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Triterpenoids CDDO-Methyl Ester or CDDO-Ethyl Amide and Rexinoids LG100268 or NRX194204 for Prevention and Treatment of Lung Cancer in Mice.

Liby K, Risingsong R, Royce DB, Williams CR, Ma T, Yore MM, Sporn MB.

Cancer Prev Res (Phila Pa). 2009 Dec 1. [Epub ahead of print]PMID: 19952361 [PubMed - as supplied by publisher]Related articles

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide.

Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW.

Eur J Pharmacol. 2009 Oct 12;620(1-3):138-44. Epub 2009 Aug 19.PMID: 19698707 [PubMed - in process]Related articles

The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.

Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP.

Am J Respir Crit Care Med. 2009 Nov 1;180(9):867-74. Epub 2009 Aug 13.PMID: 19679692 [PubMed - in process]Related articles

Nrf2 is a critical modulator of the innate immune response in a model of uveitis.

Nagai N, Thimmulappa RK, Cano M, Fujihara M, Izumi-Nagai K, Kong X, Sporn MB, Kensler TW, Biswal S, Handa JT.

Free Radic Biol Med. 2009 Aug 1;47(3):300-6. Epub 2009 May 3.PMID: 19410644 [PubMed - in process]Related articles

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW.

Carcinogenesis. 2009 Jun;30(6):1024-31. Epub 2009 Apr 21.PMID: 19386581 [PubMed - indexed for MEDLINE]Related articles

Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin.

Soriano FX, Baxter P, Murray LM, Sporn MB, Gillingwater TH, Hardingham GE.

Mol Cells. 2009 Mar;27(3):279-82. Epub 2009 Mar 19. Review.PMID: 19326073 [PubMed - indexed for MEDLINE]Related articles

Anti-angiogenic activity of a novel class of chemopreventive compounds: oleanic acid terpenoids.

Sogno I, Vannini N, Lorusso G, Cammarota R, Noonan DM, Generoso L, Sporn MB, Albini A.

Recent Results Cancer Res. 2009;181:209-12. Review.PMID: 19213570 [PubMed - indexed for MEDLINE]Related articles

Clinical prevention of recurrence of colorectal adenomas by the combination of difluoromethylornithine and sulindac: an important milestone.

Sporn MB, Hong WK.

Cancer Prev Res (Phila Pa). 2008 Jun;1(1):9-11. Epub 2008 Apr 14. No abstract available. PMID: 19138930 [PubMed - indexed for MEDLINE]Related articles

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.

Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S.

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5. Epub 2008 Dec 22.PMID: 19104057 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression.

Burrage PS, Schmucker AC, Ren Y, Sporn MB, Brinckerhoff CE.

Arthritis Res Ther. 2008;10(6):R139. Epub 2008 Dec 1.PMID: 19046432 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycogen synthase kinase 3beta regulates cell death induced by synthetic triterpenoids.

Venè R, Larghero P, Arena G, Sporn MB, Albini A, Tosetti F.

Cancer Res. 2008 Sep 1;68(17):6987-96.PMID: 18757413 [PubMed - indexed for MEDLINE]Related articlesFree article

Concomitant DFMO and sulindac chemoprevention of colorectal adenomas: a major clinical advance.

Sporn MB, Hong WK.

Nat Clin Pract Oncol. 2008 Nov;5(11):628-9. Epub 2008 Aug 26.PMID: 18725921 [PubMed]Related articles

A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.

Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, Groopman JD, Kensler TW, Sporn MB.

Cancer Res. 2008 Aug 15;68(16):6727-33.PMID: 18701497 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.

Liby K, Risingsong R, Royce DB, Williams CR, Yore MM, Honda T, Gribble GW, Lamph WW, Vannini N, Sogno I, Albini A, Sporn MB.

Clin Cancer Res. 2008 Jul 15;14(14):4556-63.PMID: 18628471 [PubMed - indexed for MEDLINE]Related articlesFree article

The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis.

Liby K, Black CC, Royce DB, Williams CR, Risingsong R, Yore MM, Liu X, Honda T, Gribble GW, Lamph WW, Sporn TA, Dmitrovsky E, Sporn MB.

Mol Cancer Ther. 2008 May;7(5):1251-7.PMID: 18483313 [PubMed - indexed for MEDLINE]Related articlesFree article

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection.

Tran TA, McCoy MK, Sporn MB, Tansey MG.

J Neuroinflammation. 2008 May 12;5:14.PMID: 18474101 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice.

Osburn WO, Yates MS, Dolan PD, Chen S, Liby KT, Sporn MB, Taguchi K, Yamamoto M, Kensler TW.

Toxicol Sci. 2008 Jul;104(1):218-27. Epub 2008 Apr 15.PMID: 18417483 [PubMed - indexed for MEDLINE]Related articlesFree article

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex.

To C, Kulkarni S, Pawson T, Honda T, Gribble GW, Sporn MB, Wrana JL, Di Guglielmo GM.

J Biol Chem. 2008 Apr 25;283(17):11700-13. Epub 2008 Feb 18.PMID: 18283107 [PubMed - indexed for MEDLINE]Related articlesFree article

c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.

Zou W, Chen S, Liu X, Yue P, Sporn MB, Khuri FR, Sun SY.

Cancer Biol Ther. 2007 Oct;6(10):1614-20. Epub 2007 Jul 19.PMID: 18253090 [PubMed - indexed for MEDLINE]Related articles

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice.

Dinkova-Kostova AT, Jenkins SN, Wehage SL, Huso DL, Benedict AL, Stephenson KK, Fahey JW, Liu H, Liby KT, Honda T, Gribble GW, Sporn MB, Talalay P.

Biochem Biophys Res Commun. 2008 Mar 21;367(4):859-65. Epub 2008 Jan 17.PMID: 18206646 [PubMed - indexed for MEDLINE]Related articles

The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent.

Vannini N, Lorusso G, Cammarota R, Barberis M, Noonan DM, Sporn MB, Albini A.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3139-46. Epub 2007 Dec 7.PMID: 18065492 [PubMed - indexed for MEDLINE]Related articlesFree article

A new tumor suppressor gene, selective for lung cancer.

Sporn MB.

J Natl Cancer Inst. 2007 Nov 21;99(22):1654-5. Epub 2007 Nov 13. No abstract available. PMID: 18000215 [PubMed - indexed for MEDLINE]Related articlesFree article

A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland.

Liby K, Royce DB, Risingsong R, Williams CR, Wood MD, Chandraratna RA, Sporn MB.

Clin Cancer Res. 2007 Oct 15;13(20):6237-43.PMID: 17947492 [PubMed - indexed for MEDLINE]Related articlesFree article

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.

Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S.

Antioxid Redox Signal. 2007 Nov;9(11):1963-70.PMID: 17822364 [PubMed - indexed for MEDLINE]Related articlesFree article

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha.

Koschmieder S, D'Alò F, Radomska H, Schöneich C, Chang JS, Konopleva M, Kobayashi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R, Sargin B, Kantarjian H, Andreeff M, Sporn MB, Perrotti D, Berdel WE, Müller-Tidow C, Serve H, Tenen DG.

Blood. 2007 Nov 15;110(10):3695-705. Epub 2007 Aug 1.PMID: 17671235 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

Liby K, Honda T, Williams CR, Risingsong R, Royce DB, Suh N, Dinkova-Kostova AT, Stephenson KK, Talalay P, Sundararajan C, Gribble GW, Sporn MB.

Mol Cancer Ther. 2007 Jul;6(7):2113-9.PMID: 17620440 [PubMed - indexed for MEDLINE]Related articlesFree article

Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

Liby KT, Yore MM, Sporn MB.

Nat Rev Cancer. 2007 May;7(5):357-69. Epub 2007 Apr 19. Review.PMID: 17446857 [PubMed - indexed for MEDLINE]Related articles

Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents.

Honda T, Sundararajan C, Yoshizawa H, Su X, Honda Y, Liby KT, Sporn MB, Gribble GW.

J Med Chem. 2007 Apr 19;50(8):1731-4. Epub 2007 Mar 17.PMID: 17367124 [PubMed - indexed for MEDLINE]Related articlesFree article

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.

Liby K, Royce DB, Williams CR, Risingsong R, Yore MM, Honda T, Gribble GW, Dmitrovsky E, Sporn TA, Sporn MB.

Cancer Res. 2007 Mar 15;67(6):2414-9.PMID: 17363558 [PubMed - indexed for MEDLINE]Related articlesFree article

The synthetic triterpenoid TP-222 inhibits RANKL stimulation of osteoclastogenesis and matrix metalloproteinase-9 expression.

Fava RA, Elliott S, Raymond L, Mollmark J, Hays E, Honda T, Gribble GW, Sporn MB, Vincenti MP.

J Rheumatol. 2007 May;34(5):1058-68. Epub 2007 Mar 15.PMID: 17361985 [PubMed - indexed for MEDLINE]Related articles

Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand.

Burrage PS, Huntington JT, Sporn MB, Brinckerhoff CE.

Arthritis Rheum. 2007 Mar;56(3):892-904.PMID: 17328062 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, Kensler TW.

Mol Cancer Ther. 2007 Jan;6(1):154-62.PMID: 17237276 [PubMed - indexed for MEDLINE]Related articlesFree article

The tumour microenvironment as a target for chemoprevention.

Albini A, Sporn MB.

Nat Rev Cancer. 2007 Feb;7(2):139-47. Review.PMID: 17218951 [PubMed - indexed for MEDLINE]Related articles

The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta.

Yore MM, Liby KT, Honda T, Gribble GW, Sporn MB.

Mol Cancer Ther. 2006 Dec;5(12):3232-9. Epub 2006 Dec 5.PMID: 17148759 [PubMed - indexed for MEDLINE]Related articlesFree article

Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide.

Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M, Kensler TW, Biswal S.

Biochem Biophys Res Commun. 2006 Dec 29;351(4):883-9. Epub 2006 Oct 30.PMID: 17097057 [PubMed - indexed for MEDLINE]Related articlesFree article

The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer.

Liby K, Rendi M, Suh N, Royce DB, Risingsong R, Williams CR, Lamph W, Labrie F, Krajewski S, Xu X, Kim H, Brown P, Sporn MB.

Clin Cancer Res. 2006 Oct 1;12(19):5902-9.PMID: 17020999 [PubMed - indexed for MEDLINE]Related articlesFree article

Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A.

Honda T, Liby KT, Su X, Sundararajan C, Honda Y, Suh N, Risingsong R, Williams CR, Royce DB, Sporn MB, Gribble GW.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6306-9. Epub 2006 Sep 25.PMID: 16996735 [PubMed - indexed for MEDLINE]Related articlesFree article

The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells.

Liby K, Voong N, Williams CR, Risingsong R, Royce DB, Honda T, Gribble GW, Sporn MB, Letterio JJ.

Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4288-93.PMID: 16857804 [PubMed - indexed for MEDLINE]Related articlesFree article

Dichotomies in cancer research: some suggestions for a new synthesis.

Sporn MB.

Nat Clin Pract Oncol. 2006 Jul;3(7):364-73. Review.PMID: 16826217 [PubMed - indexed for MEDLINE]Related articles

CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms.

Han SS, Peng L, Chung ST, DuBois W, Maeng SH, Shaffer AL, Sporn MB, Janz S.

Mol Cancer. 2006 Jun 7;5:22.PMID: 16759389 [PubMed - indexed for MEDLINE]Related articlesFree article

Fifteen-year results of a randomized phase III trial of fenretinide to prevent second breast cancer.

Veronesi U, Mariani L, Decensi A, Formelli F, Camerini T, Miceli R, Di Mauro MG, Costa A, Marubini E, Sporn MB, De Palo G.

Ann Oncol. 2006 Jul;17(7):1065-71. Epub 2006 May 4.PMID: 16675486 [PubMed - indexed for MEDLINE]Related articlesFree article

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.

Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW.

Cancer Res. 2006 Feb 15;66(4):2488-94.PMID: 16489057 [PubMed - indexed for MEDLINE]Related articlesFree article

2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule polymerization: a possible mechanism contributing to apoptosis.

Couch RD, Ganem NJ, Zhou M, Popov VM, Honda T, Veenstra TD, Sporn MB, Anderson AC.

Mol Pharmacol. 2006 Apr;69(4):1158-65. Epub 2006 Jan 11.PMID: 16407469 [PubMed - indexed for MEDLINE]Related articlesFree article

The early history of TGF-beta, and a brief glimpse of its future.

Sporn MB.

Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):3-7. Epub 2005 Nov 14. Review. No abstract available. PMID: 16290110 [PubMed - indexed for MEDLINE]Related articles

Cancer chemoprevention: scientific promise, clinical uncertainty.

Sporn MB, Liby KT.

Nat Clin Pract Oncol. 2005 Oct;2(10):518-25. Review.PMID: 16205771 [PubMed - indexed for MEDLINE]Related articles

Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.

Hyer ML, Croxton R, Krajewska M, Krajewski S, Kress CL, Lu M, Suh N, Sporn MB, Cryns VL, Zapata JM, Reed JC.

Cancer Res. 2005 Jun 1;65(11):4799-808.PMID: 15930300 [PubMed - indexed for MEDLINE]Related articlesFree article

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.

Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB.

Cancer Res. 2005 Jun 1;65(11):4789-98.PMID: 15930299 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action.

Couch RD, Browning RG, Honda T, Gribble GW, Wright DL, Sporn MB, Anderson AC.

Bioorg Med Chem Lett. 2005 May 2;15(9):2215-9.PMID: 15837296 [PubMed - indexed for MEDLINE]Related articles

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.

Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9. Epub 2005 Mar 14.PMID: 15767573 [PubMed - indexed for MEDLINE]Related articlesFree article

Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation.

Vázquez N, Greenwell-Wild T, Marinos NJ, Swaim WD, Nares S, Ott DE, Schubert U, Henklein P, Orenstein JM, Sporn MB, Wahl SM.

J Virol. 2005 Apr;79(7):4479-91.PMID: 15767448 [PubMed - indexed for MEDLINE]Related articlesFree article