PubMed

Acute hyperinsulinemia differentially regulates interstitial and circulating adiponectin oligomeric pattern in lean and insulin-resistant, obese individuals.

Murdolo G, Hammarstedt A, Schmelz M, Jansson PA, Smith U.

J Clin Endocrinol Metab. 2009 Nov;94(11):4508-16. Epub 2009 Oct 9.PMID: 19820029 [PubMed - in process]Related articles

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study.

Boesgaard TW, Gjesing AP, Grarup N, Rutanen J, Jansson PA, Hribal ML, Sesti G, Fritsche A, Stefan N, Staiger H, Häring H, Smith U, Laakso M, Pedersen O, Hansen T; EUGENE2 Consortium.

PLoS One. 2009 Sep 30;4(9):e7236.PMID: 19789630 [PubMed - in process]Related articlesFree article

Incretin-based therapy: how do incretin mimetics and DPP-4 inhibitors fit into treatment algorithms for type 2 diabetic patients?

Nauck M, Smith U.

Best Pract Res Clin Endocrinol Metab. 2009 Aug;23(4):513-23.PMID: 19748068 [PubMed - in process]Related articles

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.

Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring HU, Hansen T, Pedersen O, Smith U, Hanefeld M, Williams RW, Auwerx J.

PLoS Genet. 2009 Aug;5(8):e1000591. Epub 2009 Aug 7.PMID: 19662162 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammation and impaired adipogenesis in hypertrophic obesity in man.

Gustafson B, Gogg S, Hedjazifar S, Jenndahl L, Hammarstedt A, Smith U.

Am J Physiol Endocrinol Metab. 2009 Jul 21. [Epub ahead of print]PMID: 19622783 [PubMed - as supplied by publisher]Related articles

Does diabetes therapy influence the risk of cancer?

Smith U, Gale EA.

Diabetologia. 2009 Sep;52(9):1699-708. No abstract available. PMID: 19597799 [PubMed - in process]Related articles

Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin-1.

Gogg S, Smith U, Jansson PA.

Diabetes. 2009 Oct;58(10):2238-45. Epub 2009 Jul 6.PMID: 19581418 [PubMed - indexed for MEDLINE]Related articles

Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation.

Isakson P, Hammarstedt A, Gustafson B, Smith U.

Diabetes. 2009 Jul;58(7):1550-7. Epub 2009 Apr 7.PMID: 19351711 [PubMed - indexed for MEDLINE]Related articlesFree article

One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial.

Bunck MC, Diamant M, Cornér A, Eliasson B, Malloy JL, Shaginian RM, Deng W, Kendall DM, Taskinen MR, Smith U, Yki-Järvinen H, Heine RJ.

Diabetes Care. 2009 May;32(5):762-8. Epub 2009 Feb 5.PMID: 19196887 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men.

Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, Tivesten A, Smith U, Mellström D.

J Bone Miner Res. 2009 May;24(5):785-91.PMID: 19063687 [PubMed - indexed for MEDLINE]Related articles

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.

Friedrich B, Weyrich P, Stancáková A, Wang J, Kuusisto J, Laakso M, Sesti G, Succurro E, Smith U, Hansen T, Pedersen O, Machicao F, Schäfer S, Lang F, Risler T, Ullrich S, Stefan N, Fritsche A, Häring HU.

PLoS One. 2008;3(11):e3506. Epub 2008 Nov 5.PMID: 18985156 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin and free oestradiol are independent risk factors for benign prostatic hyperplasia.

Hammarsten J, Damber JE, Karlsson M, Knutson T, Ljunggren O, Ohlsson C, Peeker R, Smith U, Mellström D.

Prostate Cancer Prostatic Dis. 2009;12(2):160-5. Epub 2008 Sep 30.PMID: 18825163 [PubMed - indexed for MEDLINE]Related articles

Inflamed adipose tissue, insulin resistance and vascular injury.

Andersson CX, Gustafson B, Hammarstedt A, Hedjazifar S, Smith U.

Diabetes Metab Res Rev. 2008 Nov-Dec;24(8):595-603. Review.PMID: 18756581 [PubMed - indexed for MEDLINE]Related articles

Order! Order! Order in the House! DIAMAP: a road map for European diabetes research.

Halban PA, Smith U.

Diabetologia. 2008 Oct;51(10):1765-7. No abstract available. PMID: 18696048 [PubMed - indexed for MEDLINE]Related articles

WNT signalling is both an inducer and effector of glucagon-like peptide-1.

Gustafson B, Smith U.

Diabetologia. 2008 Oct;51(10):1768-70. Epub 2008 Jul 30. No abstract available. PMID: 18665346 [PubMed - indexed for MEDLINE]Related articles

[Reply on new drugs against type 2 diabetes: important to gain experience and knowledge]

Sjöholm A, Agardh CD, Brismar K, Efendic S, Eliasson B, Eriksson JW, Frid A, Groop L, Holmgren J, Ridderstråle M, Smith U.

Lakartidningen. 2008 Apr 23-May 6;105(17-18):1310, 1312. Swedish. No abstract available. PMID: 18561535 [PubMed - indexed for MEDLINE]Related articles

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice.

Franckhauser S, Elias I, Rotter Sopasakis V, Ferré T, Nagaev I, Andersson CX, Agudo J, Ruberte J, Bosch F, Smith U.

Diabetologia. 2008 Jul;51(7):1306-16. Epub 2008 Apr 24.PMID: 18437347 [PubMed - indexed for MEDLINE]Related articles

High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects.

Hammarstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U.

J Intern Med. 2008 Apr;263(4):440-9.PMID: 18324929 [PubMed - indexed for MEDLINE]Related articlesFree article

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study.

Boesgaard TW, Zilinskaite J, Vänttinen M, Laakso M, Jansson PA, Hammarstedt A, Smith U, Stefan N, Fritsche A, Häring H, Hribal M, Sesti G, Zobel DP, Pedersen O, Hansen T; EUGENE 2 Consortium.

Diabetologia. 2008 May;51(5):816-20. Epub 2008 Mar 7.PMID: 18324385 [PubMed - indexed for MEDLINE]Related articles

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.

Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M; EUGENE2 Consortium.

J Clin Endocrinol Metab. 2008 May;93(5):1924-30. Epub 2008 Feb 19.PMID: 18285412 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent advances in the molecular pathology, cell biology and genetics of ciliopathies.

Adams M, Smith UM, Logan CV, Johnson CA.

J Med Genet. 2008 May;45(5):257-67. Epub 2008 Jan 4. Review.PMID: 18178628 [PubMed - indexed for MEDLINE]Related articles

Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.

Laakso M, Zilinskaite J, Hansen T, Boesgaard TW, Vänttinen M, Stancáková A, Jansson PA, Pellmé F, Holst JJ, Kuulasmaa T, Hribal ML, Sesti G, Stefan N, Fritsche A, Häring H, Pedersen O, Smith U; EUGENE2 Consortium.

Diabetologia. 2008 Mar;51(3):502-11. Epub 2007 Dec 14.PMID: 18080106 [PubMed - indexed for MEDLINE]Related articles

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.

Staiger H, Stancáková A, Zilinskaite J, Vänttinen M, Hansen T, Marini MA, Hammarstedt A, Jansson PA, Sesti G, Smith U, Pedersen O, Laakso M, Stefan N, Fritsche A, Häring HU.

Diabetes. 2008 Feb;57(2):514-7. Epub 2007 Nov 26.PMID: 18039816 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals.

Murdolo G, Kempf K, Hammarstedt A, Herder C, Smith U, Jansson PA.

J Endocrinol Invest. 2007 Sep;30(8):RC17-21.PMID: 17923791 [PubMed - indexed for MEDLINE]Related articles

Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis.

Gustafson B, Hammarstedt A, Andersson CX, Smith U.

Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2276-83. Epub 2007 Sep 6. Review.PMID: 17823366 [PubMed - indexed for MEDLINE]Related articlesFree article

Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men.

Vandenput L, Mellström D, Lorentzon M, Swanson C, Karlsson MK, Brandberg J, Lönn L, Orwoll E, Smith U, Labrie F, Ljunggren O, Tivesten A, Ohlsson C.

J Clin Endocrinol Metab. 2007 Nov;92(11):4130-7. Epub 2007 Aug 21.PMID: 17711928 [PubMed - indexed for MEDLINE]Related articlesFree article

The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.

Swanson C, Mellström D, Lorentzon M, Vandenput L, Jakobsson J, Rane A, Karlsson M, Ljunggren O, Smith U, Eriksson AL, Bélanger A, Labrie F, Ohlsson C.

J Clin Endocrinol Metab. 2007 Dec;92(12):4878-82. Epub 2007 Aug 14.PMID: 17698910 [PubMed - indexed for MEDLINE]Related articlesFree article

Introduction: Symposium on diabetes, inflammation and cardiovascular disease.

Smith U.

J Intern Med. 2007 Aug;262(2):142-4. No abstract available. PMID: 17645582 [PubMed - indexed for MEDLINE]Related articles

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.

Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen AL, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J, Laakso M.

Mol Cell Biol. 2007 Jul;27(13):4953-67. Epub 2007 May 7.PMID: 17485446 [PubMed - indexed for MEDLINE]Related articlesFree article

Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: characterization of interstitial concentration and regulation of gene expression by insulin.

Murdolo G, Hammarstedt A, Sandqvist M, Schmelz M, Herder C, Smith U, Jansson PA.

J Clin Endocrinol Metab. 2007 Jul;92(7):2688-95. Epub 2007 Apr 24.PMID: 17456576 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt-signaling is maintained and adipogenesis inhibited by TNFalpha but not MCP-1 and resistin.

Hammarstedt A, Isakson P, Gustafson B, Smith U.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):700-6. Epub 2007 Apr 10.PMID: 17442272 [PubMed - indexed for MEDLINE]Related articles

Spectrum of MKS1 and MKS3 mutations in Meckel syndrome: a genotype-phenotype correlation. Mutation in brief #960. Online.

Khaddour R, Smith U, Baala L, Martinovic J, Clavering D, Shaffiq R, Ozilou C, Cullinane A, Kyttälä M, Shalev S, Audollent S, d'Humières C, Kadhom N, Esculpavit C, Viot G, Boone C, Oien C, Encha-Razavi F, Batman PA, Bennett CP, Woods CG, Roume J, Lyonnet S, Génin E, Le Merrer M, Munnich A, Gubler MC, Cox P, Macdonald F, Vekemans M, Johnson CA, Attié-Bitach T; SOFFOET (Société Française de Foetopathologie).

Hum Mutat. 2007 May;28(5):523-4.PMID: 17397051 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer?

Yang X, Smith U.

Diabetologia. 2007 Jun;50(6):1127-39. Epub 2007 Mar 29. Review.PMID: 17393135 [PubMed - indexed for MEDLINE]Related articles

Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes.

Andersson CX, Sopasakis VR, Wallerstedt E, Smith U.

J Biol Chem. 2007 Mar 30;282(13):9430-5. Epub 2007 Jan 31.PMID: 17267401 [PubMed - indexed for MEDLINE]Related articlesFree article

Weight loss and metabolic effects of topiramate in overweight and obese type 2 diabetic patients: randomized double-blind placebo-controlled trial.

Eliasson B, Gudbjörnsdottir S, Cederholm J, Liang Y, Vercruysse F, Smith U.

Int J Obes (Lond). 2007 Jul;31(7):1140-7. Epub 2007 Feb 13.PMID: 17264849 [PubMed - indexed for MEDLINE]Related articles

The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation.

Dawe HR, Smith UM, Cullinane AR, Gerrelli D, Cox P, Badano JL, Blair-Reid S, Sriram N, Katsanis N, Attie-Bitach T, Afford SC, Copp AJ, Kelly DA, Gull K, Johnson CA.

Hum Mol Genet. 2007 Jan 15;16(2):173-86. Epub 2006 Dec 21.PMID: 17185389 [PubMed - indexed for MEDLINE]Related articlesFree article

Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes.

Nagaev I, Bokarewa M, Tarkowski A, Smith U.

PLoS One. 2006 Dec 20;1:e31.PMID: 17183659 [PubMed]Related articlesFree article

The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert syndrome.

Baala L, Romano S, Khaddour R, Saunier S, Smith UM, Audollent S, Ozilou C, Faivre L, Laurent N, Foliguet B, Munnich A, Lyonnet S, Salomon R, Encha-Razavi F, Gubler MC, Boddaert N, de Lonlay P, Johnson CA, Vekemans M, Antignac C, Attie-Bitach T.

Am J Hum Genet. 2007 Jan;80(1):186-94. Epub 2006 Nov 15.PMID: 17160906 [PubMed - indexed for MEDLINE]Related articlesFree article

Autozygosity mapping of Bardet-Biedl syndrome to 12q21.2 and confirmation of FLJ23560 as BBS10.

White DR, Ganesh A, Nishimura D, Rattenberry E, Ahmed S, Smith UM, Pasha S, Raeburn S, Trembath RC, Rajab A, Macdonald F, Banin E, Stone EM, Johnson CA, Sheffield VC, Maher ER.

Eur J Hum Genet. 2007 Feb;15(2):173-8. Epub 2006 Nov 15.PMID: 17106446 [PubMed - indexed for MEDLINE]Related articlesFree article

TCF7L2 and type 2 diabetes--we WNT to know.

Smith U.

Diabetologia. 2007 Jan;50(1):5-7. Epub 2006 Nov 11. No abstract available. PMID: 17102948 [PubMed - indexed for MEDLINE]Related articles

Pathogenesis and treatment of diabetic vascular disease - illustrated by two cases.

Smith U, Laakso M, Eliasson B, Wesslau C, Borén J, Wiklund O, Attvall S.

J Intern Med. 2006 Nov;260(5):409-20. Review.PMID: 17040246 [PubMed - indexed for MEDLINE]Related articles

Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.

Graham TE, Yang Q, Blüher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, Kahn BB.

N Engl J Med. 2006 Jun 15;354(24):2552-63.PMID: 16775236 [PubMed - indexed for MEDLINE]Related articlesFree article

Postprandial interstitial insulin concentrations in type 2 diabetes relatives.

Sandqvist M, Johanson EH, Ahrén B, Axelsen M, Schmelz M, Smith U, Jansson PA.

Eur J Clin Invest. 2006 Jun;36(6):383-8.PMID: 16684121 [PubMed - indexed for MEDLINE]Related articles

The dysregulated adipose tissue: a connecting link between insulin resistance, type 2 diabetes mellitus and atherosclerosis.

Murdolo G, Smith U.

Nutr Metab Cardiovasc Dis. 2006 Mar;16 Suppl 1:S35-8. Epub 2006 Feb 9. Review.PMID: 16530128 [PubMed - indexed for MEDLINE]Related articles

Plasma cells and Fc receptors in human adipose tissue--lipogenic and anti-inflammatory effects of immunoglobulins on adipocytes.

Palming J, Gabrielsson BG, Jennische E, Smith U, Carlsson B, Carlsson LM, Lönn M.

Biochem Biophys Res Commun. 2006 Apr 28;343(1):43-8. Epub 2006 Feb 28.PMID: 16527253 [PubMed - indexed for MEDLINE]Related articles

Increased levels of acylation-stimulating protein in interleukin-6-deficient (IL-6(-/-)) mice.

Wernstedt I, Olsson B, Jernås M, Paglialunga S, Carlsson LM, Smith U, Cianflone K, Wallenius K, Wallenius V.

Endocrinology. 2006 Jun;147(6):2690-5. Epub 2006 Mar 2.PMID: 16513824 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes.

Gustafson B, Smith U.

J Biol Chem. 2006 Apr 7;281(14):9507-16. Epub 2006 Feb 7.PMID: 16464856 [PubMed - indexed for MEDLINE]Related articlesFree article

The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat.

Smith UM, Consugar M, Tee LJ, McKee BM, Maina EN, Whelan S, Morgan NV, Goranson E, Gissen P, Lilliquist S, Aligianis IA, Ward CJ, Pasha S, Punyashthiti R, Malik Sharif S, Batman PA, Bennett CP, Woods CG, McKeown C, Bucourt M, Miller CA, Cox P, Algazali L, Trembath RC, Torres VE, Attie-Bitach T, Kelly DA, Maher ER, Gattone VH 2nd, Harris PC, Johnson CA.

Nat Genet. 2006 Feb;38(2):191-6. Epub 2006 Jan 15.PMID: 16415887 [PubMed - indexed for MEDLINE]Related articles

Visfatin is an adipokine, but it is not regulated by thiazolidinediones.

Hammarstedt A, Pihlajamäki J, Rotter Sopasakis V, Gogg S, Jansson PA, Laakso M, Smith U.

J Clin Endocrinol Metab. 2006 Mar;91(3):1181-4. Epub 2006 Jan 4.PMID: 16394088 [PubMed - indexed for MEDLINE]Related articlesFree article

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial.

Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefèbvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J; PROactive investigators.

Lancet. 2005 Oct 8;366(9493):1279-89.PMID: 16214598 [PubMed - indexed for MEDLINE]Related articles