PubMed

Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.

Frédérick R, Mawson C, Kendall JD, Chaussade C, Rewcastle GW, Shepherd PR, Denny WA.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5842-7. Epub 2009 Aug 29.PMID: 19748269 [PubMed - in process]Related articles

Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: implications for glucose metabolism and food choice behaviour.

Smith GC, Vickers MH, Cognard E, Shepherd PR.

Schizophr Res. 2009 Nov;115(1):30-40. Epub 2009 Aug 12.PMID: 19679451 [PubMed - in process]Related articles

Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.

Lam JB, Chow KH, Xu A, Lam KS, Liu J, Wong NS, Moon RT, Shepherd PR, Cooper GJ, Wang Y.

PLoS One. 2009;4(3):e4968. Epub 2009 Mar 25. Erratum in: PLoS One. 2009;4(4). doi: 10.1371/annotation/14cb7d7e-a921-4ae6-a405-99c60656579f. PMID: 19319191 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional differences between two classes of oncogenic mutation in the PIK3CA gene.

Chaussade C, Cho K, Mawson C, Rewcastle GW, Shepherd PR.

Biochem Biophys Res Commun. 2009 Apr 17;381(4):577-81. Epub 2009 Feb 20.PMID: 19233141 [PubMed - indexed for MEDLINE]Related articles

Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation.

Kim JE, Shepherd PR, Chaussade C.

Biochem Biophys Res Commun. 2009 Feb 20;379(4):830-4. Epub 2008 Dec 27.PMID: 19114029 [PubMed - indexed for MEDLINE]Related articles

Atypical antipsychotic drugs induce derangements in glucose homeostasis by acutely increasing glucagon secretion and hepatic glucose output in the rat.

Smith GC, Chaussade C, Vickers M, Jensen J, Shepherd PR.

Diabetologia. 2008 Dec;51(12):2309-17. Epub 2008 Oct 9.PMID: 18843478 [PubMed - indexed for MEDLINE]Related articles

Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.

Anagnostou SH, Shepherd PR.

Biochem J. 2008 Dec 1;416(2):211-8.PMID: 18823284 [PubMed - indexed for MEDLINE]Related articles

Adrenaline potentiates insulin-stimulated PKB activation in the rat fast-twitch epitrochlearis muscle without affecting IRS-1-associated PI 3-kinase activity.

Jensen J, Grønning-Wang LM, Jebens E, Whitehead JP, Zorec R, Shepherd PR.

Pflugers Arch. 2008 Aug;456(5):969-78. Epub 2008 Feb 26.PMID: 18299886 [PubMed - indexed for MEDLINE]Related articles

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

Kendall JD, Rewcastle GW, Frederick R, Mawson C, Denny WA, Marshall ES, Baguley BC, Chaussade C, Jackson SP, Shepherd PR.

Bioorg Med Chem. 2007 Dec 15;15(24):7677-87. Epub 2007 Sep 4.PMID: 17869522 [PubMed - indexed for MEDLINE]Related articles

The role of phosphoinositide 3-kinase C2alpha in insulin signaling.

Falasca M, Hughes WE, Dominguez V, Sala G, Fostira F, Fang MQ, Cazzolli R, Shepherd PR, James DE, Maffucci T.

J Biol Chem. 2007 Sep 21;282(38):28226-36. Epub 2007 Jul 20.PMID: 17644513 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

Chaussade C, Rewcastle GW, Kendall JD, Denny WA, Cho K, Grønning LM, Chong ML, Anagnostou SH, Jackson SP, Daniele N, Shepherd PR.

Biochem J. 2007 Jun 15;404(3):449-58.PMID: 17362206 [PubMed - indexed for MEDLINE]Related articlesFree article

GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3.

Jensen J, Brennesvik EO, Lai YC, Shepherd PR.

Cell Signal. 2007 Jan;19(1):204-10. Epub 2006 Aug 24.PMID: 16934435 [PubMed - indexed for MEDLINE]Related articles

Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway.

Grønning LM, Tingsabadh R, Hardy K, Dalen KT, Jat PS, Gnudi L, Shepherd PR.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E599-606. Epub 2005 Oct 18.PMID: 16234270 [PubMed - indexed for MEDLINE]Related articlesFree article

Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline.

Brennesvik EO, Ktori C, Ruzzin J, Jebens E, Shepherd PR, Jensen J.

Cell Signal. 2005 Dec;17(12):1551-9.PMID: 15908181 [PubMed - indexed for MEDLINE]Related articles

PI 3-kinase p110beta: a new target for antithrombotic therapy.

Jackson SP, Schoenwaelder SM, Goncalves I, Nesbitt WS, Yap CL, Wright CE, Kenche V, Anderson KE, Dopheide SM, Yuan Y, Sturgeon SA, Prabaharan H, Thompson PE, Smith GD, Shepherd PR, Daniele N, Kulkarni S, Abbott B, Saylik D, Jones C, Lu L, Giuliano S, Hughan SC, Angus JA, Robertson AD, Salem HH.

Nat Med. 2005 May;11(5):507-14. Epub 2005 Apr 17.PMID: 15834429 [PubMed - indexed for MEDLINE]Related articles

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues.

Shepherd PR.

Acta Physiol Scand. 2005 Jan;183(1):3-12. Review.PMID: 15654916 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases.

Jones DR, Pañeda C, Villar AV, Alonso A, Goñi FM, Bütikofer P, Brodbeck U, Shepherd PR, Varela-Nieto I.

FEBS Lett. 2005 Jan 3;579(1):59-65.PMID: 15620691 [PubMed - indexed for MEDLINE]Related articles

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF.

J Cell Biol. 2004 Jul 19;166(2):213-23. Epub 2004 Jul 12.PMID: 15249583 [PubMed - indexed for MEDLINE]Related articlesFree article

eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.

Foukas LC, Shepherd PR.

Biochem Biophys Res Commun. 2004 Jun 25;319(2):541-9.PMID: 15178440 [PubMed - indexed for MEDLINE]Related articles

Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.

Li L, Grønning LM, Anderson PO, Li S, Edvardsen K, Johnston J, Kioussis D, Shepherd PR, Wang P.

J Biol Chem. 2004 Aug 13;279(33):34107-14. Epub 2004 Apr 27.PMID: 15123678 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphoinositide 3-kinase: the protein kinase that time forgot.

Foukas LC, Shepherd PR.

Biochem Soc Trans. 2004 Apr;32(Pt 2):330-1. Review.PMID: 15046601 [PubMed - indexed for MEDLINE]Related articles

Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.

Cheng SW, Fryer LG, Carling D, Shepherd PR.

J Biol Chem. 2004 Apr 16;279(16):15719-22. Epub 2004 Feb 17.PMID: 14970221 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.

Foukas LC, Beeton CA, Jensen J, Phillips WA, Shepherd PR.

Mol Cell Biol. 2004 Feb;24(3):966-75.PMID: 14729945 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuregulin signaling on glucose transport in muscle cells.

Cantó C, Suárez E, Lizcano JM, Griñó E, Shepherd PR, Fryer LG, Carling D, Bertran J, Palacín M, Zorzano A, Gumà A.

J Biol Chem. 2004 Mar 26;279(13):12260-8. Epub 2004 Jan 6.PMID: 14711829 [PubMed - indexed for MEDLINE]Related articlesFree article

Secrets of insulin and IGF-1 regulation of insulin secretion revealed.

Shepherd PR.

Biochem J. 2004 Jan 1;377(Pt 1):e1-2.PMID: 14672535 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct interaction of major histocompatibility complex class II-derived peptides with class Ia phosphoinositide 3-kinase results in dose-dependent stimulatory effects.

Foukas LC, Panayotou G, Shepherd PR.

J Biol Chem. 2004 Feb 27;279(9):7505-11. Epub 2003 Dec 3.PMID: 14660637 [PubMed - indexed for MEDLINE]Related articlesFree article

Human cell systems for drug discovery.

Horrocks C, Halse R, Suzuki R, Shepherd PR.

Curr Opin Drug Discov Devel. 2003 Jul;6(4):570-5. Review.PMID: 12951820 [PubMed - indexed for MEDLINE]Related articles

Saturated-fat diet induces moderate diabetes and severe glomerulosclerosis in hamsters.

Popov D, Simionescu M, Shepherd PR.

Diabetologia. 2003 Oct;46(10):1408-18. Epub 2003 Jul 29.PMID: 12898005 [PubMed - indexed for MEDLINE]Related articles

TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase.

Ktori C, Shepherd PR, O'Rourke L.

Biochem Biophys Res Commun. 2003 Jun 20;306(1):139-43.PMID: 12788079 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent regulation of cholesterol ester metabolism in macrophages by insulin and leptin.

O'Rourke L, Gronning LM, Yeaman SJ, Shepherd PR.

J Biol Chem. 2002 Nov 8;277(45):42557-62. Epub 2002 Aug 27.PMID: 12200416 [PubMed - indexed for MEDLINE]Related articlesFree article

Conditionally immortalized cell lines as model systems for high-throughput biology in drug discovery.

Daniele N, Halse R, Grinyo E, Yeaman SJ, Shepherd PR.

Biochem Soc Trans. 2002 Aug;30(4):800-2.PMID: 12196201 [PubMed - indexed for MEDLINE]Related articles

Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.

Foukas LC, Daniele N, Ktori C, Anderson KE, Jensen J, Shepherd PR.

J Biol Chem. 2002 Oct 4;277(40):37124-30. Epub 2002 Jul 26.PMID: 12145276 [PubMed - indexed for MEDLINE]Related articlesFree article

Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser727 phosphorylation and DNA binding.

O'Rourke L, Shepherd PR.

Biochem J. 2002 Jun 15;364(Pt 3):875-9.PMID: 12049654 [PubMed - indexed for MEDLINE]Related articlesFree article

Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle.

Soos MA, Jensen J, Brown RA, O'Rahilly S, Shepherd PR, Whitehead JP.

Arch Biochem Biophys. 2001 Dec 15;396(2):244-8.PMID: 11747303 [PubMed - indexed for MEDLINE]Related articles

Growth factor regulation of the novel class II phosphoinositide 3-kinases.

Brown RA, Shepherd PR.

Biochem Soc Trans. 2001 Aug;29(Pt 4):535-7. Review.PMID: 11498023 [PubMed - indexed for MEDLINE]Related articles

Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways.

O'Rourke L, Yeaman SJ, Shepherd PR.

Diabetes. 2001 May;50(5):955-61.PMID: 11334438 [PubMed - indexed for MEDLINE]Related articlesFree article

What can we learn by growing equine cells in culture?

Shepherd PR.

Equine Vet J. 2000 Sep;32(5):366-7. Review. No abstract available. PMID: 11037256 [PubMed - indexed for MEDLINE]Related articles

Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110alpha and p110beta catalytic subunits of class-Ia phosphoinositide 3-kinases.

Beeton CA, Chance EM, Foukas LC, Shepherd PR.

Biochem J. 2000 Sep 1;350 Pt 2:353-9.PMID: 10947948 [PubMed - indexed for MEDLINE]Related articlesFree article

Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity.

Baynes KC, Beeton CA, Panayotou G, Stein R, Soos M, Hansen T, Simpson H, O'Rahilly S, Shepherd PR, Whitehead JP.

Diabetologia. 2000 Mar;43(3):321-31.PMID: 10768093 [PubMed - indexed for MEDLINE]Related articles

The SH3 and BH domains of the p85alpha adapter subunit play a critical role in regulating class Ia phosphoinositide 3-kinase function.

Beeton CA, Das P, Waterfield MD, Shepherd PR.

Mol Cell Biol Res Commun. 1999 May;1(2):153-7.PMID: 10356365 [PubMed - indexed for MEDLINE]Related articles

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

Navé BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.

Biochem J. 1999 Dec 1;344 Pt 2:427-31.PMID: 10567225 [PubMed - indexed for MEDLINE]Related articlesFree article

The alpha-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs.

Ursø B, Brown RA, O'Rahilly S, Shepherd PR, Siddle K.

FEBS Lett. 1999 Nov 5;460(3):423-6.PMID: 10556509 [PubMed - indexed for MEDLINE]Related articles

Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus.

Shepherd PR, Kahn BB.

N Engl J Med. 1999 Jul 22;341(4):248-57. Review. No abstract available. PMID: 10413738 [PubMed - indexed for MEDLINE]Related articles

Insulin activates the alpha isoform of class II phosphoinositide 3-kinase.

Brown RA, Domin J, Arcaro A, Waterfield MD, Shepherd PR.

J Biol Chem. 1999 May 21;274(21):14529-32.PMID: 10329640 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling.

Shepherd PR, Withers DJ, Siddle K.

Biochem J. 1998 Aug 1;333 ( Pt 3):471-90. Review. Erratum in: Biochem J 1998 Nov 1;335(Pt 3):711. PMID: 9677303 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism.

Shepherd PR, Nave BT, Rincon J, Haigh RJ, Foulstone E, Proud C, Zierath JR, Siddle K, Wallberg-Henriksson H.

Diabetologia. 1997 Oct;40(10):1172-7.PMID: 9349598 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells.

Kaliman P, Canicio J, Shepherd PR, Beeton CA, Testar X, Palacín M, Zorzano A.

Mol Endocrinol. 1998 Jan;12(1):66-77.PMID: 9440811 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.

Withers DJ, Ouwens DM, Nave BT, van der Zon GC, Alarcon CM, Cardenas ME, Heitman J, Maassen JA, Shepherd PR.

Biochem Biophys Res Commun. 1997 Dec 29;241(3):704-9.PMID: 9434772 [PubMed - indexed for MEDLINE]Related articles

Is stimulation of class-1 phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism.

Shepherd PR, Siddle K, Navé BT.

Biochem Soc Trans. 1997 Aug;25(3):978-81. Review.PMID: 9388585 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.

Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP, Siddle K, Zierath JR, Wallberg-Henriksson H.

J Biol Chem. 1997 Jul 25;272(30):19000-7.PMID: 9228082 [PubMed - indexed for MEDLINE]Related articlesFree article