PubMed

Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.

Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, Semenkovich CF.

Cell. 2009 Aug 7;138(3):476-88. Epub 2009 Jul 30.PMID: 19646743 [PubMed - indexed for MEDLINE]Related articles

Calpain-10 is a component of the obesity-related quantitative trait locus, Adip1.

Cheverud JM, Fawcett GL, Jarvis JP, Norgard EA, Pavlicev M, Pletscher LS, Polonsky KS, Ye H, Bell GI, Semenkovich CF.

J Lipid Res. 2009 May 12. [Epub ahead of print]PMID: 19436065 [PubMed - as supplied by publisher]Related articlesFree article

Getting away from glucose: stop sugarcoating diabetes.

Razani B, Semenkovich CF.

Nat Med. 2009 Apr;15(4):372-3. No abstract available. PMID: 19350008 [PubMed - indexed for MEDLINE]Related articles

Why we should put clothes on mice.

Lodhi IJ, Semenkovich CF.

Cell Metab. 2009 Feb;9(2):111-2.PMID: 19187768 [PubMed - indexed for MEDLINE]Related articles

Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation.

Chakravarthy MV, Zhu Y, Yin L, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF.

J Lipid Res. 2009 Apr;50(4):630-40. Epub 2008 Nov 22.PMID: 19029118 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance and atherosclerosis.

Razani B, Chakravarthy MV, Semenkovich CF.

Endocrinol Metab Clin North Am. 2008 Sep;37(3):603-21, viii. Review.PMID: 18775354 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models.

Newberry EP, Kennedy SM, Xie Y, Luo J, Stanley SE, Semenkovich CF, Crooke RM, Graham MJ, Davidson NO.

Hepatology. 2008 Oct;48(4):1097-105.PMID: 18697204 [PubMed - indexed for MEDLINE]Related articlesFree article

Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury.

Proctor BM, Jin X, Lupu TS, Muglia LJ, Semenkovich CF, Muslin AJ.

Circulation. 2008 Aug 5;118(6):658-66. Epub 2008 Jul 21.PMID: 18645058 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age.

Chakravarthy MV, Zhu Y, Wice MB, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF.

Diabetes. 2008 Oct;57(10):2698-707. Epub 2008 Jun 30.PMID: 18591393 [PubMed - indexed for MEDLINE]Related articlesFree article

Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking.

Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS.

J Clin Invest. 2008 Jun;118(6):2281-90.PMID: 18483620 [PubMed - indexed for MEDLINE]Related articlesFree article

Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease.

Gates AC, Bernal-Mizrachi C, Chinault SL, Feng C, Schneider JG, Coleman T, Malone JP, Townsend RR, Chakravarthy MV, Semenkovich CF.

Cell Metab. 2007 Dec;6(6):497-505.PMID: 18054318 [PubMed - indexed for MEDLINE]Related articles

Macrophage beta3 integrin suppresses hyperlipidemia-induced inflammation by modulating TNFalpha expression.

Schneider JG, Zhu Y, Coleman T, Semenkovich CF.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2699-706. Epub 2007 Oct 19. Erratum in: Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):e12. PMID: 17951320 [PubMed - indexed for MEDLINE]Related articlesFree article

Lysosomal dysfunction results in altered energy balance.

Woloszynek JC, Coleman T, Semenkovich CF, Sands MS.

J Biol Chem. 2007 Dec 7;282(49):35765-71. Epub 2007 Oct 2.PMID: 17911106 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of peroxisome proliferator-activated receptor-alpha abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse.

Tordjman KM, Semenkovich CF, Coleman T, Yudovich R, Bak S, Osher E, Vechoropoulos M, Stern N.

Hypertension. 2007 Nov;50(5):945-51. Epub 2007 Oct 1.PMID: 17909121 [PubMed - indexed for MEDLINE]Related articlesFree article

Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase.

Gustafsson M, Levin M, Skålén K, Perman J, Fridén V, Jirholt P, Olofsson SO, Fazio S, Linton MF, Semenkovich CF, Olivecrona G, Borén J.

Circ Res. 2007 Oct 12;101(8):777-83. Epub 2007 Aug 30.PMID: 17761930 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF.

Circulation. 2007 Sep 18;116(12):1404-12. Epub 2007 Aug 27.PMID: 17724261 [PubMed - indexed for MEDLINE]Related articlesFree article

Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis.

Chakravarthy MV, Zhu Y, López M, Yin L, Wozniak DF, Coleman T, Hu Z, Wolfgang M, Vidal-Puig A, Lane MD, Semenkovich CF.

J Clin Invest. 2007 Sep;117(9):2539-52.PMID: 17694178 [PubMed - indexed for MEDLINE]Related articlesFree article

Bone weighs in on obesity.

Semenkovich CF, Teitelbaum SL.

Cell. 2007 Aug 10;130(3):409-11. Review.PMID: 17693252 [PubMed - indexed for MEDLINE]Related articles

Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.

Bao S, Li Y, Lei X, Wohltmann M, Jin W, Bohrer A, Semenkovich CF, Ramanadham S, Tabas I, Turk J.

J Biol Chem. 2007 Sep 14;282(37):27100-14. Epub 2007 Jul 12.PMID: 17627946 [PubMed - indexed for MEDLINE]Related articlesFree article

Grb2 is required for atherosclerotic lesion formation.

Proctor BM, Ren J, Chen Z, Schneider JG, Coleman T, Lupu TS, Semenkovich CF, Muslin AJ.

Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1361-7. Epub 2007 Mar 15.PMID: 17363695 [PubMed - indexed for MEDLINE]Related articlesFree article

The ABCs of beta-cell dysfunction in type 2 diabetes.

Chakravarthy MV, Semenkovich CF.

Nat Med. 2007 Mar;13(3):241-2. No abstract available. PMID: 17342111 [PubMed - indexed for MEDLINE]Related articles

An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension.

Bernal-Mizrachi C, Xiaozhong L, Yin L, Knutsen RH, Howard MJ, Arends JJ, Desantis P, Coleman T, Semenkovich CF.

Cell Metab. 2007 Feb;5(2):91-102.PMID: 17276352 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice.

Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):979-84. Epub 2007 Jan 8.PMID: 17210919 [PubMed - indexed for MEDLINE]Related articlesFree article

ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.

Schneider JG, Finck BN, Ren J, Standley KN, Takagi M, Maclean KH, Bernal-Mizrachi C, Muslin AJ, Kastan MB, Semenkovich CF.

Cell Metab. 2006 Nov;4(5):377-89.PMID: 17084711 [PubMed - indexed for MEDLINE]Related articles

PPARalpha activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans.

Subramanian S, DeRosa MA, Bernal-Mizrachi C, Laffely N, Cade WT, Yarasheski KE, Cryer PE, Semenkovich CF.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1365-71. Epub 2006 Jul 25.PMID: 16868225 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance and atherosclerosis.

Semenkovich CF.

J Clin Invest. 2006 Jul;116(7):1813-22. Review.PMID: 16823479 [PubMed - indexed for MEDLINE]Related articlesFree article

Fast predators or fast food, the fit still survive.

Bernal-Mizrachi C, Semenkovich CF.

Nat Med. 2006 Jan;12(1):46-7; discussion 47. No abstract available. PMID: 16397564 [PubMed - indexed for MEDLINE]Related articles

PPARalpha: savior or savage?

Schneider JG, Semenkovich CF.

Cell Metab. 2005 Dec;2(6):341-2. No abstract available. PMID: 16330317 [PubMed - indexed for MEDLINE]Related articles

Targeted intestinal overexpression of the immediate early gene tis7 in transgenic mice increases triglyceride absorption and adiposity.

Wang Y, Iordanov H, Swietlicki EA, Wang L, Fritsch C, Coleman T, Semenkovich CF, Levin MS, Rubin DC.

J Biol Chem. 2005 Oct 14;280(41):34764-75. Epub 2005 Aug 5.PMID: 16085642 [PubMed - indexed for MEDLINE]Related articlesFree article

TZDs and diabetes: testing the waters.

Semenkovich CF.

Nat Med. 2005 Aug;11(8):822-4. No abstract available. PMID: 16079871 [PubMed - indexed for MEDLINE]Related articles

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis.

Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J, Semenkovich CF.

Cell Metab. 2005 May;1(5):309-22.PMID: 16054078 [PubMed - indexed for MEDLINE]Related articles

A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.

Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP.

Cell Metab. 2005 Feb;1(2):133-44.PMID: 16054054 [PubMed - indexed for MEDLINE]Related articles

Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity.

Ehrich TH, Hrbek T, Kenney-Hunt JP, Pletscher LS, Wang B, Semenkovich CF, Cheverud JM.

Diabetes. 2005 Jun;54(6):1863-72.PMID: 15919810 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular respiratory uncoupling increases blood pressure and atherosclerosis.

Bernal-Mizrachi C, Gates AC, Weng S, Imamura T, Knutsen RH, DeSantis P, Coleman T, Townsend RR, Muglia LJ, Semenkovich CF.

Nature. 2005 May 26;435(7041):502-6.PMID: 15917810 [PubMed - indexed for MEDLINE]Related articles

Maternal genotype affects adult offspring lipid, obesity, and diabetes phenotypes in LGXSM recombinant inbred strains.

Jarvis JP, Kenney-Hunt J, Ehrich TH, Pletscher LS, Semenkovich CF, Cheverud JM.

J Lipid Res. 2005 Aug;46(8):1692-702. Epub 2005 May 16.PMID: 15897602 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in thigh subcutaneous adipose tissue gene expression in protease inhibitor-based highly active antiretroviral therapy.

Chaparro J, Reeds DN, Wen W, Xueping E, Klein S, Semenkovich CF, Bae KT, Quirk EK, Powderly WG, Yarasheski KE, Li E.

Metabolism. 2005 May;54(5):561-7.PMID: 15877283 [PubMed - indexed for MEDLINE]Related articlesFree article

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP.

PLoS Biol. 2005 Apr;3(4):e101. Epub 2005 Mar 15.PMID: 15760270 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion.

Pappan KL, Pan Z, Kwon G, Marshall CA, Coleman T, Goldberg IJ, McDaniel ML, Semenkovich CF.

J Biol Chem. 2005 Mar 11;280(10):9023-9. Epub 2005 Jan 6.PMID: 15637076 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains.

Cheverud JM, Ehrich TH, Hrbek T, Kenney JP, Pletscher LS, Semenkovich CF.

Diabetes. 2004 Dec;53(12):3328-36.PMID: 15561968 [PubMed - indexed for MEDLINE]Related articlesFree article

The gut microbiota as an environmental factor that regulates fat storage.

Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI.

Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23. Epub 2004 Oct 25.PMID: 15505215 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains.

Cheverud JM, Ehrich TH, Kenney JP, Pletscher LS, Semenkovich CF.

Diabetes. 2004 Oct;53(10):2700-8.PMID: 15448104 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid metabolism and vascular disease.

Semenkovich CF.

Trends Cardiovasc Med. 2004 Feb;14(2):72-6. Review.PMID: 15030793 [PubMed - indexed for MEDLINE]Related articles

Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII.

Woloszynek JC, Roberts M, Coleman T, Vogler C, Sly W, Semenkovich CF, Sands MS.

Biochem J. 2004 Apr 15;379(Pt 2):461-9.PMID: 14705966 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association.

Nesto RW, Bell D, Bonow RO, Fonseca V, Grundy SM, Horton ES, Le Winter M, Porte D, Semenkovich CF, Smith S, Young LH, Kahn R.

Diabetes Care. 2004 Jan;27(1):256-63. Review. No abstract available. PMID: 14693998 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003.

Nesto RW, Bell D, Bonow RO, Fonseca V, Grundy SM, Horton ES, Le Winter M, Porte D, Semenkovich CF, Smith S, Young LH, Kahn R; American Heart Association; American Diabetes Association.

Circulation. 2003 Dec 9;108(23):2941-8. Review. No abstract available. PMID: 14662691 [PubMed - indexed for MEDLINE]Related articlesFree article

UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction.

Han DH, Nolte LA, Ju JS, Coleman T, Holloszy JO, Semenkovich CF.

Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E347-53. Epub 2003 Nov 12.PMID: 14613927 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk.

Grenache DG, Coleman T, Semenkovich CF, Santoro SA, Zutter MM.

Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2104-9. Epub 2003 Sep 25.PMID: 14512368 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity.

Baar K, Song Z, Semenkovich CF, Jones TE, Han DH, Nolte LA, Ojuka EO, Chen M, Holloszy JO.

FASEB J. 2003 Sep;17(12):1666-73.PMID: 12958173 [PubMed - indexed for MEDLINE]Related articlesFree article

Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice.

Bernal-Mizrachi C, Weng S, Feng C, Finck BN, Knutsen RH, Leone TC, Coleman T, Mecham RP, Kelly DP, Semenkovich CF.

Nat Med. 2003 Aug;9(8):1069-75. Epub 2003 Jul 6.PMID: 12847522 [PubMed - indexed for MEDLINE]Related articles

Visceral adiposity, C-peptide levels, and low lipase activities predict HIV-dyslipidemia.

Yarasheski KE, Tebas P, Claxton S, Marin D, Coleman T, Powderly WG, Semenkovich CF.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E899-905. Epub 2003 Jul 1.PMID: 12837664 [PubMed - indexed for MEDLINE]Related articlesFree article