PubMed

Dynamic changes of neuroskeletal proteins in DRGs underlie impaired axonal maturation and progressive axonal degeneration in type 1 diabetes.

Kamiya H, Zhang W, Sima AA.

Exp Diabetes Res. 2009;2009:793281. Epub 2009 Oct 12.PMID: 19834568 [PubMed - in process]Related articlesFree article

Zinc-activated C-peptide resistance to the type 2 diabetic erythrocyte is associated with hyperglycemia-induced phosphatidylserine externalization and reversed by metformin.

Meyer JA, Subasinghe W, Sima AA, Keltner Z, Reid GE, Daleke D, Spence DM.

Mol Biosyst. 2009 Oct;5(10):1157-62. Epub 2009 Jul 21.PMID: 19756305 [PubMed - in process]Related articles

Neuronal loss in Pelizaeus-Merzbacher disease differs in various mutations of the proteolipid protein 1.

Sima AA, Pierson CR, Woltjer RL, Hobson GM, Golden JA, Kupsky WJ, Schauer GM, Bird TD, Skoff RP, Garbern JY.

Acta Neuropathol. 2009 Oct;118(4):531-9. Epub 2009 Jun 27.PMID: 19562355 [PubMed - indexed for MEDLINE]Related articles

Inflammation in Diabetic Encephalopathy is Prevented by C-Peptide.

Sima AA, Zhang W, Kreipke CW, Rafols JA, Hoffman WH.

Rev Diabet Stud. 2009 Spring;6(1):37-42. Epub 2009 May 10.PMID: 19557294 [PubMed - in process]Related articles

Elevated triglycerides correlate with progression of diabetic neuropathy.

Wiggin TD, Sullivan KA, Pop-Busui R, Amato A, Sima AA, Feldman EL.

Diabetes. 2009 Jul;58(7):1634-40. Epub 2009 May 1.PMID: 19411614 [PubMed - indexed for MEDLINE]Related articlesFree article

Receptor for advanced glycation end products and neuronal deficit in the fatal brain edema of diabetic ketoacidosis.

Hoffman WH, Artlett CM, Zhang W, Kreipke CW, Passmore GG, Rafols JA, Sima AA.

Brain Res. 2008 Oct 31;1238:154-62. Epub 2008 Aug 26.PMID: 18775683 [PubMed - indexed for MEDLINE]Related articles

The heterogeneity of diabetic neuropathy.

Sima AA.

Front Biosci. 2008 May 1;13:4809-16. Review.PMID: 18508546 [PubMed - indexed for MEDLINE]Related articles

The effects of C-peptide on type 1 diabetic polyneuropathies and encephalopathy in the BB/Wor-rat.

Sima AA, Zhang W, Li ZG, Kamiya H.

Exp Diabetes Res. 2008;2008:230458. Review.PMID: 18437223 [PubMed - indexed for MEDLINE]Related articlesFree article

Is C-peptide replacement the missing link for successful treatment of neurological complications in type 1 diabetes?

Sima AA, Kamiya H.

Curr Drug Targets. 2008 Jan;9(1):37-46. Review.PMID: 18220711 [PubMed - indexed for MEDLINE]Related articles

Acetyl-L-carnitine in diabetic polyneuropathy: experimental and clinical data.

Sima AA.

CNS Drugs. 2007;21 Suppl 1:13-23; discussion 45-6. Review.PMID: 17696589 [PubMed - indexed for MEDLINE]Related articles

SREBP-1c expression in Schwann cells is affected by diabetes and nutritional status.

de Preux AS, Goosen K, Zhang W, Sima AA, Shimano H, Ouwens DM, Diamant M, Hillebrands JL, Rozing J, Lemke G, Beckmann JS, Smit AB, Verheijen MH, Chrast R.

Mol Cell Neurosci. 2007 Aug;35(4):525-34. Epub 2007 May 1.PMID: 17632011 [PubMed - indexed for MEDLINE]Related articles

Will C-peptide substitution make a difference in combating complications in insulin-deficient diabetes?

Sima AA.

Rev Diabet Stud. 2004 Summer;1(2):55-7. Epub 2004 Aug 10. No abstract available. PMID: 17491666 [PubMed]Related articlesFree article

Diabetes and Alzheimer's disease - is there a connection?

Sima AA, Li ZG.

Rev Diabet Stud. 2006 Winter;3(4):161-8. Epub 2007 Feb 10.PMID: 17487340 [PubMed - in process]Related articlesFree article

Alzheimer-like changes in rat models of spontaneous diabetes.

Li ZG, Zhang W, Sima AA.

Diabetes. 2007 Jul;56(7):1817-24. Epub 2007 Apr 24. Erratum in: Diabetes. 2007 Oct;56(10):2650. PMID: 17456849 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic neuropathy differs in type 1 and type 2 diabetes.

Sima AA, Kamiya H.

Ann N Y Acad Sci. 2006 Nov;1084:235-49. Review.PMID: 17151305 [PubMed - indexed for MEDLINE]Related articles

C-Peptide reverses nociceptive neuropathy in type 1 diabetes.

Kamiya H, Zhang W, Ekberg K, Wahren J, Sima AA.

Diabetes. 2006 Dec;55(12):3581-7.PMID: 17130507 [PubMed - indexed for MEDLINE]Related articlesFree article

Degeneration of the Golgi and neuronal loss in dorsal root ganglia in diabetic BioBreeding/Worcester rats.

Kamiya H, Zhang W, Sima AA.

Diabetologia. 2006 Nov;49(11):2763-74. Epub 2006 Sep 20.PMID: 17047923 [PubMed - indexed for MEDLINE]Related articles

C-peptide improves neuropathy in type 1 diabetic BB/Wor-rats.

Zhang W, Kamiya H, Ekberg K, Wahren J, Sima AA.

Diabetes Metab Res Rev. 2007 Jan;23(1):63-70.PMID: 16845685 [PubMed - indexed for MEDLINE]Related articles

The preventive and therapeutic effects of GCPII (NAALADase) inhibition on painful and sensory diabetic neuropathy.

Zhang W, Murakawa Y, Wozniak KM, Slusher B, Sima AA.

J Neurol Sci. 2006 Sep 25;247(2):217-23. Epub 2006 Jun 15.PMID: 16780883 [PubMed - indexed for MEDLINE]Related articles

Pathological mechanisms involved in diabetic neuropathy: can we slow the process?

Sima AA.

Curr Opin Investig Drugs. 2006 Apr;7(4):324-37. Review.PMID: 16625819 [PubMed - indexed for MEDLINE]Related articles

Apoptotic stress is counterbalanced by survival elements preventing programmed cell death of dorsal root ganglions in subacute type 1 diabetic BB/Wor rats.

Kamiya H, Zhangm W, Sima AA.

Diabetes. 2005 Nov;54(11):3288-95.PMID: 16249457 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 diabetic rats.

Sima AA, Li ZG.

Diabetes. 2005 May;54(5):1497-505.PMID: 15855338 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of impaired insulin/IGF action in primary diabetic encephalopathy.

Li ZG, Zhang W, Sima AA.

Brain Res. 2005 Mar 10;1037(1-2):12-24.PMID: 15777748 [PubMed - indexed for MEDLINE]Related articles

Unmyelinated fiber sensory neuropathy differs in type 1 and type 2 diabetes.

Kamiya H, Murakawa Y, Zhang W, Sima AA.

Diabetes Metab Res Rev. 2005 Sep-Oct;21(5):448-58.PMID: 15747389 [PubMed - indexed for MEDLINE]Related articles

Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials.

Sima AA, Calvani M, Mehra M, Amato A; Acetyl-L-Carnitine Study Group.

Diabetes Care. 2005 Jan;28(1):89-94.PMID: 15616239 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes enhances apoptosis induced by cerebral ischemia.

Li ZG, Britton M, Sima AA, Dunbar JC.

Life Sci. 2004 Dec 3;76(3):249-62.PMID: 15531378 [PubMed - indexed for MEDLINE]Related articles

C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes.

Kamiya H, Zhang W, Sima AA.

Ann Neurol. 2004 Dec;56(6):827-35.PMID: 15497155 [PubMed - indexed for MEDLINE]Related articles

Diabetes underlies common neurological disorders.

Sima AA.

Ann Neurol. 2004 Oct;56(4):459-61. No abstract available. PMID: 15455395 [PubMed - indexed for MEDLINE]Related articles

Effects of C-peptide on expression of eNOS and iNOS in human cavernosal smooth muscle cells.

Li H, Xu L, Dunbar JC, Dhabuwala CB, Sima AA.

Urology. 2004 Sep;64(3):622-7.PMID: 15351621 [PubMed - indexed for MEDLINE]Related articles

C-peptide and retinal microangiopathy in diabetes.

Chakrabarti S, Khan ZA, Cukiernik M, Zhang W, Sima AA.

Exp Diabesity Res. 2004 Jan-Mar;5(1):91-6. Review.PMID: 15198374 [PubMed - indexed for MEDLINE]Related articlesFree article

C-peptide and central nervous system complications in diabetes.

Li ZG, Sima AA.

Exp Diabesity Res. 2004 Jan-Mar;5(1):79-90. Review.PMID: 15198373 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 diabetic neuropathy and C-peptide.

Sima AA, Zhang W, Grunberger G.

Exp Diabesity Res. 2004 Jan-Mar;5(1):65-77. Review.PMID: 15198372 [PubMed - indexed for MEDLINE]Related articlesFree article

The C-peptide signaling.

Grunberger G, Sima AA.

Exp Diabesity Res. 2004 Jan-Mar;5(1):25-36. Review.PMID: 15198369 [PubMed - indexed for MEDLINE]Related articlesFree article

Experimental rat models of types 1 and 2 diabetes differ in sympathetic neuroaxonal dystrophy.

Schmidt RE, Dorsey DA, Beaudet LN, Parvin CA, Zhang W, Sima AA.

J Neuropathol Exp Neurol. 2004 May;63(5):450-60.PMID: 15198124 [PubMed - indexed for MEDLINE]Related articles

Molecular alterations underlie nodal and paranodal degeneration in type 1 diabetic neuropathy and are prevented by C-peptide.

Sima AA, Zhang W, Li ZG, Murakawa Y, Pierson CR.

Diabetes. 2004 Jun;53(6):1556-63.PMID: 15161761 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic neuropathy in type 1 and type 2 diabetes and the effects of C-peptide.

Sima AA.

J Neurol Sci. 2004 May 15;220(1-2):133-6. Review. No abstract available. PMID: 15140622 [PubMed - indexed for MEDLINE]Related articles

C-peptide corrects endoneurial blood flow but not oxidative stress in type 1 BB/Wor rats.

Stevens MJ, Zhang W, Li F, Sima AA.

Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E497-505. Epub 2004 May 4.PMID: 15126237 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes.

Sima AA, Kamiya H, Li ZG.

Eur J Pharmacol. 2004 Apr 19;490(1-3):187-97. Review. Erratum in: Eur J Pharmacol. 2004 Jun 21;494(1):77. Kamiya, Hideke [corrected to Kamiya, Hideki]. PMID: 15094085 [PubMed - indexed for MEDLINE]Related articles

The insulin-like growth factor system and neurological complications in diabetes.

Sima AA, Li ZG, Zhang W.

Exp Diabesity Res. 2003 Oct-Dec;4(4):235-56. Review.PMID: 14668047 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights into the metabolic and molecular basis for diabetic neuropathy.

Sima AA.

Cell Mol Life Sci. 2003 Nov;60(11):2445-64. Review.PMID: 14625688 [PubMed - indexed for MEDLINE]Related articles

C-peptide enhances insulin-mediated cell growth and protection against high glucose-induced apoptosis in SH-SY5Y cells.

Li ZG, Zhang W, Sima AA.

Diabetes Metab Res Rev. 2003 Sep-Oct;19(5):375-85.PMID: 12951645 [PubMed - indexed for MEDLINE]Related articles

C-peptide and diabetic neuropathy.

Sima AA.

Expert Opin Investig Drugs. 2003 Sep;12(9):1471-88. Review.PMID: 12943492 [PubMed - indexed for MEDLINE]Related articles

Proinsulin C-peptide replacement in type 1 diabetic BB/Wor-rats prevents deficits in nerve fiber regeneration.

Pierson CR, Zhang W, Sima AA.

J Neuropathol Exp Neurol. 2003 Jul;62(7):765-79.PMID: 12901702 [PubMed - indexed for MEDLINE]Related articles

Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 diabetic neuropathy.

Pierson CR, Zhang W, Murakawa Y, Sima AA.

J Neuropathol Exp Neurol. 2003 Mar;62(3):260-71.PMID: 12638730 [PubMed - indexed for MEDLINE]Related articles

C-peptide prevents hippocampal apoptosis in type 1 diabetes.

Li ZG, Zhang W, Sima AA.

Int J Exp Diabetes Res. 2002 Oct-Dec;3(4):241-5.PMID: 12546277 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired glucose tolerance and insulinopenia in the GK-rat causes peripheral neuropathy.

Murakawa Y, Zhang W, Pierson CR, Brismar T, Ostenson CG, Efendic S, Sima AA.

Diabetes Metab Res Rev. 2002 Nov-Dec;18(6):473-83.PMID: 12469361 [PubMed - indexed for MEDLINE]Related articles

Early gene responses of trophic factors in nerve regeneration differ in experimental type 1 and type 2 diabetic polyneuropathies.

Pierson CR, Zhang W, Murakawa Y, Sima AA.

J Neuropathol Exp Neurol. 2002 Oct;61(10):857-71.PMID: 12387452 [PubMed - indexed for MEDLINE]Related articles

Has C-peptide come of age?

Sima AA.

Int J Exp Diabetes Res. 2001;2(2):81-2. No abstract available. PMID: 12369719 [PubMed - indexed for MEDLINE]Related articlesFree article

Proinsulin C-peptide--a consensus statement.

Sima AA, Grunberger G, Jörnvall H, Wahren J; C-peptide Study Group.

Int J Exp Diabetes Res. 2001;2(2):145-51. Review.PMID: 12369718 [PubMed - indexed for MEDLINE]Related articlesFree article

Human C-peptide dose dependently prevents early neuropathy in the BB/Wor-rat.

Zhang W, Yorek M, Pierson CR, Murakawa Y, Breidenbach A, Sima AA.

Int J Exp Diabetes Res. 2001;2(3):187-93.PMID: 12369706 [PubMed - indexed for MEDLINE]Related articlesFree article