PubMed

Coexpression network based on natural variation in human gene expression reveals gene interactions and functions.

Nayak RR, Kearns M, Spielman RS, Cheung VG.

Genome Res. 2009 Nov;19(11):1953-62. Epub 2009 Oct 1.PMID: 19797678 [PubMed - in process]Related articles

Genetics of human gene expression: mapping DNA variants that influence gene expression.

Cheung VG, Spielman RS.

Nat Rev Genet. 2009 Sep;10(9):595-604. Epub 2009 Jul 28. Review.PMID: 19636342 [PubMed - indexed for MEDLINE]Related articles

PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women.

Chen C, Wickenheisser J, Ewens KG, Ankener W, Legro RS, Dunaif A, McAllister JM, Spielman RS, Strauss JF 3rd.

Mol Hum Reprod. 2009 Aug;15(8):459-69. Epub 2009 May 29.PMID: 19482904 [PubMed - indexed for MEDLINE]Related articles

Genetic analysis of radiation-induced changes in human gene expression.

Smirnov DA, Morley M, Shin E, Spielman RS, Cheung VG.

Nature. 2009 May 28;459(7246):587-91. Epub 2009 Apr 6.PMID: 19349959 [PubMed - indexed for MEDLINE]Related articles

Effects of cis and trans genetic ancestry on gene expression in African Americans.

Price AL, Patterson N, Hancks DC, Myers S, Reich D, Cheung VG, Spielman RS.

PLoS Genet. 2008 Dec;4(12):e1000294. Epub 2008 Dec 5.PMID: 19057673 [PubMed - indexed for MEDLINE]Related articlesFree article

A review of family-based tests for linkage disequilibrium between a quantitative trait and a genetic marker.

Ewens WJ, Li M, Spielman RS.

PLoS Genet. 2008 Sep 26;4(9):e1000180. Review.PMID: 18818728 [PubMed - indexed for MEDLINE]Related articlesFree article

Disease associations and family-based tests.

Ewens WJ, Spielman RS, Kaplan NL, Gao X, Morris RW, Martin ER.

Curr Protoc Hum Genet. 2008 Jul;Chapter 1:Unit 1.12.PMID: 18633973 [PubMed - indexed for MEDLINE]Related articles

Monozygotic twins reveal germline contribution to allelic expression differences.

Cheung VG, Bruzel A, Burdick JT, Morley M, Devlin JL, Spielman RS.

Am J Hum Genet. 2008 Jun;82(6):1357-60.PMID: 18513681 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic heterogeneity and trans regulators of gene expression.

Bastone LA, Putt ME, Ten Have TR, Cheung VG, Spielman RS.

BMC Proc. 2007;1 Suppl 1:S80. Epub 2007 Dec 18.PMID: 18466583 [PubMed - in process]Related articlesFree article

Data for Genetic Analysis Workshop (GAW) 15, Problem 1: genetics of gene expression variation in humans.

Cheung VG, Spielman RS.

BMC Proc. 2007;1 Suppl 1:S2. Epub 2007 Dec 18.PMID: 18466516 [PubMed - in process]Related articlesFree article

Disease associations and family-based tests.

Ewens WJ, Spielman RS, Kaplan NL, Martin ER.

Curr Protoc Hum Genet. 2003 Nov;Chapter 1:Unit 1.12.PMID: 18428340 [PubMed - indexed for MEDLINE]Related articles

Introduction to Genetic Analysis Workshop 15 summaries.

Witte JS, Schnell AH, Cordell HJ, Spielman RS, Amos CI, Miller MB, Almasy L, MacCluer JW.

Genet Epidemiol. 2007;31 Suppl 1:S1-6.PMID: 18046756 [PubMed - indexed for MEDLINE]Related articles

Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.

Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, Coutifaris C, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Giudice LC, Ewens KG, Spielman RS, Leppert PC, Myers ER; Reproductive Medicine Network.

J Clin Endocrinol Metab. 2008 Mar;93(3):792-800. Epub 2007 Nov 13.PMID: 18000088 [PubMed - indexed for MEDLINE]Related articlesFree article

Common genetic variants account for differences in gene expression among ethnic groups.

Spielman RS, Bastone LA, Burdick JT, Morley M, Ewens WJ, Cheung VG.

Nat Genet. 2007 Feb;39(2):226-31. Epub 2007 Jan 7.PMID: 17206142 [PubMed - indexed for MEDLINE]Related articles

Fine mapping of genetic susceptibility to polycystic ovary syndrome on chromosome 19p13.2 and tests for regulatory activity.

Stewart DR, Dombroski BA, Urbanek M, Ankener W, Ewens KG, Wood JR, Legro RS, Strauss JF 3rd, Dunaif A, Spielman RS.

J Clin Endocrinol Metab. 2006 Oct;91(10):4112-7. Epub 2006 Jul 25.PMID: 16868051 [PubMed - indexed for MEDLINE]Related articlesFree article

What is the significance of a significant TDT?

Ewens WJ, Spielman RS.

Hum Hered. 2005;60(4):206-10. Epub 2006 Jan 2.PMID: 16391488 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping determinants of human gene expression by regional and genome-wide association.

Cheung VG, Spielman RS, Ewens KG, Weber TM, Morley M, Burdick JT.

Nature. 2005 Oct 27;437(7063):1365-9.PMID: 16251966 [PubMed - indexed for MEDLINE]Related articles

Assessment of 115 candidate genes for diabetic nephropathy by transmission/disequilibrium test.

Ewens KG, George RA, Sharma K, Ziyadeh FN, Spielman RS.

Diabetes. 2005 Nov;54(11):3305-18.PMID: 16249459 [PubMed - indexed for MEDLINE]Related articlesFree article

Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2.

Urbanek M, Woodroffe A, Ewens KG, Diamanti-Kandarakis E, Legro RS, Strauss JF 3rd, Dunaif A, Spielman RS.

J Clin Endocrinol Metab. 2005 Dec;90(12):6623-9. Epub 2005 Aug 9.PMID: 16091490 [PubMed - indexed for MEDLINE]Related articlesFree article

The keeshond defect in cardiac conotruncal development is oligogenic.

Werner P, Raducha MG, Prociuk U, Ostrander EA, Spielman RS, Kirkness EF, Patterson DF, Henthorn PS.

Hum Genet. 2005 Apr;116(5):368-77. Epub 2005 Feb 12.PMID: 15711798 [PubMed - indexed for MEDLINE]Related articles

The TDT is a statistically valid test: comments on Wittkowski and Liu.

Ewens WJ, Spielman RS.

Hum Hered. 2004;58(1):59-60; author reply 60-1; discussion 61-2. No abstract available. PMID: 15604566 [PubMed - indexed for MEDLINE]Related articlesFree article

A functional polymorphism (1858C/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families.

Onengut-Gumuscu S, Ewens KG, Spielman RS, Concannon P.

Genes Immun. 2004 Dec;5(8):678-80.PMID: 15526003 [PubMed - indexed for MEDLINE]Related articles

A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A.

Jiang YH, Sahoo T, Michaelis RC, Bercovich D, Bressler J, Kashork CD, Liu Q, Shaffer LG, Schroer RJ, Stockton DW, Spielman RS, Stevenson RE, Beaudet AL.

Am J Med Genet A. 2004 Nov 15;131(1):1-10.PMID: 15389703 [PubMed - indexed for MEDLINE]Related articles

Genetics of quantitative variation in human gene expression.

Cheung VG, Jen KY, Weber T, Morley M, Devlin JL, Ewens KG, Spielman RS.

Cold Spring Harb Symp Quant Biol. 2003;68:403-7. No abstract available. PMID: 15338642 [PubMed - indexed for MEDLINE]Related articles

Genetic analysis of genome-wide variation in human gene expression.

Morley M, Molony CM, Weber TM, Devlin JL, Ewens KG, Spielman RS, Cheung VG.

Nature. 2004 Aug 12;430(7001):743-7. Epub 2004 Jul 21.PMID: 15269782 [PubMed - indexed for MEDLINE]Related articles

Natural variation in human gene expression assessed in lymphoblastoid cells.

Cheung VG, Conlin LK, Weber TM, Arcaro M, Jen KY, Morley M, Spielman RS.

Nat Genet. 2003 Mar;33(3):422-5. Epub 2003 Feb 3.PMID: 12567189 [PubMed - indexed for MEDLINE]Related articles

Variation in resistin gene promoter not associated with polycystic ovary syndrome.

Urbanek M, Du Y, Silander K, Collins FS, Steppan CM, Strauss JF 3rd, Dunaif A, Spielman RS, Legro RS.

Diabetes. 2003 Jan;52(1):214-7.PMID: 12502516 [PubMed - indexed for MEDLINE]Related articlesFree article

The genetics of variation in gene expression.

Cheung VG, Spielman RS.

Nat Genet. 2002 Dec;32 Suppl:522-5. Review.PMID: 12454648 [PubMed - indexed for MEDLINE]Related articles

Bridging genetics and genomics in neurology.

Cheung VG, Spielman RS.

Neurol Clin. 2002 Aug;20(3):867-77, viii. Review.PMID: 12432833 [PubMed - indexed for MEDLINE]Related articles

Linkage and association with type 1 diabetes on chromosome 1q42.

Ewens KG, Johnson LN, Wapelhorst B, O'Brien K, Gutin S, Morrison VA, Street C, Gregory SG, Spielman RS, Concannon P.

Diabetes. 2002 Nov;51(11):3318-25.PMID: 12401725 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression phenotype in heterozygous carriers of ataxia telangiectasia.

Watts JA, Morley M, Burdick JT, Fiori JL, Ewens WJ, Spielman RS, Cheung VG.

Am J Hum Genet. 2002 Oct;71(4):791-800. Epub 2002 Sep 11.PMID: 12226795 [PubMed - indexed for MEDLINE]Related articlesFree article

Locating genes by linkage and association.

Ewens WJ, Spielman RS.

Theor Popul Biol. 2001 Nov;60(3):135-9. No abstract available. PMID: 11855947 [PubMed - indexed for MEDLINE]Related articles

Nuclear and mitochondrial genetic variation in the Yanomamö: a test case for ancient DNA studies of prehistoric populations.

Williams SR, Chagnon NA, Spielman RS.

Am J Phys Anthropol. 2002 Mar;117(3):246-59.PMID: 11842404 [PubMed - indexed for MEDLINE]Related articles

Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.

Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, Spielman RS, Todd JA, Concannon P.

Am J Hum Genet. 2001 Oct;69(4):820-30. Epub 2001 Aug 15.PMID: 11507694 [PubMed - indexed for MEDLINE]Related articlesFree article

Allelic variants of the follistatin gene in polycystic ovary syndrome.

Urbanek M, Wu X, Vickery KR, Kao LC, Christenson LK, Schneyer A, Legro RS, Driscoll DA, Strauss JF 3rd, Dunaif A, Spielman RS.

J Clin Endocrinol Metab. 2000 Dec;85(12):4455-61.PMID: 11134093 [PubMed - indexed for MEDLINE]Related articlesFree article

Searching for the polycystic ovary syndrome genes.

Urbanek M, Legro RS, Driscoll D, Strauss JF 3rd, Dunaif A, Spielman RS.

J Pediatr Endocrinol Metab. 2000;13 Suppl 5:1311-3. Review.PMID: 11117677 [PubMed - indexed for MEDLINE]Related articles

Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin.

Urbanek M, Legro RS, Driscoll DA, Azziz R, Ehrmann DA, Norman RJ, Strauss JF 3rd, Spielman RS, Dunaif A.

Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8573-8.PMID: 10411917 [PubMed - indexed for MEDLINE]Related articlesFree article

TDT clarification.

Spielman RS, Ewens WJ.

Am J Hum Genet. 1999 Feb;64(2):668. No abstract available. PMID: 9973308 [PubMed - indexed for MEDLINE]Related articlesFree article

A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus.

Concannon P, Gogolin-Ewens KJ, Hinds DA, Wapelhorst B, Morrison VA, Stirling B, Mitra M, Farmer J, Williams SR, Cox NJ, Bell GI, Risch N, Spielman RS.

Nat Genet. 1998 Jul;19(3):292-6.PMID: 9662408 [PubMed - indexed for MEDLINE]Related articles

A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test.

Spielman RS, Ewens WJ.

Am J Hum Genet. 1998 Feb;62(2):450-8.PMID: 9463321 [PubMed - indexed for MEDLINE]Related articlesFree article

Linkage-disequilibrium mapping without genotyping.

Cheung VG, Gregg JP, Gogolin-Ewens KJ, Bandong J, Stanley CA, Baker L, Higgins MJ, Nowak NJ, Shows TB, Ewens WJ, Nelson SF, Spielman RS.

Nat Genet. 1998 Mar;18(3):225-30.PMID: 9500543 [PubMed - indexed for MEDLINE]Related articles

The TDT and other family-based tests for linkage disequilibrium and association.

Spielman RS, Ewens WJ.

Am J Hum Genet. 1996 Nov;59(5):983-9. Review. No abstract available. PMID: 8900224 [PubMed - indexed for MEDLINE]Related articlesFree article

Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle.

Yamagata K, Takeda J, Menzel S, Chen X, Eng S, Lim LR, Concannon P, Hanis CL, Spielman RS, Cox NJ, Bell GI.

Diabetologia. 1996 Jun;39(6):725-30.PMID: 8781769 [PubMed - indexed for MEDLINE]Related articles

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DL, Concannon P, Stirling B, Morrison VA, Wapelhorst B, Spielman RS, Gogolin-Ewens KJ, Shepard JM, Williams SR, Risch N, Hinds D, Iwasaki N, Ogata M, Omori Y, Petzold C, Rietzch H, Schröder HE, Schulze J, Cox NJ, Menzel S, Boriraj VV, Chen X, Lim LR, Lindner T, Mereu LE, Wang YQ, Xiang K, Yamagata K, Yang Y, Bell GI.

Nat Genet. 1996 Jun;13(2):161-6.PMID: 8640221 [PubMed - indexed for MEDLINE]Related articles

Harry Harris (1919-94): in memoriam.

Childs B, Spielman RS.

Am J Hum Genet. 1996 Apr;58(4):896-8. No abstract available. PMID: 8644757 [PubMed - indexed for MEDLINE]Related articlesFree article

An approach for identifying simple sequence repeat DNA polymorphisms near cloned cDNAs and genes. Linkage studies of the islet amyloid polypeptide/amylin and liver glycogen synthase genes and NIDDM.

Gambino V, Menzel S, Trabb JB, Xiang KS, Lindner T, Louït A, Chen E, Mereu LE, Furuta H, Iwasaki N, Kawamura M, Omori Y, Rietzsch H, Schulze J, Schröder HE, Concannon P, Hanis CL, Spielman RS, Yamagata K, Cox NJ, Bell GI.

Diabetes. 1996 Mar;45(3):291-4.PMID: 8593932 [PubMed - indexed for MEDLINE]Related articles

Linkage studies in NIDDM with markers near the sulphonylurea receptor gene.

Stirling B, Cox NJ, Bell GI, Hanis CL, Spielman RS, Concannon P.

Diabetologia. 1995 Dec;38(12):1479-81.PMID: 8786023 [PubMed - indexed for MEDLINE]Related articles

Insulin gene 5' flanking polymorphism. Length of class 1 alleles in number of repeat units.

McGinnis RE, Spielman RS.

Diabetes. 1995 Nov;44(11):1296-302.PMID: 7589827 [PubMed - indexed for MEDLINE]Related articles

Insulin expression: is VNTR allele 698 really anomalous?

McGinnis RE, Spielman RS.

Nat Genet. 1995 Aug;10(4):378-80. No abstract available. PMID: 7670485 [PubMed - indexed for MEDLINE]Related articles

The transmission/disequilibrium test: history, subdivision, and admixture.

Ewens WJ, Spielman RS.

Am J Hum Genet. 1995 Aug;57(2):455-64.PMID: 7668272 [PubMed - indexed for MEDLINE]Related articlesFree article