PubMed

LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.

Touvier T, Conte-Auriol F, Briand O, Cudejko C, Paumelle R, Caron S, Baugé E, Rouillé Y, Salles JP, Staels B, Bailleul B.

J Clin Invest. 2009 Nov 9. pii: 34997. doi: 10.1172/JCI34997. [Epub ahead of print]PMID: 19907080 [PubMed - as supplied by publisher]Related articlesFree article

Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration.

Staels B, Fonseca VA.

Diabetes Care. 2009 Nov;32 Suppl 2:S237-45. No abstract available. PMID: 19875558 [PubMed - in process]Related articles

Combination therapy of statins and fibrates in the management of cardiovascular risk.

Fiévet C, Staels B.

Curr Opin Lipidol. 2009 Oct 13. [Epub ahead of print]PMID: 19829109 [PubMed - as supplied by publisher]Related articles

Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis and elongation in mice.

Oosterveer MH, Grefhorst A, van Dijk TH, Havinga R, Staels B, Kuipers F, Groen AK, Reijngoud DJ.

J Biol Chem. 2009 Oct 2. [Epub ahead of print]PMID: 19801551 [PubMed - as supplied by publisher]Related articlesFree article

Rev-erb{alpha}: an integrator of Circadian Rhythms and Metabolism.

Duez H, Staels B.

J Appl Physiol. 2009 Aug 20. [Epub ahead of print]PMID: 19696364 [PubMed - as supplied by publisher]Related articles

Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPARalpha.

Bougarne N, Paumelle R, Haegeman G, Staels B, De Bosscher K.

Cell Cycle. 2009 Aug;8(15):2311-2. Epub 2009 Aug 15. No abstract available. PMID: 19625768 [PubMed - indexed for MEDLINE]Related articles

Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver.

Lalloyer F, Pedersen TA, Gross B, Lestavel S, Yous S, Vallez E, Gustafsson JA, Mandrup S, Fiévet C, Staels B, Tailleux A.

Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1488-95. Epub 2009 Jul 10.PMID: 19592467 [PubMed - indexed for MEDLINE]Related articles

A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation.

Røst TH, Haugan Moi LL, Berge K, Staels B, Mellgren G, Berge RK.

Biochim Biophys Acta. 2009 Nov;1791(11):1076-83. Epub 2009 Jul 3.PMID: 19577662 [PubMed - indexed for MEDLINE]Related articles

Is the current therapeutic armamentarium in diabetes enough to control the epidemic and its consequences? What are the current shortcomings?

Giugliano D, Standl E, Vilsbøll T, Betteridge J, Bonadonna R, Campbell IW, Schernthaner GH, Staels B, Trichopoulou A, Farinaro E.

Acta Diabetol. 2009 Sep;46(3):173-81. Epub 2009 Jun 20. Review.PMID: 19543848 [PubMed - indexed for MEDLINE]Related articles

Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.

Mysiorek C, Culot M, Dehouck L, Derudas B, Staels B, Bordet R, Cecchelli R, Fenart L, Berezowski V.

Curr Neurovasc Res. 2009 Aug;6(3):181-93. Epub 2009 Aug 1.PMID: 19534718 [PubMed - in process]Related articles

Unlike PPARgamma, PPARalpha or PPARbeta/delta activation does not promote human monocyte differentiation toward alternative macrophages.

Bouhlel MA, Brozek J, Derudas B, Zawadzki C, Jude B, Staels B, Chinetti-Gbaguidi G.

Biochem Biophys Res Commun. 2009 Aug 28;386(3):459-62. Epub 2009 Jun 13.PMID: 19527689 [PubMed - indexed for MEDLINE]Related articles

A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus.

Staels B.

Postgrad Med. 2009 May;121(3 Suppl 1):25-30. Review.PMID: 19494475 [PubMed - indexed for MEDLINE]Related articles

Characterization of new PPARgamma agonists: benzimidazole derivatives - the importance of position 2.

Goebel M, Staels B, Unger T, Kintscher U, Gust R.

ChemMedChem. 2009 Jul;4(7):1136-42.PMID: 19504532 [PubMed - indexed for MEDLINE]Related articles

Efficacy of peroxisome proliferator-activated receptor agonists in diabetes and coronary artery disease.

Fiévet C, Staels B.

Curr Atheroscler Rep. 2009 Jul;11(4):281-8. Review.PMID: 19500491 [PubMed - indexed for MEDLINE]Related articles

Inhibition of adipocyte differentiation by RORalpha.

Duez H, Duhem C, Laitinen S, Patole PS, Abdelkarim M, Bois-Joyeux B, Danan JL, Staels B.

FEBS Lett. 2009 Jun 18;583(12):2031-6. Epub 2009 May 18.PMID: 19450581 [PubMed - indexed for MEDLINE]Related articles

Morphologic and electroretinographic phenotype of SR-BI knockout mice after a long-term atherogenic diet.

Provost AC, Vede L, Bigot K, Keller N, Tailleux A, Jaïs JP, Savoldelli M, Ameqrane I, Lacassagne E, Legeais JM, Staels B, Menasche M, Mallat Z, Behar-Cohen F, Abitbol M.

Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3931-42. Epub 2009 May 6.PMID: 19420333 [PubMed - indexed for MEDLINE]Related articles

Lipid ligand-activated transcription factors regulating lipid storage and release in human macrophages.

Chinetti-Gbaguidi G, Staels B.

Biochim Biophys Acta. 2009 Jun;1791(6):486-93. Epub 2009 Jan 27. Review.PMID: 19416654 [PubMed - indexed for MEDLINE]Related articles

PPARalpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappaB.

Bougarne N, Paumelle R, Caron S, Hennuyer N, Mansouri R, Gervois P, Staels B, Haegeman G, De Bosscher K.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7397-402. Epub 2009 Apr 17.PMID: 19376972 [PubMed - indexed for MEDLINE]Related articlesFree article

4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.

Parmenon C, Guillard J, Caignard DH, Hennuyer N, Staels B, Audinot-Bouchez V, Boutin JA, Dacquet C, Ktorza A, Viaud-Massuard MC.

Bioorg Med Chem Lett. 2009 May 15;19(10):2683-7. Epub 2009 Apr 1.PMID: 19376700 [PubMed - indexed for MEDLINE]Related articles

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens.

Brinster S, Lamberet G, Staels B, Trieu-Cuot P, Gruss A, Poyart C.

Nature. 2009 Mar 5;458(7234):83-6.PMID: 19262672 [PubMed - indexed for MEDLINE]Related articles

Rev-erbalpha2 mRNA encodes a stable protein with a potential role in circadian clock regulation.

Rambaud J, Triqueneaux G, Masse I, Staels B, Laudet V, Benoit G.

Mol Endocrinol. 2009 May;23(5):630-9. Epub 2009 Feb 19.PMID: 19228794 [PubMed - indexed for MEDLINE]Related articles

An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice.

van Dijk TH, Grefhorst A, Oosterveer MH, Bloks VW, Staels B, Reijngoud DJ, Kuipers F.

J Biol Chem. 2009 Apr 17;284(16):10315-23. Epub 2009 Feb 9.PMID: 19204003 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.

Brunham LR, Singaraja RR, Duong M, Timmins JM, Fievet C, Bissada N, Kang MH, Samra A, Fruchart JC, McManus B, Staels B, Parks JS, Hayden MR.

Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):548-54. Epub 2009 Feb 5.PMID: 19201688 [PubMed - indexed for MEDLINE]Related articles

On the mechanism for PPAR agonists to enhance ABCA1 gene expression.

Ogata M, Tsujita M, Hossain MA, Akita N, Gonzalez FJ, Staels B, Suzuki S, Fukutomi T, Kimura G, Yokoyama S.

Atherosclerosis. 2009 Aug;205(2):413-9. Epub 2009 Jan 19.PMID: 19201410 [PubMed - in process]Related articles

Characterization of new PPARgamma agonists: analysis of telmisartan's structural components.

Goebel M, Clemenz M, Staels B, Unger T, Kintscher U, Gust R.

ChemMedChem. 2009 Mar;4(3):445-56.PMID: 19197922 [PubMed - indexed for MEDLINE]Related articles

Role of bile acids and bile acid receptors in metabolic regulation.

Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B.

Physiol Rev. 2009 Jan;89(1):147-91. Review.PMID: 19126757 [PubMed - indexed for MEDLINE]Related articles

Effects of Microdesmis keayana alkaloids on vascular parameters of erectile dysfunction.

Zamblé A, Martin-Nizard F, Sahpaz S, Reynaert ML, Staels B, Bordet R, Duriez P, Gressier B, Bailleul F.

Phytother Res. 2009 Jun;23(6):892-5.PMID: 19107738 [PubMed - indexed for MEDLINE]Related articles

Liver X receptor modulators: effects on lipid metabolism and potential use in the treatment of atherosclerosis.

Fiévet C, Staels B.

Biochem Pharmacol. 2009 Apr 15;77(8):1316-27. Epub 2008 Dec 3. Review.PMID: 19101522 [PubMed - indexed for MEDLINE]Related articles

Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis.

MacDonald ML, van Eck M, Hildebrand RB, Wong BW, Bissada N, Ruddle P, Kontush A, Hussein H, Pouladi MA, Chapman MJ, Fievet C, van Berkel TJ, Staels B, McManus BM, Hayden MR.

Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):341-7. Epub 2008 Dec 18.PMID: 19095997 [PubMed - indexed for MEDLINE]Related articles

Tissue factor pathway inhibitor-2 gene methylation is associated with low expression in carotid atherosclerotic plaques.

Zawadzki C, Chatelain N, Delestre M, Susen S, Quesnel B, Juthier F, Jeanpierre E, Azzaoui R, Corseaux D, Breyne J, Torpier G, Staels B, Van Belle E, Jude B.

Atherosclerosis. 2009 Jun;204(2):e4-14. Epub 2008 Oct 19.PMID: 19081094 [PubMed - indexed for MEDLINE]Related articles

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia.

Fruchart JC, Sacks F, Hermans MP, Assmann G, Brown WV, Ceska R, Chapman MJ, Dodson PM, Fioretto P, Ginsberg HN, Kadowaki T, Lablanche JM, Marx N, Plutzky J, Reiner Z, Rosenson RS, Staels B, Stock JK, Sy R, Wanner C, Zambon A, Zimmet P.

Am J Cardiol. 2008 Nov 17;102(10 Suppl):1K-34K. Review.PMID: 19068318 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein CIII: a link between hypertriglyceridemia and vascular dysfunction?

Caron S, Staels B.

Circ Res. 2008 Dec 5;103(12):1348-50. No abstract available. PMID: 19059836 [PubMed - indexed for MEDLINE]Related articles

Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.

Charton J, Deprez-Poulain R, Hennuyer N, Tailleux A, Staels B, Deprez B.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):489-92. Epub 2008 Nov 18.PMID: 19058965 [PubMed - indexed for MEDLINE]Related articles

Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties.

Porta N, Vallée L, Lecointe C, Bouchaert E, Staels B, Bordet R, Auvin S.

Epilepsia. 2009 Apr;50(4):943-8. Epub 2008 Nov 24.PMID: 19054409 [PubMed - indexed for MEDLINE]Related articles

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient.

Fruchart JC, Sacks FM, Hermans MP, Assmann G, Brown WV, Ceska R, Chapman MJ, Dodson PM, Fioretto P, Ginsberg HN, Kadowaki T, Lablanche JM, Marx N, Plutzky J, Reiner Z, Rosenson RS, Staels B, Stock JK, Sy R, Wanner C, Zambon A, Zimmet P; Residual Risk Reduction Initiative (R3I).

Diab Vasc Dis Res. 2008 Nov;5(4):319-35. Review.PMID: 18958843 [PubMed - indexed for MEDLINE]Related articles

Rimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor-deficient mice.

Dol-Gleizes F, Paumelle R, Visentin V, Marés AM, Desitter P, Hennuyer N, Gilde A, Staels B, Schaeffer P, Bono F.

Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):12-8. Epub 2008 Oct 9.PMID: 18845788 [PubMed - indexed for MEDLINE]Related articles

The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation.

Gizard F, Nomiyama T, Zhao Y, Findeisen HM, Heywood EB, Jones KL, Staels B, Bruemmer D.

Circ Res. 2008 Nov 7;103(10):1155-63. Epub 2008 Sep 25.PMID: 18818403 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages.

Bultel S, Helin L, Clavey V, Chinetti-Gbaguidi G, Rigamonti E, Colin M, Fruchart JC, Staels B, Lestavel S.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2288-95. Epub 2008 Sep 18.PMID: 18802017 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.

Gineste R, Sirvent A, Paumelle R, Helleboid S, Aquilina A, Darteil R, Hum DW, Fruchart JC, Staels B.

Mol Endocrinol. 2008 Nov;22(11):2433-47. Epub 2008 Aug 28.PMID: 18755856 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis.

Wouters K, van Gorp PJ, Bieghs V, Gijbels MJ, Duimel H, Lütjohann D, Kerksiek A, van Kruchten R, Maeda N, Staels B, van Bilsen M, Shiri-Sverdlov R, Hofker MH.

Hepatology. 2008 Aug;48(2):474-86.PMID: 18666236 [PubMed - indexed for MEDLINE]Related articles

Atheroprotective effect of human apolipoprotein A5 in a mouse model of mixed dyslipidemia.

Mansouri RM, Baugé E, Gervois P, Fruchart-Najib J, Fiévet C, Staels B, Fruchart JC.

Circ Res. 2008 Aug 29;103(5):450-3. Epub 2008 Jul 24.PMID: 18658049 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibrates and future PPARalpha agonists in the treatment of cardiovascular disease.

Staels B, Maes M, Zambon A.

Nat Clin Pract Cardiovasc Med. 2008 Sep;5(9):542-53. Epub 2008 Jul 15. Review.PMID: 18628776 [PubMed - indexed for MEDLINE]Related articles

[PPAR receptors at the crossroads of obesity, diabetes and cardiovascular diseases]

Gilde A, Fruchart JC, Staels B.

Journ Annu Diabetol Hotel Dieu. 2007:21-38. Review. French. No abstract available. PMID: 18610756 [PubMed - indexed for MEDLINE]Related articles

Intestine-specific regulation of PPARalpha gene transcription by liver X receptors.

Colin S, Bourguignon E, Boullay AB, Tousaint JJ, Huet S, Caira F, Staels B, Lestavel S, Lobaccaro JM, Delerive P.

Endocrinology. 2008 Oct;149(10):5128-35. Epub 2008 Jun 19.PMID: 18566121 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha.

Duez H, van der Veen JN, Duhem C, Pourcet B, Touvier T, Fontaine C, Derudas B, Baugé E, Havinga R, Bloks VW, Wolters H, van der Sluijs FH, Vennström B, Kuipers F, Staels B.

Gastroenterology. 2008 Aug;135(2):689-98. Epub 2008 May 15.PMID: 18565334 [PubMed - indexed for MEDLINE]Related articles

The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism.

Duez H, Staels B.

Diab Vasc Dis Res. 2008 Jun;5(2):82-8. Review.PMID: 18537094 [PubMed - indexed for MEDLINE]Related articles

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages.

Fontaine C, Rigamonti E, Pourcet B, Duez H, Duhem C, Fruchart JC, Chinetti-Gbaguidi G, Staels B.

Mol Endocrinol. 2008 Aug;22(8):1797-811. Epub 2008 May 29.PMID: 18511497 [PubMed - indexed for MEDLINE]Related articlesFree article

Beneficial effects of fenofibrate on plaque thrombogenicity and plaque stability in atherosclerotic rabbits.

Jeanpierre E, Le Tourneau T, Zawadzki C, Van Belle E, Mouquet F, Susen S, Ezekowitz MD, Staels B, Jude B, Corseaux D.

Cardiovasc Pathol. 2009 May-Jun;18(3):140-7. Epub 2008 Apr 23.PMID: 18436454 [PubMed - indexed for MEDLINE]Related articles

Cross-talk between statins and PPARalpha in cardiovascular diseases: clinical evidence and basic mechanisms.

Paumelle R, Staels B.

Trends Cardiovasc Med. 2008 Apr;18(3):73-8. Review.PMID: 18436144 [PubMed - indexed for MEDLINE]Related articles

PPARs/RXRs in Cardiovascular Physiology and Disease.

Finck BN, Chinetti G, Staels B.

PPAR Res. 2008;2008:173780. No abstract available. PMID: 18389071 [PubMed - in process]Related articlesFree article