PubMed

Increased muscle PGC-1{alpha} expression protects from sarcopenia and metabolic disease during aging.

Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT.

Proc Natl Acad Sci U S A. 2009 Nov 16. [Epub ahead of print]PMID: 19918075 [PubMed - as supplied by publisher]Related articles

Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.

Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM.

Nature. 2009 Aug 27;460(7259):1154-8. Epub 2009 Jul 29.PMID: 19641492 [PubMed - indexed for MEDLINE]Related articles

Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.

Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM.

Diabetes. 2009 Jul;58(7):1499-508. Epub 2009 Apr 14.PMID: 19366863 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional control of brown adipocyte development and physiological function--of mice and men.

Seale P, Kajimura S, Spiegelman BM.

Genes Dev. 2009 Apr 1;23(7):788-97. Review.PMID: 19339685 [PubMed - indexed for MEDLINE]Related articlesFree article

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. Epub 2008 Dec 9.PMID: 19066218 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell Differentiation.

Farmer SR, Spiegelman BM.

Curr Opin Cell Biol. 2007 Dec;19(6):603-604. Epub 2007 Dec 3. No abstract available. PMID: 19050740 [PubMed]Related articlesFree article

Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.

Girnun GD, Chen L, Silvaggi J, Drapkin R, Chirieac LR, Padera RF, Upadhyay R, Vafai SB, Weissleder R, Mahmood U, Naseri E, Buckley S, Li D, Force J, McNamara K, Demetri G, Spiegelman BM, Wong KK.

Clin Cancer Res. 2008 Oct 15;14(20):6478-86.PMID: 18927287 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype.

Wenz T, Diaz F, Spiegelman BM, Moraes CT.

Cell Metab. 2008 Sep;8(3):249-56.PMID: 18762025 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130.

Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM.

J Biol Chem. 2008 Nov 14;283(46):31960-7. Epub 2008 Aug 26.PMID: 18728005 [PubMed - indexed for MEDLINE]Related articlesFree article

PRDM16 controls a brown fat/skeletal muscle switch.

Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM.

Nature. 2008 Aug 21;454(7207):961-7.PMID: 18719582 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of exercise and PGC1alpha in inflammation and chronic disease.

Handschin C, Spiegelman BM.

Nature. 2008 Jul 24;454(7203):463-9. Review.PMID: 18650917 [PubMed - indexed for MEDLINE]Related articlesFree article

A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis.

Walkey CJ, Spiegelman BM.

J Biol Chem. 2008 Sep 5;283(36):24290-4. Epub 2008 Jul 11.PMID: 18622018 [PubMed - indexed for MEDLINE]Related articlesFree article

Fat and beyond: the diverse biology of PPARgamma.

Tontonoz P, Spiegelman BM.

Annu Rev Biochem. 2008;77:289-312. Review.PMID: 18518822 [PubMed - indexed for MEDLINE]Related articles

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.

Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM.

Genes Dev. 2008 May 15;22(10):1397-409.PMID: 18483224 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.

Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, Spiegelman BM.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4721-6. Epub 2008 Mar 17.PMID: 18347329 [PubMed - indexed for MEDLINE]Related articlesFree article

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.

Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM.

Nature. 2008 Feb 21;451(7181):1008-12.PMID: 18288196 [PubMed - indexed for MEDLINE]Related articles

Transcriptional control of energy homeostasis through the PGC1 coactivators.

Spiegelman BM.

Novartis Found Symp. 2007;286:3-6; discusssion 6-12, 162-3, 196-203.PMID: 18269170 [PubMed - indexed for MEDLINE]Related articles

Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake.

Calvo JA, Daniels TG, Wang X, Paul A, Lin J, Spiegelman BM, Stevenson SC, Rangwala SM.

J Appl Physiol. 2008 May;104(5):1304-12. Epub 2008 Jan 31.PMID: 18239076 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.

Spiegelman BM.

Novartis Found Symp. 2007;287:60-3; discussion 63-9. Review.PMID: 18074631 [PubMed - indexed for MEDLINE]Related articles

Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.

Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM.

J Clin Invest. 2007 Nov;117(11):3463-74.PMID: 17932564 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.

Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, Lebrasseur NK, Yan Z, Spiegelman BM.

J Biol Chem. 2007 Oct 12;282(41):30014-21. Epub 2007 Aug 16.PMID: 17702743 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional control of brown fat determination by PRDM16.

Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM.

Cell Metab. 2007 Jul;6(1):38-54.PMID: 17618855 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.

Jäger S, Handschin C, St-Pierre J, Spiegelman BM.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12017-22. Epub 2007 Jul 3.PMID: 17609368 [PubMed - indexed for MEDLINE]Related articlesFree article

Synergy between PPARgamma ligands and platinum-based drugs in cancer.

Girnun GD, Naseri E, Vafai SB, Qu L, Szwaya JD, Bronson R, Alberta JA, Spiegelman BM.

Cancer Cell. 2007 May;11(5):395-406.PMID: 17482130 [PubMed - indexed for MEDLINE]Related articlesFree article

A fundamental system of cellular energy homeostasis regulated by PGC-1alpha.

Rohas LM, St-Pierre J, Uldry M, Jäger S, Handschin C, Spiegelman BM.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7933-8. Epub 2007 Apr 30.PMID: 17470778 [PubMed - indexed for MEDLINE]Related articlesFree article

PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.

Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM.

Genes Dev. 2007 Apr 1;21(7):770-83.PMID: 17403779 [PubMed - indexed for MEDLINE]Related articlesFree article

"The adipocyte: a multifunctional cell".

Spiegelman BM, Enerbäck S.

Cell Metab. 2006 Dec;4(6):425-7.PMID: 17211937 [PubMed - indexed for MEDLINE]Related articles

The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle.

Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, Chin S, Spiegelman BM.

Cell Metab. 2007 Jan;5(1):35-46.PMID: 17189205 [PubMed - indexed for MEDLINE]Related articles

Adipocytes as regulators of energy balance and glucose homeostasis.

Rosen ED, Spiegelman BM.

Nature. 2006 Dec 14;444(7121):847-53. Review.PMID: 17167472 [PubMed - indexed for MEDLINE]Related articles

Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.

Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB.

Cell Metab. 2006 Dec;4(6):453-64.PMID: 17141629 [PubMed - indexed for MEDLINE]Related articlesFree article

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.

Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W.

Pharmacol Rev. 2006 Dec;58(4):726-41. Review.PMID: 17132851 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.

St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM.

Cell. 2006 Oct 20;127(2):397-408.PMID: 17055439 [PubMed - indexed for MEDLINE]Related articles

PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.

Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH, Goldberg AL, Spiegelman BM.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16260-5. Epub 2006 Oct 19.PMID: 17053067 [PubMed - indexed for MEDLINE]Related articlesFree article

Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.

Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM.

Genes Dev. 2006 Nov 1;20(21):2996-3009. Epub 2006 Oct 18.PMID: 17050673 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.

Handschin C, Spiegelman BM.

Endocr Rev. 2006 Dec;27(7):728-35. Epub 2006 Oct 3. Review.PMID: 17018837 [PubMed - indexed for MEDLINE]Related articlesFree article

Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.

Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10086-91. Epub 2006 Jun 14.PMID: 16775082 [PubMed - indexed for MEDLINE]Related articlesFree article

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.

Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM.

Cell Metab. 2006 May;3(5):333-41.PMID: 16679291 [PubMed - indexed for MEDLINE]Related articles

Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism.

Rhee J, Ge H, Yang W, Fan M, Handschin C, Cooper M, Lin J, Li C, Spiegelman BM.

J Biol Chem. 2006 May 26;281(21):14683-90. Epub 2006 Mar 29.PMID: 16574644 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.

Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM.

Cell. 2005 Aug 26;122(4):505-15.PMID: 16122419 [PubMed - indexed for MEDLINE]Related articles

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.

Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB.

Science. 2005 Aug 12;309(5737):1074-8.PMID: 16099986 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic control through the PGC-1 family of transcription coactivators.

Lin J, Handschin C, Spiegelman BM.

Cell Metab. 2005 Jun;1(6):361-70. Review.PMID: 16054085 [PubMed - indexed for MEDLINE]Related articles

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM.

Cell Metab. 2005 Apr;1(4):259-71.PMID: 16054070 [PubMed - indexed for MEDLINE]Related articles

Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms.

Chen Z, Torrens JI, Anand A, Spiegelman BM, Friedman JM.

Cell Metab. 2005 Feb;1(2):93-106.PMID: 16054051 [PubMed - indexed for MEDLINE]Related articles

Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.

Andersen G, Wegner L, Yanagisawa K, Rose CS, Lin J, Glümer C, Drivsholm T, Borch-Johnsen K, Jørgensen T, Hansen T, Spiegelman BM, Pedersen O.

J Med Genet. 2005 May;42(5):402-7.PMID: 15863669 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P.

Nature. 2005 Mar 3;434(7029):113-8.PMID: 15744310 [PubMed - indexed for MEDLINE]Related articles

Hic-5 regulates an epithelial program mediated by PPARgamma.

Drori S, Girnun GD, Tou L, Szwaya JD, Mueller E, Xia K, Shivdasani RA, Spiegelman BM.

Genes Dev. 2005 Feb 1;19(3):362-75. Erratum in: Genes Dev. 2005 Apr 1;19(7):875. Kia, Xia [corrected to Xia, Kai]. PMID: 15687259 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM.

Cell. 2005 Jan 28;120(2):261-73.PMID: 15680331 [PubMed - indexed for MEDLINE]Related articles

Biological control through regulated transcriptional coactivators.

Spiegelman BM, Heinrich R.

Cell. 2004 Oct 15;119(2):157-67. Review.PMID: 15479634 [PubMed - indexed for MEDLINE]Related articles

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.

Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM.

Cell. 2004 Oct 1;119(1):121-35.PMID: 15454086 [PubMed - indexed for MEDLINE]Related articles

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6570-5. Epub 2004 Apr 20. Erratum in: Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10405. PMID: 15100410 [PubMed - indexed for MEDLINE]Related articlesFree article