PubMed

Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence intensity.

Kim SR, Jang YP, Sparrow JR.

Vision Res. 2009 Oct 1. [Epub ahead of print]PMID: 19800359 [PubMed - as supplied by publisher]Related articles

Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin.

Vasireddy V, Jablonski MM, Khan NW, Wang XF, Sahu P, Sparrow JR, Ayyagari R.

Exp Eye Res. 2009 Dec;89(6):905-12. Epub 2009 Aug 13.PMID: 19682985 [PubMed - in process]Related articles

Phospholipid meets all-trans-retinal: the making of RPE bisretinoids.

Sparrow JR, Wu Y, Kim CY, Zhou J.

J Lipid Res. 2009 Aug 7. [Epub ahead of print]PMID: 19666736 [PubMed - as supplied by publisher]Related articlesFree article

Rdh12 activity and effects on retinoid processing in the murine retina.

Chrispell JD, Feathers KL, Kane MA, Kim CY, Brooks M, Khanna R, Kurth I, Hübner CA, Gal A, Mears AJ, Swaroop A, Napoli JL, Sparrow JR, Thompson DA.

J Biol Chem. 2009 Aug 7;284(32):21468-77. Epub 2009 Jun 8.PMID: 19506076 [PubMed - indexed for MEDLINE]Related articles

Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease.

Wu Y, Fishkin NE, Pande A, Pande J, Sparrow JR.

J Biol Chem. 2009 Jul 24;284(30):20155-66. Epub 2009 May 28.PMID: 19478335 [PubMed - indexed for MEDLINE]Related articles

Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells.

Damek-Poprawa M, Diemer T, Lopes VS, Lillo C, Harper DC, Marks MS, Wu Y, Sparrow JR, Rachel RA, Williams DS, Boesze-Battaglia K.

J Biol Chem. 2009 Apr 17;284(16):10877-89. Epub 2009 Feb 23.PMID: 19240024 [PubMed - indexed for MEDLINE]Related articles

Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli.

Lukinova N, Iacovelli J, Dentchev T, Wolkow N, Hunter A, Amado D, Ying GS, Sparrow JR, Dunaief JL.

Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1440-7. Epub 2009 Jan 31.PMID: 19182262 [PubMed - indexed for MEDLINE]Related articles

Involvement of c-Abl, p53 and the MAP kinase JNK in the cell death program initiated in A2E-laden ARPE-19 cells by exposure to blue light.

Westlund BS, Cai B, Zhou J, Sparrow JR.

Apoptosis. 2009 Jan;14(1):31-41.PMID: 19052872 [PubMed - indexed for MEDLINE]Related articles

Complement activation by bisretinoid constituents of RPE lipofuscin.

Zhou J, Kim SR, Westlund BS, Sparrow JR.

Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1392-9. Epub 2008 Nov 21.PMID: 19029031 [PubMed - indexed for MEDLINE]Related articles

Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy.

Kong J, Kim SR, Binley K, Pata I, Doi K, Mannik J, Zernant-Rajang J, Kan O, Iqball S, Naylor S, Sparrow JR, Gouras P, Allikmets R.

Gene Ther. 2008 Oct;15(19):1311-20. Epub 2008 May 8.PMID: 18463687 [PubMed - indexed for MEDLINE]Related articles

Mechanisms involved in A2E oxidation.

Kim SR, Jockusch S, Itagaki Y, Turro NJ, Sparrow JR.

Exp Eye Res. 2008 Jun;86(6):975-82. Epub 2008 Mar 28.PMID: 18439997 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal pigment epithelium lipofuscin proteomics.

Ng KP, Gugiu B, Renganathan K, Davies MW, Gu X, Crabb JS, Kim SR, Rózanowska MB, Bonilha VL, Rayborn ME, Salomon RG, Sparrow JR, Boulton ME, Hollyfield JG, Crabb JW.

Mol Cell Proteomics. 2008 Jul;7(7):1397-405. Epub 2008 Apr 24.PMID: 18436525 [PubMed - indexed for MEDLINE]Related articlesFree article

Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice.

Allocca M, Doria M, Petrillo M, Colella P, Garcia-Hoyos M, Gibbs D, Kim SR, Maguire A, Rex TS, Di Vicino U, Cutillo L, Sparrow JR, Williams DS, Bennett J, Auricchio A.

J Clin Invest. 2008 May;118(5):1955-64.PMID: 18414684 [PubMed - indexed for MEDLINE]Related articlesFree article

The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells.

Zhang X, Zhou J, Fernandes AF, Sparrow JR, Pereira P, Taylor A, Shang F.

Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3622-30. Epub 2008 Apr 11.PMID: 18408178 [PubMed - indexed for MEDLINE]Related articlesFree article

A2E, a pigment of RPE lipofuscin, is generated from the precursor, A2PE by a lysosomal enzyme activity.

Sparrow JR, Kim SR, Cuervo AM, Bandhyopadhyayand U.

Adv Exp Med Biol. 2008;613:393-8. No abstract available. PMID: 18188969 [PubMed - indexed for MEDLINE]Related articles

OT-674 suppresses photooxidative processes initiated by an RPE lipofuscin fluorophore.

Zhou J, Jang YP, Chang S, Sparrow JR.

Photochem Photobiol. 2008 Jan-Feb;84(1):75-80.PMID: 18173705 [PubMed - indexed for MEDLINE]Related articles

The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model.

Kim SR, Jang YP, Jockusch S, Fishkin NE, Turro NJ, Sparrow JR.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19273-8. Epub 2007 Nov 28.PMID: 18048333 [PubMed - indexed for MEDLINE]Related articlesFree article

SOD2 knockdown mouse model of early AMD.

Justilien V, Pang JJ, Renganathan K, Zhan X, Crabb JW, Kim SR, Sparrow JR, Hauswirth WW, Lewin AS.

Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4407-20.PMID: 17898259 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunochemical recognition of A2E, a pigment in the lipofuscin of retinal pigment epithelial cells.

Abeywickrama C, Matsuda H, Jockusch S, Zhou J, Jang YP, Chen BX, Itagaki Y, Erlanger BF, Nakanishi K, Turro NJ, Sparrow JR.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14610-5. Epub 2007 Sep 5.PMID: 17804788 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway.

Kim SR, He J, Yanase E, Jang YP, Berova N, Sparrow JR, Nakanishi K.

Biochemistry. 2007 Sep 4;46(35):10122-9. Epub 2007 Aug 8.PMID: 17685561 [PubMed - indexed for MEDLINE]Related articlesFree article

Chlorophyll derivatives as visual pigments for super vision in the red.

Washington I, Zhou J, Jockusch S, Turro NJ, Nakanishi K, Sparrow JR.

Photochem Photobiol Sci. 2007 Jul;6(7):775-9. Epub 2007 May 1.PMID: 17609771 [PubMed - indexed for MEDLINE]Related articles

Scotopic sensitivity and color vision with a blue-light-absorbing intraocular lens.

Greenstein VC, Chiosi F, Baker P, Seiple W, Holopigian K, Braunstein RE, Sparrow JR.

J Cataract Refract Surg. 2007 Apr;33(4):667-72.PMID: 17397741 [PubMed - indexed for MEDLINE]Related articlesFree article

A2E, a fluorophore of RPE lipofuscin, can destabilize membrane.

Sparrow JR, Cai B, Jang YP, Zhou J, Nakanishi K.

Adv Exp Med Biol. 2006;572:63-8. No abstract available. PMID: 17249556 [PubMed - indexed for MEDLINE]Related articles

Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium.

Zhou J, Jang YP, Kim SR, Sparrow JR.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16182-7. Epub 2006 Oct 23.PMID: 17060630 [PubMed - indexed for MEDLINE]Related articlesFree article

Indirect antioxidant protection against photooxidative processes initiated in retinal pigment epithelial cells by a lipofuscin pigment.

Zhou J, Gao X, Cai B, Sparrow JR.

Rejuvenation Res. 2006 Summer;9(2):256-63.PMID: 16706653 [PubMed - indexed for MEDLINE]Related articles

Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation.

Maiti P, Kong J, Kim SR, Sparrow JR, Allikmets R, Rando RR.

Biochemistry. 2006 Jan 24;45(3):852-60. Erratum in: Biochemistry. 2007 Jul 24;46(29):8700. PMID: 16411761 [PubMed - indexed for MEDLINE]Related articles

Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin.

Kim SR, Nakanishi K, Itagaki Y, Sparrow JR.

Exp Eye Res. 2006 May;82(5):828-39. Epub 2005 Dec 20.PMID: 16364293 [PubMed - indexed for MEDLINE]Related articles

Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin.

Jang YP, Matsuda H, Itagaki Y, Nakanishi K, Sparrow JR.

J Biol Chem. 2005 Dec 2;280(48):39732-9. Epub 2005 Sep 26.PMID: 16186115 [PubMed - indexed for MEDLINE]Related articlesFree article

Autofluorescence characteristics of normal foveas and reconstruction of foveal autofluorescence from limited data subsets.

Smith RT, Koniarek JP, Chan J, Nagasaki T, Sparrow JR, Langton K.

Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2940-6.PMID: 16043869 [PubMed - indexed for MEDLINE]Related articlesFree article

Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases.

de Grey AD, Alvarez PJ, Brady RO, Cuervo AM, Jerome WG, McCarty PL, Nixon RA, Rittmann BE, Sparrow JR.

Ageing Res Rev. 2005 Aug;4(3):315-38. Review.PMID: 16040282 [PubMed - indexed for MEDLINE]Related articles

Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate.

Fishkin NE, Sparrow JR, Allikmets R, Nakanishi K.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7091-6. Epub 2005 May 3.PMID: 15870200 [PubMed - indexed for MEDLINE]Related articlesFree article

RPE lipofuscin and its role in retinal pathobiology.

Sparrow JR, Boulton M.

Exp Eye Res. 2005 May;80(5):595-606. Review.PMID: 15862166 [PubMed - indexed for MEDLINE]Related articles

A blue-blocking intraocular lens should be used in cataract surgery.

Braunstein RE, Sparrow JR.

Arch Ophthalmol. 2005 Apr;123(4):547-9. Review. No abstract available. PMID: 15824231 [PubMed - indexed for MEDLINE]Related articles

Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells.

Zhou J, Cai B, Jang YP, Pachydaki S, Schmidt AM, Sparrow JR.

Exp Eye Res. 2005 Apr;80(4):567-80.PMID: 15781285 [PubMed - indexed for MEDLINE]Related articles

Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells.

Jang YP, Zhou J, Nakanishi K, Sparrow JR.

Photochem Photobiol. 2005 May-Jun;81(3):529-36.PMID: 15745429 [PubMed - indexed for MEDLINE]Related articlesFree article

A method of drusen measurement based on reconstruction of fundus background reflectance.

Smith RT, Chan JK, Nagasaki T, Sparrow JR, Barbazetto I.

Br J Ophthalmol. 2005 Jan;89(1):87-91.PMID: 15615753 [PubMed - indexed for MEDLINE]Related articlesFree article

Absolute configurational determination of an all-trans-retinal dimer isolated from photoreceptor outer segments.

Fishkin N, Pescitelli G, Sparrow JR, Nakanishi K, Berova N.

Chirality. 2004 Nov;16(9):637-41.PMID: 15382205 [PubMed - indexed for MEDLINE]Related articles

Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

Kim SR, Fishkin N, Kong J, Nakanishi K, Allikmets R, Sparrow JR.

Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11668-72. Epub 2004 Jul 26.PMID: 15277666 [PubMed - indexed for MEDLINE]Related articlesFree article

A2E, a fluorophore of RPE lipofuscin: can it cause RPE degeneration?

Sparrow JR, Cai B, Fishkin N, Jang YP, Krane S, Vollmer HR, Zhou J, Nakanishi K.

Adv Exp Med Biol. 2003;533:205-11. Review. No abstract available. PMID: 15180266 [PubMed - indexed for MEDLINE]Related articles

Blue light-absorbing intraocular lens and retinal pigment epithelium protection in vitro.

Sparrow JR, Miller AS, Zhou J.

J Cataract Refract Surg. 2004 Apr;30(4):873-8.PMID: 15093654 [PubMed - indexed for MEDLINE]Related articles

Photochemistry of A1E, a retinoid with a conjugated pyridinium moiety: competition between pericyclic photooxygenation and pericyclization.

Jockusch S, Ren RX, Jang YP, Itagaki Y, Vollmer-Snarr HR, Sparrow JR, Nakanishi K, Turro NJ.

J Am Chem Soc. 2004 Apr 14;126(14):4646-52.PMID: 15070381 [PubMed - indexed for MEDLINE]Related articles

Photographic patterns in macular images: representation by a mathematical model.

Smith RT, Nagasaki T, Sparrow JR, Barbazetto I, Koniarek JP, Bickmann LJ.

J Biomed Opt. 2004 Jan-Feb;9(1):162-72.PMID: 14715069 [PubMed - indexed for MEDLINE]Related articles

How much blue light should an IOL transmit?

Mainster MA, Sparrow JR.

Br J Ophthalmol. 2003 Dec;87(12):1523-9.PMID: 14660465 [PubMed - indexed for MEDLINE]Related articlesFree article

A2E, a byproduct of the visual cycle.

Sparrow JR, Fishkin N, Zhou J, Cai B, Jang YP, Krane S, Itagaki Y, Nakanishi K.

Vision Res. 2003 Dec;43(28):2983-90. Review.PMID: 14611934 [PubMed - indexed for MEDLINE]Related articles

A2-rhodopsin: a new fluorophore isolated from photoreceptor outer segments.

Fishkin N, Jang YP, Itagaki Y, Sparrow JR, Nakanishi K.

Org Biomol Chem. 2003 Apr 7;1(7):1101-5.PMID: 12926382 [PubMed - indexed for MEDLINE]Related articles

A method of drusen measurement based on the geometry of fundus reflectance.

Smith RT, Nagasaki T, Sparrow JR, Barbazetto I, Klaver CC, Chan JK.

Biomed Eng Online. 2003 Apr 18;2:10.PMID: 12740042 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA is a target of the photodynamic effects elicited in A2E-laden RPE by blue-light illumination.

Sparrow JR, Zhou J, Cai B.

Invest Ophthalmol Vis Sci. 2003 May;44(5):2245-51.PMID: 12714667 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapy for macular degeneration: insights from acne.

Sparrow JR.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4353-4. Epub 2003 Apr 7. No abstract available. PMID: 12682280 [PubMed - indexed for MEDLINE]Related articlesFree article

A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation.

Sparrow JR, Vollmer-Snarr HR, Zhou J, Jang YP, Jockusch S, Itagaki Y, Nakanishi K.

J Biol Chem. 2003 May 16;278(20):18207-13. Epub 2003 Mar 19.PMID: 12646558 [PubMed - indexed for MEDLINE]Related articlesFree article

Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement.

Ben-Shabat S, Itagaki Y, Jockusch S, Sparrow JR, Turro NJ, Nakanishi K.

Angew Chem Int Ed Engl. 2002 Mar 1;41(5):814-7. No abstract available. PMID: 12491345 [PubMed - indexed for MEDLINE]Related articles