PubMed

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.

Yamada M, Yoshida Y, Mori D, Takitoh T, Kengaku M, Umeshima H, Takao K, Miyakawa T, Sato M, Sorimachi H, Wynshaw-Boris A, Hirotsune S.

Nat Med. 2009 Oct;15(10):1202-7. Epub 2009 Sep 6.PMID: 19734909 [PubMed - indexed for MEDLINE]Related articles

Single-cell chemical lysis method for analyses of intracellular molecules using an array of picoliter-scale microwells.

Sasuga Y, Iwasawa T, Terada K, Oe Y, Sorimachi H, Ohara O, Harada Y.

Anal Chem. 2008 Dec 1;80(23):9141-9.PMID: 19551983 [PubMed]Related articles

Metabolism of amyloid precursor protein in COS cells transfected with a beta-secretase candidate.

Koike H, Kouchi Z, Kinouchi T, Maeda T, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Suzuki K, Ishiura S.

Cytotechnology. 2000 Jul;33(1-3):213-9.PMID: 19002828 [PubMed - in process]Related articles

Single-Cell Chemical Lysis Method for Analyses of Intracellular Molecules Using an Array of Picoliter-Scale Microwells.

Sasuga Y, Iwasawa T, Terada K, Oe Y, Sorimachi H, Ohara O, Harada Y.

Anal Chem. 2008 Nov 5. [Epub ahead of print]PMID: 18983178 [PubMed - as supplied by publisher]Related articles

Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle.

Hayashi C, Ono Y, Doi N, Kitamura F, Tagami M, Mineki R, Arai T, Taguchi H, Yanagida M, Hirner S, Labeit D, Labeit S, Sorimachi H.

J Biol Chem. 2008 May 23;283(21):14801-14. Epub 2008 Feb 29.PMID: 18310072 [PubMed - indexed for MEDLINE]Related articlesFree article

The importance of conserved amino acid residues in p94 protease sub-domain IIb and the IS2 region for constitutive autolysis.

Ono Y, Hayashi C, Doi N, Tagami M, Sorimachi H.

FEBS Lett. 2008 Mar 5;582(5):691-8. Epub 2008 Feb 5.PMID: 18258189 [PubMed - indexed for MEDLINE]Related articles

Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.

Koyama S, Hata S, Witt CC, Ono Y, Lerche S, Ojima K, Chiba T, Doi N, Kitamura F, Tanaka K, Abe K, Witt SH, Rybin V, Gasch A, Franz T, Labeit S, Sorimachi H.

J Mol Biol. 2008 Mar 7;376(5):1224-36. Epub 2007 Nov 22.PMID: 18222470 [PubMed - indexed for MEDLINE]Related articles

Asymmetric hydrogenation of aromatic, aliphatic, and alpha,beta-unsaturated acyl silanes catalyzed by Tol-binap/Pica ruthenium(II) complexes: practical synthesis of optically active alpha-hydroxysilanes.

Arai N, Suzuki K, Sugizaki S, Sorimachi H, Ohkuma T.

Angew Chem Int Ed Engl. 2008;47(9):1770-3. No abstract available. PMID: 18213562 [PubMed]Related articles

Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.

Hata S, Doi N, Kitamura F, Sorimachi H.

J Biol Chem. 2007 Sep 21;282(38):27847-56. Epub 2007 Jul 23.PMID: 17646163 [PubMed - indexed for MEDLINE]Related articlesFree article

Comprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94.

Ono Y, Hayashi C, Doi N, Kitamura F, Shindo M, Kudo K, Tsubata T, Yanagida M, Sorimachi H.

Biotechnol J. 2007 May;2(5):565-76.PMID: 17373644 [PubMed - indexed for MEDLINE]Related articlesFree article

Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain.

Ojima K, Ono Y, Doi N, Yoshioka K, Kawabata Y, Labeit S, Sorimachi H.

J Biol Chem. 2007 May 11;282(19):14493-504. Epub 2007 Mar 19.PMID: 17371879 [PubMed - indexed for MEDLINE]Related articlesFree article

[New biology of calpain in relation with intracellular membrane systems]

Hata S, Sorimachi H.

Seikagaku. 2007 Jan;79(1):46-50. Review. Japanese. No abstract available. PMID: 17319514 [PubMed - indexed for MEDLINE]Related articles

Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation.

Kamei H, Saito T, Ozawa M, Fujita Y, Asada A, Bibb JA, Saido TC, Sorimachi H, Hisanaga S.

J Biol Chem. 2007 Jan 19;282(3):1687-94. Epub 2006 Nov 22.PMID: 17121855 [PubMed - indexed for MEDLINE]Related articlesFree article

Neoculin, a taste-modifying protein, is recognized by human sweet taste receptor.

Nakajima K, Asakura T, Oike H, Morita Y, Shimizu-Ibuka A, Misaka T, Sorimachi H, Arai S, Abe K.

Neuroreport. 2006 Aug 21;17(12):1241-4.PMID: 16951562 [PubMed - indexed for MEDLINE]Related articles

Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region.

Takahara T, Hara K, Yonezawa K, Sorimachi H, Maeda T.

J Biol Chem. 2006 Sep 29;281(39):28605-14. Epub 2006 Jul 26.PMID: 16870609 [PubMed - indexed for MEDLINE]Related articlesFree article

Calpain system regulates the differentiation of adult primitive mesenchymal ST-13 adipocytes.

Yajima Y, Sato M, Sorimachi H, Inomata M, Maki M, Kawashima S.

Endocrinology. 2006 Oct;147(10):4811-9. Epub 2006 Jul 20.PMID: 16857754 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular production of neoculin, a sweet-tasting heterodimeric protein with taste-modifying activity, by Aspergillus oryzae.

Nakajima K, Asakura T, Maruyama J, Morita Y, Oike H, Shimizu-Ibuka A, Misaka T, Sorimachi H, Arai S, Kitamoto K, Abe K.

Appl Environ Microbiol. 2006 May;72(5):3716-23.PMID: 16672522 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.

Ono Y, Torii F, Ojima K, Doi N, Yoshioka K, Kawabata Y, Labeit D, Labeit S, Suzuki K, Abe K, Maeda T, Sorimachi H.

J Biol Chem. 2006 Jul 7;281(27):18519-31. Epub 2006 Apr 20.PMID: 16627476 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystal structure of neoculin: insights into its sweetness and taste-modifying activity.

Shimizu-Ibuka A, Morita Y, Terada T, Asakura T, Nakajima K, Iwata S, Misaka T, Sorimachi H, Arai S, Abe K.

J Mol Biol. 2006 May 26;359(1):148-58. Epub 2006 Mar 29.PMID: 16616933 [PubMed - indexed for MEDLINE]Related articles

Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP.

Hata S, Koyama S, Kawahara H, Doi N, Maeda T, Toyama-Sorimachi N, Abe K, Suzuki K, Sorimachi H.

J Biol Chem. 2006 Apr 21;281(16):11214-24. Epub 2006 Feb 13.PMID: 16476741 [PubMed - indexed for MEDLINE]Related articlesFree article

Possible functions of p94 in connectin-mediated signaling pathways in skeletal muscle cells.

Ojima K, Ono Y, Hata S, Koyama S, Doi N, Sorimachi H.

J Muscle Res Cell Motil. 2005;26(6-8):409-17.PMID: 16453164 [PubMed - indexed for MEDLINE]Related articles

Aspergillus oryzae palBory encodes a calpain-like protease: homology to Emericella nidulans PalB and conservation of functional regions.

Futai E, Sorimachi H, Jeong SY, Kitamoto K, Ishiura S, Suzuki K.

J Biosci Bioeng. 1999;88(4):438-40.PMID: 16232641 [PubMed]Related articles

Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway.

Hayashi M, Fukuzawa T, Sorimachi H, Maeda T.

Mol Cell Biol. 2005 Nov;25(21):9478-90.PMID: 16227598 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner.

Toyama-Sorimachi N, Omatsu Y, Onoda A, Tsujimura Y, Iyoda T, Kikuchi-Maki A, Sorimachi H, Dohi T, Taki S, Inaba K, Karasuyama H.

J Immunol. 2005 Apr 15;174(8):4621-9.PMID: 15814685 [PubMed - indexed for MEDLINE]Related articlesFree article

Degradation of fodrin by m-calpain in fibroblasts adhering to fibrillar collagen I gel.

Sato K, Hattori S, Irie S, Sorimachi H, Inomata M, Kawashima S.

J Biochem. 2004 Dec;136(6):777-85.PMID: 15671488 [PubMed - indexed for MEDLINE]Related articles

Neoculin as a new taste-modifying protein occurring in the fruit of Curculigo latifolia.

Shirasuka Y, Nakajima K, Asakura T, Yamashita H, Yamamoto A, Hata S, Nagata S, Abo M, Sorimachi H, Abe K.

Biosci Biotechnol Biochem. 2004 Jun;68(6):1403-7.PMID: 15215616 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure, activation, and biology of calpain.

Suzuki K, Hata S, Kawabata Y, Sorimachi H.

Diabetes. 2004 Feb;53 Suppl 1:S12-8. Review.PMID: 14749260 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.

Witt CC, Ono Y, Puschmann E, McNabb M, Wu Y, Gotthardt M, Witt SH, Haak M, Labeit D, Gregorio CC, Sorimachi H, Granzier H, Labeit S.

J Mol Biol. 2004 Feb 6;336(1):145-54.PMID: 14741210 [PubMed - indexed for MEDLINE]Related articles

Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the alpha-glucosidase C gene.

Kawabata Y, Hata S, Ono Y, Ito Y, Suzuki K, Abe K, Sorimachi H.

FEBS Lett. 2003 Dec 18;555(3):623-30. Erratum in: FEBS Lett. 2004 Jan 16;557(1-3):293. PMID: 14675785 [PubMed - indexed for MEDLINE]Related articles

Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3.

Ono Y, Kakinuma K, Torii F, Irie A, Nakagawa K, Labeit S, Abe K, Suzuki K, Sorimachi H.

J Biol Chem. 2004 Jan 23;279(4):2761-71. Epub 2003 Nov 1.PMID: 14594950 [PubMed - indexed for MEDLINE]Related articlesFree article

Heterogeneous nuclear ribonucleoprotein K interacts with and is proteolyzed by calpain in vivo.

Kimura E, Abe K, Suzuki K, Sorimachi H.

Biosci Biotechnol Biochem. 2003 Aug;67(8):1786-96.PMID: 12951515 [PubMed - indexed for MEDLINE]Related articlesFree article

[Calpain and pathology in view of structure-function relationships]

Sorimachi H, Kawabata Y.

Nippon Yakurigaku Zasshi. 2003 Jul;122(1):21-9. Review. Japanese. PMID: 12843569 [PubMed - indexed for MEDLINE]Related articles

Flexibility analysis and structure comparison of two crystal forms of calcium-free human m-calpain.

Reverter D, Braun M, Fernandez-Catalan C, Strobl S, Sorimachi H, Bode W.

Biol Chem. 2002 Sep;383(9):1415-22.PMID: 12437134 [PubMed - indexed for MEDLINE]Related articles

C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells.

Welm AL, Timchenko NA, Ono Y, Sorimachi H, Radomska HS, Tenen DG, Lekstrom-Himes J, Darlington GJ.

J Biol Chem. 2002 Sep 13;277(37):33848-56. Epub 2002 Jul 8.PMID: 12105198 [PubMed - indexed for MEDLINE]Related articlesFree article

Stable expression of calpain 3 from a muscle transgene in vivo: immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation.

Spencer MJ, Guyon JR, Sorimachi H, Potts A, Richard I, Herasse M, Chamberlain J, Dalkilic I, Kunkel LM, Beckmann JS.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8874-9. Epub 2002 Jun 19.PMID: 12084932 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.

McElhinny AS, Kakinuma K, Sorimachi H, Labeit S, Gregorio CC.

J Cell Biol. 2002 Apr 1;157(1):125-36. Epub 2002 Apr 1.PMID: 11927605 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation of m-calpain subunits occurs after autolysis of the N-terminus of the catalytic subunit, and is not required for activation.

Nakagawa K, Masumoto H, Sorimachi H, Suzuki K.

J Biochem. 2001 Nov;130(5):605-11.PMID: 11686922 [PubMed - indexed for MEDLINE]Related articles

Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells.

Takahashi N, Sasagawa N, Usuki F, Kino Y, Kawahara H, Sorimachi H, Maeda T, Suzuki K, Ishiura S.

J Biochem. 2001 Nov;130(5):581-7.PMID: 11686919 [PubMed - indexed for MEDLINE]Related articles

[Structure and function of calpain superfamily]

Hata S, Sorimachi H, Suzuki K.

Seikagaku. 2001 Sep;73(9):1129-40. Review. Japanese. No abstract available. PMID: 11675995 [PubMed - indexed for MEDLINE]Related articles

The structure of calcium-free human m-calpain: implications for calcium activation and function.

Reverter D, Sorimachi H, Bode W.

Trends Cardiovasc Med. 2001 Aug;11(6):222-9. Review.PMID: 11673052 [PubMed - indexed for MEDLINE]Related articles

[Muscular dystrophy and calpain]

Sorimachi H.

Tanpakushitsu Kakusan Koso. 2001 Aug;46(11 Suppl):1772-80. Review. Japanese. No abstract available. PMID: 11579578 [PubMed - indexed for MEDLINE]Related articles

Limited proteolysis of filamin is catalyzed by caspase-3 in U937 and Jurkat cells.

Umeda T, Kouchi Z, Kawahara H, Tomioka S, Sasagawa N, Maeda T, Sorimachi H, Ishiura S, Suzuki K.

J Biochem. 2001 Oct;130(4):535-42.PMID: 11574073 [PubMed - indexed for MEDLINE]Related articles

Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution.

Hata S, Nishi K, Kawamoto T, Lee HJ, Kawahara H, Maeda T, Shintani Y, Sorimachi H, Suzuki K.

J Mol Evol. 2001 Sep;53(3):191-203.PMID: 11523006 [PubMed - indexed for MEDLINE]Related articles

Structural basis for possible calcium-induced activation mechanisms of calpains.

Reverter D, Strobl S, Fernandez-Catalan C, Sorimachi H, Suzuki K, Bode W.

Biol Chem. 2001 May;382(5):753-66.PMID: 11517928 [PubMed - indexed for MEDLINE]Related articles

Domain II of m-calpain is a Ca(2+)-dependent cysteine protease.

Hata S, Sorimachi H, Nakagawa K, Maeda T, Abe K, Suzuki K.

FEBS Lett. 2001 Jul 20;501(2-3):111-4.PMID: 11470267 [PubMed - indexed for MEDLINE]Related articles

Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB.

Futai E, Kubo T, Sorimachi H, Suzuki K, Maeda T.

Biochim Biophys Acta. 2001 Jan 26;1517(2):316-9.PMID: 11342116 [PubMed - indexed for MEDLINE]Related articles

The structure of calpain.

Sorimachi H, Suzuki K.

J Biochem. 2001 May;129(5):653-64. Review.PMID: 11328585 [PubMed - indexed for MEDLINE]Related articles

Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.

Bang ML, Mudry RE, McElhinny AS, Trombitás K, Geach AJ, Yamasaki R, Sorimachi H, Granzier H, Gregorio CC, Labeit S.

J Cell Biol. 2001 Apr 16;153(2):413-27.PMID: 11309420 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of preslaughter feed withdrawal period on longissimus tenderness and the expression of calpains in the ovine.

Ilian MA, Morton JD, Bekhit AE, Roberts N, Palmer B, Sorimachi H, Bickerstaffe R.

J Agric Food Chem. 2001 Apr;49(4):1990-8.PMID: 11308358 [PubMed - indexed for MEDLINE]Related articles

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S.

J Mol Biol. 2001 Mar 2;306(4):717-26.PMID: 11243782 [PubMed - indexed for MEDLINE]Related articles