML, Farese RV.

J Biol Chem. 2000 Jun 2;275(22):16690-6.PMID: 10749857 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes.

Sajan MP, Standaert ML, Bandyopadhyay G, Quon MJ, Burke TR Jr, Farese RV.

J Biol Chem. 1999 Oct 22;274(43):30495-500.PMID: 10521430 [PubMed - indexed for MEDLINE]Related articlesFree article

Dependence of insulin-stimulated glucose transporter 4 translocation on 3-phosphoinositide-dependent protein kinase-1 and its target threonine-410 in the activation loop of protein kinase C-zeta.

Bandyopadhyay G, Standaert ML, Sajan MP, Karnitz LM, Cong L, Quon MJ, Farese RV.

Mol Endocrinol. 1999 Oct;13(10):1766-72.PMID: 10517677 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis.

Standaert ML, Bandyopadhyay G, Galloway L, Soto J, Ono Y, Kikkawa U, Farese RV, Leitges M.

Endocrinology. 1999 Oct;140(10):4470-7.PMID: 10499500 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes.

Standaert ML, Bandyopadhyay G, Perez L, Price D, Galloway L, Poklepovic A, Sajan MP, Cenni V, Sirri A, Moscat J, Toker A, Farese RV.

J Biol Chem. 1999 Sep 3;274(36):25308-16.PMID: 10464256 [PubMed - indexed for MEDLINE]Related articlesFree article

Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport.

Standaert ML, Bandyopadhyay G, Sajan MP, Cong L, Quon MJ, Farese RV.

J Biol Chem. 1999 May 14;274(20):14074-8.PMID: 10318822 [PubMed - indexed for MEDLINE]Related articlesFree article

RO 31-8220 activates c-Jun N-terminal kinase and glycogen synthase in rat adipocytes and L6 myotubes. Comparison to actions of insulin.

Standaert ML, Bandyopadhyay G, Antwi EK, Farese RV.

Endocrinology. 1999 May;140(5):2145-51.PMID: 10218965 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of transiently expressed atypical (zeta, lambda), conventional (alpha, beta) and novel (delta, epsilon) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-zeta and C-lambda.

Bandyopadhyay G, Standaert ML, Kikkawa U, Ono Y, Moscat J, Farese RV.

Biochem J. 1999 Feb 1;337 ( Pt 3):461-70.PMID: 9895289 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport.

Standaert ML, Galloway L, Karnam P, Bandyopadhyay G, Moscat J, Farese RV.

J Biol Chem. 1997 Nov 28;272(48):30075-82.PMID: 9374484 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes.

Bandyopadhyay G, Standaert ML, Galloway L, Moscat J, Farese RV.

Endocrinology. 1997 Nov;138(11):4721-31.PMID: 9348199 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes. Apparent involvement of phosphatidylinositol 3-kinase.

Karnam P, Standaert ML, Galloway L, Farese RV.

J Biol Chem. 1997 Mar 7;272(10):6136-40.PMID: 9045624 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport.

Bandyopadhyay G, Standaert ML, Zhao L, Yu B, Avignon A, Galloway L, Karnam P, Moscat J, Farese RV.

J Biol Chem. 1997 Jan 24;272(4):2551-8.PMID: 8999972 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis.

Avignon A, Yamada K, Zhou X, Spencer B, Cardona O, Saba-Siddique S, Galloway L, Standaert ML, Farese RV.

Diabetes. 1996 Oct;45(10):1396-404.PMID: 8826977 [PubMed - indexed for MEDLINE]Related articles

Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes.

Standaert ML, Bandyopadhyay G, Zhou X, Galloway L, Farese RV.

Endocrinology. 1996 Jul;137(7):3014-20.PMID: 8770926 [PubMed - indexed for MEDLINE]Related articles

Effects of phorbol esters on insulin-induced activation of phosphatidylinositol 3-kinase, glucose transport, and glycogen synthase in rat adipocytes.

Standaert ML, Bandyopadhyay G, Galloway L, Farese RV.

FEBS Lett. 1996 Jun 10;388(1):26-8.PMID: 8654582 [PubMed - indexed for MEDLINE]Related articles

Insulin translocates PKC-epsilon and phorbol esters induce and persistently translocate PKC-beta 2 in BC3H-1 myocytes.

Standaert ML, Avignon A, Arnold T, Saba-Siddique SI, Copper DR, Watson J, Zhou X, Galloway L, Farese RV.

Cell Signal. 1996 Jun;8(4):313-6.PMID: 8842533 [PubMed - indexed for MEDLINE]Related articles

The phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C translocation in rat adipocytes.

Standaert ML, Avignon A, Yamada K, Bandyopadhyay G, Farese RV.

Biochem J. 1996 Feb 1;313 ( Pt 3):1039-46.PMID: 8611143 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle.

Avignon A, Standaert ML, Yamada K, Mischak H, Spencer B, Farese RV.

Biochem J. 1995 May 15;308 ( Pt 1):181-7.PMID: 7755564 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of insulin on the translocation of protein kinase C-theta and other protein kinase C isoforms in rat skeletal muscles.

Yamada K, Avignon A, Standaert ML, Cooper DR, Spencer B, Farese RV.

Biochem J. 1995 May 15;308 ( Pt 1):177-80.PMID: 7755563 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies with wortmannin suggest a role for phosphatidylinositol 3-kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat adipocytes: comparison of insulin and protein kinase C modulators.

Standaert ML, Bandyopadhyay G, Farese RV.

Biochem Biophys Res Commun. 1995 Apr 26;209(3):1082-8.PMID: 7733962 [PubMed - indexed for MEDLINE]Related articles

Effects of insulin on protein kinase-C (PKC) in HIRC-B cells: specific activation of PKC epsilon and its resistance to phorbol ester-induced down-regulation.

Zhao L, Standaert ML, Cooper DR, Avignon A, Farese RV.

Endocrinology. 1994 Dec;135(6):2504-10.PMID: 7988438 [PubMed - indexed for MEDLINE]Related articles