PubMed

Differences in the TGF-{beta}1-induced pro-fibrotic response of anterior and posterior corneal keratocytes in vitro.

Hindman HB, Swanton JN, Phipps R, Sime PJ, Huxlin KR.

Invest Ophthalmol Vis Sci. 2009 Nov 11. [Epub ahead of print]PMID: 19907023 [PubMed - as supplied by publisher]Related articles

Determinants of initiation and progression of idiopathic pulmonary fibrosis.

Kottmann RM, Hogan CM, Phipps RP, Sime PJ.

Respirology. 2009 Sep;14(7):917-33. Review.PMID: 19740254 [PubMed - in process]Related articles

Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism.

Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Strong ER, Phipps RP, Sime PJ.

Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L912-9. Epub 2009 Sep 4.PMID: 19734319 [PubMed - indexed for MEDLINE]Related articles

Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.

Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ.

Am J Respir Cell Mol Biol. 2009 Dec;41(6):722-30. Epub 2009 Mar 13.PMID: 19286977 [PubMed - indexed for MEDLINE]Related articles

Exogenous lipoid pneumonia: an unexpected complication of substance abuse.

Gurell MN, Kottmann RM, Xu H, Sime PJ.

Ann Intern Med. 2008 Sep 2;149(5):364-5. No abstract available. PMID: 18765715 [PubMed - indexed for MEDLINE]Related articlesFree article

The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.

Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ.

J Biol Chem. 2008 Oct 24;283(43):28944-57. Epub 2008 Aug 12.PMID: 18697742 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise.

Bernard MP, Bancos S, Sime PJ, Phipps RP.

Curr Pharm Des. 2008;14(21):2051-60. Review.PMID: 18691115 [PubMed - indexed for MEDLINE]Related articlesFree article

Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione.

Baglole CJ, Sime PJ, Phipps RP.

Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L624-36. Epub 2008 Aug 8.PMID: 18689604 [PubMed - indexed for MEDLINE]Related articlesFree article

RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke.

Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ Jr, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I.

Am J Respir Cell Mol Biol. 2009 Feb;40(2):147-58. Epub 2008 Aug 7.PMID: 18688039 [PubMed - indexed for MEDLINE]Related articles

High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function.

Thatcher TH, Benson RP, Phipps RP, Sime PJ.

Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L412-21. Epub 2008 Jun 20.PMID: 18567739 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies.

Garcia-Bates TM, Lehmann GM, Simpson-Haidaris PJ, Bernstein SH, Sime PJ, Phipps RP.

PPAR Res. 2008;2008:834612.PMID: 18528522 [PubMed - in process]Related articlesFree article

The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis.

Sime PJ.

J Investig Med. 2008 Feb;56(2):534-8. Review.PMID: 18317437 [PubMed - indexed for MEDLINE]Related articles

PPARgamma: a novel molecular target in lung disease.

Hart CM, Roman J, Reddy R, Sime PJ.

J Investig Med. 2008 Feb;56(2):515-7.PMID: 18317433 [PubMed - indexed for MEDLINE]Related articles

The Role of PPARs in Lung Fibrosis.

Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ.

PPAR Res. 2007;2007:71323.PMID: 17710235 [PubMed - in process]Related articlesFree article

Asbestos-related lung disease.

O'Reilly KM, Mclaughlin AM, Beckett WS, Sime PJ.

Am Fam Physician. 2007 Mar 1;75(5):683-8. Review.PMID: 17375514 [PubMed - indexed for MEDLINE]Related articles

Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.

Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ.

Am J Pathol. 2007 Mar;170(3):855-64.PMID: 17322371 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome.

Shah AP, Xu H, Sime PJ, Trawick DR.

Eur Respir J. 2006 Dec;28(6):1276-9.PMID: 17138682 [PubMed - indexed for MEDLINE]Related articlesFree article

More than structural cells, fibroblasts create and orchestrate the tumor microenvironment.

Baglole CJ, Ray DM, Bernstein SH, Feldon SE, Smith TJ, Sime PJ, Phipps RP.

Immunol Invest. 2006;35(3-4):297-325. Review.PMID: 16916756 [PubMed - indexed for MEDLINE]Related articles

Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation.

Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ.

Exp Lung Res. 2006 May;32(5):181-99.PMID: 16908446 [PubMed - indexed for MEDLINE]Related articles

Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lung.

Viscardi RM, Atamas SP, Luzina IG, Hasday JD, He JR, Sime PJ, Coalson JJ, Yoder BA.

Pediatr Res. 2006 Aug;60(2):141-6.PMID: 16864693 [PubMed - indexed for MEDLINE]Related articles

Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema.

Baglole CJ, Bushinsky SM, Garcia TM, Kode A, Rahman I, Sime PJ, Phipps RP.

Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L19-29. Epub 2006 Jan 27.PMID: 16443644 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire.

Thatcher TH, Sime PJ, Barth RK.

Exp Lung Res. 2005 Sep;31(7):685-700.PMID: 16203623 [PubMed - indexed for MEDLINE]Related articles

Isolation and phenotypic characterization of lung fibroblasts.

Baglole CJ, Reddy SY, Pollock SJ, Feldon SE, Sime PJ, Smith TJ, Phipps RP.

Methods Mol Med. 2005;117:115-27.PMID: 16118449 [PubMed - indexed for MEDLINE]Related articles

The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts.

Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP.

Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L391-9. Epub 2005 Apr 29.PMID: 15863442 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of CXCR2 in cigarette smoke-induced lung inflammation.

Thatcher TH, McHugh NA, Egan RW, Chapman RW, Hey JA, Turner CK, Redonnet MR, Seweryniak KE, Sime PJ, Phipps RP.

Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L322-8. Epub 2005 Apr 15.PMID: 15833762 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis.

Vallance BA, Gunawan MI, Hewlett B, Bercik P, Van Kampen C, Galeazzi F, Sime PJ, Gauldie J, Collins SM.

Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G116-28. Epub 2005 Mar 18.PMID: 15778431 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis.

Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ.

Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1146-53. Epub 2005 Feb 25.PMID: 15734787 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis.

O'Reilly KM, Phipps RP, Thatcher TH, Graf BA, Van Kirk J, Sime PJ.

Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1010-6. Epub 2005 Jan 21.PMID: 15665045 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel ELISpot method for adherent cells.

Turner CK, Blieden TM, Smith TJ, Feldon SE, Foster DC, Sime PJ, Phipps RP.

J Immunol Methods. 2004 Aug;291(1-2):63-70.PMID: 15345305 [PubMed - indexed for MEDLINE]Related articles

Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.

Martey CA, Pollock SJ, Turner CK, O'Reilly KM, Baglole CJ, Phipps RP, Sime PJ.

Am J Physiol Lung Cell Mol Physiol. 2004 Nov;287(5):L981-91. Epub 2004 Jul 2.PMID: 15234907 [PubMed - indexed for MEDLINE]Related articlesFree article

A case of steroid responsive pulmonary hyalinising granuloma: complicated by deep venous thrombosis.

O'Reilly KM, Boscia JA, Kaplan KL, Sime PJ.

Eur Respir J. 2004 Jun;23(6):954-6.PMID: 15219012 [PubMed - indexed for MEDLINE]Related articlesFree article

Asbestos-derived reactive oxygen species activate TGF-beta1.

Pociask DA, Sime PJ, Brody AR.

Lab Invest. 2004 Aug;84(8):1013-23.PMID: 15122306 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis.

Kaufman J, Sime PJ, Phipps RP.

J Immunol. 2004 Feb 1;172(3):1862-71.PMID: 14734771 [PubMed - indexed for MEDLINE]Related articlesFree article

Titration of non-replicating adenovirus as a vector for transducing active TGF-beta1 gene expression causing inflammation and fibrogenesis in the lungs of C57BL/6 mice.

Warshamana GS, Pociask DA, Fisher KJ, Liu JY, Sime PJ, Brody AR.

Int J Exp Pathol. 2002 Aug;83(4):183-201.PMID: 12485463 [PubMed - indexed for MEDLINE]Related articles

Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains.

Kolb M, Bonniaud P, Galt T, Sime PJ, Kelly MM, Margetts PJ, Gauldie J.

Am J Respir Cell Mol Biol. 2002 Aug;27(2):141-50.PMID: 12151305 [PubMed - indexed for MEDLINE]Related articlesFree article

A new direction in the pathogenesis of idiopathic pulmonary fibrosis?

Gauldie J, Kolb M, Sime PJ.

Respir Res. 2002;3:1. Epub 2001 Sep 26. Review.PMID: 11806836 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta(1) overexpression in tumor necrosis factor-alpha receptor knockout mice induces fibroproliferative lung disease.

Liu JY, Sime PJ, Wu T, Warshamana GS, Pociask D, Tsai SY, Brody AR.

Am J Respir Cell Mol Biol. 2001 Jul;25(1):3-7.PMID: 11472967 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment.

Sime PJ, O'Reilly KM.

Clin Immunol. 2001 Jun;99(3):308-19. Review.PMID: 11358425 [PubMed - indexed for MEDLINE]Related articles

Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung.

Kolb M, Margetts PJ, Sime PJ, Gauldie J.

Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1327-34.PMID: 11350814 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin.

Kolb M, Margetts PJ, Galt T, Sime PJ, Xing Z, Schmidt M, Gauldie J.

Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):770-7.PMID: 11254537 [PubMed - indexed for MEDLINE]Related articlesFree article

Spatial-specific TGF-beta1 adenoviral expression determines morphogenetic phenotypes in embryonic mouse lung.

Zhao J, Sime PJ, Bringas P Jr, Tefft JD, Buckley S, Bu D, Gauldie J, Warburton D.

Eur J Cell Biol. 1999 Oct;78(10):715-25.PMID: 10569244 [PubMed - indexed for MEDLINE]Related articles

Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis.

Zhao J, Sime PJ, Bringas P Jr, Gauldie J, Warburton D.

Am J Physiol. 1999 Aug;277(2 Pt 1):L412-22.PMID: 10444536 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis.

Gauldie J, Sime PJ, Xing Z, Marr B, Tremblay GM.

Curr Top Pathol. 1999;93:35-45. Review. No abstract available. PMID: 10339897 [PubMed - indexed for MEDLINE]Related articles

Enhancement of dendritic cell tolerogenicity by genetic modification using adenoviral vectors encoding cDNA for TGF beta 1.

Lee WC, Wan YH, Li W, Fu F, Sime PJ, Gauldie J, Thomson AW, Fung JJ, Lu L, Qian S.

Transplant Proc. 1999 Feb-Mar;31(1-2):1195. No abstract available. PMID: 10083533 [PubMed - indexed for MEDLINE]Related articles

Adenoviral infection inhibits allergic airways inflammation in mice.

Stämpfli MR, Ritz SA, Neigh GS, Sime PJ, Lei XF, Xing Z, Croitoru K, Jordana M.

Clin Exp Allergy. 1998 Dec;28(12):1581-90.PMID: 10024231 [PubMed - indexed for MEDLINE]Related articles

Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts.

Sime PJ, Marr RA, Gauldie D, Xing Z, Hewlett BR, Graham FL, Gauldie J.

Am J Pathol. 1998 Sep;153(3):825-32.PMID: 9736031 [PubMed - indexed for MEDLINE]Related articlesFree article

Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-beta type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA.

Zhao J, Sime PJ, Bringas P Jr, Gauldie J, Warburton D.

Mech Dev. 1998 Mar;72(1-2):89-100.PMID: 9533955 [PubMed - indexed for MEDLINE]Related articles

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J.

J Clin Invest. 1997 Aug 15;100(4):768-76.PMID: 9259574 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated gene transfer of the proteoglycan biglycan induces fibroblastic responses in the lung.

Sime PJ, Sarnstrand B, Xing Z, Graham F, Fisher L, Gauldie J.

Chest. 1997 Jun;111(6 Suppl):137S. No abstract available. PMID: 9184564 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient gene transfer and expression in the lung.

Sime PJ, Xing Z, Foley R, Graham FL, Gauldie J.

Chest. 1997 Jun;111(6 Suppl):89S-94S. Review. No abstract available. PMID: 9184545 [PubMed - indexed for MEDLINE]Related articlesFree article