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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1999 1
2000 2
2001 1
2002 6
2003 2
2004 5
2005 1
2006 2
2007 4
2008 4
2009 9
2010 8
2011 9
2012 8
2013 9
2014 8
2015 16
2016 15
2017 17
2018 21
2019 20
2020 21
2021 35
2022 24
2023 29
2024 11

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259 results

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Page 1
AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis.
Sun Z, Jiang Q, Gao B, Zhang X, Bu L, Wang L, Lin Y, Xie W, Li J, Guo J. Sun Z, et al. Cancer Res. 2023 Apr 14;83(8):1264-1279. doi: 10.1158/0008-5472.CAN-22-3407. Cancer Res. 2023. PMID: 36806887
Mass spectrometry-based analyses demonstrated that salt-inducible kinase 1 (SIK1) binds AKT and undergoes AKT-mediated phosphorylation, which compromises SIK1 tumor-suppressive functions. ...Following AKT-mediated phosphorylation, SIK1 interacted with 14-3-3 …
Mass spectrometry-based analyses demonstrated that salt-inducible kinase 1 (SIK1) binds AKT and undergoes AKT-mediated phosphorylatio …
The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.
Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ. Hollstein PE, et al. Cancer Discov. 2019 Nov;9(11):1606-1627. doi: 10.1158/2159-8290.CD-18-1261. Epub 2019 Jul 26. Cancer Discov. 2019. PMID: 31350328 Free PMC article.
Here, we combine CRISPR and genetic analysis of the AMPKR family in NSCLC cell lines and mouse models, revealing a surprising critical role for the SIK subfamily. Conditional genetic loss of Sik1 revealed increased tumor growth in mouse models of Kras-dependent lung cancer …
Here, we combine CRISPR and genetic analysis of the AMPKR family in NSCLC cell lines and mouse models, revealing a surprising critical role …
Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of beta-catenin by promoting delta-catenin ubiquitin degradation and upregulating SIK1.
Zang X, Jiang J, Gu J, Chen Y, Wang M, Zhang Y, Fu M, Shi H, Cai H, Qian H, Xu W, Zhang X. Zang X, et al. Mol Cancer. 2022 Jul 2;21(1):141. doi: 10.1186/s12943-022-01606-9. Mol Cancer. 2022. PMID: 35780119 Free PMC article.
Mechanistic studies revealed that circEIF4G3 bound to delta-catenin protein to promote its TRIM25-mediated ubiquitin degradation and interacted with miR-4449 to upregulate SIK1 expression. CONCLUSION: Our findings uncovered a tumor suppressor function of circEIF4G3 in GC t …
Mechanistic studies revealed that circEIF4G3 bound to delta-catenin protein to promote its TRIM25-mediated ubiquitin degradation and interac …
SIK1 suppresses colorectal cancer metastasis and chemoresistance via the TGF-beta signaling pathway.
Gao Y, Li H, Wang P, Wang J, Yao X. Gao Y, et al. J Cancer. 2023 Aug 6;14(13):2455-2467. doi: 10.7150/jca.83708. eCollection 2023. J Cancer. 2023. PMID: 37670972 Free PMC article.
Our findings revealed that SIK1 expression was low in CRC cells. The results of a KEGG pathway analysis showed a strong association between SIK1 and the TGF-beta signaling pathway. ...Additionally, SIK1 reduced cell migration and invasion. Our results suggest …
Our findings revealed that SIK1 expression was low in CRC cells. The results of a KEGG pathway analysis showed a strong association b …
SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
Wang C, Song D, Fu J, Wen X. Wang C, et al. Front Endocrinol (Lausanne). 2020 Sep 2;11:580. doi: 10.3389/fendo.2020.00580. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33013689 Free PMC article.
Manipulation of SIK1 activity using plasmid-mediated SIK1 over-expression and the use of the SIKs inhibitor HG-9-91-01 confirmed that SIK1 regulated the CRTC2 signaling pathway in HepG2 cells. Furthermore, in mouse primary hepatocytes, high glucose exposure d …
Manipulation of SIK1 activity using plasmid-mediated SIK1 over-expression and the use of the SIKs inhibitor HG-9-91-01 confirm …
SIK1-LNC represses the proliferative, migrative, and invasive abilities of lung cancer cells.
Yang L, Xie N, Huang J, Huang H, Xu S, Wang Z, Cai J. Yang L, et al. Onco Targets Ther. 2018 Jul 19;11:4197-4206. doi: 10.2147/OTT.S165278. eCollection 2018. Onco Targets Ther. 2018. PMID: 30050311 Free PMC article.
PURPOSE: In this study, we aimed to explore the association between SIK1-LNC expression and SIK1 in lung cancer cells and further identify the impact of SIK1-LNC on the proliferation, migration invasion of lung cancer cells. ...SIK1 expression showed a …
PURPOSE: In this study, we aimed to explore the association between SIK1-LNC expression and SIK1 in lung cancer cells and furt …
SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways.
Bertorello AM, Zhu JK. Bertorello AM, et al. Pflugers Arch. 2009 Jul;458(3):613-9. doi: 10.1007/s00424-009-0646-2. Epub 2009 Feb 27. Pflugers Arch. 2009. PMID: 19247687 Free PMC article. Review.
Changes in cellular ion levels can modulate distinct signaling networks aimed at correcting major disruptions in ion balances that might otherwise threaten cell growth and development. Salt-inducible kinase 1 (SIK1) and salt overly sensitive 2 (SOS2) are key protein kinase …
Changes in cellular ion levels can modulate distinct signaling networks aimed at correcting major disruptions in ion balances that might oth …
The Arabidopsis STE20/Hippo kinase SIK1 regulates polarity independently of PIN proteins.
Zhang P, Yu X, Bai J, Gong Q. Zhang P, et al. Biochem Biophys Res Commun. 2021 Apr 16;549:21-26. doi: 10.1016/j.bbrc.2021.02.083. Epub 2021 Feb 27. Biochem Biophys Res Commun. 2021. PMID: 33652206
Here we explore the possible link between SIK1, auxin, PIN, and polarity. Abnormal phyllotaxis and gravitropism were observed in sik1. sik1 was more sensitive to exogenous auxin in primary root elongation and lateral root emergence. ...The dark-induced vacuol …
Here we explore the possible link between SIK1, auxin, PIN, and polarity. Abnormal phyllotaxis and gravitropism were observed in s …
The SIK1/CRTC2/CREB1 and TWIST1/PI3K/Akt/GSK3beta signaling pathways mediated by microRNA-25-3p are altered in the schizophrenic rat brain.
Pan B, Zhu X, Han B, Weng J, Wang Y, Liu Y. Pan B, et al. Front Cell Neurosci. 2023 Jan 20;17:1087335. doi: 10.3389/fncel.2023.1087335. eCollection 2023. Front Cell Neurosci. 2023. PMID: 36744005 Free PMC article.
MiR-25-3p was shown to be involved in various neuropsychiatric diseases and can regulate SIK1 and TWIST1. The CRTC2/CREB1 and PI3K/Akt/GSK3beta signaling pathways are downstream pathways of SIK1 and TWIST1, respectively. ...The RNA-seq data revealed down-regulated m …
MiR-25-3p was shown to be involved in various neuropsychiatric diseases and can regulate SIK1 and TWIST1. The CRTC2/CREB1 and PI3K/Ak …
Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.
Hu J, Qiao J, Yu Q, Liu B, Zhen J, Liu Y, Ma Q, Li Y, Wang Q, Wang C, Lv Z. Hu J, et al. J Transl Med. 2021 Feb 15;19(1):69. doi: 10.1186/s12967-021-02717-5. J Transl Med. 2021. PMID: 33588892 Free PMC article.
However, whether SIK1 is involved in AKI-CKD transition and by what mechanism it regulates AKI-CKD transition remains unknown. ...Functional analysis revealed that overexpression of SIK1 alleviated AA-induced AKI-CKD transition and HK2 cells injury in vivo and in vi …
However, whether SIK1 is involved in AKI-CKD transition and by what mechanism it regulates AKI-CKD transition remains unknown. ...Fun …
259 results