PubMed

SCAP is required for timely and proper myelin membrane synthesis.

Verheijen MH, Camargo N, Verdier V, Nadra K, de Preux Charles AS, Médard JJ, Luoma A, Crowther M, Inouye H, Shimano H, Chen S, Brouwers JF, Helms JB, Feltri ML, Wrabetz L, Kirschner D, Chrast R, Smit AB.

Proc Natl Acad Sci U S A. 2009 Nov 30. [Epub ahead of print]PMID: 19948958 [PubMed - as supplied by publisher]Related articles

ApoAII controversy still in rabbit?

Shimano H.

Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):1984-5. No abstract available. PMID: 19923556 [PubMed - in process]Related articles

Effects of pitavastatin (LIVALO Tablet) on high density lipoprotein cholesterol (HDL-C) in hypercholesterolemia.

Teramoto T, Shimano H, Yokote K, Urashima M.

J Atheroscler Thromb. 2009 Oct;16(5):654-61.PMID: 19907105 [PubMed - in process]Related articlesFree article

Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription.

Furumatsu T, Shukunami C, Amemiya-Kudo M, Shimano H, Ozaki T.

Int J Biochem Cell Biol. 2010 Jan;42(1):148-56. Epub 2009 Oct 12.PMID: 19828133 [PubMed - in process]Related articles

Adiponectin and adiponectin receptors in human pheochromocytoma.

Isobe K, Fu L, Tatsuno I, Takahashi H, Nissato S, Hara H, Yashiro T, Suzukawa K, Takekoshi K, Shimano H, Kawakami Y.

J Atheroscler Thromb. 2009 Aug;16(4):442-7. Epub 2009 Aug 11.PMID: 19672024 [PubMed - in process]Related articlesFree article

Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.

Sekiya M, Yahagi N, Tamura Y, Okazaki H, Igarashi M, Ohta K, Takanashi M, Kumagai M, Takase S, Nishi M, Takeuchi Y, Izumida Y, Kubota M, Ohashi K, Iizuka Y, Yagyu H, Gotoda T, Nagai R, Shimano H, Yamada N, Kadowaki T, Ishibashi S, Osuga J.

Biochem Biophys Res Commun. 2009 Sep 25;387(3):511-5. Epub 2009 Jul 18.PMID: 19619509 [PubMed - indexed for MEDLINE]Related articles

TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN.

Kato M, Putta S, Wang M, Yuan H, Lanting L, Nair I, Gunn A, Nakagawa Y, Shimano H, Todorov I, Rossi JJ, Natarajan R.

Nat Cell Biol. 2009 Jul;11(7):881-9. Epub 2009 Jun 21.PMID: 19543271 [PubMed - indexed for MEDLINE]Related articles

The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice.

Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, Yahagi N, Kobayashi K, Yatoh S, Takahashi A, Suzuki H, Urayama O, Yamada N, Shimano H.

Biochem Biophys Res Commun. 2009 Aug 7;385(4):492-6. Epub 2009 May 19.PMID: 19460359 [PubMed - indexed for MEDLINE]Related articles

Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis.

Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H.

JAMA. 2009 May 20;301(19):2024-35.PMID: 19454641 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of fat and carbohydrate proportions on the metabolic profile in patients with type 2 diabetes: a meta-analysis.

Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Sato M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H.

Diabetes Care. 2009 May;32(5):959-65.PMID: 19407076 [PubMed - indexed for MEDLINE]Related articlesFree article

SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy.

Watanabe K, Okamoto F, Yokoo T, Iida KT, Suzuki H, Shimano H, Oshika T, Yamada N, Toyoshima H.

J Atheroscler Thromb. 2009 Apr;16(2):69-76. Epub 2009 Apr 30.PMID: 19403984 [PubMed - indexed for MEDLINE]Related articlesFree article

Elovl6: a new player in fatty acid metabolism and insulin sensitivity.

Matsuzaka T, Shimano H.

J Mol Med. 2009 Apr;87(4):379-84. Epub 2009 Mar 4. Review.PMID: 19259639 [PubMed - indexed for MEDLINE]Related articles

[Obesity and atherosclerosis]

Shimano H.

Nippon Rinsho. 2009 Feb;67(2):333-7. Japanese. PMID: 19202908 [PubMed - indexed for MEDLINE]Related articles

SREBPs: physiology and pathophysiology of the SREBP family.

Shimano H.

FEBS J. 2009 Feb;276(3):616-21. Review.PMID: 19143830 [PubMed - indexed for MEDLINE]Related articles

SREBPs: novel aspects of SREBPs in the regulation of lipid synthesis.

Shimano H.

FEBS J. 2009 Feb;276(3):615. No abstract available. PMID: 19143829 [PubMed - indexed for MEDLINE]Related articles

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.

Iwasaki Y, Iwasaki H, Yatoh S, Ishikawa M, Kato T, Matsuzaka T, Nakagawa Y, Yahagi N, Kobayashi K, Takahashi A, Suzuki H, Yamada N, Shimano H.

Biochem Biophys Res Commun. 2009 Jan 16;378(3):545-50. Epub 2008 Dec 3.PMID: 19056350 [PubMed - indexed for MEDLINE]Related articles

[Quality aspects of lipid accumulation in insulin resistance--a lesson from long fatty acid elongase, Elovl-6]

Shimano H.

Seikagaku. 2008 Aug;80(8):762-7. Review. Japanese. No abstract available. PMID: 18810844 [PubMed - indexed for MEDLINE]Related articles

Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages.

Tazoe F, Yagyu H, Okazaki H, Igarashi M, Eto K, Nagashima S, Inaba T, Shimano H, Osuga J, Ishibashi S.

Biochem Biophys Res Commun. 2008 Nov 7;376(1):111-5. Epub 2008 Aug 30.PMID: 18762171 [PubMed - indexed for MEDLINE]Related articles

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.

Ishikawa M, Iwasaki Y, Yatoh S, Kato T, Kumadaki S, Inoue N, Yamamoto T, Matsuzaka T, Nakagawa Y, Yahagi N, Kobayashi K, Takahashi A, Yamada N, Shimano H.

J Lipid Res. 2008 Dec;49(12):2524-34. Epub 2008 Aug 5.PMID: 18682608 [PubMed - indexed for MEDLINE]Related articlesFree article

[Ageing and metabolic syndrome]

Shimano H.

Nippon Ronen Igakkai Zasshi. 2008 May;45(3):299-301. Japanese. No abstract available. PMID: 18622114 [PubMed - indexed for MEDLINE]Related articlesFree article

Proposed guidelines for hypertriglyceridemia in Japan with non-HDL cholesterol as the second target.

Shimano H, Arai H, Harada-Shiba M, Ueshima H, Ohta T, Yamashita S, Gotoda T, Kiyohara Y, Hayashi T, Kobayashi J, Shimamoto K, Bujo H, Ishibashi S, Shirai K, Oikawa S, Saito Y, Yamada N.

J Atheroscler Thromb. 2008 Jun;15(3):116-21.PMID: 18603817 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.

Sekiya M, Osuga J, Yahagi N, Okazaki H, Tamura Y, Igarashi M, Takase S, Harada K, Okazaki S, Iizuka Y, Ohashi K, Yagyu H, Okazaki M, Gotoda T, Nagai R, Kadowaki T, Shimano H, Yamada N, Ishibashi S.

J Lipid Res. 2008 Aug;49(8):1829-38. Epub 2008 May 14.PMID: 18480494 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.

Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N.

Diabetes. 2008 Sep;57(9):2382-92. Epub 2008 May 5.PMID: 18458149 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.

Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y, Kobayashi K, Takahashi A, Suzuki H, Hasty AH, Toyoshima H, Yamada N, Shimano H.

J Biol Chem. 2008 Jul 25;283(30):21220-9. Epub 2008 Apr 29.PMID: 18445590 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2.

Oem JK, Jackel-Cram C, Li YP, Zhou Y, Zhong J, Shimano H, Babiuk LA, Liu Q.

J Gen Virol. 2008 May;89(Pt 5):1225-30.PMID: 18420801 [PubMed - indexed for MEDLINE]Related articlesFree article

[Diverse physiological and pharmacological functions of fatty acids]

Okuyama H, Hashimoto M, Ito M, Tokudome S, Shimano H, Itakura H.

Nippon Yakurigaku Zasshi. 2008 Apr;131(4):259-67. Review. Japanese. No abstract available. PMID: 18408336 [PubMed - indexed for MEDLINE]Related articles

Diffusion tensor imaging in chronic subdural hematoma: correlation between clinical signs and fractional anisotropy in the pyramidal tract.

Yokoyama K, Matsuki M, Shimano H, Sumioka S, Ikenaga T, Hanabusa K, Yasuda S, Inoue H, Watanabe T, Miyashita M, Hiramatsu R, Murao K, Kondo A, Tanabe H, Kuroiwa T.

AJNR Am J Neuroradiol. 2008 Jun;29(6):1159-63. Epub 2008 Mar 20.PMID: 18356470 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse Elovl-6 promoter is an SREBP target.

Kumadaki S, Matsuzaka T, Kato T, Yahagi N, Yamamoto T, Okada S, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H.

Biochem Biophys Res Commun. 2008 Apr 4;368(2):261-6. Epub 2008 Jan 28.PMID: 18226595 [PubMed - indexed for MEDLINE]Related articles

Abdominal Irradiation Ameliorates Obesity in ob/ob Mice.

Okada S, Kobayashi K, Ishikawa M, Inoue N, Yamada N, Shimano H.

J Clin Biochem Nutr. 2007 Mar;40(2):123-30.PMID: 18188414 [PubMed - in process]Related articlesFree article

SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing.

Diraison F, Ravier MA, Richards SK, Smith RM, Shimano H, Rutter GA.

J Lipid Res. 2008 Apr;49(4):814-22. Epub 2008 Jan 4.PMID: 18178930 [PubMed - indexed for MEDLINE]Related articlesFree article

Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.

Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.

J Clin Invest. 2008 Jan;118(1):259-71.PMID: 18060044 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of glomerular SREBP-1c in diabetic nephropathy.

Ishigaki N, Yamamoto T, Shimizu Y, Kobayashi K, Yatoh S, Sone H, Takahashi A, Suzuki H, Yamagata K, Yamada N, Shimano H.

Biochem Biophys Res Commun. 2007 Dec 21;364(3):502-8. Epub 2007 Oct 16.PMID: 17961514 [PubMed - indexed for MEDLINE]Related articles

Sterol regulatory element-binding protein-1c and pancreatic beta-cell dysfunction.

Shimano H, Amemiya-Kudo M, Takahashi A, Kato T, Ishikawa M, Yamada N.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:133-9.PMID: 17919187 [PubMed - indexed for MEDLINE]Related articles

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N.

Nat Med. 2007 Oct;13(10):1193-202. Epub 2007 Sep 30.PMID: 17906635 [PubMed - indexed for MEDLINE]Related articles

In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression.

Takeuchi Y, Yahagi N, Nakagawa Y, Matsuzaka T, Shimizu R, Sekiya M, Iizuka Y, Ohashi K, Gotoda T, Yamamoto M, Nagai R, Kadowaki T, Yamada N, Osuga J, Shimano H.

Biochem Biophys Res Commun. 2007 Nov 16;363(2):329-35. Epub 2007 Sep 6.PMID: 17880923 [PubMed - indexed for MEDLINE]Related articles

[Dysfunction of transcription factors in energy metabolism]

Shimano H.

Nippon Rinsho. 2007 Jul 28;65 Suppl 7:111-4. Review. Japanese. No abstract available. PMID: 17824021 [PubMed - indexed for MEDLINE]Related articles

[Functions of transcription factors involved in lipid metabolism]

Shimano H.

Nippon Rinsho. 2007 Jul 28;65 Suppl 7:31-4. Review. Japanese. No abstract available. PMID: 17824009 [PubMed - indexed for MEDLINE]Related articles

Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue.

Ohgaki S, Iida K, Yokoo T, Watanabe K, Kihara R, Suzuki H, Shimano H, Toyoshima H, Yamada N.

J Atheroscler Thromb. 2007 Aug;14(4):179-84. Epub 2007 Aug 14.PMID: 17704618 [PubMed - indexed for MEDLINE]Related articlesFree article

A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors.

Nakakuki M, Shimano H, Inoue N, Tamura M, Matsuzaka T, Nakagawa Y, Yahagi N, Toyoshima H, Sato R, Yamada N.

FEBS J. 2007 Sep;274(17):4440-52. Epub 2007 Jul 27.PMID: 17662109 [PubMed - indexed for MEDLINE]Related articles

Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly.

Kodama S, Shu M, Saito K, Murakami H, Tanaka K, Kuno S, Ajisaka R, Sone Y, Onitake F, Takahashi A, Shimano H, Kondo K, Yamada N, Sone H.

Intern Med. 2007;46(14):1071-7. Epub 2007 Jul 17.PMID: 17634702 [PubMed - indexed for MEDLINE]Related articlesFree article

SREBP-1c expression in Schwann cells is affected by diabetes and nutritional status.

de Preux AS, Goosen K, Zhang W, Sima AA, Shimano H, Ouwens DM, Diamant M, Hillebrands JL, Rozing J, Lemke G, Beckmann JS, Smit AB, Verheijen MH, Chrast R.

Mol Cell Neurosci. 2007 Aug;35(4):525-34. Epub 2007 May 1.PMID: 17632011 [PubMed - indexed for MEDLINE]Related articles

Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis.

Kodama S, Tanaka S, Saito K, Shu M, Sone Y, Onitake F, Suzuki E, Shimano H, Yamamoto S, Kondo K, Ohashi Y, Yamada N, Sone H.

Arch Intern Med. 2007 May 28;167(10):999-1008.PMID: 17533202 [PubMed - indexed for MEDLINE]Related articlesFree article

[Roles of energy metabolism transcription factors]

Shimano H.

Nippon Rinsho. 2006 Dec 28;64 Suppl 9:98-102. Review. Japanese. No abstract available. PMID: 17458201 [PubMed - indexed for MEDLINE]Related articles

SREBP-1-independent regulation of lipogenic gene expression in adipocytes.

Sekiya M, Yahagi N, Matsuzaka T, Takeuchi Y, Nakagawa Y, Takahashi H, Okazaki H, Iizuka Y, Ohashi K, Gotoda T, Ishibashi S, Nagai R, Yamazaki T, Kadowaki T, Yamada N, Osuga J, Shimano H.

J Lipid Res. 2007 Jul;48(7):1581-91. Epub 2007 Apr 24.PMID: 17456898 [PubMed - indexed for MEDLINE]Related articlesFree article

Risk imparted by various parameters of smoking in Japanese men with type 2 diabetes on their development of microalbuminuria: analysis from the Tsukuba Kawai Diabetes Registry.

Saito K, Sone H, Kawai K, Tanaka S, Kodama S, Shu M, Suzuki E, Kondo K, Yamamoto S, Shimano H, Ohashi Y, Yamada N.

Diabetes Care. 2007 May;30(5):1286-8. Epub 2007 Mar 2. No abstract available. PMID: 17337500 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver.

Yamamoto T, Shimano H, Inoue N, Nakagawa Y, Matsuzaka T, Takahashi A, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N.

J Biol Chem. 2007 Apr 20;282(16):11687-95. Epub 2007 Feb 12.PMID: 17296605 [PubMed - indexed for MEDLINE]Related articlesFree article

SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling.

Shimano H.

J Mol Med. 2007 May;85(5):437-44. Epub 2007 Feb 6. Review.PMID: 17279346 [PubMed - indexed for MEDLINE]Related articles

Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells.

Ishikawa M, Okajima F, Inoue N, Motomura K, Kato T, Takahashi A, Oikawa S, Yamada N, Shimano H.

J Atheroscler Thromb. 2006 Dec;13(6):329-35.PMID: 17192698 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis.

Shibata N, Jishage K, Arita M, Watanabe M, Kawase Y, Nishikawa K, Natori Y, Inoue H, Shimano H, Yamada N, Tsujimoto M, Arai H.

FASEB J. 2006 Dec;20(14):2642-4. Epub 2006 Oct 31.PMID: 17077281 [PubMed - indexed for MEDLINE]Related articlesFree article

[Oral hypoglycemic agents, present and future]

Shimano H.

Nippon Yakurigaku Zasshi. 2006 Jul;128(1):42-5. Review. Japanese. No abstract available. PMID: 16948200 [PubMed - indexed for MEDLINE]Related articles