PubMed

Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes.

Fan X, Ding Y, Brown S, Zhou L, Shaw M, Vella MC, Cheng H, McNay EC, Sherwin RS, McCrimmon RJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1702-8. Epub 2009 Apr 8.PMID: 19357294 [PubMed - indexed for MEDLINE]Related articles

Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivo.

Jiang L, Herzog RI, Mason GF, de Graaf RA, Rothman DL, Sherwin RS, Behar KL.

Diabetes. 2009 Jun;58(6):1266-74. Epub 2009 Mar 10.PMID: 19276443 [PubMed - indexed for MEDLINE]Related articlesFree article

Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia.

Page KA, Williamson A, Yu N, McNay EC, Dzuira J, McCrimmon RJ, Sherwin RS.

Diabetes. 2009 May;58(5):1237-44. Epub 2009 Feb 17.PMID: 19223595 [PubMed - indexed for MEDLINE]Related articlesFree article

Simple exercise recovery index for sympathetic overactivity is linked to insulin resistance.

Yeckel CW, Gulanski B, Zgorski ML, Dziura J, Parish R, Sherwin RS.

Med Sci Sports Exerc. 2009 Mar;41(3):505-15.PMID: 19204601 [PubMed - indexed for MEDLINE]Related articles

Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA Diabetes Trials: a position statement of the American Diabetes Association and a Scientific Statement of the American College of Cardiology Foundation and the American Heart Association.

Skyler JS, Bergenstal R, Bonow RO, Buse J, Deedwania P, Gale EA, Howard BV, Kirkman MS, Kosiborod M, Reaven P, Sherwin RS; American Diabetes Association; American College of Cardiology Foundation; American Heart Association.

J Am Coll Cardiol. 2009 Jan 20;53(3):298-304. Review. No abstract available. PMID: 19147051 [PubMed - indexed for MEDLINE]Related articles

Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association.

Skyler JS, Bergenstal R, Bonow RO, Buse J, Deedwania P, Gale EA, Howard BV, Kirkman MS, Kosiborod M, Reaven P, Sherwin RS; American Diabetes Association; American College of Cardiology Foundation; American Heart Association.

Circulation. 2009 Jan 20;119(2):351-7. Epub 2008 Dec 17. Review. No abstract available. Erratum in: Circulation. 2009 Jun 30;119(25):e605. PMID: 19095622 [PubMed - indexed for MEDLINE]Related articles

Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association.

Skyler JS, Bergenstal R, Bonow RO, Buse J, Deedwania P, Gale EA, Howard BV, Kirkman MS, Kosiborod M, Reaven P, Sherwin RS; American Diabetes Association; American College of Cardiology Foundation; American Heart Association.

Diabetes Care. 2009 Jan;32(1):187-92. Epub 2008 Dec 17. No abstract available. PMID: 19092168 [PubMed - in process]Related articlesFree article

Small decrements in systemic glucose provoke increases in hypothalamic blood flow prior to the release of counterregulatory hormones.

Page KA, Arora J, Qiu M, Relwani R, Constable RT, Sherwin RS.

Diabetes. 2009 Feb;58(2):448-52. Epub 2008 Nov 18.PMID: 19017765 [PubMed - indexed for MEDLINE]Related articlesFree article

Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener?

Fan X, Ding Y, Cheng H, Gram DX, Sherwin RS, McCrimmon RJ.

Diabetes. 2008 Dec;57(12):3327-34. Epub 2008 Sep 5.PMID: 18776135 [PubMed - indexed for MEDLINE]Related articlesFree article

Bringing light to the dark side of insulin: a journey across the blood-brain barrier.

Sherwin RS.

Diabetes. 2008 Sep;57(9):2259-68. No abstract available. PMID: 18753671 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia.

Chan O, Cheng H, Herzog R, Czyzyk D, Zhu W, Wang A, McCrimmon RJ, Seashore MR, Sherwin RS.

Diabetes. 2008 May;57(5):1363-70. Epub 2008 Mar 28.PMID: 18375441 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration.

Herzog RI, Chan O, Yu S, Dziura J, McNay EC, Sherwin RS.

Endocrinology. 2008 Apr;149(4):1499-504. Epub 2008 Jan 10.PMID: 18187548 [PubMed - indexed for MEDLINE]Related articlesFree article

Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia.

McCrimmon RJ, Shaw M, Fan X, Cheng H, Ding Y, Vella MC, Zhou L, McNay EC, Sherwin RS.

Diabetes. 2008 Feb;57(2):444-50. Epub 2007 Oct 31.PMID: 17977955 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation.

Cheng H, Zhou L, Zhu W, Wang A, Tang C, Chan O, Sherwin RS, McCrimmon RJ.

Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E705-12. Epub 2007 Jun 19.PMID: 17578887 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.

Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB.

Cell Metab. 2007 May;5(5):383-93.PMID: 17488640 [PubMed - indexed for MEDLINE]Related articlesFree article

5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells.

Shaw MM, Gurr WK, McCrimmon RJ, Schorderet DF, Sherwin RS.

J Cell Mol Med. 2007 Mar-Apr;11(2):286-98.PMID: 17488477 [PubMed - indexed for MEDLINE]Related articles

NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice.

Kim S, Millet I, Kim HS, Kim JY, Han MS, Lee MK, Kim KW, Sherwin RS, Karin M, Lee MS.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1913-8. Epub 2007 Jan 31.PMID: 17267600 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia.

Chan O, Lawson M, Zhu W, Beverly JL, Sherwin RS.

Diabetes. 2007 Apr;56(4):1120-6. Epub 2007 Jan 24.PMID: 17251273 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoglycemia reduces the blood-oxygenation level dependent signal in primary auditory and visual cortex: a functional magnetic resonance imaging study.

Driesen NR, Goldberg PA, Anderson AW, Tang L, Flanagan DE, Sherwin RS, Gore JC.

J Neurosci Res. 2007 Feb 15;85(3):575-82.PMID: 17154420 [PubMed - indexed for MEDLINE]Related articles

Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation.

McCrimmon RJ, Song Z, Cheng H, McNay EC, Weikart-Yeckel C, Fan X, Routh VH, Sherwin RS.

J Clin Invest. 2006 Jun;116(6):1723-30.PMID: 16741581 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation.

McCrimmon RJ, Fan X, Cheng H, McNay E, Chan O, Shaw M, Ding Y, Zhu W, Sherwin RS.

Diabetes. 2006 Jun;55(6):1755-60.PMID: 16731839 [PubMed - indexed for MEDLINE]Related articlesFree article

Antecedent hypercortisolemia is not primarily responsible for generating hypoglycemia-associated autonomic failure.

Goldberg PA, Weiss R, McCrimmon RJ, Hintz EV, Dziura JD, Sherwin RS.

Diabetes. 2006 Apr;55(4):1121-6.PMID: 16567537 [PubMed - indexed for MEDLINE]Related articlesFree article

Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia.

McNay EC, Williamson A, McCrimmon RJ, Sherwin RS.

Diabetes. 2006 Apr;55(4):1088-95.PMID: 16567533 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia.

Chan O, Zhu W, Ding Y, McCrimmon RJ, Sherwin RS.

Diabetes. 2006 Apr;55(4):1080-7.PMID: 16567532 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin controls hippocampal spine synapse density and memory performance.

Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, Sleeman MW, Tschöp MH, Horvath TL.

Nat Neurosci. 2006 Mar;9(3):381-8. Epub 2006 Feb 19.PMID: 16491079 [PubMed - indexed for MEDLINE]Related articles

Modulation of memory with septal injections of morphine and glucose: effects on extracellular glucose levels in the hippocampus.

McNay EC, Canal CE, Sherwin RS, Gold PE.

Physiol Behav. 2006 Feb 28;87(2):298-303. Epub 2005 Dec 15.PMID: 16343563 [PubMed - indexed for MEDLINE]Related articles

Targeted expression of the anti-apoptotic gene CrmA to NOD pancreatic islets protects from autoimmune diabetes.

Millet I, Wong FS, Gurr W, Wen L, Zawalich W, Green EA, Flavell RA, Sherwin RS.

J Autoimmun. 2006 Feb;26(1):7-15. Epub 2005 Dec 9.PMID: 16338119 [PubMed - indexed for MEDLINE]Related articles

Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats.

McCrimmon RJ, Evans ML, Fan X, McNay EC, Chan O, Ding Y, Zhu W, Gram DX, Sherwin RS.

Diabetes. 2005 Nov;54(11):3169-74.PMID: 16249441 [PubMed - indexed for MEDLINE]Related articlesFree article

The prevention of type 2 diabetes mellitus.

Inzucchi SE, Sherwin RS.

Endocrinol Metab Clin North Am. 2005 Mar;34(1):199-219, viii. Review.PMID: 15752928 [PubMed - indexed for MEDLINE]Related articles

Extracellular metabolites in the cortex and hippocampus of epileptic patients.

Cavus I, Kasoff WS, Cassaday MP, Jacob R, Gueorguieva R, Sherwin RS, Krystal JH, Spencer DD, Abi-Saab WM.

Ann Neurol. 2005 Feb;57(2):226-35.PMID: 15668975 [PubMed - indexed for MEDLINE]Related articles

The normal glucose tolerance continuum in obese youth: evidence for impairment in beta-cell function independent of insulin resistance.

Yeckel CW, Taksali SE, Dziura J, Weiss R, Burgert TS, Sherwin RS, Tamborlane WV, Caprio S.

J Clin Endocrinol Metab. 2005 Feb;90(2):747-54. Epub 2004 Nov 2.PMID: 15522932 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses.

Evans ML, McCrimmon RJ, Flanagan DE, Keshavarz T, Fan X, McNay EC, Jacob RJ, Sherwin RS.

Diabetes. 2004 Oct;53(10):2542-51.PMID: 15448082 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined hyperinsulinemia and hyperglycemia, but not hyperinsulinemia alone, suppress human skeletal muscle lipolytic activity in vivo.

Qvisth V, Hagström-Toft E, Enoksson S, Sherwin RS, Sjöberg S, Bolinder J.

J Clin Endocrinol Metab. 2004 Sep;89(9):4693-700.PMID: 15356082 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus.

McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS.

Diabetes. 2004 Aug;53(8):1953-8.PMID: 15277372 [PubMed - indexed for MEDLINE]Related articlesFree article

Experience with the continuous glucose monitoring system in a medical intensive care unit.

Goldberg PA, Siegel MD, Russell RR, Sherwin RS, Halickman JI, Cooper DA, Dziura JD, Inzucchi SE.

Diabetes Technol Ther. 2004 Jun;6(3):339-47.PMID: 15198837 [PubMed - indexed for MEDLINE]Related articles

Obesity and the metabolic syndrome in children and adolescents.

Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S.

N Engl J Med. 2004 Jun 3;350(23):2362-74.PMID: 15175438 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of alcohol on cognitive performance during mild hypoglycaemia; implications for Type 1 diabetes.

Cheyne EH, Sherwin RS, Lunt MJ, Cavan DA, Thomas PW, Kerr D.

Diabet Med. 2004 Mar;21(3):230-7.PMID: 15008832 [PubMed - indexed for MEDLINE]Related articles

Effect of recurrent hypoglycemia on spatial cognition and cognitive metabolism in normal and diabetic rats.

McNay EC, Sherwin RS.

Diabetes. 2004 Feb;53(2):418-25.PMID: 14747293 [PubMed - indexed for MEDLINE]Related articlesFree article

Implementation of a safe and effective insulin infusion protocol in a medical intensive care unit.

Goldberg PA, Siegel MD, Sherwin RS, Halickman JI, Lee M, Bailey VA, Lee SL, Dziura JD, Inzucchi SE.

Diabetes Care. 2004 Feb;27(2):461-7.PMID: 14747229 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention or delay of type 2 diabetes.

Sherwin RS, Anderson RM, Buse JB, Chin MH, Eddy D, Fradkin J, Ganiats TG, Ginsberg HN, Kahn R, Nwankwo R, Rewers M, Schlessinger L, Stern M, Vinicor F, Zinman B; American Diabetes Association; National Institute of Diabetes and Digestive and Kidney Diseases.

Diabetes Care. 2004 Jan;27 Suppl 1:S47-54. Review. No abstract available. PMID: 14693925 [PubMed - indexed for MEDLINE]Related articlesFree article

From artificial cerebro-spinal fluid (aCSF) to artificial extracellular fluid (aECF): microdialysis perfusate composition effects on in vivo brain ECF glucose measurements.

McNay EC, Sherwin RS.

J Neurosci Methods. 2004 Jan 15;132(1):35-43.PMID: 14687673 [PubMed - indexed for MEDLINE]Related articles

Effects of recurrent antecedent hypoglycaemia and chronic hyperglycaemia on brainstem extra-cellular glucose concentrations during acute hypoglycaemia in conscious diabetic BB rats.

McCrimmon RJ, Jacob RJ, Fan X, McNay EC, Sherwin RS.

Diabetologia. 2003 Dec;46(12):1658-61. Epub 2003 Nov 5.PMID: 14600813 [PubMed - indexed for MEDLINE]Related articles

In situ evidence that peripheral insulin resistance in adolescents with poorly controlled type 1 diabetes is associated with impaired suppression of lipolysis: a microdialysis study.

Heptulla RA, Stewart A, Enocksson S, Rife F, Ma TY, Sherwin RS, Tamborlane WV, Caprio S.

Pediatr Res. 2003 May;53(5):830-5.PMID: 12702748 [PubMed - indexed for MEDLINE]Related articles

Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia.

Enoksson S, Caprio SK, Rife F, Shulman GI, Tamborlane WV, Sherwin RS.

J Clin Endocrinol Metab. 2003 Apr;88(4):1503-11.PMID: 12679430 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sustained caffeine use.

Watson JM, Sherwin RS, Deary IJ, Scott L, Kerr D.

Clin Sci (Lond). 2003 Apr;104(4):447-54.PMID: 12653691 [PubMed - indexed for MEDLINE]Related articles

Blood glucose and the brain in diabetes: between a rock and a hard place?

Evans ML, Sherwin RS.

Curr Diab Rep. 2002 Apr;2(2):101-2. Review. No abstract available. PMID: 12643129 [PubMed - indexed for MEDLINE]Related articles

Brain glucose metabolism and hypoglycaemia.

Evans ML, Sherwin RS.

Diabetes Nutr Metab. 2002 Oct;15(5):294-6; discussion 296. Review. No abstract available. PMID: 12625472 [PubMed - indexed for MEDLINE]Related articles

Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation.

Borg MA, Tamborlane WV, Shulman GI, Sherwin RS.

Diabetes. 2003 Mar;52(3):663-6.PMID: 12606506 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia.

Flanagan DE, Keshavarz T, Evans ML, Flanagan S, Fan X, Jacob RJ, Sherwin RS.

Diabetes. 2003 Mar;52(3):605-13.PMID: 12606499 [PubMed - indexed for MEDLINE]Related articlesFree article

The influence of insulin on circulating ghrelin.

Flanagan DE, Evans ML, Monsod TP, Rife F, Heptulla RA, Tamborlane WV, Sherwin RS.

Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E313-6.PMID: 12531744 [PubMed - indexed for MEDLINE]Related articlesFree article