PubMed

Differential effects of PKB/Akt isoforms on glucose homeostasis and islet mass.

Buzzi F, Xu L, Zuellig RA, Boller SB, Spinas GA, Hynx D, Chang Z, Yang Z, Hemmings BA, Tschopp O, Niessen M.

Mol Cell Biol. 2009 Nov 23. [Epub ahead of print]PMID: 19933838 [PubMed - as supplied by publisher]Related articles

Diet determines features of the metabolic syndrome in 6- to 14-year-old children.

Aeberli I, Spinas GA, Lehmann R, l'Allemand D, Molinari L, Zimmermann MB.

Int J Vitam Nutr Res. 2009 Jan;79(1):14-23.PMID: 19838999 [PubMed - indexed for MEDLINE]Related articles

Glucose lowering and anti-atherogenic effects of incretin-based therapies: GLP-1 analogues and DPP-4-inhibitors.

Rizzo M, Rizvi AA, Spinas GA, Rini GB, Berneis K.

Expert Opin Investig Drugs. 2009 Oct;18(10):1495-503.PMID: 19758106 [PubMed - in process]Related articles

Atherogenic lipoprotein phenotype and LDL size and subclasses in drug-naïve patients with early rheumatoid arthritis.

Rizzo M, Spinas GA, Cesur M, Ozbalkan Z, Rini GB, Berneis K.

Atherosclerosis. 2009 Dec;207(2):502-6. Epub 2009 Jul 8.PMID: 19643412 [PubMed - in process]Related articles

Exenatide versus insulin glargine: a cost-effectiveness evaluation in patients with Type 2 diabetes in Switzerland.

Brändle M, Erny-Albrecht KM, Goodall G, Spinas GA, Streit P, Valentine WJ.

Int J Clin Pharmacol Ther. 2009 Aug;47(8):501-15.PMID: 19640359 [PubMed - indexed for MEDLINE]Related articles

Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype.

Rizzo M, Berneis K, Hersberger M, Pepe I, Di Fede G, Rini GB, Spinas GA, Carmina E.

Hum Reprod. 2009 Sep;24(9):2286-92. Epub 2009 May 19.PMID: 19454589 [PubMed - indexed for MEDLINE]Related articles

The predictive role of atherogenic dyslipidemia in subjects with non-coronary atherosclerosis.

Berneis K, Rizzo M, Spinas GA, Di Lorenzo G, Di Fede G, Pepe I, Pernice V, Rini GB.

Clin Chim Acta. 2009 Aug;406(1-2):36-40. Epub 2009 May 9.PMID: 19433079 [PubMed - indexed for MEDLINE]Related articles

Is diabetes the cost to pay for a greater cardiovascular prevention?

Rizzo M, Spinas GA, Rini GB, Berneis K.

Int J Cardiol. 2009 Mar 16. [Epub ahead of print]PMID: 19297038 [PubMed - as supplied by publisher]Related articles

Quantitative and qualitative effects of rosuvastatin on LDL-cholesterol: what is the clinical significance?

Rizzo M, Berneis K, Spinas GA, Rini GB, Kapur NK.

Int J Clin Pract. 2009 Mar;63(3):478-85. Review.PMID: 19222633 [PubMed - indexed for MEDLINE]Related articles

Atherogenic forms of dyslipidaemia in women with polycystic ovary syndrome.

Berneis K, Rizzo M, Hersberger M, Rini GB, Di Fede G, Pepe I, Spinas GA, Carmina E.

Int J Clin Pract. 2009 Jan;63(1):56-62.PMID: 19125993 [PubMed - indexed for MEDLINE]Related articles

Atherogenic lipoprotein phenotype and LDL size and subclasses in women with gestational diabetes.

Rizzo M, Berneis K, Altinova AE, Toruner FB, Akturk M, Ayvaz G, Rini GB, Spinas GA, Arslan M.

Diabet Med. 2008 Dec;25(12):1406-11.PMID: 19046238 [PubMed - indexed for MEDLINE]Related articles

The effects of ezetimibe on LDL-cholesterol: quantitative or qualitative changes?

Rizzo M, Rini GB, Spinas GA, Berneis K.

Atherosclerosis. 2009 Jun;204(2):330-3. Epub 2008 Oct 14. Review.PMID: 19027905 [PubMed - indexed for MEDLINE]Related articles

Small, dense low-density lipoproteins (LDL) are predictors of cardio- and cerebro-vascular events in subjects with the metabolic syndrome.

Rizzo M, Pernice V, Frasheri A, Di Lorenzo G, Rini GB, Spinas GA, Berneis K.

Clin Endocrinol (Oxf). 2009 Jun;70(6):870-5. Epub 2008 Sep 2.PMID: 18771560 [PubMed - indexed for MEDLINE]Related articles

The differential effects of thiazolidindiones on atherogenic dyslipidemia in type 2 diabetes: what is the clinical significance?

Rizzo M, Christ ER, Rini GB, Spinas GA, Berneis K.

Expert Opin Pharmacother. 2008 Sep;9(13):2295-303. Review.PMID: 18710354 [PubMed - indexed for MEDLINE]Related articles

The increase of fatty acid-binding protein aP2 in overweight and obese children: interactions with dietary fat and impact on measures of subclinical inflammation.

Aeberli I, Beljean N, Lehmann R, I'Allemand D, Spinas GA, Zimmermann MB.

Int J Obes (Lond). 2008 Oct;32(10):1513-20. Epub 2008 Aug 5.PMID: 18679408 [PubMed - indexed for MEDLINE]Related articles

Insulin sensitivity in type 2 diabetes is closely associated with LDL particle size.

Krayenbuehl PA, Wiesli P, Schmid C, Lehmann R, Spinas GA, Berneis K.

Swiss Med Wkly. 2008 May 3;138(19-20):275-80.PMID: 18491240 [PubMed - indexed for MEDLINE]Related articlesFree article

Has time come for new goals in human islet transplantation?

Lehmann R, Spinas GA, Moritz W, Weber M.

Am J Transplant. 2008 Jun;8(6):1096-100. Epub 2008 Apr 29.PMID: 18444937 [PubMed - indexed for MEDLINE]Related articles

Unsuspected osteomyelitis is frequent in persistent diabetic foot ulcer and better diagnosed by MRI than by 18F-FDG PET or 99mTc-MOAB.

Schwegler B, Stumpe KD, Weishaupt D, Strobel K, Spinas GA, von Schulthess GK, Hodler J, Böni T, Donath MY.

J Intern Med. 2008 Jan;263(1):99-106. Epub 2007 Nov 23.PMID: 18036160 [PubMed - indexed for MEDLINE]Related articles

Simultaneous islet-kidney vs pancreas-kidney transplantation in type 1 diabetes mellitus: a 5 year single centre follow-up.

Gerber PA, Pavlicek V, Demartines N, Zuellig R, Pfammatter T, Wüthrich R, Weber M, Spinas GA, Lehmann R.

Diabetologia. 2008 Jan;51(1):110-9. Epub 2007 Nov 1.PMID: 17973096 [PubMed - indexed for MEDLINE]Related articles

Fructose intake is a predictor of LDL particle size in overweight schoolchildren.

Aeberli I, Zimmermann MB, Molinari L, Lehmann R, l'Allemand D, Spinas GA, Berneis K.

Am J Clin Nutr. 2007 Oct;86(4):1174-8. Erratum in: Am J Clin Nutr. 2008 Dec;88(6):1707. PMID: 17921399 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children.

Aeberli I, Biebinger R, Lehmann R, L'allemand D, Spinas GA, Zimmermann MB.

J Clin Endocrinol Metab. 2007 Nov;92(11):4359-65. Epub 2007 Aug 28.PMID: 17726085 [PubMed - indexed for MEDLINE]Related articlesFree article

Superiority of small islets in human islet transplantation.

Lehmann R, Zuellig RA, Kugelmeier P, Baenninger PB, Moritz W, Perren A, Clavien PA, Weber M, Spinas GA.

Diabetes. 2007 Mar;56(3):594-603.PMID: 17327426 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor substrates 1 and 2 but not Shc can activate the insulin receptor independent of insulin and induce proliferation in CHO-IR cells.

Niessen M, Jaschinski F, Item F, McNamara MP, Spinas GA, Trüb T.

Exp Cell Res. 2007 Feb 15;313(4):805-15. Epub 2006 Dec 5.PMID: 17222824 [PubMed - indexed for MEDLINE]Related articles

Glucose-stimulated insulin production in mice deficient for the PAS kinase PASKIN.

Borter E, Niessen M, Zuellig R, Spinas GA, Spielmann P, Camenisch G, Wenger RH.

Diabetes. 2007 Jan;56(1):113-7.PMID: 17192472 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of basal insulin requirement using fasting tests in insulin-treated patients with type 2 diabetes mellitus.

Wiesli P, Lehmann R, Krayenbuehl PA, Schmid C, Spinas GA.

Exp Clin Endocrinol Diabetes. 2006 Nov;114(10):539-43.PMID: 17177134 [PubMed - indexed for MEDLINE]Related articles

Health economic implications of irbesartan plus conventional antihypertensive medications versus conventional blood pressure control alone in patients with type 2 diabetes, hypertension, and renal disease in Switzerland.

Palmer AJ, Roze S, Valentine WJ, Ray JA, Frei A, Burnier M, Hess B, Spinas GA, Brändle M.

Swiss Med Wkly. 2006 May 27;136(21-22):346-52.PMID: 16779715 [PubMed - indexed for MEDLINE]Related articlesFree article

Admission glucose concentrations independently predict early and late mortality in patients with acute myocardial infarction treated by primary or rescue percutaneous coronary intervention.

Straumann E, Kurz DJ, Muntwyler J, Stettler I, Furrer M, Naegeli B, Frielingsdorf J, Schuiki E, Mury R, Bertel O, Spinas GA.

Am Heart J. 2005 Nov;150(5):1000-6.PMID: 16290985 [PubMed - indexed for MEDLINE]Related articles

Urinary excretion of an intravenous 26Mg dose as an indicator of marginal magnesium deficiency in adults.

Wälti MK, Walczyk T, Zimmermann MB, Fortunato G, Weber M, Spinas GA, Hurrell RF.

Eur J Clin Nutr. 2006 Feb;60(2):147-54.PMID: 16234844 [PubMed - indexed for MEDLINE]Related articles

The metabolisable hexoses D-glucose and D-mannose enhance the expression of IRS-2 but not of IRS-1 in pancreatic beta-cells.

Amacker-Françoys I, Mohanty S, Niessen M, Spinas GA, Trüb T.

Exp Clin Endocrinol Diabetes. 2005 Sep;113(8):423-9.PMID: 16151975 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

Størling J, Binzer J, Andersson AK, Züllig RA, Tonnesen M, Lehmann R, Spinas GA, Sandler S, Billestrup N, Mandrup-Poulsen T.

Diabetologia. 2005 Oct;48(10):2039-50. Epub 2005 Aug 25.PMID: 16132952 [PubMed - indexed for MEDLINE]Related articles

[Islet transplantation in type I diabetes mellitus]

Lehmann R, Pavlicek V, Spinas GA, Weber M.

Ther Umsch. 2005 Jul;62(7):481-6. Review. German. PMID: 16075955 [PubMed - indexed for MEDLINE]Related articles

Acute psychological stress affects glucose concentrations in patients with type 1 diabetes following food intake but not in the fasting state.

Wiesli P, Schmid C, Kerwer O, Nigg-Koch C, Klaghofer R, Seifert B, Spinas GA, Schwegler K.

Diabetes Care. 2005 Aug;28(8):1910-5.PMID: 16043731 [PubMed - indexed for MEDLINE]Related articlesFree article

Mini-Mental State Examination is superior to plasma glucose concentrations in monitoring patients with suspected hypoglycaemic disorders during the 72-hour fast.

Wiesli P, Schwegler B, Schmid B, Spinas GA, Schmid C.

Eur J Endocrinol. 2005 Apr;152(4):605-10.PMID: 15817917 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoglycemia in response to glucose and glucagon in insulinoma patients with a negative prolonged fast: functional and morphological properties.

Wiesli P, Schmid C, Perren A, Pfammatter T, Spinas GA, Keller U.

J Endocrinol Invest. 2004 Oct;27(9):832-8.PMID: 15648547 [PubMed - indexed for MEDLINE]Related articles

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.

Mohanty S, Spinas GA, Maedler K, Zuellig RA, Lehmann R, Donath MY, Trüb T, Niessen M.

Exp Cell Res. 2005 Feb 1;303(1):68-78.PMID: 15572028 [PubMed - indexed for MEDLINE]Related articles

Selective arterial calcium stimulation and hepatic venous sampling in the evaluation of hyperinsulinemic hypoglycemia: potential and limitations.

Wiesli P, Brändle M, Schmid C, Krähenbühl L, Furrer J, Keller U, Spinas GA, Pfammatter T.

J Vasc Interv Radiol. 2004 Nov;15(11):1251-6.PMID: 15525744 [PubMed - indexed for MEDLINE]Related articles

Abnormalities of proinsulin processing in functioning insulinomas: clinical implications.

Wiesli P, Perren A, Saremaslani P, Pfammatter T, Spinas GA, Schmid C.

Clin Endocrinol (Oxf). 2004 Oct;61(4):424-30.PMID: 15473873 [PubMed - indexed for MEDLINE]Related articles

Deleterious effects of increased body weight associated with intensive insulin therapy for type 1 diabetes: increased blood pressure and worsened lipid profile partially negate improvements in life expectancy.

Palmer AJ, Roze S, Valentine WJ, Minshall ME, Lammert M, Nicklasson L, Spinas GA.

Curr Med Res Opin. 2004 Aug;20 Suppl 1:S67-73.PMID: 15324518 [PubMed - indexed for MEDLINE]Related articles

What impact would pancreatic beta-cell preservation have on life expectancy, quality-adjusted life expectancy and costs of complications in patients with type 2 diabetes? A projection using the CORE Diabetes Model.

Palmer AJ, Roze S, Valentine WJ, Minshall ME, Lammert M, Oglesby A, Hayes C, Spinas GA.

Curr Med Res Opin. 2004 Aug;20 Suppl 1:S59-66.PMID: 15324517 [PubMed - indexed for MEDLINE]Related articles

Impact of changes in HbA1c, lipids and blood pressure on long-term outcomes in type 2 diabetes patients: an analysis using the CORE Diabetes Model.

Palmer AJ, Roze S, Valentine WJ, Minshall ME, Hayes C, Oglesby A, Spinas GA.

Curr Med Res Opin. 2004 Aug;20 Suppl 1:S53-8.PMID: 15324516 [PubMed - indexed for MEDLINE]Related articles

Comparing the long-term cost-effectiveness of repaglinide plus metformin versus nateglinide plus metformin in type 2 diabetes patients with inadequate glycaemic control: an application of the CORE Diabetes Model in type 2 diabetes.

Palmer AJ, Roze S, Lammert M, Valentine WJ, Minshall ME, Nicklasson L, Gall MA, Spinas GA.

Curr Med Res Opin. 2004 Aug;20 Suppl 1:S41-51.PMID: 15324515 [PubMed - indexed for MEDLINE]Related articles

Validation of the CORE Diabetes Model against epidemiological and clinical studies.

Palmer AJ, Roze S, Valentine WJ, Minshall ME, Foos V, Lurati FM, Lammert M, Spinas GA.

Curr Med Res Opin. 2004 Aug;20 Suppl 1:S27-40.PMID: 15324514 [PubMed - indexed for MEDLINE]Related articles

The CORE Diabetes Model: Projecting long-term clinical outcomes, costs and cost-effectiveness of interventions in diabetes mellitus (types 1 and 2) to support clinical and reimbursement decision-making.

Palmer AJ, Roze S, Valentine WJ, Minshall ME, Foos V, Lurati FM, Lammert M, Spinas GA.

Curr Med Res Opin. 2004 Aug;20 Suppl 1:S5-26.PMID: 15324513 [PubMed - indexed for MEDLINE]Related articles

Insulin determination by specific and unspecific immunoassays in patients with insulinoma evaluated by the arterial stimulation and venous sampling test.

Wiesli P, Brändle M, Pfammatter T, Zapf J, Spinas GA, Schmid C.

Eur J Endocrinol. 2004 Jul;151(1):123-6.PMID: 15248832 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct medical costs of type 2 diabetes and its complications in Switzerland.

Schmitt-Koopmann I, Schwenkglenks M, Spinas GA, Szucs TD.

Eur J Public Health. 2004 Mar;14(1):3-9.PMID: 15080382 [PubMed - indexed for MEDLINE]Related articlesFree article

Intensive lifestyle changes or metformin in patients with impaired glucose tolerance: modeling the long-term health economic implications of the diabetes prevention program in Australia, France, Germany, Switzerland, and the United Kingdom.

Palmer AJ, Roze S, Valentine WJ, Spinas GA, Shaw JE, Zimmet PZ.

Clin Ther. 2004 Feb;26(2):304-21.PMID: 15038953 [PubMed - indexed for MEDLINE]Related articles

Assessment of hyperinsulinaemia at the termination of the prolonged fast.

Wiesli P, Brändle M, Zapf J, Seiler H, Zwimpfer C, Spinas GA, Schmid C.

Clin Chim Acta. 2004 Apr;342(1-2):227-31.PMID: 15026285 [PubMed - indexed for MEDLINE]Related articles

Serum cystatin C is sensitive to small changes in thyroid function.

Wiesli P, Schwegler B, Spinas GA, Schmid C.

Clin Chim Acta. 2003 Dec;338(1-2):87-90.PMID: 14637271 [PubMed - indexed for MEDLINE]Related articles

Glucose control is not improved by accelerating gastric emptying in patients with type 1 diabetes mellitus and gastroparesis. a pilot study with cisapride as a model drug.

Lehmann R, Honegger RA, Feinle C, Fried M, Spinas GA, Schwizer W.

Exp Clin Endocrinol Diabetes. 2003 Aug;111(5):255-61.PMID: 12951630 [PubMed - indexed for MEDLINE]Related articles