PubMed

Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study.

Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, Stefan N, Fritsche A, Häring HU, Staiger H.

Obesity (Silver Spring). 2009 Nov 12. [Epub ahead of print]PMID: 19910938 [PubMed - as supplied by publisher]Related articles

Circulating Palmitoleate strongly and independently predicts Insulin Sensitivity in Humans.

Stefan N, Kantartzis K, Celebi N, Staiger H, Machann J, Schick F, Cegan A, Elcnerova M, Schleicher E, Fritsche A, Häring HU.

Diabetes Care. 2009 Nov 4. [Epub ahead of print]PMID: 19889804 [PubMed - as supplied by publisher]Related articles

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study.

Boesgaard TW, Gjesing AP, Grarup N, Rutanen J, Jansson PA, Hribal ML, Sesti G, Fritsche A, Stefan N, Staiger H, Häring H, Smith U, Laakso M, Pedersen O, Hansen T; EUGENE2 Consortium.

PLoS One. 2009 Sep 30;4(9):e7236.PMID: 19789630 [PubMed - in process]Related articlesFree article

Pathomechanisms of type 2 diabetes genes.

Staiger H, Machicao F, Fritsche A, Häring HU.

Endocr Rev. 2009 Oct;30(6):557-85. Epub 2009 Sep 11.PMID: 19749172 [PubMed - in process]Related articles

Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus.

Müssig K, Staiger H, Machicao F, Machann J, Schick F, Schäfer SA, Claussen CD, Holst JJ, Gallwitz B, Stefan N, Fritsche A, Häring HU.

Metabolism. 2009 Dec;58(12):1809-11. Epub 2009 Aug 28.PMID: 19716570 [PubMed - in process]Related articles

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.

Weyrich P, Staiger H, Stancáková A, Schäfer SA, Kirchhoff K, Ullrich S, Ranta F, Gallwitz B, Stefan N, Machicao F, Kuusisto J, Laakso M, Fritsche A, Häring HU.

BMC Med Genet. 2009 Aug 14;10:77.PMID: 19682370 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss.

Haupt A, Thamer C, Heni M, Tschritter O, Machann J, Schick F, Machicao F, Häring HU, Staiger H, Fritsche A.

Obesity (Silver Spring). 2009 Oct;17(10):1942-5. Epub 2009 Jul 30.PMID: 19629057 [PubMed - in process]Related articles

Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo.

Peter A, Weigert C, Staiger H, Machicao F, Schick F, Machann J, Stefan N, Thamer C, Häring HU, Schleicher E.

Diabetes. 2009 Aug;58(8):1757-65. Epub 2009 May 28.PMID: 19478146 [PubMed - indexed for MEDLINE]Related articlesFree article

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain.

Hennige AM, Heni M, Machann J, Staiger H, Sartorius T, Hoene M, Lehmann R, Weigert C, Peter A, Bornemann A, Kroeber S, Pujol A, Franckhauser S, Bosch F, Schick F, Lammers R, Håring HU.

J Cell Mol Med. 2008 Dec 24. [Epub ahead of print]PMID: 19413892 [PubMed - as supplied by publisher]Related articles

Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion.

Müssig K, Staiger H, Machicao F, Kirchhoff K, Guthoff M, Schäfer SA, Kantartzis K, Silbernagel G, Stefan N, Holst JJ, Gallwitz B, Häring HU, Fritsche A.

Diabetes. 2009 Jul;58(7):1715-20. Epub 2009 Apr 14.PMID: 19366866 [PubMed - indexed for MEDLINE]Related articlesFree article

AHSG gene variation is not associated with regional body fat distribution--a magnetic resonance study.

Müssig K, Staiger H, Machicao F, Machann J, Hennige AM, Schick F, Claussen CD, Fritsche A, Häring HU, Stefan N.

Exp Clin Endocrinol Diabetes. 2009 Sep;117(8):432-7. Epub 2009 Apr 8.PMID: 19358088 [PubMed - in process]Related articles

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion.

Schäfer SA, Müssig K, Staiger H, Machicao F, Stefan N, Gallwitz B, Häring HU, Fritsche A.

Diabetologia. 2009 Jun;52(6):1075-82. Epub 2009 Mar 28.PMID: 19330314 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells.

Staiger K, Schatz U, Staiger H, Weyrich P, Haas C, Guirguis A, Machicao F, Häring HU, Kellerer M.

Microvasc Res. 2009 Jun;78(1):40-4. Epub 2009 Mar 25.PMID: 19327373 [PubMed - indexed for MEDLINE]Related articles

RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study.

Müssig K, Staiger H, Machicao F, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring HU.

Metabolism. 2009 Apr;58(4):519-24.PMID: 19303973 [PubMed - indexed for MEDLINE]Related articles

The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity.

Haupt A, Guthoff M, Schäfer SA, Kirchhoff K, Machicao F, Gallwitz B, Staiger H, Stefan N, Fritsche A, Häring HU.

J Clin Endocrinol Metab. 2009 May;94(5):1775-80. Epub 2009 Mar 3.PMID: 19258404 [PubMed - indexed for MEDLINE]Related articles

The risk allele load accelerates the age-dependent decline in beta cell function.

Haupt A, Staiger H, Schäfer SA, Kirchhoff K, Guthoff M, Machicao F, Gallwitz B, Stefan N, Häring HU, Fritsche A.

Diabetologia. 2009 Mar;52(3):457-62. Epub 2009 Jan 27.PMID: 19172244 [PubMed - indexed for MEDLINE]Related articles

Adiponectin oligomers and ectopic fat in liver and skeletal muscle in humans.

Kantartzis K, Staiger H, Machann J, Schick F, Claussen CD, Machicao F, Fritsche A, Häring HU, Stefan N.

Obesity (Silver Spring). 2009 Feb;17(2):390-2. Epub 2008 Oct 30.PMID: 19169222 [PubMed - indexed for MEDLINE]Related articles

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes.

Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring HU.

J Clin Endocrinol Metab. 2009 Apr;94(4):1353-60. Epub 2009 Jan 13.PMID: 19141580 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.

Staiger H, Machicao F, Schäfer SA, Kirchhoff K, Kantartzis K, Guthoff M, Silbernagel G, Stefan N, Häring HU, Fritsche A.

PLoS One. 2008;3(12):e3962. Epub 2008 Dec 17.PMID: 19088850 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans.

Staiger H, Haas C, Machann J, Werner R, Weisser M, Schick F, Machicao F, Stefan N, Fritsche A, Häring HU.

Diabetes. 2009 Mar;58(3):579-89. Epub 2008 Dec 15.PMID: 19074989 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective association of plasma non-esterified fatty acid species with circulating interleukin-8 concentrations in humans.

Staiger H, Wöll J, Haas C, Machicao F, Schleicher ED, Fritsche A, Stefan N, Häring HU.

Exp Clin Endocrinol Diabetes. 2009 Jan;117(1):21-7. Epub 2008 Dec 3.PMID: 19053024 [PubMed - indexed for MEDLINE]Related articles

Variation in the FTO gene influences food intake but not energy expenditure.

Haupt A, Thamer C, Staiger H, Tschritter O, Kirchhoff K, Machicao F, Häring HU, Stefan N, Fritsche A.

Exp Clin Endocrinol Diabetes. 2009 Apr;117(4):194-7. Epub 2008 Dec 3.PMID: 19053021 [PubMed - indexed for MEDLINE]Related articles

Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes.

Staiger H, Machicao F, Kantartzis K, Schäfer SA, Kirchhoff K, Guthoff M, Silbernagel G, Stefan N, Fritsche A, Häring HU.

PLoS One. 2008 Aug 20;3(8):e3019.PMID: 18714373 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of insulin detemir, compared to human insulin, on 3T3-L1 adipogenesis.

Böhm A, Staiger H, Hennige AM, Haas C, Machicao F, Häring HU.

Regul Pept. 2008 Nov 29;151(1-3):160-3. Epub 2008 May 24.PMID: 18571747 [PubMed - indexed for MEDLINE]Related articles

Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity.

Peter A, Weigert C, Staiger H, Rittig K, Cegan A, Lutz P, Machicao F, Häring HU, Schleicher E.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E339-49. Epub 2008 Jun 3.PMID: 18523127 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variation within the ANGPTL4 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus.

Staiger H, Machicao F, Werner R, Guirguis A, Weisser M, Stefan N, Fritsche A, Häring HU.

Metabolism. 2008 May;57(5):637-43.PMID: 18442626 [PubMed - indexed for MEDLINE]Related articles

Fetuin-A induces cytokine expression and suppresses adiponectin production.

Hennige AM, Staiger H, Wicke C, Machicao F, Fritsche A, Häring HU, Stefan N.

PLoS One. 2008 Mar 12;3(3):e1765.PMID: 18335040 [PubMed - indexed for MEDLINE]Related articlesFree article

Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans.

Stefan N, Peter A, Cegan A, Staiger H, Machann J, Schick F, Claussen CD, Fritsche A, Häring HU, Schleicher E.

Diabetologia. 2008 Apr;51(4):648-56. Epub 2008 Feb 20.PMID: 18286258 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

Kirchhoff K, Machicao F, Haupt A, Schäfer SA, Tschritter O, Staiger H, Stefan N, Häring HU, Fritsche A.

Diabetologia. 2008 Apr;51(4):597-601. Epub 2008 Feb 9.PMID: 18264689 [PubMed - indexed for MEDLINE]Related articles

Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study.

Thamer C, Machann J, Stefan N, Schäfer SA, Machicao F, Staiger H, Laakso M, Böttcher M, Claussen C, Schick F, Fritsche A, Haring HU.

J Clin Endocrinol Metab. 2008 Apr;93(4):1497-500. Epub 2008 Feb 5.PMID: 18252792 [PubMed - indexed for MEDLINE]Related articlesFree article

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.

Staiger H, Stancáková A, Zilinskaite J, Vänttinen M, Hansen T, Marini MA, Hammarstedt A, Jansson PA, Sesti G, Smith U, Pedersen O, Laakso M, Stefan N, Fritsche A, Häring HU.

Diabetes. 2008 Feb;57(2):514-7. Epub 2007 Nov 26.PMID: 18039816 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and nonobese subjects: response to Broch et al.

Stefan N, Hennige AM, Staiger H, Schleicher E, Fritsche A, Häring HU.

Diabetes Care. 2007 Aug;30(8):e91; author reply e92. No abstract available. PMID: 17855276 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function.

Staiger H, Machicao F, Stefan N, Tschritter O, Thamer C, Kantartzis K, Schäfer SA, Kirchhoff K, Fritsche A, Häring HU.

PLoS One. 2007 Sep 5;2(9):e832.PMID: 17786204 [PubMed - in process]Related articlesFree article

Role of AMP-activated protein kinase gamma 3 genetic variability in glucose and lipid metabolism in non-diabetic whites.

Weyrich P, Machicao F, Staiger H, Simon P, Thamer C, Machann J, Schick F, Guirguis A, Fritsche A, Stefan N, Häring HU.

Diabetologia. 2007 Oct;50(10):2097-106. Epub 2007 Aug 14.PMID: 17701023 [PubMed - indexed for MEDLINE]Related articles

Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy White population.

Staiger H, Machicao F, Machann J, Schick F, Kuulasmaa T, Laakso M, Fritsche A, Stefan N, Häring HU.

Diabet Med. 2007 Aug;24(8):817-22. Epub 2007 May 8.PMID: 17490420 [PubMed - indexed for MEDLINE]Related articles

Hypomagnesemia and nephrocalcinosis in a patient with two heterozygous mutations in the CLDN16 gene.

Staiger K, Staiger H, Haas C, Thamer C, Risler T, Machicao F, Häring HU.

J Nephrol. 2007 Jan-Feb;20(1):107-10.PMID: 17347984 [PubMed - indexed for MEDLINE]Related articles

Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention.

Stefan N, Thamer C, Staiger H, Machicao F, Machann J, Schick F, Venter C, Niess A, Laakso M, Fritsche A, Häring HU.

J Clin Endocrinol Metab. 2007 May;92(5):1827-33. Epub 2007 Feb 27.PMID: 17327385 [PubMed - indexed for MEDLINE]Related articlesFree article

High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans.

Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Schleicher E, Fritsche A, Häring HU.

Diabetes Care. 2007 May;30(5):1173-8. Epub 2007 Jan 26.PMID: 17259477 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of the mitogenic potency of regular human insulin and its analogue glargine in normal and transformed human breast epithelial cells.

Staiger K, Hennige AM, Staiger H, Häring HU, Kellerer M.

Horm Metab Res. 2007 Jan;39(1):65-7. No abstract available. PMID: 17226117 [PubMed - indexed for MEDLINE]Related articles

Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation.

Staiger K, Staiger H, Weigert C, Haas C, Häring HU, Kellerer M.

Diabetes. 2006 Nov;55(11):3121-6.PMID: 17065351 [PubMed - indexed for MEDLINE]Related articlesFree article

The PPAR gamma agonist troglitazone induces musclin mRNA expression in human myotubes.

Staiger H, Haas C, Machicao F, Häring HU.

Horm Metab Res. 2006 Sep;38(9):614-6. No abstract available. PMID: 16981146 [PubMed - indexed for MEDLINE]Related articles

Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans.

Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Kröber SM, Machicao F, Fritsche A, Häring HU.

Diabetes Care. 2006 Apr;29(4):853-7.PMID: 16567827 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARGC1A mRNA levels of in vitro differentiated human skeletal muscle cells are negatively associated with the plasma oleate concentrations of the donors.

Staiger H, Stefan N, Machicao F, Fritsche A, Häring HU.

Diabetologia. 2006 Jan;49(1):212-4. Epub 2005 Dec 10. No abstract available. PMID: 16341842 [PubMed - indexed for MEDLINE]Related articles

A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance.

Tschritter O, Machicao F, Stefan N, Schäfer S, Weigert C, Staiger H, Spieth C, Häring HU, Fritsche A.

J Clin Endocrinol Metab. 2006 Feb;91(2):654-8. Epub 2005 Nov 29.PMID: 16317062 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat.

Stefan N, Machicao F, Staiger H, Machann J, Schick F, Tschritter O, Spieth C, Weigert C, Fritsche A, Stumvoll M, Häring HU.

Diabetologia. 2005 Nov;48(11):2282-91. Epub 2005 Oct 5.PMID: 16205883 [PubMed - indexed for MEDLINE]Related articles

Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis.

Staiger K, Stefan N, Staiger H, Brendel MD, Brandhorst D, Bretzel RG, Machicao F, Kellerer M, Stumvoll M, Fritsche A, Häring HU.

J Clin Endocrinol Metab. 2005 Dec;90(12):6707-13. Epub 2005 Oct 4.PMID: 16204361 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro.

Staiger H, Staiger K, Haas C, Weisser M, Machicao F, Häring HU.

Diabetologia. 2005 Oct;48(10):2115-8. Epub 2005 Aug 17.PMID: 16132959 [PubMed - indexed for MEDLINE]Related articles

Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes.

Müssig K, Fiedler H, Staiger H, Weigert C, Lehmann R, Schleicher ED, Häring HU.

Biochem Biophys Res Commun. 2005 Sep 30;335(3):819-25.PMID: 16099431 [PubMed - indexed for MEDLINE]Related articles

Insulin and its analogue glargine do not affect viability and proliferation of human coronary artery endothelial and smooth muscle cells.

Staiger K, Staiger H, Schweitzer MA, Metzinger E, Balletshofer B, Häring HU, Kellerer M.

Diabetologia. 2005 Sep;48(9):1898-905. Epub 2005 Aug 3.PMID: 16078017 [PubMed - indexed for MEDLINE]Related articles

Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.

Müssig K, Staiger H, Fiedler H, Moeschel K, Beck A, Kellerer M, Häring HU.

J Biol Chem. 2005 Sep 23;280(38):32693-9. Epub 2005 Jul 29.PMID: 16055440 [PubMed - indexed for MEDLINE]Related articlesFree article