PubMed

Antigen processing patterns determine GAD65-specific regulation vs. pathogenesis.

Dai YD, Sercarz EE.

Front Biosci. 2009 Jan 1;14:344-51. Review.PMID: 19273071 [PubMed - indexed for MEDLINE]Related articles

Altered peptide ligands can modify the Th2 T cell response to the immunodominant 161-175 peptide of LACK (Leishmania homolog for the receptor of activated C kinase).

Jensen KD, Sercarz EE, Gabaglia CR.

Mol Immunol. 2009 Jan;46(3):366-74. Epub 2008 Nov 29.PMID: 19042022 [PubMed - indexed for MEDLINE]Related articles

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens.

Dai YD, Marrero IG, Gros P, Zaghouani H, Wicker LS, Sercarz EE.

Diabetes. 2009 Jan;58(1):156-64. Epub 2008 Nov 4.PMID: 18984740 [PubMed - indexed for MEDLINE]Related articlesFree article

Administration of PLP139-151 primes T cells distinct from those spontaneously responsive in vitro to this antigen.

Penitente R, Nicolò C, Van den Elzen P, Di Sante G, Agrati C, Aloisi F, Sercarz EE, Ria F.

J Immunol. 2008 May 15;180(10):6611-22.PMID: 18453580 [PubMed - indexed for MEDLINE]Related articlesFree article

N-terminal flanking residues of a diabetes-associated GAD65 determinant are necessary for activation of antigen-specific T cells in diabetes-resistant mice.

Dai YD, Jensen KP, Marrero I, Li N, Quinn A, Sercarz EE.

Eur J Immunol. 2008 Apr;38(4):968-76.PMID: 18395850 [PubMed - indexed for MEDLINE]Related articles

Presentation of a determinant by MHC class II can be prevented through competitive capture by a flanking determinant on a multideterminant peptide.

Maverakis E, Beech JT, Schneider S, Sercarz EE.

J Autoimmun. 2008 Aug;31(1):59-65. Epub 2008 Apr 2.PMID: 18375101 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunodominance in the TCR repertoire of a [corrected] TCR peptide-specific CD4+ Treg population that controls experimental autoimmune encephalomyelitis.

Madakamutil LT, Maricic I, Sercarz EE, Kumar V.

J Immunol. 2008 Apr 1;180(7):4577-85. Erratum in: J Immunol. 2008 May 15;180(10):7048. PMID: 18354180 [PubMed - indexed for MEDLINE]Related articlesFree article

On the pathogenicity of autoantigen-specific T-cell receptors.

Burton AR, Vincent E, Arnold PY, Lennon GP, Smeltzer M, Li CS, Haskins K, Hutton J, Tisch RM, Sercarz EE, Santamaria P, Workman CJ, Vignali DA.

Diabetes. 2008 May;57(5):1321-30. Epub 2008 Feb 25.PMID: 18299317 [PubMed - indexed for MEDLINE]Related articlesFree article

A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE.

Menezes JS, van den Elzen P, Thornes J, Huffman D, Droin NM, Maverakis E, Sercarz EE.

J Clin Invest. 2007 Aug;117(8):2176-85.PMID: 17627303 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyspecificity of T cell and B cell receptor recognition.

Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, Strong RK, Sercarz EE.

Semin Immunol. 2007 Aug;19(4):216-24. Epub 2007 Mar 29. Review.PMID: 17398114 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation of the glucocorticoid response during Ad5IL-12 adenovirus vector treatment enhances natural killer cell-mediated killing of MHC class I-negative LNCaP prostate tumors.

Raja Gabaglia C, Diaz de Durana Y, Graham FL, Gauldie J, Sercarz EE, Braciak TA.

Cancer Res. 2007 Mar 1;67(5):2290-7.PMID: 17332360 [PubMed - indexed for MEDLINE]Related articlesFree article

TAP1-/- mice present oligoclonal BV-BJ expansions following the rejection of grafts bearing self antigens.

Marrero I, Huffman D, Kalil J, Sercarz EE, Coelho V.

Immunology. 2006 Aug;118(4):461-71.PMID: 16895555 [PubMed - indexed for MEDLINE]Related articlesFree article

A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas.

Dai YD, Jensen KP, Lehuen A, Masteller EL, Bluestone JA, Wilson DB, Sercarz EE.

J Immunol. 2005 Sep 15;175(6):3621-7.PMID: 16148106 [PubMed - indexed for MEDLINE]Related articlesFree article

Understanding crypticity is the key to revealing the pathogenesis of autoimmunity.

Moudgil KD, Sercarz EE.

Trends Immunol. 2005 Jul;26(7):355-9. Review.PMID: 15922666 [PubMed - indexed for MEDLINE]Related articles

Limited clonality in autoimmunity: drivers and regulators.

van den Elzen P, Menezes JS, Ametani A, Maverakis E, Madakamutil L, Tang XL, Kumar V, Sercarz EE.

Autoimmun Rev. 2004 Nov;3(7-8):524-9.PMID: 15546801 [PubMed - indexed for MEDLINE]Related articles

Life-long systemic protection in mice vaccinated with L. major and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes.

Gabaglia CR, Sercarz EE, Diaz-De-Durana Y, Hitt M, Graham FL, Gauldie J, Braciak TA.

Vaccine. 2004 Nov 25;23(2):247-57.PMID: 15531044 [PubMed - indexed for MEDLINE]Related articles

Mouse lysozyme-M knockout mice reveal how the self-determinant hierarchy shapes the T cell repertoire against this circulating self antigen in wild-type mice.

Sinha P, Chi HH, Kim HR, Clausen BE, Pederson B, Sercarz EE, Forster I, Moudgil KD.

J Immunol. 2004 Aug 1;173(3):1763-71.PMID: 15265906 [PubMed - indexed for MEDLINE]Related articlesFree article

Vaccination with an immunodominant peptide of bovine type II collagen induces an anti-TCR response, and modulates the onset and severity of collagen-induced arthritis.

Honda A, Ametani A, Matsumoto T, Iwaya A, Kano H, Hachimura S, Ohkawa K, Kaminogawa S, Suzuki K, Sercarz EE, Kumar V.

Int Immunol. 2004 May;16(5):737-45. Epub 2004 Mar 29.PMID: 15096482 [PubMed - indexed for MEDLINE]Related articlesFree article

Recognition and function in a degenerate immune system.

Sercarz EE, Maverakis E.

Mol Immunol. 2004 Feb;40(14-15):1003-8. Review.PMID: 15036903 [PubMed - indexed for MEDLINE]Related articles

Selection of similar naive T cell repertoires but induction of distinct T cell responses by native and modified antigen.

Ria F, Gallard A, Gabaglia CR, Guéry JC, Sercarz EE, Adorini L.

J Immunol. 2004 Mar 15;172(6):3447-53.PMID: 15004144 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular profile of the T cell receptors of regulatory and effector CD4+ T cells recognizing overlapping determinants on glutamic acid decarboxylase (524-543).

Im JS, Quinn A, Sercarz EE, Lake DF.

Mol Immunol. 2004 Feb;40(13):971-80.PMID: 14725793 [PubMed - indexed for MEDLINE]Related articles

Nasal instillation of gpMBP can exacerbate murine EAE: effect of mucosal priming is an age-dependent phenomenon.

Melo ME, Stevens DB, Sercarz EE, Gabaglia CR.

J Autoimmun. 2004 Feb;22(1):13-20.PMID: 14709409 [PubMed - indexed for MEDLINE]Related articles

Mhc-guided processing: binding of large antigen fragments.

Sercarz EE, Maverakis E.

Nat Rev Immunol. 2003 Aug;3(8):621-9. Review. Erratum in: Nat Rev Immunol. 2003 Oct;3(10):839. PMID: 12974477 [PubMed - indexed for MEDLINE]Related articles

Arraying autoimmunity treatment.

Sercarz EE.

Nat Biotechnol. 2003 Sep;21(9):1017-9. No abstract available. PMID: 12949565 [PubMed - indexed for MEDLINE]Related articles

Large antigens such as GAD-65 become involved in pathogenic self-reactivity, but fortunately only rarely.

Sercarz EE.

J Autoimmun. 2003 May;20(3):203-6. No abstract available. PMID: 12753804 [PubMed - indexed for MEDLINE]Related articles

Regulator T cells: specific for antigen and/or antigen receptors?

Rubin B, de Durana YD, Li N, Sercarz EE.

Scand J Immunol. 2003 May;57(5):399-409. Review.PMID: 12753496 [PubMed - indexed for MEDLINE]Related articles

Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC.

Maverakis E, Beech J, Stevens DB, Ametani A, Brossay L, van den Elzen P, Mendoza R, Thai Q, Macias LH, Ethell D, Campagnoni CW, Campagnoni AT, Sette A, Sercarz EE.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5342-7. Epub 2003 Apr 21.PMID: 12707414 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the V beta 8.2 TCR is disrupted by coadministration with vectors expressing either IL-4 or -10.

Braciak TA, Pedersen B, Chin J, Hsiao C, Ward ES, Maricic I, Jahng A, Graham FL, Gauldie J, Sercarz EE, Kumar V.

J Immunol. 2003 Jan 15;170(2):765-74.PMID: 12517939 [PubMed - indexed for MEDLINE]Related articlesFree article

Strain-dependent effect of nasal instillation of antigen on the immune response in mice.

Melo ME, Gabaglia CR, Moudgil KD, Sercarz EE, Quinn A.

Isr Med Assoc J. 2002 Nov;4(11 Suppl):902-7.PMID: 12455176 [PubMed - indexed for MEDLINE]Related articlesFree article

The Wistar Kyoto (RT1(l)) rat is resistant to myelin basic protein-induced experimental autoimmune encephalomyelitis: comparison with the susceptible Lewis (RT1(l)) strain with regard to the MBP-directed CD4+ T cell repertoire and its regulation.

Stevens DB, Gold DP, Sercarz EE, Moudgil KD.

J Neuroimmunol. 2002 May;126(1-2):25-36.PMID: 12020954 [PubMed - indexed for MEDLINE]Related articles

Molecular characterization of the T cell repertoire using immunoscope analysis and its possible implementation in clinical practice.

Ria F, van den Elzen P, Madakamutil LT, Miller JE, Maverakis E, Sercarz EE.

Curr Mol Med. 2001 Jul;1(3):297-304. Review.PMID: 11899078 [PubMed - indexed for MEDLINE]Related articles

Processing creates the self.

Sercarz EE.

Nat Immunol. 2002 Feb;3(2):110-2. No abstract available. PMID: 11812983 [PubMed - indexed for MEDLINE]Related articles

Relative resistance to nasally induced tolerance in non-obese diabetic mice but not other I-A(g7)-expressing mouse strains.

Quinn A, Melo M, Ethell D, Sercarz EE.

Int Immunol. 2001 Oct;13(10):1321-33.PMID: 11581177 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions of effectors and regulators are decisive in the manifestations of type 1 diabetes in nonobese diabetic mice.

Quinn A, Kumar V, Jensen KP, Sercarz EE.

Curr Dir Autoimmun. 2001;4:171-92. Review. No abstract available. PMID: 11569402 [PubMed - indexed for MEDLINE]Related articles

MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity.

Quinn A, McInerney MF, Sercarz EE.

J Immunol. 2001 Aug 1;167(3):1748-57.PMID: 11466400 [PubMed - indexed for MEDLINE]Related articlesFree article

Self-reactive T cells and degeneracy of T cell recognition: evolving concepts-from sequence homology to shape mimicry and TCR flexibility.

Maverakis E, van den Elzen P, Sercarz EE.

J Autoimmun. 2001 May;16(3):201-9. Review. No abstract available. PMID: 11334484 [PubMed - indexed for MEDLINE]Related articles

The self-directed T cell repertoire: its creation and activation.

Moudgil KD, Sercarz EE.

Rev Immunogenet. 2000;2(1):26-37. Review.PMID: 11324691 [PubMed - indexed for MEDLINE]Related articles

Environmental modulation of autoimmune arthritis involves the spontaneous microbial induction of T cell responses to regulatory determinants within heat shock protein 65.

Moudgil KD, Kim E, Yun OJ, Chi HH, Brahn E, Sercarz EE.

J Immunol. 2001 Mar 15;166(6):4237-43. Erratum in: J Immunol 2001 Jun 1;166(11):6992. PMID: 11238677 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct V beta genes.

Quinn A, McInerney B, Reich EP, Kim O, Jensen KP, Sercarz EE.

J Immunol. 2001 Mar 1;166(5):2982-91.PMID: 11207247 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunogenicity of self antigens is unrelated to MHC-binding affinity: T-cell determinant structure of Golli-MBP in the BALB/c mouse.

Maverakis E, Mendoza R, Southwood S, Raja-Gabaglia C, Abromson-Leeman S, Campagnoni AT, Sette A, Sercarz EE.

J Autoimmun. 2000 Nov;15(3):315-22.PMID: 11040072 [PubMed - indexed for MEDLINE]Related articles

Driver clones and determinant spreading.

Sercarz EE.

J Autoimmun. 2000 Jun;14(4):275-7. Review. No abstract available. PMID: 10882052 [PubMed - indexed for MEDLINE]Related articles

Cutting edge: introduction of an endopeptidase cleavage motif into a determinant flanking region of hen egg lysozyme results in enhanced T cell determinant display.

Schneider SC, Ohmen J, Fosdick L, Gladstone B, Guo J, Ametani A, Sercarz EE, Deng H.

J Immunol. 2000 Jul 1;165(1):20-3.PMID: 10861030 [PubMed - indexed for MEDLINE]Related articlesFree article

Residual public repertoires to self.

Wilson SS, van den Elzen P, Maverakis E, Beech JT, Braciak TA, Kumar V, Sercarz EE.

J Neuroimmunol. 2000 Jul 24;107(2):233-9. Review.PMID: 10854662 [PubMed - indexed for MEDLINE]Related articles

T cell receptor complementarity determining region 3 length analysis reveals the absence of a characteristic public T cell repertoire in neonatal tolerance. The response in the "tolerant" mouse within the residual repertoire is quantitatively similar but qualitatively different.

Maverakis E, Beech JT, Wilson SS, Quinn A, Pedersen B, Sercarz EE.

J Exp Med. 2000 Feb 21;191(4):695-702.PMID: 10684861 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing and reactivity of T cell epitopes containing two cysteine residues from hen egg-white lysozyme (HEL74-90).

Kang HK, Mikszta JA, Deng H, Sercarz EE, Jensen PE, Kim BS.

J Immunol. 2000 Feb 15;164(4):1775-82.PMID: 10657624 [PubMed - indexed for MEDLINE]Related articlesFree article

The self-directed T cell repertoire against mouse lysozyme reflects the influence of the hierarchy of its own determinants and can be engaged by a foreign lysozyme.

Moudgil KD, Southwood S, Ametani A, Kim K, Sette A, Sercarz EE.

J Immunol. 1999 Oct 15;163(8):4232-7.PMID: 10510360 [PubMed - indexed for MEDLINE]Related articlesFree article

Oligodendrocyte-specific protein peptides induce experimental autoimmune encephalomyelitis in SJL/J mice.

Stevens DB, Chen K, Seitz RS, Sercarz EE, Bronstein JM.

J Immunol. 1999 Jun 15;162(12):7501-9.PMID: 10358205 [PubMed - indexed for MEDLINE]Related articlesFree article

A single intramuscular injection with an adenovirus-expressing IL-12 protects BALB/c mice against Leishmania major infection, while treatment with an IL-4-expressing vector increases disease susceptibility in B10.D2 mice.

Gabaglia CR, Pedersen B, Hitt M, Burdin N, Sercarz EE, Graham FL, Gauldie J, Braciak TA.

J Immunol. 1999 Jan 15;162(2):753-60.PMID: 9916695 [PubMed - indexed for MEDLINE]Related articlesFree article

Heterogeneity of the T cell response to immunodominant determinants within hen eggwhite lysozyme of individual syngeneic hybrid F1 mice: implications for autoimmunity and infection.

Moudgil KD, Wang J, Yeung VP, Sercarz EE.

J Immunol. 1998 Dec 1;161(11):6046-53.PMID: 9834087 [PubMed - indexed for MEDLINE]Related articlesFree article

Recognition of prostate-specific antigenic peptide determinants by human CD4 and CD8 T cells.

Corman JM, Sercarz EE, Nanda NK.

Clin Exp Immunol. 1998 Nov;114(2):166-72.PMID: 9822272 [PubMed - indexed for MEDLINE]Related articlesFree article