PubMed

Diffusion tensor imaging and Tract-Based Spatial Statistics in Alzheimer's disease and mild cognitive impairment.

Liu Y, Spulber G, Lehtimäki KK, Könönen M, Hallikainen I, Gröhn H, Kivipelto M, Hallikainen M, Vanninen R, Soininen H.

Neurobiol Aging. 2009 Nov 11. [Epub ahead of print]PMID: 19913331 [PubMed - as supplied by publisher]Related articles

Cortical Thickness Analysis to Detect Progressive Mild Cognitive Impairment: A Reference to Alzheimer's Disease.

Julkunen V, Niskanen E, Muehlboeck S, Pihlajamäki M, Könönen M, Hallikainen M, Kivipelto M, Tervo S, Vanninen R, Evans A, Soininen H.

Dement Geriatr Cogn Disord. 2009 Nov 10;28(5):404-412. [Epub ahead of print]PMID: 19907176 [PubMed - as supplied by publisher]Related articles

MRI measures of Alzheimer's disease and the AddNeuroMed study.

Simmons A, Westman E, Muehlboeck S, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Wahlund LO, Soininen H, Lovestone S, Evans A, Spenger C; AddNeuroMed Consortium.

Ann N Y Acad Sci. 2009 Oct;1180:47-55.PMID: 19906260 [PubMed - in process]Related articles

AddNeuroMed--the European collaboration for the discovery of novel biomarkers for Alzheimer's disease.

Lovestone S, Francis P, Kloszewska I, Mecocci P, Simmons A, Soininen H, Spenger C, Tsolaki M, Vellas B, Wahlund LO, Ward M; AddNeuroMed Consortium.

Ann N Y Acad Sci. 2009 Oct;1180:36-46.PMID: 19906259 [PubMed - in process]Related articles

Erratum to: Immuno-PCR-based quantification of multiple phosphorylated tau-epitopes linked to Alzheimer's disease.

Singer D, Soininen H, Alafuzoff I, Hoffmann R.

Anal Bioanal Chem. 2009 Nov 10. [Epub ahead of print] No abstract available. PMID: 19902186 [PubMed - as supplied by publisher]Related articles

Combined risk effects of IDE and NEP gene variants on Alzheimer disease.

Vepsäläinen S, Helisalmi S, Mannermaa A, Pirttilä T, Soininen H, Hiltunen M.

J Neurol Neurosurg Psychiatry. 2009 Nov;80(11):1268-70.PMID: 19864659 [PubMed - in process]Related articles

Effects of Cholinesterase Inhibitors on the Activities and Protein Levels of Cholinesterases in the Cerebrospinal Fluid of Patients with Alzheimer's Disease: A Review of Recent Clinical Studies.

Darreh-Shori T, Soininen H.

Curr Alzheimer Res. 2009 Sep 28. [Epub ahead of print]PMID: 19860725 [PubMed - as supplied by publisher]Related articles

Fast and robust multi-atlas segmentation of brain magnetic resonance images.

Lötjönen JM, Wolz R, Koikkalainen JR, Thurfjell L, Waldemar G, Soininen H, Rueckert D; The Alzheimer's Disease Neuroimaging Initiative.

Neuroimage. 2009 Oct 24. [Epub ahead of print]PMID: 19857578 [PubMed - as supplied by publisher]Related articles

Brain pathology in three subjects from the same pedigree with PSEN1 P264L mutation.

Martikainen P, Pikkarainen M, Pöntynen K, Hiltunen M, Lehtovirta M, Tuisku S, Soininen H, Alafuzoff I.

Neuropathol Appl Neurobiol. 2009 Oct 22. [Epub ahead of print]PMID: 19849793 [PubMed - as supplied by publisher]Related articles

Insight, Cognition and Quality of Life in Alzheimer'S Disease.

Hurt CS, Banerjee S, Tunnard C, Whitehead D, Tsolaki M, Mecocci P, Kloszewska I, Soininen H, Vellas B, Lovestone S.

J Neurol Neurosurg Psychiatry. 2009 Oct 13. [Epub ahead of print]PMID: 19828481 [PubMed - as supplied by publisher]Related articles

Immuno-PCR-based quantification of multiple phosphorylated tau-epitopes linked to Alzheimer's disease.

Singer D, Soininen H, Alafuzoff I, Hoffmann R.

Anal Bioanal Chem. 2009 Oct 11. [Epub ahead of print]PMID: 19821112 [PubMed - as supplied by publisher]Related articles

Down-regulation of seladin-1 increases bace1 levels and activity through enhanced GGA3 depletion during apoptosis.

Sarajarvi T, Haapasalo A, Viswanathan J, Makinen P, Laitinen M, Soininen H, Hiltunen M.

J Biol Chem. 2009 Oct 8. [Epub ahead of print]PMID: 19815556 [PubMed - as supplied by publisher]Related articlesFree article

No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease.

Turunen M, Vepsäläinen S, Mäkinen P, Helisalmi S, Haapasalo A, Soininen H, Hiltunen M.

Neurobiol Aging. 2009 Sep 22. [Epub ahead of print]PMID: 19783326 [PubMed - as supplied by publisher]Related articles

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.

Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O; European Alzheimer's Disease Initiative Investigators, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanché H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alpérovitch A, Lathrop M, Amouyel P.

Nat Genet. 2009 Oct;41(10):1094-9. Epub 2009 Sep 6.PMID: 19734903 [PubMed - indexed for MEDLINE]Related articles

Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study.

Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H; for the AddNeuroMed Consortium.

Neurobiol Aging. 2009 Aug 13. [Epub ahead of print]PMID: 19683363 [PubMed - as supplied by publisher]Related articles

Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment.

Ferris S, Nordberg A, Soininen H, Darreh-Shori T, Lane R.

Pharmacogenet Genomics. 2009 Aug;19(8):635-46.PMID: 19617863 [PubMed - indexed for MEDLINE]Related articles

Association between mid-life marital status and cognitive function in later life: population based cohort study.

Håkansson K, Rovio S, Helkala EL, Vilska AR, Winblad B, Soininen H, Nissinen A, Mohammed AH, Kivipelto M.

BMJ. 2009 Jul 2;339:b2462. doi: 10.1136/bmj.b2462.PMID: 19574312 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease.

Solomon A, Leoni V, Kivipelto M, Besga A, Oksengård AR, Julin P, Svensson L, Wahlund LO, Andreasen N, Winblad B, Soininen H, Björkhem I.

Neurosci Lett. 2009 Oct 2;462(1):89-93. Epub 2009 Jun 26.PMID: 19560513 [PubMed - indexed for MEDLINE]Related articles

Olfactory identification in non-demented elderly population and in mild cognitive impairment: a comparison of performance in clinical odor identification versus Boston Naming Test.

Laakso MP, Tervo S, Hänninen T, Vanhanen M, Hallikainen M, Soininen H.

J Neural Transm. 2009 Jul;116(7):891-5. Epub 2009 May 7.PMID: 19551462 [PubMed - indexed for MEDLINE]Related articles

White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study.

van de Pol LA, Verhey F, Frisoni GB, Tsolaki M, Papapostolou P, Nobili F, Wahlund LO, Minthon L, Frölich L, Hampel H, Soininen H, Knol DL, Barkhof F, Scheltens P, Visser PJ.

J Neurol Neurosurg Psychiatry. 2009 Oct;80(10):1069-74. Epub 2009 Jun 18.PMID: 19541689 [PubMed - indexed for MEDLINE]Related articles

Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort.

Tolppanen AM, Helisalmi S, Hiltunen M, Kolehmainen M, Schwab U, Pirttilä T, Pulkkinen L, Uusitupa M, Soininen H.

Neurobiol Aging. 2009 Jun 11. [Epub ahead of print]PMID: 19524323 [PubMed - as supplied by publisher]Related articles

Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study.

Visser PJ, Verhey F, Knol DL, Scheltens P, Wahlund LO, Freund-Levi Y, Tsolaki M, Minthon L, Wallin AK, Hampel H, Bürger K, Pirttila T, Soininen H, Rikkert MO, Verbeek MM, Spiru L, Blennow K.

Lancet Neurol. 2009 Jul;8(7):619-27. Epub 2009 Jun 10.PMID: 19523877 [PubMed - indexed for MEDLINE]Related articles

Safety of lumbar puncture procedures in patients with Alzheimer's disease.

Peskind E, Nordberg A, Darreh-Shori T, Soininen H.

Curr Alzheimer Res. 2009 Jun;6(3):290-2.PMID: 19519311 [PubMed - indexed for MEDLINE]Related articles

Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus.

Hiltunen M, Mäkinen P, Peräniemi S, Sivenius J, van Groen T, Soininen H, Jolkkonen J.

Neurobiol Dis. 2009 Jul;35(1):103-13. Epub 2009 May 5.PMID: 19426802 [PubMed - indexed for MEDLINE]Related articles

Structural and functional MRI in mild cognitive impairment.

Pihlajamäki M, Jauhiainen AM, Soininen H.

Curr Alzheimer Res. 2009 Apr;6(2):179-85. Review.PMID: 19355853 [PubMed - indexed for MEDLINE]Related articles

Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's disease.

Helisalmi S, Väkevä A, Hiltunen M, Soininen H.

Dement Geriatr Cogn Disord. 2009;27(4):318-21. Epub 2009 Mar 17.PMID: 19293566 [PubMed - indexed for MEDLINE]Related articles

Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.

Tapiola T, Alafuzoff I, Herukka SK, Parkkinen L, Hartikainen P, Soininen H, Pirttilä T.

Arch Neurol. 2009 Mar;66(3):382-9.PMID: 19273758 [PubMed - indexed for MEDLINE]Related articles

Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients.

Nordberg A, Darreh-Shori T, Peskind E, Soininen H, Mousavi M, Eagle G, Lane R.

Curr Alzheimer Res. 2009 Feb;6(1):4-14.PMID: 19199870 [PubMed - indexed for MEDLINE]Related articles

Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study.

Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M.

J Alzheimers Dis. 2009 Jan;16(1):85-91.PMID: 19158424 [PubMed - indexed for MEDLINE]Related articles

No association between CALHM1 and Alzheimer's disease risk.

Bertram L, Schjeide BM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE.

Cell. 2008 Dec 12;135(6):993-4; author reply 994-6. No abstract available. PMID: 19070563 [PubMed - indexed for MEDLINE]Related articles

The effect of midlife physical activity on structural brain changes in the elderly.

Rovio S, Spulber G, Nieminen LJ, Niskanen E, Winblad B, Tuomilehto J, Nissinen A, Soininen H, Kivipelto M.

Neurobiol Aging. 2008 Dec 3. [Epub ahead of print]PMID: 19062136 [PubMed - as supplied by publisher]Related articles

An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population.

Viswanathan J, Mäkinen P, Helisalmi S, Haapasalo A, Soininen H, Hiltunen M.

Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):747-50.PMID: 19016491 [PubMed - indexed for MEDLINE]Related articles

Differential hypometabolism patterns according to mild cognitive impairment subtypes.

Jauhiainen AM, Kangasmaa T, Rusanen M, Niskanen E, Tervo S, Kivipelto M, Vanninen RL, Kuikka JT, Soininen H.

Dement Geriatr Cogn Disord. 2008;26(6):490-8. Epub 2008 Nov 6.PMID: 18987469 [PubMed - indexed for MEDLINE]Related articles

Effects of ubiquilin 1 on the unfolded protein response.

Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE.

J Mol Neurosci. 2009 May;38(1):19-30. Epub 2008 Oct 25.PMID: 18953672 [PubMed - indexed for MEDLINE]Related articles

PET amyloid ligand [11C]PIB uptake and cerebrospinal fluid beta-amyloid in mild cognitive impairment.

Koivunen J, Pirttilä T, Kemppainen N, Aalto S, Herukka SK, Jauhianen AM, Hänninen T, Hallikainen M, Någren K, Rinne JO, Soininen H.

Dement Geriatr Cogn Disord. 2008;26(4):378-83. Epub 2008 Oct 16.PMID: 18931497 [PubMed - indexed for MEDLINE]Related articles

Mixed brain pathologies in dementia: the BrainNet Europe consortium experience.

Kovacs GG, Alafuzoff I, Al-Sarraj S, Arzberger T, Bogdanovic N, Capellari S, Ferrer I, Gelpi E, Kövari V, Kretzschmar H, Nagy Z, Parchi P, Seilhean D, Soininen H, Troakes C, Budka H.

Dement Geriatr Cogn Disord. 2008;26(4):343-50. Epub 2008 Oct 10.PMID: 18849605 [PubMed - indexed for MEDLINE]Related articles

Whole brain atrophy rate predicts progression from MCI to Alzheimer's disease.

Spulber G, Niskanen E, Macdonald S, Smilovici O, Chen K, Reiman EM, Jauhiainen AM, Hallikainen M, Tervo S, Wahlund LO, Vanninen R, Kivipelto M, Soininen H.

Neurobiol Aging. 2008 Sep 29. [Epub ahead of print]PMID: 18829136 [PubMed - as supplied by publisher]Related articles

Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment.

Jauhiainen AM, Pihlajamäki M, Tervo S, Niskanen E, Tanila H, Hänninen T, Vanninen RL, Soininen H.

Hippocampus. 2009 Feb;19(2):166-75.PMID: 18777563 [PubMed - indexed for MEDLINE]Related articles

A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease.

Tukiainen T, Tynkkynen T, Mäkinen VP, Jylänki P, Kangas A, Hokkanen J, Vehtari A, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Groop PH, Kaski K, Laatikainen R, Soininen P, Pirttilä T, Ala-Korpela M.

Biochem Biophys Res Commun. 2008 Oct 24;375(3):356-61. Epub 2008 Aug 26.PMID: 18700135 [PubMed - indexed for MEDLINE]Related articles

Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B.

Leinonen V, Alafuzoff I, Aalto S, Suotunen T, Savolainen S, Någren K, Tapiola T, Pirttilä T, Rinne J, Jääskeläinen JE, Soininen H, Rinne JO.

Arch Neurol. 2008 Oct;65(10):1304-9. Epub 2008 Aug 11.PMID: 18695050 [PubMed - indexed for MEDLINE]Related articlesFree article

Brain anatomy of persistent violent offenders: more rather than less.

Tiihonen J, Rossi R, Laakso MP, Hodgins S, Testa C, Perez J, Repo-Tiihonen E, Vaurio O, Soininen H, Aronen HJ, Könönen M, Thompson PM, Frisoni GB.

Psychiatry Res. 2008 Aug 30;163(3):201-12. Epub 2008 Jul 26.PMID: 18662866 [PubMed - indexed for MEDLINE]Related articles

Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease.

Helisalmi S, Tarvainen T, Vepsäläinen S, Koivisto AM, Hiltunen M, Soininen H.

Neurosci Lett. 2008 Aug 22;441(2):233-6. Epub 2008 Jun 17.PMID: 18573313 [PubMed - indexed for MEDLINE]Related articles

Navigated TMS combined with EEG in mild cognitive impairment and Alzheimer's disease: a pilot study.

Julkunen P, Jauhiainen AM, Westerén-Punnonen S, Pirinen E, Soininen H, Könönen M, Pääkkönen A, Määttä S, Karhu J.

J Neurosci Methods. 2008 Jul 30;172(2):270-6. Epub 2008 Apr 29.PMID: 18533272 [PubMed - indexed for MEDLINE]Related articles

CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy.

Herukka SK, Pennanen C, Soininen H, Pirttilä T.

J Alzheimers Dis. 2008 May;14(1):51-7. Erratum in: J Alzheimers Dis. 2008 Oct;15(2):347. PMID: 18525127 [PubMed - indexed for MEDLINE]Related articles

Development of screening guidelines and clinical criteria for predementia Alzheimer's disease. The DESCRIPA Study.

Visser PJ, Verhey FR, Boada M, Bullock R, De Deyn PP, Frisoni GB, Frolich L, Hampel H, Jolles J, Jones R, Minthon L, Nobili F, Olde Rikkert M, Ousset PJ, Rigaud AS, Scheltens P, Soininen H, Spiru L, Touchon J, Tsolaki M, Vellas B, Wahlund LO, Wilcock G, Winblad B.

Neuroepidemiology. 2008;30(4):254-65. Epub 2008 Jun 2.PMID: 18515975 [PubMed - indexed for MEDLINE]Related articles

Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology.

Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H.

Neurosci Lett. 2008 Jun 20;438(2):216-20. Epub 2008 Apr 12.PMID: 18455870 [PubMed - indexed for MEDLINE]Related articles

Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease.

Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, Soininen H.

J Neurol. 2008 May;255(5):668-73. Epub 2008 Apr 30.PMID: 18438697 [PubMed - indexed for MEDLINE]Related articles

Beta-amyloid deposition in brains of subjects with diabetes.

Alafuzoff I, Aho L, Helisalmi S, Mannermaa A, Soininen H.

Neuropathol Appl Neurobiol. 2009 Feb;35(1):60-8. Epub 2008 Mar 10.PMID: 18346114 [PubMed - indexed for MEDLINE]Related articles

Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease.

Lane R, Feldman HH, Meyer J, He Y, Ferris SH, Nordberg A, Darreh-Shori T, Soininen H, Pirttilä T, Farlow MR, Sfikas N, Ballard C, Greig NH.

Pharmacogenet Genomics. 2008 Apr;18(4):289-98.PMID: 18334913 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study.

Hämäläinen A, Grau-Olivares M, Tervo S, Niskanen E, Pennanen C, Huuskonen J, Kivipelto M, Hänninen T, Tapiola M, Vanhanen M, Hallikainen M, Helkala EL, Nissinen A, Vanninen RL, Soininen H.

Neurodegener Dis. 2008;5(3-4):186-9. Epub 2008 Mar 6.PMID: 18322386 [PubMed - indexed for MEDLINE]Related articles