PubMed

Rapid onset of seizure suppression with pregabalin adjunctive treatment in patients with partial seizures.

Ramsay RE, Perucca E, Robbins J, Barrett JA, Spiegel K.

Epilepsia. 2009 Aug;50(8):1891-8. Epub 2009 Jun 1.PMID: 19490035 [PubMed - indexed for MEDLINE]Related articles

Effects of poor and short sleep on glucose metabolism and obesity risk.

Spiegel K, Tasali E, Leproult R, Van Cauter E.

Nat Rev Endocrinol. 2009 May;5(5):253-61. Review.PMID: 19444258 [PubMed - indexed for MEDLINE]Related articles

Fluid-dynamic modeling of the human left ventricle: methodology and application to surgical ventricular reconstruction.

Doenst T, Spiegel K, Reik M, Markl M, Hennig J, Nitzsche S, Beyersdorf F, Oertel H.

Ann Thorac Surg. 2009 Apr;87(4):1187-95.PMID: 19324149 [PubMed - indexed for MEDLINE]Related articles

Reduced sleep duration or quality: relationships with insulin resistance and type 2 diabetes.

Tasali E, Leproult R, Spiegel K.

Prog Cardiovasc Dis. 2009 Mar-Apr;51(5):381-91. Review. No abstract available. PMID: 19249444 [PubMed - indexed for MEDLINE]Related articles

Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma.

Franz M, Spiegel K, Umbreit C, Richter P, Codina-Canet C, Berndt A, Altendorf-Hofmann A, Koscielny S, Hyckel P, Kosmehl H, Virtanen I, Berndt A.

Histochem Cell Biol. 2009 May;131(5):651-60. Epub 2009 Feb 6.PMID: 19198871 [PubMed - indexed for MEDLINE]Related articles

Metabolic consequences of sleep and sleep loss.

Van Cauter E, Spiegel K, Tasali E, Leproult R.

Sleep Med. 2008 Sep;9 Suppl 1:S23-8. Review.PMID: 18929315 [PubMed - indexed for MEDLINE]Related articles

Sleep loss as a risk factor for obesity and diabetes.

Spiegel K.

Int J Pediatr Obes. 2008 Oct 1;3 Suppl 2:27-8. No abstract available. PMID: 18850410 [PubMed - indexed for MEDLINE]Related articles

Shiga toxins, and the genes encoding them, in fecal samples from native Idaho ungulates.

Gilbreath JJ, Shields MS, Smith RL, Farrell LD, Sheridan PP, Spiegel KM.

Appl Environ Microbiol. 2009 Feb;75(3):862-5. Epub 2008 Dec 5.PMID: 19060170 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib.

Day E, Waters B, Spiegel K, Alnadaf T, Manley PW, Buchdunger E, Walker C, Jarai G.

Eur J Pharmacol. 2008 Dec 3;599(1-3):44-53. Epub 2008 Oct 11.PMID: 18938156 [PubMed - indexed for MEDLINE]Related articles

Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin.

Briggs DE, Lee CM, Spiegel K, French JA.

Epilepsy Res. 2008 Nov;82(1):86-92. Epub 2008 Aug 26.PMID: 18752932 [PubMed - indexed for MEDLINE]Related articles

Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement.

Calhoun JR, Liu W, Spiegel K, Dal Peraro M, Klein ML, Valentine KG, Wand AJ, DeGrado WF.

Structure. 2008 Feb;16(2):210-5.PMID: 18275812 [PubMed - indexed for MEDLINE]Related articles

Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks.

Lee JE, Reed J, Shields MS, Spiegel KM, Farrell LD, Sheridan PP.

BMC Microbiol. 2007 Dec 4;7:109.PMID: 18053224 [PubMed - indexed for MEDLINE]Related articlesFree article

PCR versus hybridization for detecting virulence genes of enterohemorrhagic Escherichia coli.

Gerrish RS, Lee JE, Reed J, Williams J, Farrell LD, Spiegel KM, Sheridan PP, Shields MS.

Emerg Infect Dis. 2007 Aug;13(8):1253-5.PMID: 17953106 [PubMed - indexed for MEDLINE]Related articlesFree article

Azole-bridged diplatinum anticancer compounds. Modulating DNA flexibility to escape repair mechanism and avoid cross resistance.

Spiegel K, Magistrato A, Carloni P, Reedijk J, Klein ML.

J Phys Chem B. 2007 Oct 18;111(41):11873-6.PMID: 17927270 [PubMed - indexed for MEDLINE]Related articles

Parameterization of azole-bridged dinuclear platinum anticancer drugs via a QM/MM force matching procedure.

Spiegel K, Magistrato A, Maurer P, Ruggerone P, Rothlisberger U, Carloni P, Reedijk J, Klein ML.

J Comput Chem. 2008 Jan 15;29(1):38-49.PMID: 17705162 [PubMed - indexed for MEDLINE]Related articles

The metabolic consequences of sleep deprivation.

Knutson KL, Spiegel K, Penev P, Van Cauter E.

Sleep Med Rev. 2007 Jun;11(3):163-78. Epub 2007 Apr 17. Review.PMID: 17442599 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of sleep and sleep loss on neuroendocrine and metabolic function.

Van Cauter E, Holmback U, Knutson K, Leproult R, Miller A, Nedeltcheva A, Pannain S, Penev P, Tasali E, Spiegel K.

Horm Res. 2007;67 Suppl 1:2-9. Epub 2007 Feb 15. Review.PMID: 17308390 [PubMed - indexed for MEDLINE]Related articles

The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders.

Parmentier R, Anaclet C, Guhennec C, Brousseau E, Bricout D, Giboulot T, Bozyczko-Coyne D, Spiegel K, Ohtsu H, Williams M, Lin JS.

Biochem Pharmacol. 2007 Apr 15;73(8):1157-71. Epub 2007 Jan 7.PMID: 17288995 [PubMed - indexed for MEDLINE]Related articles

Modeling the charge distribution at metal sites in proteins for molecular dynamics simulations.

Dal Peraro M, Spiegel K, Lamoureux G, De Vivo M, DeGrado WF, Klein ML.

J Struct Biol. 2007 Mar;157(3):444-53. Epub 2006 Oct 27.PMID: 17188512 [PubMed - indexed for MEDLINE]Related articles

Structural and dynamical properties of manganese catalase and the synthetic protein DF1 and their implication for reactivity from classical molecular dynamics calculations.

Spiegel K, De Grado WF, Klein ML.

Proteins. 2006 Nov 1;65(2):317-30.PMID: 16917908 [PubMed - indexed for MEDLINE]Related articles

Modeling anticancer drug-DNA interactions via mixed QM/MM molecular dynamics simulations.

Spiegel K, Magistrato A.

Org Biomol Chem. 2006 Jul 7;4(13):2507-17. Epub 2006 May 17.PMID: 16791311 [PubMed - indexed for MEDLINE]Related articlesFree article

Ab initio calculations of intramolecular parameters for a class of arylamide polymers.

Vemparala S, Ivanov I, Pophristic V, Spiegel K, Klein ML.

J Comput Chem. 2006 Apr 30;27(6):693-700.PMID: 16634095 [PubMed - indexed for MEDLINE]Related articles

Duocarmycins binding to DNA investigated by molecular simulation.

Spiegel K, Rothlisberger U, Carloni P.

J Phys Chem B. 2006 Mar 2;110(8):3647-60.PMID: 16494420 [PubMed - indexed for MEDLINE]Related articles

Binding of novel azole-bridged dinuclear platinum(II) anticancer drugs to DNA: insights from hybrid QM/MM molecular dynamics simulations.

Magistrato A, Ruggerone P, Spiegel K, Carloni P, Reedijk J.

J Phys Chem B. 2006 Mar 2;110(8):3604-13.PMID: 16494416 [PubMed - indexed for MEDLINE]Related articles

Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes.

Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E.

J Appl Physiol. 2005 Nov;99(5):2008-19. Review.PMID: 16227462 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of carbohydrate-rich meals on plasma epinephrine levels: dysregulation with aging.

Penev P, Spiegel K, Marcinkowski T, Van Cauter E.

J Clin Endocrinol Metab. 2005 Nov;90(11):6198-206. Epub 2005 Aug 9.PMID: 16091491 [PubMed - indexed for MEDLINE]Related articlesFree article

Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite.

Spiegel K, Tasali E, Penev P, Van Cauter E.

Ann Intern Med. 2004 Dec 7;141(11):846-50.PMID: 15583226 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin.

Spiegel K, Leproult R, L'hermite-Balériaux M, Copinschi G, Penev PD, Van Cauter E.

J Clin Endocrinol Metab. 2004 Nov;89(11):5762-71.PMID: 15531540 [PubMed - indexed for MEDLINE]Related articlesFree article

Green oxidation catalysts: computational design of high-efficiency models of galactose oxidase.

Guidoni L, Spiegel K, Zumstein M, Röthlisberger U.

Angew Chem Int Ed Engl. 2004 Jun 21;43(25):3286-9. No abstract available. PMID: 15213955 [PubMed - indexed for MEDLINE]Related articles

Reciprocal interactions between the GH axis and sleep.

Van Cauter E, Latta F, Nedeltcheva A, Spiegel K, Leproult R, Vandenbril C, Weiss R, Mockel J, Legros JJ, Copinschi G.

Growth Horm IGF Res. 2004 Jun;14 Suppl A:S10-7. Review.PMID: 15135771 [PubMed - indexed for MEDLINE]Related articles

[Impact of sleep debt on physiological rhythms]

Spiegel K, Leproult R, Van Cauter E.

Rev Neurol (Paris). 2003 Nov;159(11 Suppl):6S11-20. French. PMID: 14646794 [PubMed - indexed for MEDLINE]Related articles

Functional requirement for symmetric assembly of archaeal box C/D small ribonucleoprotein particles.

Rashid R, Aittaleb M, Chen Q, Spiegel K, Demeler B, Li H.

J Mol Biol. 2003 Oct 17;333(2):295-306. Erratum in: J Mol Biol. 2004 Sep 24;342(4):1347. PMID: 14529617 [PubMed - indexed for MEDLINE]Related articles

Relationship between REM sleep and testosterone secretion in older men.

Penev P, Spiegel K, L'Hermite-Balériaux M, Schneider R, Van Cauter E.

Ann Endocrinol (Paris). 2003 Apr;64(2):157. No abstract available. PMID: 12773954 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.

Raja SM, Wang B, Dantuluri M, Desai UR, Demeler B, Spiegel K, Metkar SS, Froelich CJ.

J Biol Chem. 2002 Dec 20;277(51):49523-30. Epub 2002 Oct 17.PMID: 12388539 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of sleep deprivation on response to immunization.

Spiegel K, Sheridan JF, Van Cauter E.

JAMA. 2002 Sep 25;288(12):1471-2. No abstract available. PMID: 12243633 [PubMed - indexed for MEDLINE]Related articles

Analysis of fatty acid ethyl esters in hair as possible markers of chronically elevated alcohol consumption by headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS).

Pragst F, Auwaerter V, Sporkert F, Spiegel K.

Forensic Sci Int. 2001 Sep 15;121(1-2):76-88.PMID: 11516891 [PubMed - indexed for MEDLINE]Related articles

On the similarity of properties in solution or in the crystalline state: a molecular dynamics study of hen lysozyme.

Stocker U, Spiegel K, van Gunsteren WF.

J Biomol NMR. 2000 Sep;18(1):1-12.PMID: 11061223 [PubMed - indexed for MEDLINE]Related articles

Adaptation of the 24-h growth hormone profile to a state of sleep debt.

Spiegel K, Leproult R, Colecchia EF, L'Hermite-Balériaux M, Nie Z, Copinschi G, Van Cauter E.

Am J Physiol Regul Integr Comp Physiol. 2000 Sep;279(3):R874-83.PMID: 10956244 [PubMed - indexed for MEDLINE]Related articles

Doxepin toxicity in a child following topical administration.

Zell-Kanter M, Toerne TS, Spiegel K, Negrusz A.

Ann Pharmacother. 2000 Mar;34(3):328-9.PMID: 10917379 [PubMed - indexed for MEDLINE]Related articles

The role of complement in Alzheimer's disease pathology.

Emmerling MR, Watson MD, Raby CA, Spiegel K.

Biochim Biophys Acta. 2000 Jul 26;1502(1):158-71. Review.PMID: 10899441 [PubMed - indexed for MEDLINE]Related articles

Traumatic brain injury elevates the Alzheimer's amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury.

Emmerling MR, Morganti-Kossmann MC, Kossmann T, Stahel PF, Watson MD, Evans LM, Mehta PD, Spiegel K, Kuo YM, Roher AE, Raby CA.

Ann N Y Acad Sci. 2000 Apr;903:118-22.PMID: 10818496 [PubMed - indexed for MEDLINE]Related articles

CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology.

Tecle H, Schwarz RD, Barrett SD, Callahan MJ, Caprathe BW, Davis RE, Doyle P, Emmerling M, Lauffer DJ, Mirzadegan T, Moreland DW, Lipiniski W, Nelson C, Raby C, Spencer C, Spiegel K, Thomas AJ, Jaen JC.

Pharm Acta Helv. 2000 Mar;74(2-3):141-8.PMID: 10812951 [PubMed - indexed for MEDLINE]Related articles

The cholinergic deficit coincides with Abeta deposition at the earliest histopathologic stages of Alzheimer disease.

Beach TG, Kuo YM, Spiegel K, Emmerling MR, Sue LI, Kokjohn K, Roher AE.

J Neuropathol Exp Neurol. 2000 Apr;59(4):308-13.PMID: 10759186 [PubMed - indexed for MEDLINE]Related articles

Pathophysiology of human circadian rhythms.

Copinschi G, Spiegel K, Leproult R, Van Cauter E.

Novartis Found Symp. 2000;227:143-57; discussion 157-62. Review.PMID: 10752069 [PubMed - indexed for MEDLINE]Related articles

Are there possibilities for the detection of chronically elevated alcohol consumption by hair analysis? A report about the state of investigation.

Pragst F, Spiegel K, Sporkert F, Bohnenkamp M.

Forensic Sci Int. 2000 Jan 10;107(1-3):201-23.PMID: 10689573 [PubMed - indexed for MEDLINE]Related articles

Sleep as a mediator of the relationship between socioeconomic status and health: a hypothesis.

Van Cauter E, Spiegel K.

Ann N Y Acad Sci. 1999;896:254-61.PMID: 10681902 [PubMed - indexed for MEDLINE]Related articles

Impact of sleep debt on metabolic and endocrine function.

Spiegel K, Leproult R, Van Cauter E.

Lancet. 1999 Oct 23;354(9188):1435-9.PMID: 10543671 [PubMed - indexed for MEDLINE]Related articles

Detection of 6-acetylmorphine in vitreous humor and cerebrospinal fluid--comparison with urinary analysis for proving heroin administration in opiate fatalities.

Pragst F, Spiegel K, Leuschner U, Hager A.

J Anal Toxicol. 1999 May-Jun;23(3):168-72.PMID: 10369325 [PubMed - indexed for MEDLINE]Related articles

Lactoferrin increases the output of neutrophil precursors and attenuates the spontaneous production of TNF-alpha and IL-6 by peripheral blood cells.

Zimecki M, Spiegel K, Właszczyk A, Kübler A, Kruzel ML.

Arch Immunol Ther Exp (Warsz). 1999;47(2):113-8.PMID: 10202564 [PubMed - indexed for MEDLINE]Related articles

Traumatic brain injury increases beta-amyloid peptide 1-42 in cerebrospinal fluid.

Raby CA, Morganti-Kossmann MC, Kossmann T, Stahel PF, Watson MD, Evans LM, Mehta PD, Spiegel K, Kuo YM, Roher AE, Emmerling MR.

J Neurochem. 1998 Dec;71(6):2505-9.PMID: 9832149 [PubMed - indexed for MEDLINE]Related articles