PubMed

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA.

J Med Chem. 2009 Apr 9;52(7):1828-44.PMID: 19284751 [PubMed - indexed for MEDLINE]Related articles

Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.

Araújo NC, Barton V, Jones M, Stocks PA, Ward SA, Davies J, Bray PG, Shone AE, Cristiano ML, O'Neill PM.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):2038-43. Epub 2009 Feb 8.PMID: 19251414 [PubMed - indexed for MEDLINE]Related articles

Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century.

O'Neill PM, Park BK, Shone AE, Maggs JL, Roberts P, Stocks PA, Biagini GA, Bray PG, Gibbons P, Berry N, Winstanley PA, Mukhtar A, Bonar-Law R, Hindley S, Bambal RB, Davis CB, Bates M, Hart TK, Gresham SL, Lawrence RM, Brigandi RA, Gomez-Delas-Heras FM, Gargallo DV, Ward SA.

J Med Chem. 2009 Feb 17. [Epub ahead of print]PMID: 19222165 [PubMed - as supplied by publisher]Related articles

Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.

Davis CB, Bambal R, Moorthy GS, Hugger E, Xiang H, Park BK, Shone AE, O'Neill PM, Ward SA.

J Pharm Sci. 2009 Jan;98(1):362-77.PMID: 18563832 [PubMed - indexed for MEDLINE]Related articles

Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM.

J Med Chem. 2008 Apr 10;51(7):2170-7. Epub 2008 Mar 15.PMID: 18341274 [PubMed - indexed for MEDLINE]Related articles

Probing the validity of the probe-to-bone test in the diagnosis of osteomyelitis of the foot in diabetes.

Shone A, Burnside J, Chipchase S, Game F, Jeffcoate W.

Diabetes Care. 2006 Apr;29(4):945. No abstract available. PMID: 16567847 [PubMed - indexed for MEDLINE]Related articlesFree article

Crossover clustering and rapid decay of linkage disequilibrium in the Xp/Yp pseudoautosomal gene SHOX.

May CA, Shone AC, Kalaydjieva L, Sajantila A, Jeffreys AJ.

Nat Genet. 2002 Jul;31(3):272-5. Epub 2002 Jun 24.PMID: 12089524 [PubMed - indexed for MEDLINE]Related articles

Integrated analysis of sequence evolution and population history using hypervariable compound haplotypes.

Rogers EJ, Shone AC, Alonso S, May CA, Armour JA.

Hum Mol Genet. 2000 Nov 1;9(18):2675-81.PMID: 11063726 [PubMed - indexed for MEDLINE]Related articlesFree article

Meiotic recombination and flanking marker exchange at the highly unstable human minisatellite CEB1 (D2S90).

Buard J, Shone AC, Jeffreys AJ.

Am J Hum Genet. 2000 Aug;67(2):333-44. Epub 2000 Jun 26.PMID: 10869237 [PubMed - indexed for MEDLINE]Related articlesFree article

Human minisatellites, repeat DNA instability and meiotic recombination.

Jeffreys AJ, Barber R, Bois P, Buard J, Dubrova YE, Grant G, Hollies CR, May CA, Neumann R, Panayi M, Ritchie AE, Shone AC, Signer E, Stead JD, Tamaki K.

Electrophoresis. 1999 Jun;20(8):1665-75. Review.PMID: 10435430 [PubMed - indexed for MEDLINE]Related articles