PubMed

iNKT-cell control of Type-1 Diabetes: a Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette.

Driver JP, Scheuplein F, Chen YG, Grier AE, Wilson SB, Serreze DV.

Diabetes. 2009 Nov 10. [Epub ahead of print]PMID: 19903740 [PubMed - as supplied by publisher]Related articles

A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes.

Scheuplein F, Rissiek B, Driver JP, Chen YG, Koch-Nolte F, Serreze DV.

J Autoimmun. 2009 Sep 29. [Epub ahead of print]PMID: 19796917 [PubMed - as supplied by publisher]Related articles

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.

Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K, Urrutia M, Cauerhff A, Danquah W, Rissiek B, Scheuplein F, Schwarz N, Adriouch S, Boyer O, Seman M, Licea A, Serreze DV, Goldbaum FA, Haag F, Koch-Nolte F.

Med Microbiol Immunol. 2009 Aug;198(3):157-74. Epub 2009 Jun 16. Review.PMID: 19529959 [PubMed - indexed for MEDLINE]Related articlesFree article

Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.

Mangada J, Pearson T, Brehm MA, Wicker LS, Peterson LB, Shultz LD, Serreze DV, Rossini AA, Greiner DL.

Diabetes. 2009 Jan;58(1):165-73. Epub 2008 Nov 4.PMID: 18984741 [PubMed - indexed for MEDLINE]Related articlesFree article

Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.

Chen YG, Scheuplein F, Osborne MA, Tsaih SW, Chapman HD, Serreze DV.

Diabetes. 2008 Dec;57(12):3273-80. Epub 2008 Sep 5.PMID: 18776136 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells.

Chaparro RJ, Burton AR, Serreze DV, Vignali DA, DiLorenzo TP.

J Immunol Methods. 2008 Jun 1;335(1-2):106-15. Epub 2008 Apr 8.PMID: 18439618 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice.

Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y, Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6374-9. Epub 2008 Apr 22.PMID: 18430797 [PubMed - indexed for MEDLINE]Related articlesFree article

Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice.

Serreze DV, Choisy-Rossi CM, Grier AE, Holl TM, Chapman HD, Gahagan JR, Osborne MA, Zhang W, King BL, Brown A, Roopenian D, Marron MP.

J Immunol. 2008 Mar 1;180(5):3250-9.PMID: 18292549 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative therapeutic effects of orally administered 1,25-dihydroxyvitamin D(3) and 1alpha-hydroxyvitamin D(3) on type-1 diabetes in non-obese diabetic mice fed a normal-calcaemic diet.

Driver JP, Foreman O, Mathieu C, van Etten E, Serreze DV.

Clin Exp Immunol. 2008 Jan;151(1):76-85. Epub 2007 Nov 5.PMID: 17983444 [PubMed - indexed for MEDLINE]Related articlesFree article

Unexpected functional consequences of xenogeneic transgene expression in beta-cells of NOD mice.

Leiter EH, Reifsnyder P, Driver J, Kamdar S, Choisy-Rossi C, Serreze DV, Hara M, Chervonsky A.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:14-22.PMID: 17919174 [PubMed - indexed for MEDLINE]Related articles

In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice.

Jarchum I, Baker JC, Yamada T, Takaki T, Marron MP, Serreze DV, DiLorenzo TP.

Diabetes. 2007 Oct;56(10):2551-60. Epub 2007 Jul 9.PMID: 17620420 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice.

Chen YG, Driver JP, Silveira PA, Serreze DV.

Immunogenetics. 2007 Sep;59(9):705-12. Epub 2007 Jul 10.PMID: 17619875 [PubMed - indexed for MEDLINE]Related articles

Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.

Unger WW, Pinkse GG, Mulder-van der Kracht S, van der Slik AR, Kester MG, Ossendorp F, Drijfhout JW, Serreze DV, Roep BO.

Ann N Y Acad Sci. 2007 Apr;1103:192-5. Epub 2007 Mar 21.PMID: 17376840 [PubMed - indexed for MEDLINE]Related articles

"Humanized" HLA transgenic NOD mice to identify pancreatic beta cell autoantigens of potential clinical relevance to type 1 diabetes.

Serreze DV, Marron MP, Dilorenzo TP.

Ann N Y Acad Sci. 2007 Apr;1103:103-11. Epub 2007 Mar 21.PMID: 17376821 [PubMed - indexed for MEDLINE]Related articles

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P.

Nat Genet. 2007 Mar;39(3):329-37. Epub 2007 Feb 4.PMID: 17277778 [PubMed - indexed for MEDLINE]Related articles

Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype.

Chen YG, Silveira PA, Osborne MA, Chapman HD, Serreze DV.

Diabetes. 2007 Feb;56(2):424-30.PMID: 17259387 [PubMed - indexed for MEDLINE]Related articlesFree article

Invasion of the killer B's in type 1 diabetes.

Silveira PA, Serreze DV, Grey ST.

Front Biosci. 2007 Jan 1;12:2183-93. Review.PMID: 17127455 [PubMed - indexed for MEDLINE]Related articles

Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic mice.

Silveira PA, Chapman HD, Stolp J, Johnson E, Cox SL, Hunter K, Wicker LS, Serreze DV.

J Immunol. 2006 Nov 15;177(10):7033-41.PMID: 17082619 [PubMed - indexed for MEDLINE]Related articlesFree article

Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.

Serreze DV, Osborne MA, Chen YG, Chapman HD, Pearson T, Brehm MA, Greiner DL.

J Immunol. 2006 Nov 15;177(10):6675-84.PMID: 17082580 [PubMed - indexed for MEDLINE]Related articlesFree article

CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice.

Chen YG, Chen J, Osborne MA, Chapman HD, Besra GS, Porcelli SA, Leiter EH, Wilson SB, Serreze DV.

J Immunol. 2006 Sep 1;177(5):2939-47.PMID: 16920929 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.

Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH.

J Immunol. 2006 Apr 15;176(8):4590-9.PMID: 16585549 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.

Takaki T, Marron MP, Mathews CE, Guttmann ST, Bottino R, Trucco M, DiLorenzo TP, Serreze DV.

J Immunol. 2006 Mar 1;176(5):3257-65.PMID: 16493087 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.

Lee CH, Chen YG, Chen J, Reifsnyder PC, Serreze DV, Clare-Salzler M, Rodriguez M, Wasserfall C, Atkinson MA, Leiter EH.

Diabetes. 2006 Jan;55(1):171-8.PMID: 16380490 [PubMed - indexed for MEDLINE]Related articlesFree article

Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans.

Serreze DV, Chen YG.

Trends Immunol. 2005 Nov;26(11):603-7. Epub 2005 Sep 2. Review.PMID: 16140038 [PubMed - indexed for MEDLINE]Related articles

Rapid destruction of encapsulated islet xenografts by NOD mice is CD4-dependent and facilitated by B-cells: innate immunity and autoimmunity do not play significant roles.

Xu BY, Yang H, Serreze DV, MacIntosh R, Yu W, Wright JR Jr.

Transplantation. 2005 Aug 15;80(3):402-9.PMID: 16082337 [PubMed - indexed for MEDLINE]Related articles

Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice.

Reifsnyder PC, Li R, Silveira PA, Churchill G, Serreze DV, Leiter EH.

Genes Immun. 2005 Sep;6(6):528-38. Erratum in: Genes Immun. 2006 Mar;7(2):184. PMID: 16015371 [PubMed - indexed for MEDLINE]Related articles

Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex.

Pomerleau DP, Bagley RJ, Serreze DV, Mathews CE, Leiter EH.

Diabetes. 2005 May;54(5):1603-6.PMID: 15855353 [PubMed - indexed for MEDLINE]Related articlesFree article

The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice.

DiLorenzo TP, Serreze DV.

Immunol Rev. 2005 Apr;204:250-63. Review. Erratum in: Immunol Rev. 2005 Aug;206:336. PMID: 15790363 [PubMed - indexed for MEDLINE]Related articles

Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes.

Chen YG, Choisy-Rossi CM, Holl TM, Chapman HD, Besra GS, Porcelli SA, Shaffer DJ, Roopenian D, Wilson SB, Serreze DV.

J Immunol. 2005 Feb 1;174(3):1196-204.PMID: 15661873 [PubMed - indexed for MEDLINE]Related articlesFree article

Was there type 1 diabetes in the Olduvai Gorge?

Serreze DV, Roopenian DC.

Adv Exp Med Biol. 2004;552:322-5. Review. No abstract available. PMID: 15622973 [PubMed - indexed for MEDLINE]Related articles

Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.

Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP.

Diabetes. 2005 Jan;54(1):107-15.PMID: 15616017 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.

Serreze DV, Wasserfall C, Ottendorfer EW, Stalvey M, Pierce MA, Gauntt C, O'Donnell B, Flanagan JB, Campbell-Thompson M, Ellis TM, Atkinson MA.

J Virol. 2005 Jan;79(2):1045-52.PMID: 15613333 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11.6K.

Pierce MA, Svetlanov A, Horwitz MS, Serreze DV.

J Virol. 2005 Jan;79(1):619-21.PMID: 15596856 [PubMed - indexed for MEDLINE]Related articlesFree article

Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase.

Lieberman SM, Takaki T, Han B, Santamaria P, Serreze DV, DiLorenzo TP.

J Immunol. 2004 Dec 1;173(11):6727-34.PMID: 15557165 [PubMed - indexed for MEDLINE]Related articlesFree article

CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice.

Fallarino F, Bianchi R, Orabona C, Vacca C, Belladonna ML, Fioretti MC, Serreze DV, Grohmann U, Puccetti P.

J Exp Med. 2004 Oct 18;200(8):1051-62.PMID: 15492127 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.

Choisy-Rossi CM, Holl TM, Pierce MA, Chapman HD, Serreze DV.

J Immunol. 2004 Sep 15;173(6):3791-800.PMID: 15356126 [PubMed - indexed for MEDLINE]Related articlesFree article

Requirement for both H-2Db and H-2Kd for the induction of diabetes by the promiscuous CD8+ T cell clonotype AI4.

Takaki T, Lieberman SM, Holl TM, Han B, Santamaria P, Serreze DV, DiLorenzo TP.

J Immunol. 2004 Aug 15;173(4):2530-41.PMID: 15294969 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.

Pearson T, Weiser P, Markees TG, Serreze DV, Wicker LS, Peterson LB, Cumisky AM, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Diabetes. 2004 Aug;53(8):1972-8.PMID: 15277375 [PubMed - indexed for MEDLINE]Related articlesFree article

B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice.

Silveira PA, Dombrowsky J, Johnson E, Chapman HD, Nemazee D, Serreze DV.

J Immunol. 2004 Apr 15;172(8):5086-94.PMID: 15067092 [PubMed - indexed for MEDLINE]Related articlesFree article

MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice.

Serreze DV, Holl TM, Marron MP, Graser RT, Johnson EA, Choisy-Rossi C, Slattery RM, Lieberman SM, DiLorenzo TP.

J Immunol. 2004 Jan 15;172(2):871-9.PMID: 14707058 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?

Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2003 Nov;1005:148-56.PMID: 14679049 [PubMed - indexed for MEDLINE]Related articles

Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress.

Mathews CE, Graser RT, Bagley RJ, Caldwell JW, Li R, Churchill GA, Serreze DV, Leiter EH.

Immunogenetics. 2003 Oct;55(7):491-6. Epub 2003 Sep 25.PMID: 14513297 [PubMed - indexed for MEDLINE]Related articles

Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.

Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Rev Endocr Metab Disord. 2003 Sep;4(3):255-61. Review. No abstract available. PMID: 14501176 [PubMed - indexed for MEDLINE]Related articles

Tracking autoimmune T cells in diabetes.

Serreze DV, Leiter EH.

J Clin Invest. 2003 Sep;112(6):826-8.PMID: 12975466 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.

Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

J Immunol. 2003 Jul 1;171(1):185-95.PMID: 12816997 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA, Serreze DV, Shabanowitz J, Hunt DF, Nathenson SG, Santamaria P, DiLorenzo TP.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8384-8. Epub 2003 Jun 18.PMID: 12815107 [PubMed - indexed for MEDLINE]Related articlesFree article

By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma.

Mo JS, Anderson MG, Gregory M, Smith RS, Savinova OV, Serreze DV, Ksander BR, Streilein JW, John SW.

J Exp Med. 2003 May 19;197(10):1335-44.PMID: 12756269 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice.

Pierce MA, Chapman HD, Post CM, Svetlanov A, Efrat S, Horwitz M, Serreze DV.

Diabetes. 2003 May;52(5):1119-27.PMID: 12716741 [PubMed - indexed for MEDLINE]Related articlesFree article

Paralytic autoimmune myositis develops in nonobese diabetic mice made Th1 cytokine-deficient by expression of an IFN-gamma receptor beta-chain transgene.

Serreze DV, Pierce MA, Post CM, Chapman HD, Savage H, Bronson RT, Rothman PB, Cox GA.

J Immunol. 2003 Mar 1;170(5):2742-9.PMID: 12594305 [PubMed - indexed for MEDLINE]Related articlesFree article

NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.

Pearson T, Markees TG, Wicker LS, Serreze DV, Peterson LB, Mordes JP, Rossini AA, Greiner DL.

Diabetes. 2003 Feb;52(2):321-6.PMID: 12540603 [PubMed - indexed for MEDLINE]Related articlesFree article