PubMed

HDAC6 is a target for protection and regeneration following injury in the nervous system.

Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19599-604. Epub 2009 Nov 2.PMID: 19884510 [PubMed - in process]Related articles

Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

Yeager M, Chatterjee N, Ciampa J, Jacobs KB, Gonzalez-Bosquet J, Hayes RB, Kraft P, Wacholder S, Orr N, Berndt S, Yu K, Hutchinson A, Wang Z, Amundadottir L, Feigelson HS, Thun MJ, Diver WR, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Crawford ED, Haiman CA, Henderson B, Kolonel L, Le Marchand L, Siddiq A, Riboli E, Key TJ, Kaaks R, Isaacs W, Isaacs S, Wiley KE, Gronberg H, Wiklund F, Stattin P, Xu J, Zheng SL, Sun J, Vatten LJ, Hveem K, Kumle M, Tucker M, Gerhard DS, Hoover RN, Fraumeni JF Jr, Hunter DJ, Thomas G, Chanock SJ.

Nat Genet. 2009 Oct;41(10):1055-7. Epub 2009 Sep 20.PMID: 19767755 [PubMed - indexed for MEDLINE]Related articles

Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease.

Lee DW, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal MF, Ratan RR, Andersen JK.

J Biol Chem. 2009 Oct 16;284(42):29065-76. Epub 2009 Aug 13.PMID: 19679656 [PubMed - in process]Related articles

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.

Siddiq A, Aminova LR, Troy CM, Suh K, Messer Z, Semenza GL, Ratan RR.

J Neurosci. 2009 Jul 8;29(27):8828-38.PMID: 19587290 [PubMed - indexed for MEDLINE]Related articles

Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.

Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I.

Ann N Y Acad Sci. 2008 Dec;1147:383-94.PMID: 19076458 [PubMed - indexed for MEDLINE]Related articles

Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line.

Aminova LR, Siddiq A, Ratan RR.

Antioxid Redox Signal. 2008 Dec;10(12):1989-98.PMID: 18774900 [PubMed - indexed for MEDLINE]Related articlesFree article

Acetylenic anticancer agents.

Siddiq A, Dembitsky V.

Anticancer Agents Med Chem. 2008 Feb;8(2):132-70. Review.PMID: 18288919 [PubMed - indexed for MEDLINE]Related articles

Harnessing hypoxic adaptation to prevent, treat, and repair stroke.

Ratan RR, Siddiq A, Smirnova N, Karpisheva K, Haskew-Layton R, McConoughey S, Langley B, Estevez A, Huerta PT, Volpe B, Roy S, Sen CK, Gazaryan I, Cho S, Fink M, LaManna J.

J Mol Med. 2007 Dec;85(12):1331-8. Epub 2007 Nov 28. Review.PMID: 18043901 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolyl 4-hydroxylase activity-responsive transcription factors: from hydroxylation to gene expression and neuroprotection.

Siddiq A, Aminova LR, Ratan RR.

Front Biosci. 2008 Jan 1;13:2875-87. Review.PMID: 17981760 [PubMed - indexed for MEDLINE]Related articlesFree article

Reporting questionnaire for children as a screening instrument for child mental health problems in Iraqi Kurdistan.

Ahmad A, Abdul-Majeed AM, Siddiq AA, Jabar F, Qahar J, Rasheed J, von Knorring AL.

Transcult Psychiatry. 2007 Mar;44(1):5-26.PMID: 17379607 [PubMed - indexed for MEDLINE]Related articles

Stent material surface and glucose activate mononuclear cells of control, type 1 and type 2 diabetes subjects.

Harrison M, Siddiq A, Guildford A, Bone A, Santin M.

J Biomed Mater Res A. 2007 Oct;83(1):52-7.PMID: 17377967 [PubMed - indexed for MEDLINE]Related articles

Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress.

Siddiq A, Aminova LR, Ratan RR.

Neurochem Res. 2007 Apr-May;32(4-5):931-46. Epub 2007 Mar 7. Review.PMID: 17342411 [PubMed - indexed for MEDLINE]Related articlesFree article

Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects.

Siddiq A, Gueorguiev M, Samson C, Hercberg S, Heude B, Levy-Marchal C, Jouret B, Weill J, Meyre D, Walley A, Froguel P.

Diabetologia. 2007 Mar;50(3):574-84. Epub 2007 Jan 18.PMID: 17235527 [PubMed - indexed for MEDLINE]Related articles

Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity.

Fanzo JC, Yang W, Jang SY, Gupta S, Chen Q, Siddiq A, Greenberg S, Pernis AB.

J Clin Invest. 2006 Mar;116(3):703-14. Epub 2006 Feb 9.PMID: 16470246 [PubMed - indexed for MEDLINE]Related articlesFree article

ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity.

Tankó LB, Siddiq A, Lecoeur C, Larsen PJ, Christiansen C, Walley A, Froguel P.

Obes Res. 2005 Dec;13(12):2113-21.PMID: 16421345 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system.

Siddiq A, Ayoub IA, Chavez JC, Aminova L, Shah S, LaManna JC, Patton SM, Connor JR, Cherny RA, Volitakis I, Bush AI, Langsetmo I, Seeley T, Gunzler V, Ratan RR.

J Biol Chem. 2005 Dec 16;280(50):41732-43. Epub 2005 Oct 13.PMID: 16227210 [PubMed - indexed for MEDLINE]Related articlesFree article

A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians.

Siddiq A, Lepretre F, Hercberg S, Froguel P, Gibson F.

Diabetes. 2005 Aug;54(8):2477-81.PMID: 16046317 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in metabolism and gap junction expression may determine the role of astrocytes as "good samaritans" or executioners.

Farahani R, Pina-Benabou MH, Kyrozis A, Siddiq A, Barradas PC, Chiu FC, Cavalcante LA, Lai JC, Stanton PK, Rozental R.

Glia. 2005 Jun;50(4):351-61.PMID: 15846800 [PubMed - indexed for MEDLINE]Related articles

A 2-year follow-up of orphans' competence, socioemotional problems and post-traumatic stress symptoms in traditional foster care and orphanages in Iraqi Kurdistan.

Ahmad A, Qahar J, Siddiq A, Majeed A, Rasheed J, Jabar F, von Knorring AL.

Child Care Health Dev. 2005 Mar;31(2):203-15.PMID: 15715699 [PubMed - indexed for MEDLINE]Related articles

Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity.

van Leyen K, Siddiq A, Ratan RR, Lo EH.

J Neurochem. 2005 Feb;92(4):824-30.PMID: 15686484 [PubMed - indexed for MEDLINE]Related articlesFree article

Translation of ischemic preconditioning to the patient: prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy.

Ratan RR, Siddiq A, Aminova L, Lange PS, Langley B, Ayoub I, Gensert J, Chavez J.

Stroke. 2004 Nov;35(11 Suppl 1):2687-9. Epub 2004 Oct 7. Review.PMID: 15472113 [PubMed - indexed for MEDLINE]Related articlesFree article

The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism.

Chin PC, Liu L, Morrison BE, Siddiq A, Ratan RR, Bottiglieri T, D'Mello SR.

J Neurochem. 2004 Aug;90(3):595-608.PMID: 15255937 [PubMed - indexed for MEDLINE]Related articles

Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q.

Bell CG, Benzinou M, Siddiq A, Lecoeur C, Dina C, Lemainque A, Clément K, Basdevant A, Guy-Grand B, Mein CA, Meyre D, Froguel P.

Diabetes. 2004 Jul;53(7):1857-65.PMID: 15220211 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study.

Fumeron F, Aubert R, Siddiq A, Betoulle D, Péan F, Hadjadj S, Tichet J, Wilpart E, Chesnier MC, Balkau B, Froguel P, Marre M; Epidemiologic Data on the Insulin Resistance Syndrome (DESIR) Study Group.

Diabetes. 2004 Apr;53(4):1150-7.PMID: 15047634 [PubMed - indexed for MEDLINE]Related articlesFree article

The human homolog of Diminuto/Dwarf1 gene (hDiminuto): a novel ACTH-responsive gene overexpressed in benign cortisol-producing adrenocortical adenomas.

Sarkar D, Imai T, Kambe F, Shibata A, Ohmori S, Siddiq A, Hayasaka S, Funahashi H, Seo H.

J Clin Endocrinol Metab. 2001 Nov;86(11):5130-7.PMID: 11701665 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism.

Siddiq A, Miyazaki T, Takagishi Y, Kanou Y, Hayasaka S, Inouye M, Seo H, Murata Y.

Endocrinology. 2001 May;142(5):1752-9.PMID: 11316738 [PubMed - indexed for MEDLINE]Related articlesFree article

UT841 purified from sea urchin (Toxopneustes pileolus) venom inhibits time-dependent (45)Ca(2+) uptake in crude synaptosome fraction from chick brain.

Zhang Y, Abe J, Siddiq A, Nakagawa H, Honda S, Wada T, Ichida S.

Toxicon. 2001 Aug;39(8):1223-9.PMID: 11306134 [PubMed - indexed for MEDLINE]Related articles