PubMed

Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel.

Zhao Y, Fang Q, Straub SG, Sharp GW.

J Biol Chem. 2008 Feb 29;283(9):5306-16. Epub 2007 Dec 27.PMID: 18162464 [PubMed - indexed for MEDLINE]Related articlesFree article

The inhibitors of protein acylation, cerulenin and tunicamycin, increase voltage-dependent Ca(2+) currents in the insulin-secreting INS 832/13 cell.

Zhao Y, Sharp GW, Straub SG.

Biochem Pharmacol. 2007 Jul 15;74(2):273-80. Epub 2007 Apr 19.PMID: 17548064 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory role of Src family tyrosine kinases on Ca2+-dependent insulin release.

Cheng H, Straub SG, Sharp GW.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E845-52. Epub 2006 Nov 22.PMID: 17122086 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of insulin secretion by cerulenin might be due to impaired glucose metabolism.

Straub SG, Sharp GW.

Diabetes Metab Res Rev. 2007 Feb;23(2):146-51.PMID: 16705622 [PubMed - indexed for MEDLINE]Related articles

Stimulation of insulin release by glucose is associated with an increase in the number of docked granules in the beta-cells of rat pancreatic islets.

Straub SG, Shanmugam G, Sharp GW.

Diabetes. 2004 Dec;53(12):3179-83.PMID: 15561948 [PubMed - indexed for MEDLINE]Related articlesFree article

Massive augmentation of stimulated insulin secretion induced by fatty acid-free BSA in rat pancreatic islets.

Straub SG, Sharp GW.

Diabetes. 2004 Dec;53(12):3152-8.PMID: 15561945 [PubMed - indexed for MEDLINE]Related articlesFree article

Anaplerotic input is sufficient to induce time-dependent potentiation of insulin release in rat pancreatic islets.

Gunawardana SC, Liu YJ, Macdonald MJ, Straub SG, Sharp GW.

Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E828-33.PMID: 15475511 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion.

Straub SG, Sharp GW.

Am J Physiol Cell Physiol. 2004 Sep;287(3):C565-71. Review.PMID: 15308461 [PubMed - indexed for MEDLINE]Related articlesFree article

Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic beta-cells.

Cosgrove KE, Straub SG, Barnes PD, Chapman J, Sharp GW, Dunne MJ.

Eur J Pharmacol. 2004 Feb 20;486(2):133-9.PMID: 14975702 [PubMed - indexed for MEDLINE]Related articles

Activation of the KATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH.

Liu YJ, Cheng H, Drought H, MacDonald MJ, Sharp GW, Straub SG.

Am J Physiol Endocrinol Metab. 2003 Aug;285(2):E380-9. Epub 2003 Apr 22.PMID: 12709398 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2.

Cheng H, Straub SG, Sharp GW.

Am J Physiol Endocrinol Metab. 2003 Aug;285(2):E287-94. Epub 2003 Apr 8.PMID: 12684222 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of insulin secretion by denatonium, one of the most bitter-tasting substances known.

Straub SG, Mulvaney-Musa J, Yajima H, Weiland GA, Sharp GW.

Diabetes. 2003 Feb;52(2):356-64.PMID: 12540608 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-stimulated signaling pathways in biphasic insulin secretion.

Straub SG, Sharp GW.

Diabetes Metab Res Rev. 2002 Nov-Dec;18(6):451-63. Review.PMID: 12469359 [PubMed - indexed for MEDLINE]Related articles

Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription.

Noda M, Yamashita S, Takahashi N, Eto K, Shen LM, Izumi K, Daniel S, Tsubamoto Y, Nemoto T, Iino M, Kasai H, Sharp GW, Kadowaki T.

J Biol Chem. 2002 Nov 1;277(44):41817-26. Epub 2002 Aug 6.PMID: 12169697 [PubMed - indexed for MEDLINE]Related articlesFree article

Progesterone inhibits insulin secretion by a membrane delimited, non-genomic action.

Straub SG, Sharp GW, Meglasson MD, De Souza CJ.

Biosci Rep. 2001 Oct;21(5):653-66.PMID: 12168772 [PubMed - indexed for MEDLINE]Related articles

A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release.

Daniel S, Noda M, Cerione RA, Sharp GW.

Biochemistry. 2002 Jul 30;41(30):9663-71.PMID: 12135388 [PubMed - indexed for MEDLINE]Related articles

Hyposmotic shock stimulates insulin secretion by two distinct mechanisms. Studies with the betaHC9 cell.

Straub SG, Daniel S, Sharp GW.

Am J Physiol Endocrinol Metab. 2002 May;282(5):E1070-6.PMID: 11934672 [PubMed - indexed for MEDLINE]Related articlesFree article

Norepinephrine inhibits glucose-stimulated, Ca2+-independent insulin release independently from its action on adenylyl cyclase.

Yajima H, Komatsu M, Sato Y, Yamada S, Yamauchi K, Sharp GW, Aizawa T, Hashizume K.

Endocr J. 2001 Dec;48(6):647-54.PMID: 11873862 [PubMed - indexed for MEDLINE]Related articles

The effects of cerulenin, an inhibitor of protein acylation, on the two phases of glucose-stimulated insulin secretion.

Straub SG, Yajima H, Komatsu M, Aizawa T, Sharp GW.

Diabetes. 2002 Feb;51 Suppl 1:S91-5.PMID: 11815464 [PubMed - indexed for MEDLINE]Related articlesFree article

Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion.

Bratanova-Tochkova TK, Cheng H, Daniel S, Gunawardana S, Liu YJ, Mulvaney-Musa J, Schermerhorn T, Straub SG, Yajima H, Sharp GW.

Diabetes. 2002 Feb;51 Suppl 1:S83-90. Review.PMID: 11815463 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular pH plays a critical role in glucose-induced time-dependent potentiation of insulin release in rat islets.

Gunawardana SC, Sharp GW.

Diabetes. 2002 Jan;51(1):105-13.PMID: 11756329 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinism of infancy: the regulated release of insulin by KATP channel-independent pathways.

Straub SG, Cosgrove KE, Ammälä C, Shepherd RM, O'Brien RE, Barnes PD, Kuchinski N, Chapman JC, Schaeppi M, Glaser B, Lindley KJ, Sharp GW, Aynsley-Green A, Dunne MJ.

Diabetes. 2001 Feb;50(2):329-39.PMID: 11272144 [PubMed - indexed for MEDLINE]Related articlesFree article

Hexamminecobalt(III) chloride inhibits glucose-induced insulin secretion at the exocytotic process.

Tsubamoto Y, Eto K, Noda M, Daniel S, Suga S, Yamashita S, Kasai H, Wakui M, Sharp GW, Kimura S, Kadowaki T.

J Biol Chem. 2001 Feb 2;276(5):2979-85. Epub 2000 Nov 7.PMID: 11069902 [PubMed - indexed for MEDLINE]Related articlesFree article

Norepinephrine acts on the KATP channel and produces different effects on [Ca2+]i in oscillating and non-oscillating HIT-T15 cells.

Schermerhorn T, Sharp GW.

Cell Calcium. 2000 Mar;27(3):163-73.PMID: 11007129 [PubMed - indexed for MEDLINE]Related articles

Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets.

Yajima H, Komatsu M, Yamada S, Straub SG, Kaneko T, Sato Y, Yamauchi K, Hashizume K, Sharp GW, Aizawa T.

Diabetes. 2000 May;49(5):712-7.PMID: 10905478 [PubMed - indexed for MEDLINE]Related articlesFree article

The calcimimetic R-467 potentiates insulin secretion in pancreatic beta cells by activation of a nonspecific cation channel.

Straub SG, Kornreich B, Oswald RE, Nemeth EF, Sharp GW.

J Biol Chem. 2000 Jun 23;275(25):18777-84.PMID: 10751384 [PubMed - indexed for MEDLINE]Related articlesFree article

Calbindin-D(28k) controls [Ca(2+)](i) and insulin release. Evidence obtained from calbindin-d(28k) knockout mice and beta cell lines.

Sooy K, Schermerhorn T, Noda M, Surana M, Rhoten WB, Meyer M, Fleischer N, Sharp GW, Christakos S.

J Biol Chem. 1999 Nov 26;274(48):34343-9.PMID: 10567411 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.

Daniel S, Noda M, Straub SG, Sharp GW.

Diabetes. 1999 Sep;48(9):1686-90.PMID: 10480595 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets.

Yajima H, Komatsu M, Schermerhorn T, Aizawa T, Kaneko T, Nagai M, Sharp GW, Hashizume K.

Diabetes. 1999 May;48(5):1006-12.PMID: 10331404 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose action 'beyond ionic events' in the pancreatic beta cell.

Aizawa T, Komatsu M, Asanuma N, Sato Y, Sharp GW.

Trends Pharmacol Sci. 1998 Dec;19(12):496-9. Review. Erratum in: Trends Pharmacol Sci 1999 Mar;20(3):124. PMID: 9871411 [PubMed - indexed for MEDLINE]Related articles

Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line betaHC9.

Hayakawa T, Noda M, Yasuda K, Yorifuji H, Taniguchi S, Miwa I, Sakura H, Terauchi Y, Hayashi J, Sharp GW, Kanazawa Y, Akanuma Y, Yazaki Y, Kadowaki T.

J Biol Chem. 1998 Aug 7;273(32):20300-7.PMID: 9685380 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets.

Straub SG, James RF, Dunne MJ, Sharp GW.

Diabetes. 1998 Jul;47(7):1053-7.PMID: 9648828 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells.

Tang SH, Sharp GW.

Diabetes. 1998 Jun;47(6):905-12.PMID: 9604867 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets.

Straub SG, James RF, Dunne MJ, Sharp GW.

Diabetes. 1998 May;47(5):758-63.PMID: 9588447 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate and myristate selectively mimic the effect of glucose in augmenting insulin release in the absence of extracellular Ca2+.

Komatsu M, Sharp GW.

Diabetes. 1998 Mar;47(3):352-7.PMID: 9519739 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutrient augmentation of Ca2+-dependent and Ca2+-independent pathways in stimulus-coupling to insulin secretion can be distinguished by their guanosine triphosphate requirements: studies on rat pancreatic islets.

Komatsu M, Noda M, Sharp GW.

Endocrinology. 1998 Mar;139(3):1172-83.PMID: 9492052 [PubMed - indexed for MEDLINE]Related articlesFree article

Augmentation of insulin release by glucose in the absence of extracellular Ca2+: new insights into stimulus-secretion coupling.

Komatsu M, Schermerhorn T, Noda M, Straub SG, Aizawa T, Sharp GW.

Diabetes. 1997 Dec;46(12):1928-38. Review.PMID: 9392476 [PubMed - indexed for MEDLINE]Related articles

Identification of muscarinic receptor subtypes in RINm5F cells by means of polymerase chain reaction, subcloning, and DNA sequencing.

Tang SH, Sharp GW.

Diabetes. 1997 Sep;46(9):1419-23.PMID: 9287041 [PubMed - indexed for MEDLINE]Related articles

The alpha2-adrenergic receptor is more effective than the galanin receptor in activating G-proteins in RINm5F beta-cell membranes.

Gillison SL, Straub SG, Sharp GW.

Diabetes. 1997 Mar;46(3):401-7.PMID: 9032095 [PubMed - indexed for MEDLINE]Related articles

Two signaling pathways, from the upper glycolytic flux and from the mitochondria, converge to potentiate insulin release.

Asanuma N, Aizawa T, Sato Y, Schermerhorn T, Komatsu M, Sharp GW, Hashizume K.

Endocrinology. 1997 Feb;138(2):751-5.PMID: 9003011 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced time-dependent potentiation and "run down" of insulin secretion in islets of young rats.

Bliss CR, Sharp GW.

Adv Exp Med Biol. 1997;426:21-6.PMID: 9544251 [PubMed - indexed for MEDLINE]Related articles

Glucose stimulation of insulin release without an increase in cytosolic free Ca2+ concentration: a possible involvement of GTP.

Komatsu M, Sharp GW, Aizawa T, Hashizume K.

Jpn J Physiol. 1997;47 Suppl 1:S22-4. No abstract available. PMID: 9266317 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of action of VIP and PACAP in the stimulation of insulin release.

Straub SG, Sharp GW.

Ann N Y Acad Sci. 1996 Dec 26;805:607-12.PMID: 8993448 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of inhibition of insulin release.

Sharp GW.

Am J Physiol. 1996 Dec;271(6 Pt 1):C1781-99. Review.PMID: 8997178 [PubMed - indexed for MEDLINE]Related articles

The betaHC-9 pancreatic beta-cell line preserves the characteristics of progenitor mouse islets.

Noda M, Komatsu M, Sharp GW.

Diabetes. 1996 Dec;45(12):1766-73.PMID: 8922364 [PubMed - indexed for MEDLINE]Related articles

Pituitary adenylate cyclase-activating peptide, carbachol, and glucose stimulate insulin release in the absence of an increase in intracellular Ca2+.

Komatsu M, Schermerhorn T, Straub SG, Sharp GW.

Mol Pharmacol. 1996 Oct;50(4):1047-54.PMID: 8863853 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent insulinotropic polypeptide stimulates insulin secretion via increased cyclic AMP and [Ca2+]1 and a wortmannin-sensitive signalling pathway.

Straub SG, Sharp GW.

Biochem Biophys Res Commun. 1996 Jul 16;224(2):369-74.PMID: 8702397 [PubMed - indexed for MEDLINE]Related articles

A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide.

Straub SG, Sharp GW.

J Biol Chem. 1996 Jan 19;271(3):1660-8.PMID: 8576167 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of tight junction resistance in T84 monolayers by elevation in intracellular Ca2+: a protein kinase C effect.

Tai YH, Flick J, Levine SA, Madara JL, Sharp GW, Donowitz M.

J Membr Biol. 1996 Jan;149(1):71-9.PMID: 8825530 [PubMed - indexed for MEDLINE]Related articles

Glucose stimulation of insulin release in the absence of extracellular Ca2+ and in the absence of any increase in intracellular Ca2+ in rat pancreatic islets.

Komatsu M, Schermerhorn T, Aizawa T, Sharp GW.

Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10728-32.PMID: 7479873 [PubMed - indexed for MEDLINE]Related articlesFree article