PubMed

Experimental aspects of copy number variant assays at CCL3L1.

Field SF, Howson JM, Maier LM, Walker S, Walker NM, Smyth DJ, Armour JA, Clayton DG, Todd JA.

Nat Med. 2009 Oct;15(10):1115-7. No abstract available. PMID: 19812562 [PubMed - indexed for MEDLINE]Related articles

Alloantibodies against low-frequency human platelet antigens do not account for a significant proportion of cases of fetomaternal alloimmune thrombocytopenia: evidence from 1054 cases.

Ghevaert C, Rankin A, Huiskes E, Porcelijn L, Javela K, Kekomaki R, Bakchoul T, Santoso S, Nutland S, Smyth DJ, Smith GA, McBride S, Watkins NA, Ouwehand WH.

Transfusion. 2009 Oct;49(10):2084-9. Epub 2009 Jun 4.PMID: 19500319 [PubMed - in process]Related articles

No association of multiple type 2 diabetes loci with type 1 diabetes.

Raj SM, Howson JM, Walker NM, Cooper JD, Smyth DJ, Field SF, Stevens HE, Todd JA.

Diabetologia. 2009 Oct;52(10):2109-16. Epub 2009 May 20.PMID: 19455305 [PubMed - in process]Related articlesFree article

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS; The Type 1 Diabetes Genetics Consortium.

Nat Genet. 2009 May 10. [Epub ahead of print]PMID: 19430480 [PubMed - as supplied by publisher]Related articles

Treatment of arsenic, heavy metals, and acidity using a mixed ZVI-compost PRB.

Ludwig RD, Smyth DJ, Blowes DW, Spink LE, Wilkin RT, Jewett DG, Weisener CJ.

Environ Sci Technol. 2009 Mar 15;43(6):1970-6.PMID: 19368200 [PubMed - indexed for MEDLINE]Related articles

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.

Fung EY, Smyth DJ, Howson JM, Cooper JD, Walker NM, Stevens H, Wicker LS, Todd JA.

Genes Immun. 2009 Mar;10(2):188-91. Epub 2008 Dec 25.PMID: 19110536 [PubMed - indexed for MEDLINE]Related articles

Shared and distinct genetic variants in type 1 diabetes and celiac disease.

Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA.

N Engl J Med. 2008 Dec 25;359(26):2767-77. Epub 2008 Dec 10.PMID: 19073967 [PubMed - indexed for MEDLINE]Related articlesFree article

Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13.

Plagnol V, Smyth DJ, Todd JA, Clayton DG.

Biostatistics. 2009 Apr;10(2):327-34. Epub 2008 Nov 27.PMID: 19039033 [PubMed - indexed for MEDLINE]Related articlesFree article

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

Cooper JD, Smyth DJ, Smiles AM, Plagnol V, Walker NM, Allen JE, Downes K, Barrett JC, Healy BC, Mychaleckyj JC, Warram JH, Todd JA.

Nat Genet. 2008 Dec;40(12):1399-401. Epub 2008 Nov 2.PMID: 18978792 [PubMed - indexed for MEDLINE]Related articlesFree article

A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.

Concannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, Bergholdt R, Akolkar B, Erlich HA, Hilner JE, Julier C, Morahan G, Nerup J, Nierras CR, Chen WM, Rich SS; Type 1 Diabetes Genetics Consortium.

Diabetes. 2008 Oct;57(10):2858-61. Epub 2008 Jul 22.PMID: 18647951 [PubMed - indexed for MEDLINE]Related articlesFree article

PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.

Smyth DJ, Cooper JD, Howson JM, Walker NM, Plagnol V, Stevens H, Clayton DG, Todd JA.

Diabetes. 2008 Jun;57(6):1730-7. Epub 2008 Feb 27.PMID: 18305142 [PubMed - indexed for MEDLINE]Related articlesFree article

The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.

Cooper JD, Smyth DJ, Bailey R, Payne F, Downes K, Godfrey LM, Masters J, Zeitels LR, Vella A, Walker NM, Todd JA.

BMC Med Genet. 2007 Nov 28;8:71.PMID: 18045485 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning and characterization of an orphan seven transmembrane receptor from Schistosoma mansoni.

Pearson MS, McManus DP, Smyth DJ, Jones MK, Sykes AM, Loukas A.

Parasitology. 2007 Dec;134(Pt.14):2001-8. Epub 2007 Aug 23.PMID: 17714602 [PubMed - indexed for MEDLINE]Related articlesFree article

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R, Bourget K, Plagnol V, Field S, Atkinson M, Clayton DG, Wicker LS, Todd JA.

Nat Genet. 2007 Sep;39(9):1074-82. Epub 2007 Aug 5.PMID: 17676041 [PubMed - indexed for MEDLINE]Related articles

Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes.

Bailey R, Cooper JD, Zeitels L, Smyth DJ, Yang JH, Walker NM, Hyppönen E, Dunger DB, Ramos-Lopez E, Badenhoop K, Nejentsev S, Todd JA.

Diabetes. 2007 Oct;56(10):2616-21. Epub 2007 Jul 2.PMID: 17606874 [PubMed - indexed for MEDLINE]Related articlesFree article

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C; Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC; Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG.

Nat Genet. 2007 Jul;39(7):857-64. Epub 2007 Jun 6.PMID: 17554260 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects.

Field SF, Howson JM, Smyth DJ, Walker NM, Dunger DB, Todd JA.

Diabetologia. 2007 Jan;50(1):212-3. Epub 2006 Oct 25. No abstract available. PMID: 17063324 [PubMed - indexed for MEDLINE]Related articlesFree article

Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis.

Tran MH, Pearson MS, Bethony JM, Smyth DJ, Jones MK, Duke M, Don TA, McManus DP, Correa-Oliveira R, Loukas A.

Nat Med. 2006 Jul;12(7):835-40. Epub 2006 Jun 18.PMID: 16783371 [PubMed - indexed for MEDLINE]Related articles

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.

Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, Guja C, Ionescu-Tirgoviste C, Widmer B, Dunger DB, Savage DA, Walker NM, Clayton DG, Todd JA.

Nat Genet. 2006 Jun;38(6):617-9. Epub 2006 May 14.PMID: 16699517 [PubMed - indexed for MEDLINE]Related articles

No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases.

Smyth DJ, Cooper JD, Lowe CE, Nutland S, Walker NM, Clayton DG, Todd JA.

Diabetes. 2006 May;55(5):1525-8.PMID: 16644715 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.

Taniguchi H, Lowe CE, Cooper JD, Smyth DJ, Bailey R, Nutland S, Healy BC, Lam AC, Burren O, Walker NM, Smink LJ, Wicker LS, Todd JA.

BMC Genet. 2006 Apr 20;7:22.PMID: 16626483 [PubMed]Related articlesFree article

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

Smyth DJ, Howson JM, Payne F, Maier LM, Bailey R, Holland K, Lowe CE, Cooper JD, Hulme JS, Vella A, Dahlman I, Lam AC, Nutland S, Walker NM, Twells RC, Todd JA.

BMC Med Genet. 2006 Mar 6;7:20.PMID: 16519819 [PubMed - indexed for MEDLINE]Related articlesFree article

Two isoforms of a divalent metal transporter (DMT1) in Schistosoma mansoni suggest a surface-associated pathway for iron absorption in schistosomes.

Smyth DJ, Glanfield A, McManus DP, Hacker E, Blair D, Anderson GJ, Jones MK.

J Biol Chem. 2006 Jan 27;281(4):2242-8. Epub 2005 Nov 2.PMID: 16267047 [PubMed - indexed for MEDLINE]Related articlesFree article

Population structure, differential bias and genomic control in a large-scale, case-control association study.

Clayton DG, Walker NM, Smyth DJ, Pask R, Cooper JD, Maier LM, Smink LJ, Lam AC, Ovington NR, Stevens HE, Nutland S, Howson JM, Faham M, Moorhead M, Jones HB, Falkowski M, Hardenbol P, Willis TD, Todd JA.

Nat Genet. 2005 Nov;37(11):1243-6. Epub 2005 Oct 9.PMID: 16228001 [PubMed - indexed for MEDLINE]Related articles

Field column study using zerovalent iron for mercury removal from contaminated groundwater.

Weisener CG, Sale KS, Smyth DJ, Blowes DW.

Environ Sci Technol. 2005 Aug 15;39(16):6306-12.PMID: 16173597 [PubMed - indexed for MEDLINE]Related articles

Comment to: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905.

Maier LM, Cooper JD, Walker N, Smyth DJ, Todd JA.

Diabetologia. 2005 Oct;48(10):2180-2; author reply 2185-6. Epub 2005 Aug 13. No abstract available. PMID: 16132953 [PubMed - indexed for MEDLINE]Related articles

In vitro and in silico analysis of signal peptides from the human blood fluke, Schistosoma mansoni.

Pearson MS, McManus DP, Smyth DJ, Lewis FA, Loukas A.

FEMS Immunol Med Microbiol. 2005 Aug 1;45(2):201-11.PMID: 16051070 [PubMed - indexed for MEDLINE]Related articles

No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.

Payne F, Smyth DJ, Pask R, Cooper JD, Masters J, Wang WY, Godfrey LM, Bowden G, Szeszko J, Smink LJ, Lam AC, Burren O, Walker NM, Nutland S, Rance H, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Todd JA, Twells RC.

Biochem Biophys Res Commun. 2005 Jun 3;331(2):435-41.PMID: 15850778 [PubMed - indexed for MEDLINE]Related articles

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes.

Maier LM, Smyth DJ, Vella A, Payne F, Cooper JD, Pask R, Lowe C, Hulme J, Smink LJ, Fraser H, Moule C, Hunter KM, Chamberlain G, Walker N, Nutland S, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgoviste C, Savage DA, Strachan DP, Peterson LB, Todd JA, Wicker LS, Twells RC.

BMC Genet. 2005 Feb 18;6(1):9.PMID: 15720714 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.

Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tîrgoviste C, Undlien DE, Rønningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA.

Nat Genet. 2005 Feb;37(2):110-1; author reply 112-3. No abstract available. Erratum in: Nat Genet. 2005 Mar;37(3):328. PMID: 15678134 [PubMed - indexed for MEDLINE]Related articles

The fugitive LTR retrotransposon from the genome of the human blood fluke, Schistosoma mansoni.

Laha T, Loukas A, Smyth DJ, Copeland CS, Brindley PJ.

Int J Parasitol. 2004 Nov;34(12):1365-75. Erratum in: Int J Parasitol. 2005 Apr 1;35(4):461. PMID: 15542097 [PubMed - indexed for MEDLINE]Related articles

Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping.

Pask R, Rance HE, Barratt BJ, Nutland S, Smyth DJ, Sebastian M, Twells RC, Smith A, Lam AC, Smink LJ, Walker NM, Todd JA.

BMC Biotechnol. 2004 Jul 27;4:15.PMID: 15279678 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.

Eftychi C, Howson JM, Barratt BJ, Vella A, Payne F, Smyth DJ, Twells RC, Walker NM, Rance HE, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîirgovişte C, Savage DA, Todd JA.

Diabetes. 2004 Mar;53(3):870-3.PMID: 14988278 [PubMed - indexed for MEDLINE]Related articlesFree article

Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.

Payne F, Smyth DJ, Pask R, Barratt BJ, Cooper JD, Twells RC, Walker NM, Lam AC, Smink LJ, Nutland S, Rance HE, Todd JA.

Diabetes. 2004 Feb;53(2):505-9.PMID: 14747305 [PubMed - indexed for MEDLINE]Related articlesFree article

The deleted in colorectal carcinoma (DCC) gene 201 R --> G polymorphism: no evidence for genetic association with autoimmune disease.

Hall RJ, Merriman ME, Green RA, Markham VH, Smyth DJ, Heward JM, Jennings CE, Braithwaite AW, Cundy T, Darlow BA, Gow PJ, Harrison AA, Highton J, Hunt PJ, Manning P, Pokorny V, Scott RS, Taylor BJ, Willis JA, Yeoman S, McLean L, Gough SC, Pearce SH, Merriman TR.

Eur J Hum Genet. 2003 Nov;11(11):840-4.PMID: 14571268 [PubMed - indexed for MEDLINE]Related articlesFree article

Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.

Maier LM, Twells RC, Howson JM, Lam AC, Clayton DG, Smyth DJ, Savage D, Carson D, Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Rønningen KS, Cucca F, Todd JA.

Genes Immun. 2003 Oct;4(7):469-75.PMID: 14551599 [PubMed - indexed for MEDLINE]Related articles

Selectable marker-free transgenic barley producing a high level of cellulase (1,4-beta-glucanase) in developing grains.

Xue GP, Patel M, Johnson JS, Smyth DJ, Vickers CE.

Plant Cell Rep. 2003 Jul;21(11):1088-94. Epub 2003 Apr 16.PMID: 12836003 [PubMed - indexed for MEDLINE]Related articles

Proteolysis of human hemoglobin by schistosome cathepsin D.

Brindley PJ, Kalinna BH, Wong JY, Bogitsh BJ, King LT, Smyth DJ, Verity CK, Abbenante G, Brinkworth RI, Fairlie DP, Smythe ML, Milburn PJ, Bielefeldt-Ohmann H, Zheng Y, McManus DP.

Mol Biochem Parasitol. 2001 Jan 15;112(1):103-12.PMID: 11166391 [PubMed - indexed for MEDLINE]Related articles

Temperature-regulated expression of the tac/lacl system for overproduction of a fungal xylanase in Escherichia coli.

Xue GP, Johnson JS, Smyth DJ, Dierens LM, Wang X, Simpson GD, Gobius KS, Aylward JH.

Appl Microbiol Biotechnol. 1996 Mar;45(1-2):120-6.PMID: 8920187 [PubMed - indexed for MEDLINE]Related articles