PubMed

Challenges of investigating community outbreaks of cyclosporiasis, British Columbia, Canada.

Shah L, MacDougall L, Ellis A, Ong C, Shyng S, LeBlanc L; British Columbia Cyclospora Investigation Team.

Emerg Infect Dis. 2009 Aug;15(8):1286-8.PMID: 19751593 [PubMed - in process]Related articlesFree article

Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion.

Fu Y, Tian W, Pratt EB, Dirling LB, Shyng SL, Meshul CK, Cohen DM.

PLoS One. 2009 May 25;4(5):e5679.PMID: 19479076 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure.

Pratt EB, Yan FF, Gay JW, Stanley CA, Shyng SL.

J Biol Chem. 2009 Mar 20;284(12):7951-9. Epub 2009 Jan 16.PMID: 19151370 [PubMed - indexed for MEDLINE]Related articles

Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations.

Pinney SE, MacMullen C, Becker S, Lin YW, Hanna C, Thornton P, Ganguly A, Shyng SL, Stanley CA.

J Clin Invest. 2008 Aug;118(8):2877-86.PMID: 18596924 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence.

Abdulhadi-Atwan M, Bushman J, Tornovsky-Babaey S, Perry A, Abu-Libdeh A, Glaser B, Shyng SL, Zangen DH.

Diabetes. 2008 Jul;57(7):1935-40. Epub 2008 Apr 4. Erratum in: Diabetes. 2008 Sep;57(9):2552. Bushmann, Jeremy [corrected to Bushman, Jeremy]. PMID: 18390792 [PubMed - indexed for MEDLINE]Related articlesFree article

Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism.

Lin YW, Bushman JD, Yan FF, Haidar S, MacMullen C, Ganguly A, Stanley CA, Shyng SL.

J Biol Chem. 2008 Apr 4;283(14):9146-56. Epub 2008 Feb 4.PMID: 18250167 [PubMed - indexed for MEDLINE]Related articlesFree article

Congenital hyperinsulinism associated ABCC8 mutations that cause defective trafficking of ATP-sensitive K+ channels: identification and rescue.

Yan FF, Lin YW, MacMullen C, Ganguly A, Stanley CA, Shyng SL.

Diabetes. 2007 Sep;56(9):2339-48. Epub 2007 Jun 15.PMID: 17575084 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylureas correct trafficking defects of disease-causing ATP-sensitive potassium channels by binding to the channel complex.

Yan FF, Casey J, Shyng SL.

J Biol Chem. 2006 Nov 3;281(44):33403-13. Epub 2006 Sep 6.PMID: 16956886 [PubMed - indexed for MEDLINE]Related articlesFree article

Kir6.2 mutations associated with neonatal diabetes reduce expression of ATP-sensitive K+ channels: implications in disease mechanism and sulfonylurea therapy.

Lin CW, Lin YW, Yan FF, Casey J, Kochhar M, Pratt EB, Shyng SL.

Diabetes. 2006 Jun;55(6):1738-46.PMID: 16731837 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels.

Lin YW, MacMullen C, Ganguly A, Stanley CA, Shyng SL.

J Biol Chem. 2006 Feb 3;281(5):3006-12. Epub 2005 Dec 6.PMID: 16332676 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity.

Lin CW, Yan F, Shimamura S, Barg S, Shyng SL.

Diabetes. 2005 Oct;54(10):2852-8.PMID: 16186385 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels.

Yan FF, Lin CW, Cartier EA, Shyng SL.

Am J Physiol Cell Physiol. 2005 Nov;289(5):C1351-9. Epub 2005 Jun 29.PMID: 15987767 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial leucine-sensitive hypoglycemia of infancy due to a dominant mutation of the beta-cell sulfonylurea receptor.

Magge SN, Shyng SL, MacMullen C, Steinkrauss L, Ganguly A, Katz LE, Stanley CA.

J Clin Endocrinol Metab. 2004 Sep;89(9):4450-6.PMID: 15356046 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptor.

Yan F, Lin CW, Weisiger E, Cartier EA, Taschenberger G, Shyng SL.

J Biol Chem. 2004 Mar 19;279(12):11096-105. Epub 2004 Jan 5.PMID: 14707124 [PubMed - indexed for MEDLINE]Related articlesFree article

Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits.

Lin YW, Jia T, Weinsoft AM, Shyng SL.

J Gen Physiol. 2003 Aug;122(2):225-37.PMID: 12885877 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor.

Cartier EA, Shen S, Shyng SL.

J Biol Chem. 2003 Feb 28;278(9):7081-90. Epub 2002 Dec 21.PMID: 12496311 [PubMed - indexed for MEDLINE]Related articlesFree article

K(ATP) channels and insulin secretion disorders.

Huopio H, Shyng SL, Otonkoski T, Nichols CG.

Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E207-16. Review.PMID: 12110524 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a familial hyperinsulinism-causing mutation in the sulfonylurea receptor 1 that prevents normal trafficking and function of KATP channels.

Taschenberger G, Mougey A, Shen S, Lester LB, LaFranchi S, Shyng SL.

J Biol Chem. 2002 May 10;277(19):17139-46. Epub 2002 Feb 26.PMID: 11867634 [PubMed - indexed for MEDLINE]Related articlesFree article

Transmembrane topology of the sulfonylurea receptor SUR1.

Conti LR, Radeke CM, Shyng SL, Vandenberg CA.

J Biol Chem. 2001 Nov 2;276(44):41270-8. Epub 2001 Aug 23.PMID: 11546780 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective trafficking and function of KATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancy.

Cartier EA, Conti LR, Vandenberg CA, Shyng SL.

Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2882-7.PMID: 11226335 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels.

Shyng SL, Cukras CA, Harwood J, Nichols CG.

J Gen Physiol. 2000 Nov;116(5):599-608.PMID: 11055989 [PubMed - indexed for MEDLINE]Related articlesFree article

The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.

Enkvetchakul D, Loussouarn G, Makhina E, Shyng SL, Nichols CG.

Biophys J. 2000 May;78(5):2334-48.PMID: 10777731 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase.

Shyng SL, Barbieri A, Gumusboga A, Cukras C, Pike L, Davis JN, Stahl PD, Nichols CG.

Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):937-41.PMID: 10639183 [PubMed - indexed for MEDLINE]Related articlesFree article

Nucleotides and insulin secretion.

Shyng SL, Nichols CG.

Nutrition. 1999 Sep;15(9):717-9. No abstract available. PMID: 10467619 [PubMed - indexed for MEDLINE]Related articles

ATP inhibition of KATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit.

Koster JC, Sha Q, Shyng S, Nichols CG.

J Physiol. 1999 Feb 15;515 ( Pt 1):19-30.PMID: 9925874 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane phospholipid control of nucleotide sensitivity of KATP channels.

Shyng SL, Nichols CG.

Science. 1998 Nov 6;282(5391):1138-41.PMID: 9804554 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.

Shyng SL, Ferrigni T, Shepard JB, Nestorowicz A, Glaser B, Permutt MA, Nichols CG.

Diabetes. 1998 Jul;47(7):1145-51.PMID: 9648840 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic heterogeneity in familial hyperinsulinism.

Nestorowicz A, Glaser B, Wilson BA, Shyng SL, Nichols CG, Stanley CA, Thornton PS, Permutt MA.

Hum Mol Genet. 1998 Jul;7(7):1119-28. Erratum in: Hum Mol Genet 1998 Sep;7(9):1527. PMID: 9618169 [PubMed - indexed for MEDLINE]Related articlesFree article

Octameric stoichiometry of the KATP channel complex.

Shyng S, Nichols CG.

J Gen Physiol. 1997 Dec;110(6):655-64.PMID: 9382894 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor.

Shyng S, Ferrigni T, Nichols CG.

J Gen Physiol. 1997 Dec;110(6):643-54.PMID: 9382893 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of rectification and gating of cloned KATP channels by the Kir6.2 subunit.

Shyng S, Ferrigni T, Nichols CG.

J Gen Physiol. 1997 Aug;110(2):141-53.PMID: 9236207 [PubMed - indexed for MEDLINE]Related articlesFree article

Depletion of intracellular polyamines relieves inward rectification of potassium channels.

Shyng SL, Sha Q, Ferrigni T, Lopatin AN, Nichols CG.

Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):12014-9.PMID: 8876254 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenosine diphosphate as an intracellular regulator of insulin secretion.

Nichols CG, Shyng SL, Nestorowicz A, Glaser B, Clement JP 4th, Gonzalez G, Aguilar-Bryan L, Permutt MA, Bryan J.

Science. 1996 Jun 21;272(5269):1785-7.PMID: 8650576 [PubMed - indexed for MEDLINE]Related articles

Cell biology of the prion protein.

Harris DA, Gorodinsky A, Lehmann S, Moulder K, Shyng SL.

Curr Top Microbiol Immunol. 1996;207:77-93. Review. No abstract available. PMID: 8575208 [PubMed - indexed for MEDLINE]Related articles

Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.

Shyng SL, Lehmann S, Moulder KL, Harris DA.

J Biol Chem. 1995 Dec 15;270(50):30221-9.PMID: 8530433 [PubMed - indexed for MEDLINE]Related articlesFree article

The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits.

Shyng SL, Moulder KL, Lesko A, Harris DA.

J Biol Chem. 1995 Jun 16;270(24):14793-800.PMID: 7782345 [PubMed - indexed for MEDLINE]Related articlesFree article

The development of a purification procedure for saxitoxin-induced protein.

Smith DS, Kitts DD, Fenske B, Owen TG, Shyng S.

Biotechnol Appl Biochem. 1995 Feb;21 ( Pt 1):7-18.PMID: 7710704 [PubMed - indexed for MEDLINE]Related articles

A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.

Shyng SL, Heuser JE, Harris DA.

J Cell Biol. 1994 Jun;125(6):1239-50.PMID: 7911471 [PubMed - indexed for MEDLINE]Related articlesFree article

A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells.

Shyng SL, Huber MT, Harris DA.

J Biol Chem. 1993 Jul 25;268(21):15922-8.PMID: 8101844 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

Harris DA, Huber MT, van Dijken P, Shyng SL, Chait BT, Wang R.

Biochemistry. 1993 Feb 2;32(4):1009-16.PMID: 8093841 [PubMed - indexed for MEDLINE]Related articles

Cyclic AMP stabilizes the degradation of original junctional acetylcholine receptors in denervated muscle.

Shyng SL, Xu R, Salpeter MM.

Neuron. 1991 Mar;6(3):469-75.PMID: 1848083 [PubMed - indexed for MEDLINE]Related articles

Effect of reinnervation on the degradation rate of junctional acetylcholine receptors synthesized in denervated skeletal muscles.

Shyng SL, Salpeter MM.

J Neurosci. 1990 Dec;10(12):3905-15.PMID: 2269890 [PubMed - indexed for MEDLINE]Related articlesFree article

Degradation rate of acetylcholine receptors inserted into denervated vertebrate neuromuscular junctions.

Shyng SL, Salpeter MM.

J Cell Biol. 1989 Feb;108(2):647-51.PMID: 2918028 [PubMed - indexed for MEDLINE]Related articlesFree article