PubMed

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.

Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A.

Cell. 2009 Aug 7;138(3):449-62.PMID: 19665969 [PubMed - indexed for MEDLINE]Related articles

Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis.

Bayha E, Jørgensen MC, Serup P, Grapin-Botton A.

PLoS One. 2009 Jun 10;4(6):e5845.PMID: 19516907 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.

Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9715-20. Epub 2009 Jun 1.PMID: 19487660 [PubMed - indexed for MEDLINE]Related articles

A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.

Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P.

Dev Biol. 2009 Jun 15;330(2):286-304. Epub 2009 Apr 7.PMID: 19358838 [PubMed - indexed for MEDLINE]Related articles

Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction.

Klein T, Heremans Y, Heimberg H, Pipeleers D, Madsen OD, Serup P, Heller RS.

Pancreas. 2009 Jan;38(1):36-48.PMID: 18665014 [PubMed - indexed for MEDLINE]Related articles

Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation.

Wang S, Hecksher-Sorensen J, Xu Y, Zhao A, Dor Y, Rosenberg L, Serup P, Gu G.

Dev Biol. 2008 May 15;317(2):531-40. Epub 2008 Mar 12.PMID: 18394599 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development.

Hald J, Sprinkel AE, Ray M, Serup P, Wright C, Madsen OD.

J Histochem Cytochem. 2008 Jun;56(6):587-95. Epub 2008 Mar 17.PMID: 18347078 [PubMed - indexed for MEDLINE]Related articlesFree article

Specificity of four monoclonal anti-NKx6-1 antibodies.

Klinck R, Serup P, Madsen OD, Jørgensen MC.

J Histochem Cytochem. 2008 Apr;56(4):415-24. Epub 2008 Jan 22.PMID: 18212389 [PubMed - indexed for MEDLINE]Related articlesFree article

An illustrated review of early pancreas development in the mouse.

Jørgensen MC, Ahnfelt-Rønne J, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J.

Endocr Rev. 2007 Oct;28(6):685-705. Epub 2007 Sep 19. Review.PMID: 17881611 [PubMed - indexed for MEDLINE]Related articlesFree article

Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas.

Ahnfelt-Rønne J, Hald J, Bødker A, Yassin H, Serup P, Hecksher-Sørensen J.

BMC Dev Biol. 2007 Jun 7;7:63.PMID: 17555568 [PubMed - indexed for MEDLINE]Related articlesFree article

An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs.

Ahnfelt-Rønne J, Jørgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J.

J Histochem Cytochem. 2007 Sep;55(9):925-30. Epub 2007 May 3.PMID: 17478445 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutant neurogenin-3 in congenital malabsorptive diarrhea.

Jensen JN, Rosenberg LC, Hecksher-Sørensen J, Serup P.

N Engl J Med. 2007 Apr 26;356(17):1781-2; author reply 1782. No abstract available. PMID: 17460236 [PubMed - indexed for MEDLINE]Related articles

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

Collombat P, Hecksher-Sørensen J, Krull J, Berger J, Riedel D, Herrera PL, Serup P, Mansouri A.

J Clin Invest. 2007 Apr;117(4):961-70.PMID: 17404619 [PubMed - indexed for MEDLINE]Related articlesFree article

Towards cell therapy for diabetes.

Madsen OD, Serup P.

Nat Biotechnol. 2006 Dec;24(12):1481-3. No abstract available. PMID: 17160042 [PubMed - indexed for MEDLINE]Related articles

The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice.

Petri A, Ahnfelt-Rønne J, Frederiksen KS, Edwards DG, Madsen D, Serup P, Fleckner J, Heller RS.

J Mol Endocrinol. 2006 Oct;37(2):301-16.PMID: 17032746 [PubMed - indexed for MEDLINE]Related articlesFree article

Embryonic stem cell-based diabetes therapy--a long road to travel.

Serup P.

Diabetologia. 2006 Nov;49(11):2537-40. Epub 2006 Sep 23. No abstract available. PMID: 17019597 [PubMed - indexed for MEDLINE]Related articles

Analysis of pancreatic endocrine development in GDF11-deficient mice.

Dichmann DS, Yassin H, Serup P.

Dev Dyn. 2006 Nov;235(11):3016-25.PMID: 16964608 [PubMed - indexed for MEDLINE]Related articlesFree article

Specifying pancreatic endocrine cell fates.

Collombat P, Hecksher-Sørensen J, Serup P, Mansouri A.

Mech Dev. 2006 Jul;123(7):501-12. Epub 2006 May 25. Review.PMID: 16822656 [PubMed - indexed for MEDLINE]Related articles

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.

Eldor R, Yeffet A, Baum K, Doviner V, Amar D, Ben-Neriah Y, Christofori G, Peled A, Carel JC, Boitard C, Klein T, Serup P, Eizirik DL, Melloul D.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5072-7. Epub 2006 Mar 21.PMID: 16551748 [PubMed - indexed for MEDLINE]Related articlesFree article

Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate.

Taneera J, Rosengren A, Renstrom E, Nygren JM, Serup P, Rorsman P, Jacobsen SE.

Diabetes. 2006 Feb;55(2):290-6.PMID: 16443759 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation and characterization of monoclonal antibodies against the transcription factor Nkx6.1.

Pedersen IL, Klinck R, Hecksher-Sorensen J, Zahn S, Madsen OD, Serup P, Jorgensen MC.

J Histochem Cytochem. 2006 May;54(5):567-74. Epub 2006 Jan 9.PMID: 16401696 [PubMed - indexed for MEDLINE]Related articlesFree article

Endodermal expression of Nkx6 genes depends differentially on Pdx1.

Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P; Beta Cell Biology Consortium.

Dev Biol. 2005 Dec 15;288(2):487-501. Epub 2005 Nov 16.PMID: 16297379 [PubMed - indexed for MEDLINE]Related articles

Genetic determinants of pancreatic epsilon-cell development.

Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P.

Dev Biol. 2005 Oct 1;286(1):217-24.PMID: 16122727 [PubMed - indexed for MEDLINE]Related articles

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.

Collombat P, Hecksher-Sørensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A.

Development. 2005 Jul;132(13):2969-80. Epub 2005 Jun 1.PMID: 15930104 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation of monoclonal antibodies against mouse neurogenin 3: a new immunocytochemical tool to study the pancreatic endocrine progenitor cell.

Zahn S, Hecksher-Sørensen J, Pedersen IL, Serup P, Madsen O.

Hybrid Hybridomics. 2004 Dec;23(6):385-8.PMID: 15684667 [PubMed - indexed for MEDLINE]Related articles

Artifactual insulin release from differentiated embryonic stem cells.

Hansson M, Tonning A, Frandsen U, Petri A, Rajagopal J, Englund MC, Heller RS, Håkansson J, Fleckner J, Sköld HN, Melton D, Semb H, Serup P.

Diabetes. 2004 Oct;53(10):2603-9.PMID: 15448090 [PubMed - indexed for MEDLINE]Related articlesFree article

The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2.

Hecksher-Sørensen J, Watson RP, Lettice LA, Serup P, Eley L, De Angelis C, Ahlgren U, Hill RE.

Development. 2004 Oct;131(19):4665-75. Epub 2004 Aug 25.PMID: 15329346 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity.

Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB 3rd, Madsen OD, Serup P.

Dev Biol. 2004 Apr 1;268(1):123-34.PMID: 15031110 [PubMed - indexed for MEDLINE]Related articles

Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas.

Heller RS, Klein T, Ling Z, Heimberg H, Katoh M, Madsen OD, Serup P.

Gene Expr. 2003;11(3-4):141-7.PMID: 14686787 [PubMed - indexed for MEDLINE]Related articles

Opposing actions of Arx and Pax4 in endocrine pancreas development.

Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P.

Genes Dev. 2003 Oct 15;17(20):2591-603.PMID: 14561778 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.

Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J.

Dev Biol. 2003 Aug 15;260(2):426-37.PMID: 12921743 [PubMed - indexed for MEDLINE]Related articles

Nestin is expressed in vascular endothelial cells in the adult human pancreas.

Klein T, Ling Z, Heimberg H, Madsen OD, Heller RS, Serup P.

J Histochem Cytochem. 2003 Jun;51(6):697-706.PMID: 12754281 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas.

Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P.

Dev Dyn. 2003 Apr;226(4):663-74.PMID: 12666204 [PubMed - indexed for MEDLINE]Related articlesFree article

Unspecific labeling of pancreatic islets by antisera against fibroblast growth factors and their receptors.

Dichmann DS, Rescan C, Frandsen U, Serup P.

J Histochem Cytochem. 2003 Mar;51(3):397-400.PMID: 12588967 [PubMed - indexed for MEDLINE]Related articlesFree article

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice.

Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, Charron MJ.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1438-43. Epub 2003 Jan 24.PMID: 12552113 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.

Heller RS, Dichmann DS, Jensen J, Miller C, Wong G, Madsen OD, Serup P.

Dev Dyn. 2002 Nov;225(3):260-70.PMID: 12412008 [PubMed - indexed for MEDLINE]Related articlesFree article

Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.

Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H.

J Cell Biol. 2002 Oct 28;159(2):303-12. Epub 2002 Oct 28.PMID: 12403815 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization.

Petersen HV, Jensen JN, Stein R, Serup P.

FEBS Lett. 2002 Sep 25;528(1-3):241-5.PMID: 12297313 [PubMed - indexed for MEDLINE]Related articles

The transcription factors CREB and c-Fos play key roles in NCAM-mediated neuritogenesis in PC12-E2 cells.

Jessen U, Novitskaya V, Pedersen N, Serup P, Berezin V, Bock E.

J Neurochem. 2001 Dec;79(6):1149-60.PMID: 11752056 [PubMed - indexed for MEDLINE]Related articles

IMPAN cells: a pancreatic model for differentiation into endocrine cells.

Klein T, Frandsen U, Heller RS, Serup P.

Arch Biochem Biophys. 2001 Nov 15;395(2):259-63.PMID: 11697865 [PubMed - indexed for MEDLINE]Related articles

Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas.

Heller RS, Stoffers DA, Bock T, Svenstrup K, Jensen J, Horn T, Miller CP, Habener JF, Madsen OD, Serup P.

Diabetes. 2001 Jul;50(7):1553-61.PMID: 11423476 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet and stem cell transplantation for treating diabetes.

Serup P, Madsen OD, Mandrup-Poulsen T.

BMJ. 2001 Jan 6;322(7277):29-32. Review. No abstract available. PMID: 11141151 [PubMed - indexed for MEDLINE]Related articlesFree article

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells.

Ammendrup A, Maillard A, Nielsen K, Aabenhus Andersen N, Serup P, Dragsbaek Madsen O, Mandrup-Poulsen T, Bonny C.

Diabetes. 2000 Sep;49(9):1468-76.PMID: 10969830 [PubMed - indexed for MEDLINE]Related articlesFree article

NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.

Hansen L, Jensen JN, Urioste S, Petersen HV, Pociot F, Eiberg H, Kristiansen OP, Hansen T, Serup P, Nerup J, Pedersen O.

Diabetes. 2000 May;49(5):876-8.PMID: 10905500 [PubMed - indexed for MEDLINE]Related articlesFree article

Pax4 represses pancreatic glucagon gene expression.

Petersen HV, Jørgensen MC, Andersen FG, Jensen J, F-Nielsen T, Jørgensen R, Madsen OD, Serup P.

Mol Cell Biol Res Commun. 2000 Apr;3(4):249-54.PMID: 10891400 [PubMed - indexed for MEDLINE]Related articles

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P.

Diabetes. 2000 Feb;49(2):163-76.PMID: 10868931 [PubMed - indexed for MEDLINE]Related articlesFree article

Panning for pancreatic stem cells.

Serup P.

Nat Genet. 2000 Jun;25(2):134-5. No abstract available. PMID: 10835620 [PubMed - indexed for MEDLINE]Related articles

Missense mutations in the human insulin promoter factor-1 gene and their relation to maturity-onset diabetes of the young and late-onset type 2 diabetes mellitus in caucasians.

Hansen L, Urioste S, Petersen HV, Jensen JN, Eiberg H, Barbetti F, Serup P, Hansen T, Pedersen O.

J Clin Endocrinol Metab. 2000 Mar;85(3):1323-6.PMID: 10720084 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of endodermal endocrine development by Hes-1.

Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD.

Nat Genet. 2000 Jan;24(1):36-44.PMID: 10615124 [PubMed - indexed for MEDLINE]Related articles

Beta-cell maturation leads to in vitro sensitivity to cytotoxins.

Nielsen K, Karlsen AE, Deckert M, Madsen OD, Serup P, Mandrup-Poulsen T, Nerup J.

Diabetes. 1999 Dec;48(12):2324-32.PMID: 10580420 [PubMed - indexed for MEDLINE]Related articlesFree article