Stacpoole PW[au] - PubMed result

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Imaging of lipids in spinal cord using intermediate pressure matrix-assisted laser desorption-linear ion trap/Orbitrap MS.

Landgraf RR, Prieto Conaway MC, Garrett TJ, Stacpoole PW, Yost RA.

Anal Chem. 2009 Oct 15;81(20):8488-95.PMID: 19751051 [PubMed - in process]Related articles

Peripheral neuropathy in rats exposed to dichloroacetate.

Calcutt NA, Lopez VL, Bautista AD, Mizisin LM, Torres BR, Shroads AL, Mizisin AP, Stacpoole PW.

J Neuropathol Exp Neurol. 2009 Sep;68(9):985-93.PMID: 19680144 [PubMed - indexed for MEDLINE]Related articles

AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells.

Glushakova LG, Lisankie MJ, Eruslanov EB, Ojano-Dirain C, Zolotukhin I, Liu C, Srivastava A, Stacpoole PW.

Mol Genet Metab. 2009 Nov;98(3):289-99. Epub 2009 Jun 23.PMID: 19586787 [PubMed - in process]Related articles

Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women.

Lamers Y, O'Rourke B, Gilbert LR, Keeling C, Matthews DE, Stacpoole PW, Gregory JF 3rd.

Am J Clin Nutr. 2009 Aug;90(2):336-43. Epub 2009 Jun 10.PMID: 19515736 [PubMed - indexed for MEDLINE]Related articles

Production of 1-carbon units from glycine is extensive in healthy men and women.

Lamers Y, Williamson J, Theriaque DW, Shuster JJ, Gilbert LR, Keeling C, Stacpoole PW, Gregory JF 3rd.

J Nutr. 2009 Apr;139(4):666-71. Epub 2009 Feb 25.PMID: 19244382 [PubMed - indexed for MEDLINE]Related articles

Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women.

Lamers Y, Williamson J, Ralat M, Quinlivan EP, Gilbert LR, Keeling C, Stevens RD, Newgard CB, Ueland PM, Meyer K, Fredriksen A, Stacpoole PW, Gregory JF 3rd.

J Nutr. 2009 Mar;139(3):452-60. Epub 2009 Jan 21.PMID: 19158217 [PubMed - indexed for MEDLINE]Related articles

The heme precursor delta-aminolevulinate blocks peripheral myelin formation.

Felitsyn N, McLeod C, Shroads AL, Stacpoole PW, Notterpek L.

J Neurochem. 2008 Sep;106(5):2068-79. Epub 2008 Jul 4.PMID: 18665889 [PubMed - indexed for MEDLINE]Related articles Free article

Role of dichloroacetate in the treatment of genetic mitochondrial diseases.

Stacpoole PW, Kurtz TL, Han Z, Langaee T.

Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1478-87. Epub 2008 Jul 4. Review.PMID: 18647626 [PubMed - indexed for MEDLINE]Related articles

Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.

Stacpoole PW, Gilbert LR, Neiberger RE, Carney PR, Valenstein E, Theriaque DW, Shuster JJ.

Pediatrics. 2008 May;121(5):e1223-8. Epub 2008 Apr 14.PMID: 18411236 [PubMed - indexed for MEDLINE]Related articles Free article

10.

A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus serotype-specific vectors and dichloroacetate.

Han Z, Berendzen K, Zhong L, Surolia I, Chouthai N, Zhao W, Maina N, Srivastava A, Stacpoole PW.

Mol Genet Metab. 2008 Apr;93(4):381-7. Epub 2008 Feb 21.PMID: 18206410 [PubMed - indexed for MEDLINE]Related articles Free article

11.

Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.

Shroads AL, Guo X, Dixit V, Liu HP, James MO, Stacpoole PW.

J Pharmacol Exp Ther. 2008 Mar;324(3):1163-71. Epub 2007 Dec 20.PMID: 18096758 [PubMed - indexed for MEDLINE]Related articles Free article

12.

Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucine.

Lamers Y, Williamson J, Gilbert LR, Stacpoole PW, Gregory JF 3rd.

J Nutr. 2007 Dec;137(12):2647-52.PMID: 18029478 [PubMed - indexed for MEDLINE]Related articles Free article

13.

Pyruvate dehydrogenase complex deficiency caused by ubiquitination and proteasome-mediated degradation of the E1 subunit.

Han Z, Zhong L, Srivastava A, Stacpoole PW.

J Biol Chem. 2008 Jan 4;283(1):237-43. Epub 2007 Oct 8.PMID: 17923481 [PubMed - indexed for MEDLINE]Related articles Free article

14.

MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue.

Landgraf RR, Garrett TJ, Calcutt NA, Stacpoole PW, Yost RA.

Anal Chem. 2007 Nov 1;79(21):8170-5. Epub 2007 Sep 26.PMID: 17894472 [PubMed - indexed for MEDLINE]Related articles

15.

Down-regulation of expression of rat pyruvate dehydrogenase E1alpha gene by self-complementary adeno-associated virus-mediated small interfering RNA delivery.

Han Z, Gorbatyuk M, Thomas J Jr, Lewin AS, Srivastava A, Stacpoole PW.

Mitochondrion. 2007 Jul;7(4):253-9. Epub 2007 Feb 20.PMID: 17392036 [PubMed - indexed for MEDLINE]Related articles Free article

16.

Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect.

Felitsyn N, Stacpoole PW, Notterpek L.

J Neurochem. 2007 Jan;100(2):429-36.PMID: 17241159 [PubMed - indexed for MEDLINE]Related articles

17.

Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate.

Jia M, Coats B, Chadha M, Frentzen B, Perez-Rodriguez J, Chadik PA, Yost RA, Henderson GN, Stacpoole PW.

J Clin Pharmacol. 2006 Dec;46(12):1449-59.PMID: 17101744 [PubMed - indexed for MEDLINE]Related articles

18.

Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate.

Simpson NE, Han Z, Berendzen KM, Sweeney CA, Oca-Cossio JA, Constantinidis I, Stacpoole PW.

Mol Genet Metab. 2006 Sep-Oct;89(1-2):97-105. Epub 2006 Jun 12.PMID: 16765624 [PubMed - indexed for MEDLINE]Related articles

19.

Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.

Berendzen K, Theriaque DW, Shuster J, Stacpoole PW.

Mitochondrion. 2006 Jun;6(3):126-35. Epub 2006 May 3.PMID: 16725381 [PubMed - indexed for MEDLINE]Related articles

20.

A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues.

Zolodz MD, Jia M, Liu H, Henderson GN, Stacpoole PW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):125-32. Epub 2006 May 19.PMID: 16713404 [PubMed - indexed for MEDLINE]Related articles

21.

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.

Stacpoole PW, Kerr DS, Barnes C, Bunch ST, Carney PR, Fennell EM, Felitsyn NM, Gilmore RL, Greer M, Henderson GN, Hutson AD, Neiberger RE, O'Brien RG, Perkins LA, Quisling RG, Shroads AL, Shuster JJ, Silverstein JH, Theriaque DW, Valenstein E.

Pediatrics. 2006 May;117(5):1519-31.PMID: 16651305 [PubMed - indexed for MEDLINE]Related articles Free article

22.

Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1.

Langlois C, Jorquera R, Finegold M, Shroads AL, Stacpoole PW, Tanguay RM.

Biochem Pharmacol. 2006 May 28;71(11):1648-61. Epub 2006 Apr 3.PMID: 16581029 [PubMed - indexed for MEDLINE]Related articles

23.

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

Kaufmann P, Engelstad K, Wei Y, Jhung S, Sano MC, Shungu DC, Millar WS, Hong X, Gooch CL, Mao X, Pascual JM, Hirano M, Stacpoole PW, DiMauro S, De Vivo DC.

Neurology. 2006 Feb 14;66(3):324-30.PMID: 16476929 [PubMed - indexed for MEDLINE]Related articles

24.

Peripheral neuropathy in genetic mitochondrial diseases.

Stickler DE, Valenstein E, Neiberger RE, Perkins LA, Carney PR, Shuster JJ, Theriaque DW, Stacpoole PW.

Pediatr Neurol. 2006 Feb;34(2):127-31.PMID: 16458825 [PubMed - indexed for MEDLINE]Related articles

25.

Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women.

Davis SR, Quinlivan EP, Stacpoole PW, Gregory JF 3rd.

J Nutr. 2006 Feb;136(2):373-8.PMID: 16424114 [PubMed - indexed for MEDLINE]Related articles Free article

26.

Metabolic complications of severe malaria.

Planche T, Dzeing A, Ngou-Milama E, Kombila M, Stacpoole PW.

Curr Top Microbiol Immunol. 2005;295:105-36. Review.PMID: 16265889 [PubMed - indexed for MEDLINE]Related articles

27.

Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.

Guo X, Dixit V, Liu H, Shroads AL, Henderson GN, James MO, Stacpoole PW.

Drug Metab Dispos. 2006 Jan;34(1):36-42. Epub 2005 Sep 30.PMID: 16199472 [PubMed - indexed for MEDLINE]Related articles Free article

28.

Effects of alginate encapsulation on mitochondrial activity.

Oca-Cossio J, Simpson NE, Han Z, Stacpoole PW, Constantinidis I.

J Mater Sci Mater Med. 2005 Jun;16(6):521-4.PMID: 15928867 [PubMed - indexed for MEDLINE]Related articles

29.

Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women.

Davis SR, Quinlivan EP, Shelnutt KP, Ghandour H, Capdevila A, Coats BS, Wagner C, Shane B, Selhub J, Bailey LB, Shuster JJ, Stacpoole PW, Gregory JF 3rd.

J Nutr. 2005 May;135(5):1045-50.PMID: 15867279 [PubMed - indexed for MEDLINE]Related articles Free article

30.

The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women.

Davis SR, Quinlivan EP, Shelnutt KP, Maneval DR, Ghandour H, Capdevila A, Coats BS, Wagner C, Selhub J, Bailey LB, Shuster JJ, Stacpoole PW, Gregory JF 3rd.

J Nutr. 2005 May;135(5):1040-4.PMID: 15867278 [PubMed - indexed for MEDLINE]Related articles Free article

31.

Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men.

Davis SR, Scheer JB, Quinlivan EP, Coats BS, Stacpoole PW, Gregory JF 3rd.

Am J Clin Nutr. 2005 Mar;81(3):648-55.PMID: 15755835 [PubMed - indexed for MEDLINE]Related articles Free article

32.

Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides.

Quinlivan EP, Davis SR, Shelnutt KP, Henderson GN, Ghandour H, Shane B, Selhub J, Bailey LB, Stacpoole PW, Gregory JF 3rd.

J Nutr. 2005 Mar;135(3):389-96.PMID: 15735068 [PubMed - indexed for MEDLINE]Related articles Free article

33.

Liquid chromatography-tandem mass spectrometry method for the simultaneous determination of delta-ALA, tyrosine and creatinine in biological fluids.

Felitsyn NM, Henderson GN, James MO, Stacpoole PW.

Clin Chim Acta. 2004 Dec;350(1-2):219-30.PMID: 15530481 [PubMed - indexed for MEDLINE]Related articles

34.

Effects of exercise on emerging and traditional cardiovascular risk factors.

Duncan GE, Perri MG, Anton SD, Limacher MC, Martin AD, Lowenthal DT, Arning E, Bottiglieri T, Stacpoole PW.

Prev Med. 2004 Nov;39(5):894-902.PMID: 15475021 [PubMed - indexed for MEDLINE]Related articles

35.

Unified gas chromatographic-mass spectrometric method for quantitating tyrosine metabolites in urine and plasma.

Shroads AL, Henderson GN, Cheung J, James MO, Stacpoole PW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Sep 5;808(2):153-61.PMID: 15261808 [PubMed - indexed for MEDLINE]Related articles

36.

Methylphenidate does not improve cognitive function in healthy sleep-deprived young adults.

Bray CL, Cahill KS, Oshier JT, Peden CS, Theriaque DW, Flotte TR, Stacpoole PW.

J Investig Med. 2004 Apr;52(3):192-201.PMID: 15222409 [PubMed - indexed for MEDLINE]Related articles

37.

Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism.

Duncan GE, Perkins LA, Theriaque DW, Neiberger RE, Stacpoole PW.

J Clin Endocrinol Metab. 2004 Apr;89(4):1733-8.PMID: 15070938 [PubMed - indexed for MEDLINE]Related articles Free article

38.

Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets.

Fuehrlein BS, Rutenberg MS, Silver JN, Warren MW, Theriaque DW, Duncan GE, Stacpoole PW, Brantly ML.

J Clin Endocrinol Metab. 2004 Apr;89(4):1641-5.PMID: 15070924 [PubMed - indexed for MEDLINE]Related articles Free article

39.

Simultaneous determination of trace levels of nine haloacetic acids in biological samples as their pentafluorobenzyl derivatives by gas chromatography/tandem mass spectrometry in electron capture negative ion chemical ionization mode.

Jia M, Wu WW, Yost RA, Chadik PA, Stacpoole PW, Henderson GN.

Anal Chem. 2003 Aug 15;75(16):4065-80.PMID: 14632119 [PubMed - indexed for MEDLINE]Related articles

40.

Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.

Ammini CV, Fernandez-Canon J, Shroads AL, Cornett R, Cheung J, James MO, Henderson GN, Grompe M, Stacpoole PW.

Biochem Pharmacol. 2003 Nov 15;66(10):2029-38.PMID: 14599561 [PubMed - indexed for MEDLINE]Related articles

41.

Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor.

Davis SR, Stacpoole PW, Williamson J, Kick LS, Quinlivan EP, Coats BS, Shane B, Bailey LB, Gregory JF 3rd.

Am J Physiol Endocrinol Metab. 2004 Feb;286(2):E272-9. Epub 2003 Oct 14.PMID: 14559726 [PubMed - indexed for MEDLINE]Related articles Free article

42.

A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management.

Planche T, Agbenyega T, Bedu-Addo G, Ansong D, Owusu-Ofori A, Micah F, Anakwa C, Asafo-Agyei E, Hutson A, Stacpoole PW, Krishna S.

Clin Infect Dis. 2003 Oct 1;37(7):890-7. Epub 2003 Sep 5.PMID: 13130399 [PubMed - indexed for MEDLINE]Related articles

43.

Efficacy of dichloroacetate as a lactate-lowering drug.

Stacpoole PW, Nagaraja NV, Hutson AD.

J Clin Pharmacol. 2003 Jul;43(7):683-91. Review.PMID: 12856382 [PubMed - indexed for MEDLINE]Related articles

44.

The pyruvate dehydrogenase complex as a target for gene therapy.

Stacpoole PW, Owen R, Flotte TR.

Curr Gene Ther. 2003 Jun;3(3):239-45. Review.PMID: 12762482 [PubMed - indexed for MEDLINE]Related articles

45.

Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.

Agbenyega T, Planche T, Bedu-Addo G, Ansong D, Owusu-Ofori A, Bhattaram VA, Nagaraja NV, Shroads AL, Henderson GN, Hutson AD, Derendorf H, Krishna S, Stacpoole PW.

J Clin Pharmacol. 2003 Apr;43(4):386-96.PMID: 12723459 [PubMed - indexed for MEDLINE]Related articles

46.

Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults.

Duncan GE, Perri MG, Theriaque DW, Hutson AD, Eckel RH, Stacpoole PW.

Diabetes Care. 2003 Mar;26(3):557-62.PMID: 12610001 [PubMed - indexed for MEDLINE]Related articles Free article

47.

Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors.

Owen R 4th, Mandel RJ, Ammini CV, Conlon TJ, Kerr DS, Stacpoole PW, Flotte TR.

Mol Ther. 2002 Sep;6(3):394-9.PMID: 12231176 [PubMed - indexed for MEDLINE]Related articles

48.

QUICKI is not a useful and accurate index of insulin sensitivity following exercise training.

Duncan GE, Hutson AD, Stacpoole PW.