PubMed

Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance.

Semjonous NM, Smith KL, Parkinson JR, Gunner DJ, Liu YL, Murphy KG, Ghatei MA, Bloom SR, Small CJ.

Int J Obes (Lond). 2009 Jul;33(7):775-85. Epub 2009 Jun 2.PMID: 19488048 [PubMed - in process]Related articles

PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones.

Parkinson JR, Dhillo WS, Small CJ, Chaudhri OB, Bewick GA, Pritchard I, Moore S, Ghatei MA, Bloom SR.

Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E698-708. Epub 2008 Feb 19.PMID: 18285527 [PubMed - indexed for MEDLINE]Related articlesFree article

The temporal sequence of gut peptide CNS interactions tracked in vivo by magnetic resonance imaging.

Kuo YT, Parkinson JR, Chaudhri OB, Herlihy AH, So PW, Dhillo WS, Small CJ, Bloom SR, Bell JD.

J Neurosci. 2007 Nov 7;27(45):12341-8.PMID: 17989298 [PubMed - indexed for MEDLINE]Related articlesFree article

Co-administration of SR141716 with peptide YY3-36 or oxyntomodulin has additive effects on food intake in mice.

White NE, Dhillo WS, Liu YL, Small CJ, Kennett GA, Gardiner JV, Ghatei MA, Bloom SR.

Diabetes Obes Metab. 2008 Feb;10(2):167-70. Epub 2007 Oct 15.PMID: 17941865 [PubMed - indexed for MEDLINE]Related articles

Low-dose oral tri-iodothyronine does not directly increase food intake in man.

Martin NM, Small CJ, Lee JL, Ellis S, Dhillo WS, Smith KL, Kong WM, Frost GS, Bloom SR.

Diabetes Obes Metab. 2007 May;9(3):435-7.PMID: 17391172 [PubMed - indexed for MEDLINE]Related articles

Low-dose pancreatic polypeptide inhibits food intake in man.

Jesudason DR, Monteiro MP, McGowan BM, Neary NM, Park AJ, Philippou E, Small CJ, Frost GS, Ghatei MA, Bloom SR.

Br J Nutr. 2007 Mar;97(3):426-9.PMID: 17313701 [PubMed - indexed for MEDLINE]Related articles

Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats.

McGowan BM, Stanley SA, Smith KL, Minnion JS, Donovan J, Thompson EL, Patterson M, Connolly MM, Abbott CR, Small CJ, Gardiner JV, Ghatei MA, Bloom SR.

Regul Pept. 2006 Sep 11;136(1-3):72-7. Epub 2006 Jun 9.PMID: 16764952 [PubMed - indexed for MEDLINE]Related articles

Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial.

Wynne K, Park AJ, Small CJ, Meeran K, Ghatei MA, Frost GS, Bloom SR.

Int J Obes (Lond). 2006 Dec;30(12):1729-36. Epub 2006 Apr 18.PMID: 16619056 [PubMed - indexed for MEDLINE]Related articles

Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat.

Jethwa PH, Smith KL, Small CJ, Abbott CR, Darch SJ, Murphy KG, Seth A, Semjonous NM, Patel SR, Todd JF, Ghatei MA, Bloom SR.

Endocrinology. 2006 Jun;147(6):2886-92. Epub 2006 Mar 23.PMID: 16556758 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors.

Murray JF, Hahn JD, Kennedy AR, Small CJ, Bloom SR, Haskell-Luevano C, Coen CW, Wilson CA.

J Neuroendocrinol. 2006 Mar;18(3):157-67.PMID: 16454799 [PubMed - indexed for MEDLINE]Related articles

Interactions between the melanocortin system and the hypothalamo-pituitary-thyroid axis.

Martin NM, Smith KL, Bloom SR, Small CJ.

Peptides. 2006 Feb;27(2):333-9. Epub 2006 Jan 18. Review.PMID: 16388877 [PubMed - indexed for MEDLINE]Related articles

Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect.

Neary NM, Druce MR, Small CJ, Bloom SR.

Gut. 2006 Jan;55(1):135. No abstract available. PMID: 16344585 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcutaneous administration of ghrelin stimulates energy intake in healthy lean human volunteers.

Druce MR, Neary NM, Small CJ, Milton J, Monteiro M, Patterson M, Ghatei MA, Bloom SR.

Int J Obes (Lond). 2006 Feb;30(2):293-6.PMID: 16247504 [PubMed - indexed for MEDLINE]Related articles

The importance of acclimatisation and habituation to experimental conditions when investigating the anorectic effects of gastrointestinal hormones in the rat.

Abbott CR, Small CJ, Sajedi A, Smith KL, Parkinson JR, Broadhead LL, Ghatei MA, Bloom SR.

Int J Obes (Lond). 2006 Feb;30(2):288-92.PMID: 16231018 [PubMed - indexed for MEDLINE]Related articles

Abnormalities of the somatotrophic axis in the obese agouti mouse.

Martin NM, Houston PA, Patterson M, Sajedi A, Carmignac DF, Ghatei MA, Bloom SR, Small CJ.

Int J Obes (Lond). 2006 Mar;30(3):430-8.PMID: 16172617 [PubMed - indexed for MEDLINE]Related articles

Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively.

Neary NM, Small CJ, Druce MR, Park AJ, Ellis SM, Semjonous NM, Dakin CL, Filipsson K, Wang F, Kent AS, Frost GS, Ghatei MA, Bloom SR.

Endocrinology. 2005 Dec;146(12):5120-7. Epub 2005 Sep 8.PMID: 16150917 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial.

Wynne K, Park AJ, Small CJ, Patterson M, Ellis SM, Murphy KG, Wren AM, Frost GS, Meeran K, Ghatei MA, Bloom SR.

Diabetes. 2005 Aug;54(8):2390-5.PMID: 16046306 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin.

Jethwa PH, Small CJ, Smith KL, Seth A, Darch SJ, Abbott CR, Murphy KG, Todd JF, Ghatei MA, Bloom SR.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E301-5. Epub 2005 Mar 22.PMID: 16014357 [PubMed - indexed for MEDLINE]Related articlesFree article

The therapeutic potential of gut hormone peptide YY3-36 in the treatment of obesity.

Small CJ, Bloom SR.

Expert Opin Investig Drugs. 2005 May;14(5):647-53. Review.PMID: 15926870 [PubMed - indexed for MEDLINE]Related articles

Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy.

le Roux CW, Neary NM, Halsey TJ, Small CJ, Martinez-Isla AM, Ghatei MA, Theodorou NA, Bloom SR.

J Clin Endocrinol Metab. 2005 Aug;90(8):4521-4. Epub 2005 May 24.PMID: 15914532 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel therapeutic targets for appetite regulation.

Small CJ, Parkinson JR, Bloom SR.

Curr Opin Investig Drugs. 2005 Apr;6(4):369-72. Review.PMID: 15898343 [PubMed - indexed for MEDLINE]Related articles

Subcutaneous ghrelin enhances acute food intake in malnourished patients who receive maintenance peritoneal dialysis: a randomized, placebo-controlled trial.

Wynne K, Giannitsopoulou K, Small CJ, Patterson M, Frost G, Ghatei MA, Brown EA, Bloom SR, Choi P.

J Am Soc Nephrol. 2005 Jul;16(7):2111-8. Epub 2005 May 11.PMID: 15888560 [PubMed - indexed for MEDLINE]Related articlesFree article

The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway.

Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JR, Ghatei MA, Bloom SR.

Brain Res. 2005 May 17;1044(1):127-31. Epub 2005 Apr 7.PMID: 15862798 [PubMed - indexed for MEDLINE]Related articles

Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake.

Abbott CR, Small CJ, Kennedy AR, Neary NM, Sajedi A, Ghatei MA, Bloom SR.

Brain Res. 2005 May 10;1043(1-2):139-44.PMID: 15862527 [PubMed - indexed for MEDLINE]Related articles

Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity.

Andersson U, Treebak JT, Nielsen JN, Smith KL, Abbott CR, Small CJ, Carling D, Richter EA.

Biochem Biophys Res Commun. 2005 Apr 8;329(2):719-25.PMID: 15737645 [PubMed - indexed for MEDLINE]Related articles

Gut hormones as peripheral anti obesity targets.

Small CJ, Bloom SR.

Curr Drug Targets CNS Neurol Disord. 2004 Oct;3(5):379-88. Review.PMID: 15544446 [PubMed - indexed for MEDLINE]Related articles

Abnormalities of the hypothalamo-pituitary-thyroid axis in the pro-opiomelanocortin deficient mouse.

Martin NM, Small CJ, Sajedi A, Liao XH, Weiss RE, Gardiner JV, Ghatei MA, Bloom SR.

Regul Pept. 2004 Nov 15;122(3):169-72.PMID: 15491787 [PubMed - indexed for MEDLINE]Related articles

Gut hormones and the control of appetite.

Small CJ, Bloom SR.

Trends Endocrinol Metab. 2004 Aug;15(6):259-63. Review.PMID: 15358278 [PubMed - indexed for MEDLINE]Related articles

Chronic administration of NMU into the paraventricular nucleus stimulates the HPA axis but does not influence food intake or body weight.

Thompson EL, Murphy KG, Todd JF, Martin NM, Small CJ, Ghatei MA, Bloom SR.

Biochem Biophys Res Commun. 2004 Oct 8;323(1):65-71.PMID: 15351702 [PubMed - indexed for MEDLINE]Related articles

Triiodothyronine stimulates food intake via the hypothalamic ventromedial nucleus independent of changes in energy expenditure.

Kong WM, Martin NM, Smith KL, Gardiner JV, Connoley IP, Stephens DA, Dhillo WS, Ghatei MA, Small CJ, Bloom SR.

Endocrinology. 2004 Nov;145(11):5252-8. Epub 2004 Aug 5.PMID: 15297436 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular energy sensor balances the scales.

Small CJ, Carling D, Bloom SR.

Nat Med. 2004 Jul;10(7):681-2. No abstract available. PMID: 15229514 [PubMed - indexed for MEDLINE]Related articles

Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial.

Neary NM, Small CJ, Wren AM, Lee JL, Druce MR, Palmieri C, Frost GS, Ghatei MA, Coombes RC, Bloom SR.

J Clin Endocrinol Metab. 2004 Jun;89(6):2832-6.PMID: 15181065 [PubMed - indexed for MEDLINE]Related articlesFree article

Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY(3-36) but resistant to ghrelin.

Martin NM, Small CJ, Sajedi A, Patterson M, Ghatei MA, Bloom SR.

Int J Obes Relat Metab Disord. 2004 Jul;28(7):886-93.PMID: 15148507 [PubMed - indexed for MEDLINE]Related articles

Regulation of rat pituitary cocaine- and amphetamine-regulated transcript (CART) by CRH and glucocorticoids.

Stanley SA, Murphy KG, Bewick GA, Kong WM, Opacka-Juffry J, Gardiner JV, Ghatei M, Small CJ, Bloom SR.

Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E583-90. Epub 2004 May 11.PMID: 15138156 [PubMed - indexed for MEDLINE]Related articlesFree article

Minireview: Gut peptides regulating satiety.

Druce MR, Small CJ, Bloom SR.

Endocrinology. 2004 Jun;145(6):2660-5. Epub 2004 Mar 24. Review.PMID: 15044353 [PubMed - indexed for MEDLINE]Related articlesFree article

Peripheral oxyntomodulin reduces food intake and body weight gain in rats.

Dakin CL, Small CJ, Batterham RL, Neary NM, Cohen MA, Patterson M, Ghatei MA, Bloom SR.

Endocrinology. 2004 Jun;145(6):2687-95. Epub 2004 Mar 4.PMID: 15001546 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase plays a role in the control of food intake.

Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ.

J Biol Chem. 2004 Mar 26;279(13):12005-8. Epub 2004 Jan 23.PMID: 14742438 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone.

Abbott CR, Kennedy AR, Wren AM, Rossi M, Murphy KG, Seal LJ, Todd JF, Ghatei MA, Small CJ, Bloom SR.

Endocrinology. 2003 Sep;144(9):3943-9.PMID: 12933668 [PubMed - indexed for MEDLINE]Related articlesFree article

Central orexin A has site-specific effects on luteinizing hormone release in female rats.

Small CJ, Goubillon ML, Murray JF, Siddiqui A, Grimshaw SE, Young H, Sivanesan V, Kalamatianos T, Kennedy AR, Coen CW, Bloom SR, Wilson CA.

Endocrinology. 2003 Jul;144(7):3225-36.PMID: 12810579 [PubMed - indexed for MEDLINE]Related articlesFree article

Gut and mind.

Neary NM, Small CJ, Bloom SR.

Gut. 2003 Jul;52(7):918-21.PMID: 12801943 [PubMed - indexed for MEDLINE]Related articlesFree article

gamma-MSH increases intracellular cAMP accumulation and GnRH release in vitro and LH release in vivo.

Stanley SA, Davies S, Small CJ, Gardiner JV, Ghatei MA, Smith DM, Bloom SR.

FEBS Lett. 2003 May 22;543(1-3):66-70.PMID: 12753907 [PubMed - indexed for MEDLINE]Related articles

Chronic CNS administration of Agouti-related protein (Agrp) reduces energy expenditure.

Small CJ, Liu YL, Stanley SA, Connoley IP, Kennedy A, Stock MJ, Bloom SR.

Int J Obes Relat Metab Disord. 2003 Apr;27(4):530-3.PMID: 12664087 [PubMed - indexed for MEDLINE]Related articles

Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis.

Dhillo WS, Small CJ, Jethwa PH, Russell SH, Gardiner JV, Bewick GA, Seth A, Murphy KG, Ghatei MA, Bloom SR.

Endocrinology. 2003 Apr;144(4):1420-5.PMID: 12639925 [PubMed - indexed for MEDLINE]Related articlesFree article

Appetite control and reproduction: leptin and beyond.

Small CJ, Stanley SA, Bloom SR.

Semin Reprod Med. 2002 Nov;20(4):389-98. Review.PMID: 12536362 [PubMed - indexed for MEDLINE]Related articles

Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland.

Dhillo WS, Small CJ, Gardiner JV, Bewick GA, Whitworth EJ, Jethwa PH, Seal LJ, Ghatei MA, Hinson JP, Bloom SR.

Biochem Biophys Res Commun. 2003 Jan 31;301(1):102-7.PMID: 12535647 [PubMed - indexed for MEDLINE]Related articles

The hypothalamic mechanisms of the hypophysiotropic action of ghrelin.

Wren AM, Small CJ, Fribbens CV, Neary NM, Ward HL, Seal LJ, Ghatei MA, Bloom SR.

Neuroendocrinology. 2002 Nov;76(5):316-24.PMID: 12457042 [PubMed - indexed for MEDLINE]Related articles

Transgenic over-expression of galanin in injured primary sensory neurons.

Bacon A, Holmes FE, Small CJ, Ghatei M, Mahoney S, Bloom S, Wynick D.

Neuroreport. 2002 Nov 15;13(16):2129-32.PMID: 12438940 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic actions of neuromedin U.

Wren AM, Small CJ, Abbott CR, Jethwa PH, Kennedy AR, Murphy KG, Stanley SA, Zollner AN, Ghatei MA, Bloom SR.

Endocrinology. 2002 Nov;143(11):4227-34.PMID: 12399416 [PubMed - indexed for MEDLINE]Related articlesFree article

Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats.

Dakin CL, Small CJ, Park AJ, Seth A, Ghatei MA, Bloom SR.

Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1173-7. Epub 2002 Jul 30.PMID: 12388165 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic interactions between neuropeptide Y, agouti-related protein, cocaine- and amphetamine-regulated transcript and alpha-melanocyte-stimulating hormone in vitro in male rats.

Dhillo WS, Small CJ, Stanley SA, Jethwa PH, Seal LJ, Murphy KG, Ghatei MA, Bloom SR.

J Neuroendocrinol. 2002 Sep;14(9):725-30.PMID: 12213133 [PubMed - indexed for MEDLINE]Related articles