PubMed

MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice.

Roth RJ, Le AM, Zhang L, Kahn M, Samuel VT, Shulman GI, Bennett AM.

J Clin Invest. 2009 Nov 16. pii: 39054. doi: 10.1172/JCI39054. [Epub ahead of print]PMID: 19920356 [PubMed - as supplied by publisher]Related articlesFree article

Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

Leavens KF, Easton RM, Shulman GI, Previs SF, Birnbaum MJ.

Cell Metab. 2009 Nov;10(5):405-18.PMID: 19883618 [PubMed - in process]Related articles

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy.

Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF.

J Cereb Blood Flow Metab. 2009 Sep 30. [Epub ahead of print]PMID: 19794401 [PubMed - as supplied by publisher]Related articles

Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.

Liu L, Shi X, Choi CS, Shulman GI, Klaus K, Nair KS, Schwartz GJ, Zhang Y, Goldberg IJ, Yu YH.

Diabetes. 2009 Nov;58(11):2516-24. Epub 2009 Aug 12.PMID: 19675136 [PubMed - in process]Related articles

Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.

Li LO, Ellis JM, Paich HA, Wang S, Gong N, Altshuller G, Thresher RJ, Koves TR, Watkins SM, Muoio DM, Cline GW, Shulman GI, Coleman RA.

J Biol Chem. 2009 Oct 9;284(41):27816-26. Epub 2009 Aug 1.PMID: 19648649 [PubMed - indexed for MEDLINE]Related articles

Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion.

Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, Kibbey RG.

J Biol Chem. 2009 Sep 25;284(39):26578-90. Epub 2009 Jul 27.PMID: 19635791 [PubMed - indexed for MEDLINE]Related articlesFree article

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.

Samuel VT, Beddow SA, Iwasaki T, Zhang XM, Chu X, Still CD, Gerhard GS, Shulman GI.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12121-6. Epub 2009 Jul 8.PMID: 19587243 [PubMed - indexed for MEDLINE]Related articlesFree article

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.

Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11288-93. Epub 2009 Jun 22.PMID: 19549853 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans.

Dufour S, Lebon V, Shulman GI, Petersen KF.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E231-5. Epub 2009 May 19.PMID: 19458062 [PubMed - indexed for MEDLINE]Related articles

Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy.

Befroy DE, Falk Petersen K, Rothman DL, Shulman GI.

Methods Enzymol. 2009;457:373-93.PMID: 19426879 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW.

J Biol Chem. 2009 Jun 19;284(25):16808-21. Epub 2009 Apr 17.PMID: 19376774 [PubMed - indexed for MEDLINE]Related articles

Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.

Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM.

Diabetes. 2009 Jul;58(7):1499-508. Epub 2009 Apr 14.PMID: 19366863 [PubMed - indexed for MEDLINE]Related articlesFree article

STAT3 inhibition of gluconeogenesis is downregulated by SirT1.

Nie Y, Erion DM, Yuan Z, Dietrich M, Shulman GI, Horvath TL, Gao Q.

Nat Cell Biol. 2009 Apr;11(4):492-500. Epub 2009 Mar 22.PMID: 19295512 [PubMed - indexed for MEDLINE]Related articles

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D, Jurczak MJ, Löffler MG, Cresswell J, Yu XX, Murray SF, Bhanot S, Monia BP, Bogan JS, Samuel V, Shulman GI.

Cell Metab. 2009 Mar;9(3):252-64.PMID: 19254570 [PubMed - indexed for MEDLINE]Related articles

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.

Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS.

Nat Med. 2009 Feb;15(2):159-68. Epub 2009 Jan 11.PMID: 19136964 [PubMed - indexed for MEDLINE]Related articles

Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity.

Ahmadian M, Duncan RE, Varady KA, Frasson D, Hellerstein MK, Birkenfeld AL, Samuel VT, Shulman GI, Wang Y, Kang C, Sul HS.

Diabetes. 2009 Apr;58(4):855-66. Epub 2009 Jan 9.PMID: 19136649 [PubMed - indexed for MEDLINE]Related articlesFree article

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. Epub 2008 Dec 9.PMID: 19066218 [PubMed - indexed for MEDLINE]Related articlesFree article

N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.

Gillum MP, Zhang D, Zhang XM, Erion DM, Jamison RA, Choi C, Dong J, Shanabrough M, Duenas HR, Frederick DW, Hsiao JJ, Horvath TL, Lo CM, Tso P, Cline GW, Shulman GI.

Cell. 2008 Nov 28;135(5):813-24.PMID: 19041747 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.

Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH.

Diabetes. 2009 Jan;58(1):116-24. Epub 2008 Oct 24.PMID: 18952837 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals.

Befroy DE, Petersen KF, Dufour S, Mason GF, Rothman DL, Shulman GI.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16701-6. Epub 2008 Oct 20.PMID: 18936488 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy.

Villena JA, Choi CS, Wang Y, Kim S, Hwang YJ, Kim YB, Cline G, Shulman GI, Sul HS.

Diabetes. 2008 Dec;57(12):3258-66. Epub 2008 Oct 3.PMID: 18835937 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice.

Rowe GC, Choi CS, Neff L, Horne WC, Shulman GI, Baron R.

Endocrinology. 2009 Jan;150(1):135-43. Epub 2008 Sep 4.PMID: 18772235 [PubMed - indexed for MEDLINE]Related articles

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.

Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S.

Nature. 2008 Aug 14;454(7206):846-51. Epub 2008 Jul 30.PMID: 18668043 [PubMed - indexed for MEDLINE]Related articles

Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.

Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI.

Diabetes. 2008 Oct;57(10):2644-51. Epub 2008 Jul 15.PMID: 18633112 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice.

Essop MF, Camp HS, Choi CS, Sharma S, Fryer RM, Reinhart GA, Guthrie PH, Bentebibel A, Gu Z, Shulman GI, Taegtmeyer H, Wakil SJ, Abu-Elheiga L.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H256-65. Epub 2008 May 16.PMID: 18487439 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL.

Kim H, Taksali SE, Dufour S, Befroy D, Goodman TR, Petersen KF, Shulman GI, Caprio S, Constable RT.

Magn Reson Med. 2008 Mar;59(3):521-7.PMID: 18306404 [PubMed - indexed for MEDLINE]Related articles

Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight.

Wolfgang MJ, Cha SH, Millington DS, Cline G, Shulman GI, Suwa A, Asaumi M, Kurama T, Shimokawa T, Lane MD.

J Neurochem. 2008 May;105(4):1550-9. Epub 2008 Jan 28.PMID: 18248603 [PubMed - indexed for MEDLINE]Related articles

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.

Savage DB, Zhai L, Ravikumar B, Choi CS, Snaar JE, McGuire AC, Wou SE, Medina-Gomez G, Kim S, Bock CB, Segvich DM, Solanky B, Deelchand D, Vidal-Puig A, Wareham NJ, Shulman GI, Karpe F, Taylor R, Pederson BA, Roach PJ, O'Rahilly S, DePaoli-Roach AA.

PLoS Med. 2008 Jan 29;5(1):e27. Erratum in: PLoS Med. 2008 Dec;5(12):e246.. Solanky, Bhavana [added]; Deelchand, Dinesh [added]. PMID: 18232732 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual role of proapoptotic BAD in insulin secretion and beta cell survival.

Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.

Nat Med. 2008 Feb;14(2):144-53. Epub 2008 Jan 27.PMID: 18223655 [PubMed - indexed for MEDLINE]Related articles

Regulation of hypothalamic malonyl-CoA by central glucose and leptin.

Wolfgang MJ, Cha SH, Sidhaye A, Chohnan S, Cline G, Shulman GI, Lane MD.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19285-90. Epub 2007 Nov 21.PMID: 18032600 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance.

Zhang D, Liu ZX, Choi CS, Tian L, Kibbey R, Dong J, Cline GW, Wood PA, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17075-80. Epub 2007 Oct 16.PMID: 17940018 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.

Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM.

J Clin Invest. 2007 Nov;117(11):3463-74.PMID: 17932564 [PubMed - indexed for MEDLINE]Related articlesFree article

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.

Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16480-5. Epub 2007 Oct 8.PMID: 17923673 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity-associated improvements in metabolic profile through expansion of adipose tissue.

Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, Schraw T, Durand JL, Li H, Li G, Jelicks LA, Mehler MF, Hui DY, Deshaies Y, Shulman GI, Schwartz GJ, Scherer PE.

J Clin Invest. 2007 Sep;117(9):2621-37.PMID: 17717599 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.

Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR Jr, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M.

J Clin Invest. 2007 Aug;117(8):2289-301. Erratum in: J Clin Invest. 2007 Oct;117(10):3141. PMID: 17641777 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.

Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12587-94. Epub 2007 Jul 18.PMID: 17640906 [PubMed - indexed for MEDLINE]Related articlesFree article

Interethnic differences in muscle, liver and abdominal fat partitioning in obese adolescents.

Liska D, Dufour S, Zern TL, Taksali S, Calí AM, Dziura J, Shulman GI, Pierpont BM, Caprio S.

PLoS One. 2007 Jun 27;2(6):e569.PMID: 17593968 [PubMed]Related articlesFree article

Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance.

Choi CS, Fillmore JJ, Kim JK, Liu ZX, Kim S, Collier EF, Kulkarni A, Distefano A, Hwang YJ, Kahn M, Chen Y, Yu C, Moore IK, Reznick RM, Higashimori T, Shulman GI.

J Clin Invest. 2007 Jul;117(7):1995-2003.PMID: 17571165 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.

Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI.

J Biol Chem. 2007 Aug 3;282(31):22678-88. Epub 2007 May 27.PMID: 17526931 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.

Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB.

Cell Metab. 2007 May;5(5):383-93.PMID: 17488640 [PubMed - indexed for MEDLINE]Related articlesFree article

Disordered lipid metabolism and the pathogenesis of insulin resistance.

Savage DB, Petersen KF, Shulman GI.

Physiol Rev. 2007 Apr;87(2):507-20. Review.PMID: 17429039 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial GTP regulates glucose-stimulated insulin secretion.

Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW, Shulman GI.

Cell Metab. 2007 Apr;5(4):253-64.PMID: 17403370 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.

Nagle CA, An J, Shiota M, Torres TP, Cline GW, Liu ZX, Wang S, Catlin RL, Shulman GI, Newgard CB, Coleman RA.

J Biol Chem. 2007 May 18;282(20):14807-15. Epub 2007 Mar 27.PMID: 17389595 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.

Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5680-5. Epub 2007 Mar 19.PMID: 17372192 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.

Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, Kahn M, Zhang XM, Monia BP, Bhanot S, Shulman GI.

J Clin Invest. 2007 Mar;117(3):739-45. Epub 2007 Feb 22.PMID: 17318260 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients.

Befroy DE, Petersen KF, Dufour S, Mason GF, de Graaf RA, Rothman DL, Shulman GI.

Diabetes. 2007 May;56(5):1376-81. Epub 2007 Feb 7.PMID: 17287462 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.

Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Liu ZX, Dong J, Mustard KJ, Hawley SA, Befroy D, Pypaert M, Hardie DG, Young LH, Shulman GI.

Cell Metab. 2007 Feb;5(2):151-6.PMID: 17276357 [PubMed - indexed for MEDLINE]Related articlesFree article

n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.

Neschen S, Morino K, Dong J, Wang-Fischer Y, Cline GW, Romanelli AJ, Rossbacher JC, Moore IK, Regittnig W, Munoz DS, Kim JH, Shulman GI.

Diabetes. 2007 Apr;56(4):1034-41. Epub 2007 Jan 24.PMID: 17251275 [PubMed - indexed for MEDLINE]Related articlesFree article

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals.

Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao XB, Mobbs C, Shulman GI, Diano S, Horvath TL.

Nat Med. 2007 Jan;13(1):89-94. Epub 2006 Dec 31.PMID: 17195839 [PubMed - indexed for MEDLINE]Related articles

Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.

Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB.

Cell Metab. 2006 Dec;4(6):453-64.PMID: 17141629 [PubMed - indexed for MEDLINE]Related articlesFree article